World Journal of Diabetes最新文献

{"title":"Influence of gut bacteria on type 2 diabetes: Mechanisms and therapeutic strategy.","authors":"Xue Wen, Lu-Ming Qi, Kui Zhao","doi":"10.4239/wjd.v16.i1.100376","DOIUrl":"https://doi.org/10.4239/wjd.v16.i1.100376","url":null,"abstract":"<p><p>The onset and progression of type 2 diabetes mellitus (T2DM) are strongly associated with imbalances in gut bacteria, making the gut microbiome a new potential therapeutic focus. This commentary examines the recent publication in <i>World Journal of Diabetes</i>. The article explores the association between T2DM and gut microbiota, with a focus on the pathophysiological changes related to dysbiosis. It proposes innovative microbiome-targeted therapeutic strategies and evaluates the challenges and future directions of such approaches. This editorial summarizes the key points of their discussion of the role of the gut microbiome in T2DM and elaborates on the influence of specific gut microbial species on the disease through the host-microbiota metabolic axis. It provides new insights for future research on gut-microbiota-based interventions for T2DM.</p>","PeriodicalId":48607,"journal":{"name":"World Journal of Diabetes","volume":"16 1","pages":"100376"},"PeriodicalIF":4.2,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11718462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global trends and hotspots of type 2 diabetes in children and adolescents: A bibliometric study and visualization analysis.","authors":"Fang-Shuo Zhang, Hai-Jing Li, Xue Yu, Yi-Ping Song, Yan-Feng Ren, Xuan-Zhu Qian, Jia-Li Liu, Wen-Xun Li, Yi-Ran Huang, Kuo Gao","doi":"10.4239/wjd.v16.i1.96032","DOIUrl":"https://doi.org/10.4239/wjd.v16.i1.96032","url":null,"abstract":"<p><strong>Background: </strong>Epidemiological surveys indicate an increasing incidence of type 2 diabetes mellitus (T2DM) among children and adolescents worldwide. Due to rapid disease progression, severe long-term cardiorenal complications, a lack of effective treatment strategies, and substantial socioeconomic burdens, it has become an urgent public health issue that requires management and resolution. Adolescent T2DM differs from adult T2DM. Despite a significant increase in our understanding of youth-onset T2DM over the past two decades, the related review and evidence-based content remain limited.</p><p><strong>Aim: </strong>To visualize the hotspots and trends in pediatric and adolescent T2DM research and to forecast their future research themes.</p><p><strong>Methods: </strong>This study utilized the terms \"children\", \"adolescents\", and \"type 2 diabetes\", retrieving relevant articles published between 1983 and 2023 from three citation databases within the Web of Science Core Collection (SCI, SSCI, ESCI). Utilizing CiteSpace and VoSviewer software, we analyze and visually represent the annual output of literature, countries involved, and participating institutions. This allows us to predict trends in this research field. Our analysis encompasses co-cited authors, journal overlays, citation overlays, time-zone views, keyword analysis, and reference analysis, <i>etc.</i></p><p><strong>Results: </strong>A total of 9210 articles were included, and the annual publication volume in this field showed a steady growth trend. The United States had the highest number of publications and the highest H-index. The United States also had the most research institutions and the strongest research capacity. The global hot journals were primarily diabetes professional journals but also included journals related to nutrition, endocrinology, and metabolism. Keyword analysis showed that research related to endothelial dysfunction, exposure risk, cardiac metabolic risk, changes in gut microbiota, the impact on comorbidities and outcomes, <i>etc.,</i> were emerging keywords. They have maintained their popularity in this field, suggesting that these areas have garnered significant research interest in recent years.</p><p><strong>Conclusion: </strong>Pediatric and adolescent T2DM is increasingly drawing global attention, with genes, behaviors, environmental factors, and multisystemic interventions potentially emerging as future research hot spots.</p>","PeriodicalId":48607,"journal":{"name":"World Journal of Diabetes","volume":"16 1","pages":"96032"},"PeriodicalIF":4.2,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11718446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ubiquitination in diabetes and its complications: A perspective from bibliometrics.","authors":"Li-Yuan Xiong, Wei Zhao, Fa-Quan Hu, Xue-Mei Zhou, Yu-Jiao Zheng","doi":"10.4239/wjd.v16.i1.100099","DOIUrl":"https://doi.org/10.4239/wjd.v16.i1.100099","url":null,"abstract":"<p><strong>Background: </strong>Diabetes has a substantial impact on public health, highlighting the need for novel treatments. Ubiquitination, an intracellular protein modification process, is emerging as a promising strategy for regulating pathological mechanisms. We hypothesize that ubiquitination plays a critical role in the development and progression of diabetes and its complications, and that understanding these mechanisms can lead to new therapeutic approaches.</p><p><strong>Aim: </strong>To uncover the research trends and advances in diabetes ubiquitination and its complications, we conducted a bibliometric analysis.</p><p><strong>Methods: </strong>Studies on ubiquitination in diabetes mellitus and its complications were retrieved from the Web of Science Core Collection. Visual mapping analysis was conducted using the CiteSpace software.</p><p><strong>Results: </strong>We gathered 791 articles published over the past 23 years, focusing on ubiquitination in diabetes and its associated complications. These articles originated from 54 countries and 386 institutions, with China as the leading contributor. Shanghai Jiao Tong University has the highest number of publications in this field. The most prominent authors contributing to this research area include Wei-Hua Zhang, with Zhang Y being the most frequently cited author. Additionally, <i>The Journal of Biological Chemistry</i> is noted as the most cited in this field. The predominant keywords included expression, activation, oxidative stress, phosphorylation, ubiquitination, degradation, and insulin resistance.</p><p><strong>Conclusion: </strong>The role of ubiquitination in diabetes and its complications, such as diabetic nephropathy and cardiomyopathy, is a key research focus. However, these areas require further investigations.</p>","PeriodicalId":48607,"journal":{"name":"World Journal of Diabetes","volume":"16 1","pages":"100099"},"PeriodicalIF":4.2,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11718460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediabetes and atrial fibrillation risk stratification, phenotyping, and possible reversal to normoglycemia.","authors":"Hyder O Mirghani","doi":"10.4239/wjd.v16.i1.98804","DOIUrl":"https://doi.org/10.4239/wjd.v16.i1.98804","url":null,"abstract":"<p><p>Patients admitted with prediabetes and atrial fibrillation are at high risk for major adverse cardiac or cerebrovascular events independent of confounding variables. The shared pathophysiology between these three serious but common diseases and their association with atherosclerotic cardiovascular risk factors establish a vicious circle culminating in high atherogenicity. Because of that, it is of paramount importance to perform risk stratification of patients with prediabetes to define phenotypes that benefit from various interventions. Furthermore, stress hyperglycemia assessment of hospitalized patients and consensus on the definition of prediabetes is vital. The roles lifestyle and metformin play in prediabetes are well established. However, the role of glucagon-like peptide agonists and metabolic surgery is less clear. Prediabetes is considered an intermediate between normoglycemia and diabetes along the blood glucose continuum. One billion people are expected to suffer from prediabetes by the year 2045. Therefore, real-world randomized controlled trials to assess major adverse cardiac or cerebrovascular event risk reduction and reversal/prevention of type 2 diabetes among patients are needed to determine the proper interventions.</p>","PeriodicalId":48607,"journal":{"name":"World Journal of Diabetes","volume":"16 1","pages":"98804"},"PeriodicalIF":4.2,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11718461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Dorzagliatin in peritoneal dialysis patients with type 2 diabetes mellitus: A case report.","authors":"Fang Chen, Bo An, Wen-Cheng An, Gang Fu, Wei Huang, Hui-Xian Yan","doi":"10.4239/wjd.v16.i1.99135","DOIUrl":"https://doi.org/10.4239/wjd.v16.i1.99135","url":null,"abstract":"<p><strong>Background: </strong>Treating diabetes in dialysis patients remains a challenge, with many hypoglycemic drugs requiring dose adjustments or avoidance in these patients.</p><p><strong>Case summary: </strong>This report describes an 83-year-old female patient with a 30-year history of type 2 diabetes (T2DM) who had struggled to control her blood sugar for more than a year. She had a history of high blood pressure for 30 years, had undergone continuous ambulatory peritoneal dialysis for more than two years, was 163 cm tall, weighed 77 kg, and had a body mass index of 28.98 kg/m². Despite intensive insulin therapy at a daily dose of 150 units, adding Dorzagliatin at a dosage of 75 mg orally twice daily led to immediate blood sugar improvement and a gradual reduction in insulin dosage. After one month of follow-up, the fasting plasma glucose was 6-8 mmol/L, and the 2-hour postprandial glucose was 8-12 mmol/L.</p><p><strong>Conclusion: </strong>To our knowledge, this report is the first to use Dorzagliatin to treat type 2 diabetes peritoneal dialysis patients with challenging glucose control. Dorzagliatin, a novel glucokinase activator primarily metabolized by the liver, exhibits no pharmacokinetic differences among patients with varying degrees of chronic kidney disease. It has a high plasma protein binding rate and may not be cleared by peritoneal dialysis, potentially offering a new glycemic control option for Type 2 diabetic patients on peritoneal dialysis.</p>","PeriodicalId":48607,"journal":{"name":"World Journal of Diabetes","volume":"16 1","pages":"99135"},"PeriodicalIF":4.2,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11718458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for developing osteoporosis in diabetic kidney disease and its correlation with calcium-phosphorus metabolism, FGF23, and Klotho.","authors":"Fan Yang, Yan Wu, Wei Zhang","doi":"10.4239/wjd.v16.i1.98714","DOIUrl":"https://doi.org/10.4239/wjd.v16.i1.98714","url":null,"abstract":"<p><strong>Background: </strong>The progression of diabetic kidney disease (DKD) affects the patient's kidney glomeruli and tubules, whose normal functioning is essential for maintaining normal calcium (Ca) and phosphorus (P) metabolism in the body. The risk of developing osteoporosis (OP) in patients with DKD increases with the aggravation of the disease, including a higher risk of fractures, which not only affects the quality of life of patients but also increases the risk of death.</p><p><strong>Aim: </strong>To analyze the risk factors for the development of OP in patients with DKD and their correlation with Ca-P metabolic indices, fibroblast growth factor 23 (FGF23), and Klotho.</p><p><strong>Methods: </strong>One hundred and fifty-eight patients with DKD who were admitted into the Wuhu Second People's Hospital from September 2019 to May 2021 were selected and divided into an OP group (<i>n</i> = 103) and a normal bone mass group (<i>n</i> = 55) according to their X-ray bone densitometry results. Baseline data and differences in Ca-P biochemical indices, FGF23, and Klotho were compared. The correlation of Ca-P metabolic indices with FGF23 and Klotho was discussed, and the related factors affecting OP in patients with DKD were examined by multivariate logistic regression analysis.</p><p><strong>Results: </strong>The OP group had a higher proportion of females, an older age, and a longer diabetes mellitus duration than the normal group (all <i>P</i> < 0.05). Patients in the OP group exhibited significantly higher levels of intact parathyroid hormone (iPTH), blood P, Ca-P product (Ca × P), fractional excretion of phosphate (FeP), and FGF23, as well as lower estimated glomerular filtration rate, blood Ca, 24-hour urinary phosphate excretion (24-hour UPE), and Klotho levels (all <i>P</i> < 0.05). In the OP group, 25-(OH)-D₃, blood Ca, and 24-hour UPE were negatively correlated with FGF23 and positively correlated with Klotho. In contrast, iPTH, blood Ca, Ca × P<b>,</b> and FeP exhibited a positive correlation with FGF23 and an inverse association with Klotho (all <i>P</i> < 0.05). Moreover, 25-(OH)-D₃, iPTH, blood Ca, FePO₄, FGF23, Klotho, age, and female gender were key factors that affected the lumbar and left femoral neck bone mineral density.</p><p><strong>Conclusion: </strong>The Ca-P metabolism metabolic indexes, FGF23, and Klotho in patients with DKD are closely related to the occurrence and development of OP.</p>","PeriodicalId":48607,"journal":{"name":"World Journal of Diabetes","volume":"16 1","pages":"98714"},"PeriodicalIF":4.2,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11718466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Betaine combined with traditional Chinese medicine ointment to treat skin wounds in microbially infected diabetic mice.","authors":"Wen-Yan Xu, Yuan-Yuan Dai, Shi-Xian Yang, Hao Chen, Yan-Qiang Huang, Pei-Pei Luo, Zhong-Heng Wei","doi":"10.4239/wjd.v16.i1.99745","DOIUrl":"https://doi.org/10.4239/wjd.v16.i1.99745","url":null,"abstract":"<p><strong>Background: </strong>Skin wounds are highly common in diabetic patients, and with increasing types of pathogenic bacteria and antibiotic resistance, wounds and infections in diabetic patients are difficult to treat and heal.</p><p><strong>Aim: </strong>To explore the effects of betaine ointment (BO) in promoting the healing of skin wounds and reducing the inflammation and apoptosis of skin cells in microbially infected diabetic mice.</p><p><strong>Methods: </strong>By detecting the minimum inhibitory concentrations (MICs) of betaine and plant monomer components such as psoralen, we prepared BO with betaine as the main ingredient, blended it with traditional Chinese medicines such as gromwell root and psoralen, and evaluated its antibacterial effects and safety <i>in vitro</i> and <i>in vivo</i>. The skin infection wound models of ordinary mice and diabetic mice were constructed, and the OTC drugs mupirocin ointment and Zicao ointment were used as controls to evaluate the antibacterial effects <i>in vivo</i> and the anti-inflammatory and anti-apoptotic effects of BO.</p><p><strong>Results: </strong>The MICs of betaine against microorganisms such as <i>Staphylococcus aureus</i> (<i>S. aureus</i>)<i>, Candida albicans</i> and <i>Cryptococcus neoformans</i> ranged from 4 to 32 μg/mL. Gromwell root and psoralea, both of which contain antimicrobial components, mixed to prepare BO with MICs ranging from 16 to 64 μg/mL, which is 32-256 times lower than those of Zicao ointment, although the MIC is greater than that of betaine. After 15 days of treatment with BO for USA300-infected ordinary mice, the wound scab removal rates were 83.3%, while those of mupirocin ointment and Zicao ointment were 66.7% and 0%, respectively, and the differences were statistically significant. In diabetic mice, the wound scab removal rate of BO and mupirolacin ointment was 80.0%, but BO reduced wound inflammation and the apoptosis of skin cells and facilitated wound healing.</p><p><strong>Conclusion: </strong>The ointment prepared by mixing betaine and traditional Chinese medicine can effectively inhibit common skin microorganisms and has a strong effect on the skin wounds of sensitive or drug-resistant <i>S. aureus</i>-infected ordinary mice and diabetic mice.</p>","PeriodicalId":48607,"journal":{"name":"World Journal of Diabetes","volume":"16 1","pages":"99745"},"PeriodicalIF":4.2,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11718449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protein nanoparticles as potent delivery vehicles for polycytosine RNA-binding protein one.","authors":"Zi-Yu Zhao, Pei-Li Luo, Xia Guo, Zheng-Wei Huang","doi":"10.4239/wjd.v16.i1.100675","DOIUrl":"https://doi.org/10.4239/wjd.v16.i1.100675","url":null,"abstract":"<p><p>Ma <i>et al</i> recently reported in the <i>World Journal of Diabetes</i> that ferroptosis occurs in osteoblasts under high glucose conditions, reflecting diabetes pathology. This condition could be protected by the upregulation of the gene encoding polycytosine RNA-binding protein 1 (PCBP1). Additionally, Ma <i>et al</i> used a lentivirus infection system to express PCBP1. As the authors' method of administration can be improved in terms of stability and cost, we propose delivering PCBP1 to treat type 2 diabetic osteoporosis by encapsulating it in protein nanoparticles. First, PCBP1 is small and druggable. Second, intravenous injection can help deliver PCBP1 across the mucosa while avoiding acid and enzyme-catalyzed degradation. Furthermore, incorporating PCBP1 into nanoparticles prevents its interaction with water or oxygen and protects PCBP1's structure and activity. Notably, the safety of the protein materials and the industrialization techniques for large-scale production of protein nanoparticles must be comprehensively investigated before clinical application.</p>","PeriodicalId":48607,"journal":{"name":"World Journal of Diabetes","volume":"16 1","pages":"100675"},"PeriodicalIF":4.2,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11718452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of macrophage polarization in diabetic foot ulcer healing: A bibliometric study.","authors":"You-Wen Zhang, Lei Sun, Yan-Nan Wang, Shi-Yu Zhan","doi":"10.4239/wjd.v16.i1.99755","DOIUrl":"https://doi.org/10.4239/wjd.v16.i1.99755","url":null,"abstract":"<p><strong>Background: </strong>Diabetic foot ulcers (DFUs) are a significant contributor to disability and mortality in diabetic patients. Macrophage polarization and functional regulation are promising areas of research and show therapeutic potential in the field of DFU healing. However, the complex mechanism, the difficulty in clinical translation, and the large heterogeneity present significant challenges. Hence, this study was to comprehensively analyze the publication status and trends of studies on macrophage polarization and DFU healing.</p><p><strong>Aim: </strong>To examine the relevant literature on macrophage polarization in DFU healing.</p><p><strong>Methods: </strong>A bibliometric analysis was conducted using the Web of Science database. Relevant literature was retrieved from the Web of Science Core Collection database between 2013 to 2023 using literature visualization and analysis software (VOSviewer and CiteSpace) and bibliometric online platforms. The obtained literature was then subjected to visualization and analysis of different countries/regions, institutions, journals, authors, and keywords to reveal the research's major trends and focus.</p><p><strong>Results: </strong>The number of publications on the role of macrophage polarization in DFU healing increased rapidly from 2013 to 2023, especially in the latter period. Chinese researchers were the most prolific in this field, with 217 publications, while American researchers had been engaged in this field for a longer period. Qian Tan of Nanjing Drum Tower Hospital and Qian Ding of Nanjing University were the first to publish in this field. Shanghai Jiao Tong University was the institution with the most publications (27). The keywords \"bone marrow\", \"adjustment, replacement, response, tissue repair\", and \"activation, repair, differentiation\" appeared more frequently. The study of macrophage polarization in DFU healing focused on the regulatory mechanism, gene expression, and other aspects.</p><p><strong>Conclusion: </strong>This study through the bibliometric method reveals the research trends and development trends in this field of macrophage polarization in DFU healing from 2013 to 2023 in the Web of Science Core Collection database. The key hotspots in this field mainly include the regulation of macrophage activation, gene expression, wound tissue repair, and new wound materials. This study provides references for future research directions.</p>","PeriodicalId":48607,"journal":{"name":"World Journal of Diabetes","volume":"16 1","pages":"99755"},"PeriodicalIF":4.2,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11718451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy, safety and treatment satisfaction of transition to a regimen of insulin degludec/aspart: A pilot study.","authors":"Na Yang, Lu Lv, Shu-Meng Han, Li-Yun He, Zi-Yi Li, Yu-Cheng Yang, Fan Ping, Ling-Ling Xu, Wei Li, Hua-Bing Zhang, Yu-Xiu Li","doi":"10.4239/wjd.v16.i1.95209","DOIUrl":"https://doi.org/10.4239/wjd.v16.i1.95209","url":null,"abstract":"<p><strong>Background: </strong>There is a lack of clinical evidence on the efficacy and safety of transitioning from a thrice-daily pre-mixed insulin or basal-prandial regimen to insulin deglu-dec/aspart (IDegAsp) therapy, with insufficient data from the Chinese popu-lation.</p><p><strong>Aim: </strong>To demonstrate the efficacy, safety, and treatment satisfaction associated with the transition to IDegAsp in type 2 diabetes mellitus (T2DM).</p><p><strong>Methods: </strong>In this 12-week open-label, non-randomized, single-center, pilot study, patients with T2DM receiving thrice-daily insulin or intensive insulin treatment were transitioned to twice-daily injections of insulin IDegAsp. Insulin doses, hemoglobin A1c (HbA1c) levels, fasting blood glucose (FBG), hypoglycemic events, a Diabetes Treatment Satisfaction Questionnaire, and other parameters were assessed at baseline and 12-weeks.</p><p><strong>Results: </strong>This study included 21 participants. A marked enhancement was observed in the FBG level (<i>P</i> = 0.02), daily total insulin dose (<i>P</i> = 0.03), and overall diabetes treatment satisfaction (<i>P</i> < 0.01) in the participants who switched to IDegAsp. There was a decrease in HbA1c levels (7.6 ± 1.1 <i>vs</i> 7.4 ± 0.9, <i>P</i> = 0.31) and the frequency of hypoglycemic events of those who switched to IDegAsp decreased, however, there was no statistically significant difference.</p><p><strong>Conclusion: </strong>The present findings suggest that treatment with IDegAsp enhances clinical outcomes, particularly FBG levels, daily cumulative insulin dose, and overall satisfaction with diabetes treatment.</p>","PeriodicalId":48607,"journal":{"name":"World Journal of Diabetes","volume":"16 1","pages":"95209"},"PeriodicalIF":4.2,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11718447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}