World Journal of Diabetes最新文献

{"title":"Safety and efficacy of sodium-glucose cotransporter-2 inhibitors in adults with type 2 diabetes fasting during Ramadan: A meta-analysis.","authors":"Abul Bashar Mohammad Kamrul-Hasan, Shehla Shaikh, Hamid Ashraf, Mohammad Shafi Kuchay, Lakshmi Nagendra, Deep Dutta, Joseph M Pappachan","doi":"10.4239/wjd.v17.i2.115495","DOIUrl":"10.4239/wjd.v17.i2.115495","url":null,"abstract":"<p><strong>Background: </strong>Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are widely used in managing type 2 diabetes (T2D). A significant number of these patients choose to observe religious fasting during Ramadan. Although existing guidelines recommend caution when administering SGLT2i during Ramadan due to potential adverse effects, there is limited data on their use in this patient population.</p><p><strong>Aim: </strong>To assess the safety and effectiveness of SGLT2i in patients with T2D who fast during Ramadan.</p><p><strong>Methods: </strong>Relevant studies involving adults with T2D who received an SGLT2i in the intervention arm and other glucose-lowering drugs in the control arm were systematically searched through electronic databases. The primary outcome was the occurrence of adverse events in the two groups; additional outcomes included changes in glycemic and anthropometric parameters during the peri-Ramadan period. RevMan Web was used to conduct meta-analysis using random-effects models. Outcomes were presented as mean differences (MDs) or risk ratios (RRs) with 95%CI.</p><p><strong>Results: </strong>Twelve studies involving 3625 subjects were included. The risks of postural dizziness (RR = 6.39, 95%CI: 1.58-25.80, <i>P</i> = 0.009, <i>I</i> ² = 44%), hypotension/postural hypotension (RR = 4.43, 95%CI: 1.35-14.55, <i>P</i> = 0.01, <i>I</i> ² = 31%), and sodium loss (MD = -1.00 mmol/L, 95%CI: -1.34 to -0.67, <i>P</i> < 0.00001, <i>I</i> ² = 0%) were higher in the SGLT2i group compared to the non-SGLT2i group. The SGLT-2i group achieved larger reductions in systolic (MD = -2.41 mmHg, 95%CI: -4.52 to -0.30, <i>P</i> = 0.02, <i>I</i> ² = 46%) and diastolic blood pressure (MD = -1.71 mmHg, 95%CI: -2.70 to -0.72, <i>P</i> = 0.0007, <i>I</i> ² = 20%), and experienced a lower risk of symptomatic hypoglycemia (RR = 0.53, 95%CI: 0.29-0.97, <i>P</i> = 0.04, <i>I</i> ² = 69%). The two groups exhibited comparable changes in glycated hemoglobin, body weight, and renal function. The risks of other specific adverse events, including dehydration, dizziness, volume depletion, symptomatic hyperglycemia, severe hypoglycemia, and genitourinary infections, were identical in the two groups.</p><p><strong>Conclusion: </strong>SGLT2i may be generally safe and effectively manage T2D during Ramadan; however, the results are less robust and should be interpreted with caution. Large multicenter randomized trials are necessary to confirm their safety, especially for at-risk groups, and to improve clinical decision-making.</p>","PeriodicalId":48607,"journal":{"name":"World Journal of Diabetes","volume":"17 2","pages":"115495"},"PeriodicalIF":4.6,"publicationDate":"2026-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12897491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146203490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RRM2 attenuates renal tubular ferroptosis in diabetic kidney disease <i>vi</i>a the PI3K/Akt/Nrf2 pathway: Strengths, limitations, and future research directions.","authors":"Ying-Chun Liu, Jing Xiao, Lin Chen","doi":"10.4239/wjd.v17.i2.115021","DOIUrl":"10.4239/wjd.v17.i2.115021","url":null,"abstract":"<p><p>Diabetic kidney disease (DKD) has become the primary cause of end-stage renal disease. However, its pathological mechanism remains incompletely understood. Ribonucleotide reductase M2 (RRM2) is a small subunit of ribonucleotide reductases, which is involved in nucleotide metabolism and catalyzes the conversion of nucleotides to deoxynucleotides, thereby maintaining the deoxyribonucleoside triphosphate pools required for DNA biosynthesis, repair, and replication. This study establishes a novel connection between the enzyme RRM2-traditionally recognized for its role in DNA synthesis-and the pathological progression of DKD, thereby filling the gap in identifying the \"bridge molecule\" between ferroptosis and the PI3K/Akt/Nrf2 pathway.</p>","PeriodicalId":48607,"journal":{"name":"World Journal of Diabetes","volume":"17 2","pages":"115021"},"PeriodicalIF":4.6,"publicationDate":"2026-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12897492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146203423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetes: A comprehensive review of the Indian landscape in contrast with global trends.","authors":"Nidhi Singh Rana, Naveen Kumar Vishvakarma, Subash Chandra Sonkar, Mirza Masroor Ali Beg","doi":"10.4239/wjd.v17.i2.110701","DOIUrl":"10.4239/wjd.v17.i2.110701","url":null,"abstract":"<p><p>In recent years, diabetes has become a major global health concern, and India is one of the countries most affected by the growing number of cases. In this review, we explore the diabetes scenario in the Indian community in comparison with global patterns. The extensive literature on diabetes suggests that poor diet, sedentary lifestyles, and genetic predisposition have been risk factors for diabetes. We further discuss disease management and treatment strategies related to diabetes in India, highlighting the challenges in healthcare accessibility and affordability. In addition, particularly in Indian scenarios, the role of traditional medicine as an alternative medicine is also discussed. This overall highlights possible interventions, including the National Diabetes Control Program, telehealth advancements, and community-based awareness campaigns. Therefore, we aim to discuss potential scenarios like rapid urbanization, changing dietary patterns, and socio-economic disparities in the diabetes epidemic in the country, and practical solutions for overall diabetes outcomes.</p>","PeriodicalId":48607,"journal":{"name":"World Journal of Diabetes","volume":"17 2","pages":"110701"},"PeriodicalIF":4.6,"publicationDate":"2026-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12897404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146203449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbiota dysbiosis, circulating microbial genetic traces, and their role in gestational diabetes.","authors":"Dinakaran Vasudevan","doi":"10.4239/wjd.v17.i2.114124","DOIUrl":"10.4239/wjd.v17.i2.114124","url":null,"abstract":"<p><p>Diabetes mellitus is a leading metabolic and non-communicable disease, affecting nearly 537 million adults worldwide. Recent research highlights the gut microbiota as a crucial factor in the onset and progression of diabetes. Gut microbial dysbiosis, an imbalance in microbial composition, has been increasingly recognized as a contributor to diabetes pathogenesis during pregnancy. The gut microbiome is influenced by multiple internal and external factors, which can worsen diabetes-related complications. A higher abundance of pathogenic microbes may lead to the release of microbial metabolites or DNA into circulation, contributing to metabolic disorders such as obesity, cardiovascular disease, and liver dysfunction. Microbial nucleic acids have been identified in the bloodstream of individuals with diabetes and in pregnant women, suggesting the existence of a circulating or blood microbiome. Various physiological and pathological conditions may permit gut microbes or their components to enter the bloodstream. This review introduces the concept that the blood microbiome may play a critical role during pregnancy, potentially increasing susceptibility to diabetes. It emphasizes the mechanistic link between gut dysbiosis, microbial translocation, and pregnancy-associated metabolic disturbances. Exploring gut and blood microbiome interactions in pregnancy could reveal early biomarkers and therapeutic targets for gestational diabetes mellitus. Future studies should focus on longitudinal microbiome analyses and interventions to restore microbial balance, offering new preventive strategies against diabetes during pregnancy.</p>","PeriodicalId":48607,"journal":{"name":"World Journal of Diabetes","volume":"17 2","pages":"114124"},"PeriodicalIF":4.6,"publicationDate":"2026-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12897392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146203393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corneal neuropathy: An overlooked biomarker for dry eye in type 2 diabetes.","authors":"Marco Zeppieri, Matteo Capobianco, Federico Visalli, Marieme Khouyyi, Caterina Gagliano, Francesco Cappellani","doi":"10.4239/wjd.v17.i2.114900","DOIUrl":"10.4239/wjd.v17.i2.114900","url":null,"abstract":"<p><p>The article by Han and associates highlights a frequently neglected consequence of type 2 diabetes mellitus (T2D): Dry eye disease associated with corneal neuropathy. Their findings indicate that patients with T2D exacerbated by dry eye disease exhibit substantial decreases in corneal nerve density, length, and count, accompanied by heightened tortuosity, all of which correlate strongly with clinical severity scores. This study contributes to the expanding literature that regards ocular surface disease not only as a secondary effect of systemic illness but also as a direct indication of neurovascular and metabolic impairment. Clinically, these findings underscore the importance of regularly evaluating dry eye in patients with T2D, extending beyond diabetic retinopathy, and incorporating ocular surface assessments into comprehensive diabetes management. This study demonstrates that the diabetic eye exhibits both tear film instability and corneal neurodegeneration, thereby expanding our understanding of diabetic eye disease and emphasizing the need for multidisciplinary care to preserve vision and improve quality of life.</p>","PeriodicalId":48607,"journal":{"name":"World Journal of Diabetes","volume":"17 2","pages":"114900"},"PeriodicalIF":4.6,"publicationDate":"2026-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12897443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146203495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Farrerol and the miR-29b-3p/sirtuin 1 pathway: A mechanistic breakthrough in protecting the diabetic heart.","authors":"Javier Donate-Correa, Carlos E Martínez-Alberto","doi":"10.4239/wjd.v17.i2.113221","DOIUrl":"10.4239/wjd.v17.i2.113221","url":null,"abstract":"<p><p>Diabetic cardiomyopathy (DCM) is a cardiac muscle disorder that causes heart failure independently of coronary artery disease. This condition remains a major clinical challenge, as current therapies primarily address traditional risk factors rather than the underlying molecular pathology. In this regard, endothelial dysfunction in the cardiac microvasculature is a key factor in DCM, linking metabolic alterations to impaired myocardial perfusion and fibrosis. Ferroptosis is a unique form of iron-dependent, regulated cell death characterized by lipid peroxidation. This mechanism has been linked to various diabetic complications, although its role in chronic diabetic heart disease remains unclear. In this editorial, we discuss new evidence highlighting endothelial cell ferroptosis as a key mechanism in DCM and a promising therapeutic target. Specifically, we discuss the recent study by Guo <i>et al</i>, demonstrating that farrerol, a natural flavonoid, improves DCM in mice by inhibiting endothelial ferroptosis through the microRNA-29b-3p/sirtuin 1 signaling axis. The findings of Guo <i>et al</i> reveal that downregulation of microRNA-29b-3p by farrerol is able to restore sirtuin 1 levels in cardiac endothelial cells, activating antioxidant defenses and preventing ferroptotic injury. Importantly, the endothelial protection generated by Farrerol translated into improvements in cardiac function and a reduction in fibrosis in diabetic mice. These results open a new therapeutic opportunity for the treatment of DCM by targeting the cardiac microvascular endothelium. Future studies should build on this mechanistic knowledge, addressing the challenges of converting Farrerol, a natural compound with antioxidant and antiferroptotic properties, or other ferroptosis inhibitors into targeted therapies that safely benefit patients with diabetic heart disease.</p>","PeriodicalId":48607,"journal":{"name":"World Journal of Diabetes","volume":"17 2","pages":"113221"},"PeriodicalIF":4.6,"publicationDate":"2026-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12897480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146202812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibroblast growth factor 1 alleviates diabetic nephropathy by reducing renal lipid accumulation in diabetic kidney.","authors":"Ying-Jian Li, He-Yu Ge, Gui-Gui Zhang, Hao-Yu Chen, Yu-Jia Xi, Kai Wang, Yin-Li Huang, Chi Zhang, Xia Fan, Xiao-Qing Yan","doi":"10.4239/wjd.v17.i2.112475","DOIUrl":"10.4239/wjd.v17.i2.112475","url":null,"abstract":"<p><strong>Background: </strong>Diabetic nephropathy (DN) is a major complication of diabetes, yet therapeutic strategies that specifically target its pathogenesis are still lacking.</p><p><strong>Aim: </strong>To evaluate the therapeutic potential of fibroblast growth factor 1 (FGF1) in DN and explore its underlying mechanisms.</p><p><strong>Methods: </strong>DN was induced <i>in vivo</i> using a type 2 diabetes mouse model, and <i>in vitro</i> using human kidney-2 (HK-2) cells treated with high glucose and palmitate acid (HGPA). Renal function, lipid accumulation and fibrosis were evaluated by urinary albumin creatinine ratio, Oil Red O staining and adipose differentiation-related protein expression, and Sirius Red staining, respectively. Oxygen consumption rate of HGPA-treated HK-2 cells with or without FGF1 was measured using the Seahorse XF Analyzer.</p><p><strong>Results: </strong>FGF1 treatment reduced urinary albumin excretion, ameliorated glomerular hypertrophy, attenuated renal fibrosis and inflammation, and diminished lipid accumulation in diabetic kidneys. Analysis of fatty acid metabolism revealed that cluster of differentiation 36, a key regulator of long-chain fatty acids uptake, was upregulated, while carnitine palmitoyl transferase 1A, a rate-limiting enzyme in fatty acid beta-oxidation (FAO), was downregulated in diabetic kidneys and HGPA-treated HK-2 cells. FGF1 treatment normalized the expression of both cluster of differentiation 36 and carnitine palmitoyl transferase 1A and enhanced FAO in HGPA-treated HK-2 cells. Mechanistically, FGF1 restored AMP-activated protein kinase (AMPK) activity and peroxisome proliferator-activated receptor alpha expression, both of which were suppressed in DN and HGPA-treated HK-2 cells. Notably, pharmacological inhibition of AMPK or FAO abolished the protective effect of FGF1.</p><p><strong>Conclusion: </strong>FGF1 alleviates DN by inhibiting fatty acid uptake and promoting lipid catabolism <i>via</i> AMPK activation and FAO enhancement.</p>","PeriodicalId":48607,"journal":{"name":"World Journal of Diabetes","volume":"17 2","pages":"112475"},"PeriodicalIF":4.6,"publicationDate":"2026-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12897520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146202890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective potential of a plant-based intervention in diabetic neuropathy: Biochemical and behavioral insights from a streptozotocin-induced rat model.","authors":"Mohd Adnan Kausar, Kehkashan Parveen, Sadaf Anwar, Yusuf Saleem Khan, Ayman A Saleh, Mai Ali Abdelfattah Ahmed, Waseem Ahmad Siddiqui, Suhel Parvez","doi":"10.4239/wjd.v17.i2.113992","DOIUrl":"10.4239/wjd.v17.i2.113992","url":null,"abstract":"<p><strong>Background: </strong>Diabetic neuropathy is a neurodegenerative complication of diabetes mellitus that occurs due to various factors, with oxidative stress, neuroinflammation and neurotrophic signalling impairment being the major causes.</p><p><strong>Aim: </strong>To evaluate the neuroprotective effects of a polyherbal extract (PHE) prepared from <i>Citrullus colocynthis</i>, <i>Curcuma longa</i>, and <i>Myristica fragrans</i> in diabetic rats.</p><p><strong>Methods: </strong>Type 2 diabetes was induced in rats with a single intraperitoneal injection of streptozotocin, and those with fasting blood glucose levels of > 250 mg/dL were included for further studies. The animals were categorised into five groups: Control, diabetic, diabetic + PHE, control + PHE and diabetic + metformin. These treatments were administered orally for 8 weeks. Behavioral tests comprised the hot plate, tail-flick, acetone drop and rotarod tests. Serum glucose, insulin, glycosylated haemoglobin and lipid profile analyses were performed, along with oxidative stress (malondialdehyde, reduced glutathione, superoxide dismutase, catalase and glutathione-S-transferase) and pro-inflammatory (tumour necrosis factor-α and interleukin-6) markers. Neurotrophic factors were measured, and the pancreas, liver and sciatic nerve were histologically examined.</p><p><strong>Results: </strong>This study demonstrated that PHE exerts a significant metabolic regulatory effect in streptozotocin-induced diabetic rat models. PHE treatment led to a marked reduction of 30.17% in fasting blood glucose levels, indicating potent antihyperglycemic activity, and also restored the lipid profile, enhanced antioxidant defenses, and reduced neuroinflammation. Serum insulin levels were significantly increased in diabetic rats receiving PHE, suggesting potential stimulation or preservation of pancreatic β-cells. Furthermore, behavioral impairments and histological damage were notably reversed following PHE administration.</p><p><strong>Conclusion: </strong>The PHE derived from <i>Curcuma longa, Myristica fragrans</i>, and <i>Citrullus colocynthis</i> mitigates diabetic neuropathy through synergistic chemical-biological interactions targeting key mediators of oxidative stress and inflammation. These findings support the need for comprehensive evaluation of this formulation as a potential therapeutic candidate. This study enhances the current understanding of integrative approaches for managing chronic diabetic complications and provides further evidence supporting the therapeutic potential of plant-based compounds.</p>","PeriodicalId":48607,"journal":{"name":"World Journal of Diabetes","volume":"17 2","pages":"113992"},"PeriodicalIF":4.6,"publicationDate":"2026-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12897518/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146203339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetes prolongs hospitalization and increases infection, cerebral edema, and neurological complications in meningioma patients: A retrospective study.","authors":"Yu-Fu Zhang, Wei Ma, Long Chen, Shu-Kai Sun, Li Gao","doi":"10.4239/wjd.v17.i2.112856","DOIUrl":"10.4239/wjd.v17.i2.112856","url":null,"abstract":"<p><strong>Background: </strong>Diabetes is linked to extended hospitalization and a heightened risk of complications in multiple surgical settings. However, its precise influence on outcomes in patients undergoing meningioma resection is still inadequately comprehended.</p><p><strong>Aim: </strong>To determine if diabetes prolongs hospital stay and elevates the risk of infection, cerebral edema, and neurological complications in patients undergoing meningioma resection.</p><p><strong>Methods: </strong>A retrospective study was conducted on 516 primary meningioma patients who underwent surgical resection between January 2018 and January 2022. Patients were categorized into non-diabetes (<i>n</i> = 411) and diabetes (<i>n</i> = 105) groups according to a clinical history of type 2 diabetes for a minimum of 6 months preceding diagnosis. The collected data encompassed baseline demographics, perioperative variables, blood glucose levels, inflammatory markers, brain edema grading, Karnofsky Performance Status, length of stay, and postoperative complications.</p><p><strong>Results: </strong>Significant differences in glycated hemoglobin levels were observed, with elevated values in the diabetes group (<i>P</i> < 0.05). The diabetes group exhibited higher rates of secondary or tertiary wound healing complications due to infection, lower postoperative albumin, higher postoperative platelet counts, white blood cell counts, C-reactive protein levels, and tumor necrosis factor-alpha levels (all <i>P</i> < 0.05). The diabetes group exhibited higher incidence of postoperative cerebral edema (<i>P</i> = 0.015), lower postoperative Karnofsky Performance Status scores (<i>P</i> = 0.011), longer hospital stays (<i>P</i> < 0.001), and longer intensive care unit stays (<i>P</i> < 0.001). Additionally, the diabetes group exhibited higher rates of seizures (<i>P</i> = 0.003) and wound infections (<i>P</i> < 0.001) and more complications (<i>P</i> < 0.001). Long-term outcomes showed higher tumor recurrence (<i>P</i> = 0.004) and mortality rates (<i>P</i> = 0.036) in the diabetes group, corroborated by Cox regression analysis as independent risk factors (recurrence: Adjusted hazard ratio = 8.92, <i>P</i> = 0.009; mortality: Adjusted hazard ratio = 10.12, <i>P</i> = 0.048).</p><p><strong>Conclusion: </strong>Diabetes markedly extends hospital stay and elevates the risk of infection, cerebral edema, and neurological complications in patients with meningioma, underscoring the necessity for meticulous perioperative management and long-term follow-up for diabetic individuals undergoing meningioma surgery.</p>","PeriodicalId":48607,"journal":{"name":"World Journal of Diabetes","volume":"17 2","pages":"112856"},"PeriodicalIF":4.6,"publicationDate":"2026-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12897507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146203440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 outbreak on the seasonality and incidence of pediatric type 1 diabetes mellitus.","authors":"Andrea Scaramuzza, Claudio Cavalli","doi":"10.4239/wjd.v17.i2.113109","DOIUrl":"10.4239/wjd.v17.i2.113109","url":null,"abstract":"<p><p>To respond to the recent study by Carmon <i>et al</i> on type 1 diabetes (T1DM) incidence/seasonality pre-coronavirus disease 2019 and peri-coronavirus disease 2019, we highlighted convergent findings from the Lombardy pediatric T1DM data (2017-2023). Carmon <i>et al</i> reported elevated T1DM incidence and lost seasonality in the pandemic first year in Israel, linking respiratory viral disruption to T1DM risk. Our data show a 2020 step-increase in Lombardy pediatric T1DM and stable elevated rates (2020-2023) unrelated to coronavirus disease 2021 vaccines. Combined Israeli-Italian data suggest the pandemic triggered lasting higher pediatric T1DM incidence, potentially <i>via</i> severe acute respiratory syndrome coronavirus 2-mediated beta cell damage or immunological shifts, emphasizing global surveillance needs for pandemic autoimmune disease links.</p>","PeriodicalId":48607,"journal":{"name":"World Journal of Diabetes","volume":"17 2","pages":"113109"},"PeriodicalIF":4.6,"publicationDate":"2026-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12897502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146203482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}