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Ripened and Revamped-Adult T Cell Leukaemia/ Lymphoma 成熟和改造的成人T细胞白血病/淋巴瘤
2区 医学
Journal of Pathology Clinical Research Pub Date : 2023-01-01 DOI: 10.23880/cprj-16000151
Anubha Bajaj
{"title":"Ripened and Revamped-Adult T Cell Leukaemia/ Lymphoma","authors":"Anubha Bajaj","doi":"10.23880/cprj-16000151","DOIUrl":"https://doi.org/10.23880/cprj-16000151","url":null,"abstract":"Adult T cell leukaemia/ lymphoma is an aggressive T cell malignant disorder comprised of significantly pleomorphic, miniature to intermediate, mature CD4+ T cells. Factors such as demographic distribution within HTLV1 endemic zones, hypercalcemia, cutaneous lesions and a leukemic phase contribute to disease emergence. Adult T cell leukaemia/ lymphoma incriminates peripheral blood, lymph nodes, spleen, cutaneous surfaces, pulmonary or hepatic parenchyma, gastrointestinal tract and central nervous system. Bone marrow may demonstrate diffuse, interstitial or sinusoidal pattern of neoplastic occurrence. Generally, tumour cells are permeated with basophilic cytoplasm, absent intracytoplasmic granules, irregular or poly-lobulated nuclei with homogeneous, condensed nuclear chromatin and miniature nucleoli.","PeriodicalId":48612,"journal":{"name":"Journal of Pathology Clinical Research","volume":"735 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135550315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oral & Maxillofacial Space Infections-A 10-Year Retrospective Study 口服,颌面部间隙感染的10年回顾性研究
2区 医学
Journal of Pathology Clinical Research Pub Date : 2023-01-01 DOI: 10.23880/cprj-16000153
Ashok Kumar
{"title":"Oral & Maxillofacial Space Infections-A 10-Year Retrospective Study","authors":"Ashok Kumar","doi":"10.23880/cprj-16000153","DOIUrl":"https://doi.org/10.23880/cprj-16000153","url":null,"abstract":"Oral & Maxillofacial space infections have been recognized since the time of Galen in the second century. In spite of great advances in health care, these infections remain a major problem. Oral & Maxillofacial space infection ranges from periapical abscess to superficial and deep neck infections. The infections generally follow the path of least resistance through connective tissue and along fascial planes [1]. The infections spread to distant sites from the site of origin. Oral & Maxillofacial infections can be potentially lethal infections, at times. Various life-threatening complications associated with oral & maxillofacial infections are respiratory obstruction, necrotizing fasciitis, descending mediastinitis, pericarditis, brain abscess, and sepsis. The successful management of orofacial infection depends on the early recognition of orofacial infection. Appropriate and prompt therapy is mandatory for successful management. Thorough knowledge of anatomy is necessary to predict pathways of spread and to drain these spaces adequately. We present our experience in treating oral & maxillofacial space infection at our centre","PeriodicalId":48612,"journal":{"name":"Journal of Pathology Clinical Research","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135550575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Compartment Syndrome of the Hand after Multiple Fractures of the Metacarpals: A Rare Localization with a Poor Prognosis: Two Case Reports and a Literature Review 掌骨多处骨折后的手部筋膜室综合征:一种罕见且预后不良的局部症状:2例报告及文献综述
2区 医学
Journal of Pathology Clinical Research Pub Date : 2023-01-01 DOI: 10.23880/cprj-16000156
Bouziane W
{"title":"Compartment Syndrome of the Hand after Multiple Fractures of the Metacarpals: A Rare Localization with a Poor Prognosis: Two Case Reports and a Literature Review","authors":"Bouziane W","doi":"10.23880/cprj-16000156","DOIUrl":"https://doi.org/10.23880/cprj-16000156","url":null,"abstract":"Compartment syndrome is a surgical emergency. In fact, it is a “race against the clock” we will discuss our experience with two cases who presented with hand compartment syndrome after suffering numerous metacarpal fractures The treatment included a discharge incisions, metacarpal pinning, and close hand surveillance.","PeriodicalId":48612,"journal":{"name":"Journal of Pathology Clinical Research","volume":"99 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135550746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case of Polymyositis Treated with the Homoeopathic Medicine Lathyrus Satyvus 顺势疗法治疗多肌炎1例
2区 医学
Journal of Pathology Clinical Research Pub Date : 2023-01-01 DOI: 10.23880/cprj-16000158
Yasmin Firdaus A
{"title":"A Case of Polymyositis Treated with the Homoeopathic Medicine Lathyrus Satyvus","authors":"Yasmin Firdaus A","doi":"10.23880/cprj-16000158","DOIUrl":"https://doi.org/10.23880/cprj-16000158","url":null,"abstract":"Polymyositis is one of the idiopathic inflammatory myopathies, a rare connective tissue disorders defined by the presence of weakness of muscles and inflammation. The estimated prevalence of polymyositis and dermatomyositis is 5 to 22 per 100,000 persons, and the incidence is approximately 1.2 to 19 per million persons at risk per year. Polymyositis rarely occurs in the paediatric age group, and the mean age is between 50 to 60 years. This article is on a case of polymyositis which was completely bed ridden before reaching our hospital. With thorough case taking and finding out the Totality Lathyrus Sativus 200 was prescribed. Muscle strength grading was done to evaluate the improvement before and after treatment. The case started improving within a period of 1 week. The muscle strength grading which was Grade 1 during the beginning of treatment improved to Grade 3 within a period of 1 month. The improvement was gradual and also within a period of 1 month the patient started walking with support. This shows the management of polymyositis with the Homeopathic medicine Lathyrus Sativus.","PeriodicalId":48612,"journal":{"name":"Journal of Pathology Clinical Research","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135550760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mesenteric Mesothelial Cyst Presented as Acute Abdominal Pain 肠系膜间皮囊肿表现为急性腹痛
2区 医学
Journal of Pathology Clinical Research Pub Date : 2023-01-01 DOI: 10.23880/cprj-16000154
Jagtap SV
{"title":"Mesenteric Mesothelial Cyst Presented as Acute Abdominal Pain","authors":"Jagtap SV","doi":"10.23880/cprj-16000154","DOIUrl":"https://doi.org/10.23880/cprj-16000154","url":null,"abstract":"Mesenteric cysts are rare intra-abdominal tumors. The preoperative diagnosis of mesenteric cysts is challenging due to its rarity. We present a case of 65 -years-old female with history of progressive increasing abdominal discomfort and swelling she presented with sudden acute abdominal pain of 5 days. Physical examination revealed a mildly tender, palpable abdominal swelling occupying right iliac fossa measuring 10x8x3 cm. Plain and contrast computed tomography scan abdomen and pelvis showed an intra-abdominal well defined, thin walled cystic lesion in right iliac fossa and extending upto right hypochondriac region. It showed multiple thin internal septae and low level mobile internal echoes. On radio imaging suggestive of a mesenteric cyst was given and histopathological correlation was advised. The exploratory laprotomy with complete surgical excisions of cystic mass was done. The histopathological diagnosis of benign mesothelial cyst of mesentry was given. We are presenting rare case of simple mesenteric cyst for its clinical, radio imaging and histomorphological features.","PeriodicalId":48612,"journal":{"name":"Journal of Pathology Clinical Research","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135551008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinicopathologic Characterization of Double PIK3CA Mutated Advanced Breast Cancer: A Retrospective Cohort Study from a Single Institution 双PIK3CA突变晚期乳腺癌的临床病理特征:来自单一机构的回顾性队列研究
2区 医学
Journal of Pathology Clinical Research Pub Date : 2023-01-01 DOI: 10.23880/cprj-16000155
Zhan H
{"title":"Clinicopathologic Characterization of Double PIK3CA Mutated Advanced Breast Cancer: A Retrospective Cohort Study from a Single Institution","authors":"Zhan H","doi":"10.23880/cprj-16000155","DOIUrl":"https://doi.org/10.23880/cprj-16000155","url":null,"abstract":"Objectives: We aimed to characterize the clinicopathologic and molecular features of double PIK3CA mutated advanced breast cancer in a retrospective cohort study. Methods: This retrospective study included 196 advanced breast cancer patients who had the Oncomine next generation sequencing analysis. The clinicopathologic parameters were recorded for each individuals including age, tumor type, grade, ER, PR, HER2, and recurrence free survival. Results: PIK3CA mutations were detected in 77.5% (152/196) of advanced breast cancer patients, 129 (84.8%) of which contained single mutations, 20 (13.1%) of which contained double mutations, and 3 (2%) of which contained triple mutations. Double PIK3CA mutated tumors were mostly seen in postmenopausal women, had lower combined histologic grade, and were enriched in hormone receptor positive human epidermal growth factor receptor negative (HR+/HER2-) disease. Double PIK3CA mutations were more frequently associated with concurrent mutations of ESR1 (p=0.017) and ARID1A (p=0.054) compared to single PIK3CA mutations. No significant progression free survival differences were observed between PIK3CA mutated and wild-type groups and between double and single PIK3CA mutated groups when applied to all patients or HR+/ HER2- patients. Conclusion: Double PIK3CA mutated advanced breast cancer have similar clinicopathologic features as single mutated ones but demonstrate unique molecular features.","PeriodicalId":48612,"journal":{"name":"Journal of Pathology Clinical Research","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135550765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cyto-Architectural Complexity of Dyshormonogenic Goitre can Closely Mimic a Thyroid Follicular Malignancy: A Case Report and Review of the Literature to Avoid Diagnostic Pitfall 激素生成障碍甲状腺的细胞结构复杂性与甲状腺滤泡性恶性肿瘤非常相似:一个病例报告和文献回顾以避免诊断缺陷
2区 医学
Journal of Pathology Clinical Research Pub Date : 2023-01-01 DOI: 10.23880/cprj-16000160
Nishat Afroz
{"title":"Cyto-Architectural Complexity of Dyshormonogenic Goitre can Closely Mimic a Thyroid Follicular Malignancy: A Case Report and Review of the Literature to Avoid Diagnostic Pitfall","authors":"Nishat Afroz","doi":"10.23880/cprj-16000160","DOIUrl":"https://doi.org/10.23880/cprj-16000160","url":null,"abstract":"A 13-year-old male child presented in the OPD with a midline 5x4cm thyroid swelling of 2 years duration with the chief complaint of difficulty in breathing. He also had growth and mental retardation since 3 years of age. His thyroid profile records revealed a severe degree of hypothyroidism and he was on thyroxine supplement since then. He underwent a right hemithyroidectomy for the right-sided nodular goitre causing on-and-off dyspnea. The gross specimen measured 5x4x3cm, which on cut section showed partially encapsulated multi-nodular solid areas. Microscopy yielded marked architectural complexity and prominent cellular and nuclear pleomorphism that mimicked a thyroid malignancy; for eg., a poorly differentiated papillary or follicular carcinoma. However, a thorough assessment of a range of histo-morphological features in the context of clinical history clinched the diagnosis of dyshormonogenetic goitre. One year postoperatively the patient is doing well on Thyroxine supplement. This case report reviews the literature about this rare benign entity of dyshormonogenetic goitre which closely mimics thyroid malignancy, notably a follicular malignancy on microscopy owing to its cytoarchitectural complexity and nuclear atypia. Hence, knowledge of its clinical presentation, gross and diverse microscopic features is extremely important to avoid misdiagnosis and thereby clinical management.","PeriodicalId":48612,"journal":{"name":"Journal of Pathology Clinical Research","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135551007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative Analysis between Absolute Neutrophil Count and Absolute Monocyte Count as a Predictor of Haematopoietic Recovery in Patients with Acute Lymphoblastic Leukaemia 中性粒细胞绝对计数和单核细胞绝对计数作为急性淋巴细胞白血病患者造血恢复预测因子的比较分析
2区 医学
Journal of Pathology Clinical Research Pub Date : 2023-01-01 DOI: 10.23880/cprj-16000159
Yesmin MS
{"title":"Comparative Analysis between Absolute Neutrophil Count and Absolute Monocyte Count as a Predictor of Haematopoietic Recovery in Patients with Acute Lymphoblastic Leukaemia","authors":"Yesmin MS","doi":"10.23880/cprj-16000159","DOIUrl":"https://doi.org/10.23880/cprj-16000159","url":null,"abstract":"Objectives: This study was aimed to find out the comparison between absolute neutrophil count and absolute monocyte count for haematopoietic recovery in acute lymphoblastic leukaemia (ALL) patients. Methods: In this study, a total of 50 patients of acute lymphoblastic leukaemia, aged between 8 months to 15 years were studied prospectively. Results: In the initial treatment phase (induction of remission phase), regularly increasing trends were seen in absolute neutrophil counts (ANC) prior to recovery of absolute monocyte counts (AMC). Of all the parameters, ANC recovered 1 day (≥0.5 x 109 /l) prior to recovery of AMC above (≥0.1 x 109 /l). Conclusion: ANC can be considered as an early predictor of haematopoietic recovery over AMC. These parameters can be used in conjunction with clinical conditions to decide about early discharge of leukaemia patients especially in developing countries where prolonged stay can result in hospital acquired infections.","PeriodicalId":48612,"journal":{"name":"Journal of Pathology Clinical Research","volume":"99 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135549384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Performance of the Thyroid Gland is Affected by the Intellectual and Psychological Pressures that College Students Endure During Exam Time 大学生在考试期间承受的智力和心理压力对甲状腺功能的影响
2区 医学
Journal of Pathology Clinical Research Pub Date : 2023-01-01 DOI: 10.23880/cprj-16000162
Majid M Mahmood
{"title":"The Performance of the Thyroid Gland is Affected by the Intellectual and Psychological Pressures that College Students Endure During Exam Time","authors":"Majid M Mahmood","doi":"10.23880/cprj-16000162","DOIUrl":"https://doi.org/10.23880/cprj-16000162","url":null,"abstract":"The thyroid gland is affected by many factors, such as age, gender, and ethnicity. The gland is also influenced by metabolism, stress, and psychological state. In this clinical scenario, establishing a reference period for TSH, T3, and T4 is critical for the diagnosis of thyroid functional disorders before and after screening. The aim of this study is to assess the effect of mental stress on the levels of TSH, T3, and T4 before and after the exam. The study was conducted from December until the end of February 2022 at the Middle Technical College, University of Baghdad. 45 healthy young students, ranging in age from 19 to 23 years, were included in this study. The results found a significant difference between T4 levels in pre- and post-exam in males when compared with females, and there was also a difference between the levels of T3 and TSH in pre- and post-exam. Conclusion: Mental stress affects thyroid hormones by affecting the central regulation of TSH levels.","PeriodicalId":48612,"journal":{"name":"Journal of Pathology Clinical Research","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135550748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Rare Torsion Case of Polycystic Ovarian Syndrome: A Natural Course with Laparoscopic, Cytological and Pathological Findings 一例罕见的多囊卵巢综合征扭转:腹腔镜、细胞学和病理结果的自然过程
2区 医学
Journal of Pathology Clinical Research Pub Date : 2023-01-01 DOI: 10.23880/cprj-16000157
Kenji Niwa
{"title":"A Rare Torsion Case of Polycystic Ovarian Syndrome: A Natural Course with Laparoscopic, Cytological and Pathological Findings","authors":"Kenji Niwa","doi":"10.23880/cprj-16000157","DOIUrl":"https://doi.org/10.23880/cprj-16000157","url":null,"abstract":"Polycystic ovary (PCO) syndrome cases with adnexal torsion in a natural cycle without ovarian induction are rare, and many torsion cases in PCOs involve pelvic masses, such as uterine fibroids. A 37-year-old woman, gravida two para two, came in an emergency because of lower abdominal pain for 2 or 3 days. PCO was followed in a previous hospital. At a visit in her Douglas pouch, a 7.3 x 4.5 cm mass that was consistent with the point of tenderness was detected by ultrasonography and magnetic resonance images. The patient underwent a semi-emergent laparoscopic surgery for a diagnosis of torsion of the left adnexa. At an abdominal exploration, the left ovary was swollen to approximate 7 cm in size and twisted 360°clockwise. The intraoperative imprint cytology showed the presence of fibrous cells alone, thus the malignancy denied. Histologically, fibrously thickened cortex and multiple follicular cysts due to atretic follicles were found, compatible with PCO. As the patient did not desire to have children and less likely to twist the right ovary, she wanted having low dose pills.","PeriodicalId":48612,"journal":{"name":"Journal of Pathology Clinical Research","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135551010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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