Journal of Eating Disorders最新文献

{"title":"Patients with anorexia nervosa have an increased burden of rare, damaging mutations in the BBOX1 gene.","authors":"Michael Lutter","doi":"10.1186/s40337-025-01323-w","DOIUrl":"10.1186/s40337-025-01323-w","url":null,"abstract":"<p><strong>Background: </strong>People with anorexia nervosa (AN) exhibit a strong aversion to eating calorically dense foods, especially those high in fat. It has previously been reported that these patients display altered metabolism of fatty acids, however it is unclear if these metabolic disturbances represent a primary biological substrate underlying predisposition to restrictive eating behaviors or occur secondarily to malnutrition.</p><p><strong>Methods: </strong>We report the frequency of rare (minor allele frequency < 1%), damaging (CADD > 15) mutations in the BBOX1 gene of 183 patients with anorexia nervosa who received whole exome sequencing (WES) as part of their psychiatric evaluation. The observed frequency from our cohort was then compared to the rate of rare, damaging mutations in BBOX1 reported in the gnomAD database to determine if there was an excessive burden of damaging mutations.</p><p><strong>Results: </strong>The 11-27127338-G-A single nucleotide polymorphism in BBOX1 was observed to be shared by four sisters with a history of AN. Subsequent analysis found that this variant was also present in five out of 182 patients who had WES results. Six more unrelated patients out of 182 were found to have one of five additional rare, damaging mutations in BBOX1. In total, 12 out of 183 patients (6.6%) with AN were found to have a rare, damaging mutation in BBOX1 compared to an expected count of 4.4 (2.4%) from the gnomAD database (odds ratio 2.86; p = 0.0117).</p><p><strong>Conclusions: </strong>Patients with a history of AN have an increased burden of rare, damaging mutations in the BBOX1 gene. Because BBOX1 is required for synthesis of carnitine, a nutrient required for transport of long-chain fatty acids into the mitochondria for beta-oxidation, this finding suggests that impaired utilization of long-chain fatty acids may increase the risk of developing AN in a subset of patients. Identification of this group of patients by genetic or blood testing may lead to improved treatment outcomes and/or secondary prevention of relapse.</p>","PeriodicalId":48605,"journal":{"name":"Journal of Eating Disorders","volume":"13 1","pages":"140"},"PeriodicalIF":3.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transgenerational transmission of eating disorders: the role of eating disorder symptoms and socio-cultural attitudes.","authors":"Bar Zissu, Helene Sher, Ortal Slobodin","doi":"10.1186/s40337-025-01317-8","DOIUrl":"10.1186/s40337-025-01317-8","url":null,"abstract":"<p><strong>Objective: </strong>Eating disorders may be transmitted from one generation to the others through various trajectories, including genetic and epigenetic factors, parent-child relationships, and behavioral factors. In the current study, we examined whether parents' eating disorder symptoms and sociocultural attitudes toward appearance are associated with the diagnosis of an eating disorder or the level of eating disorder symptoms among female adolescents and young adults, and the nature of these associations. We also examined whether fathers' and mothers' effects on offsprings' eating disorder symptoms interact.</p><p><strong>Method: </strong>The study included 65 triads of mothers, fathers, and their female offspring aged 11-22 (N = 195). Thirty-two offspring were diagnosed with an eating disorder and recruited from the in-patient eating disorder unit in a public hospital. The remaining 33 offspring, who formed the control group, were recruited via social media platforms.</p><p><strong>Results: </strong>In contrast to our expectations and previous findings, mothers' and fathers' levels of eating disorder symptoms and sociocultural attitudes toward appearance were negatively associated with their offspring's eating disorder symptoms. Also, inconsistent with mental health studies that showed that the behaviors and attitudes of one parent are exacerbated or attenuated by the other parent, we failed to find an interaction effect between mothers' and fathers' variables on their offspring's level of eating disorder symptoms.</p><p><strong>Discussion: </strong>The current study adds to the limited number of studies that focused on fathers in the transgenerational transmission of eating disorders and encourages further research on the effects of each parent and the combined effects of both in the development and maintenance of eating disorders in their offspring.</p>","PeriodicalId":48605,"journal":{"name":"Journal of Eating Disorders","volume":"13 1","pages":"137"},"PeriodicalIF":3.5,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12255978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144620941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A lifeline or a label? lived experience perspectives on the severe and enduring eating disorder (SEED) classification in eating disorder treatment.","authors":"Gabriel Lubieniecki, Isabella McGrath, Gemma Sharp","doi":"10.1186/s40337-025-01335-6","DOIUrl":"10.1186/s40337-025-01335-6","url":null,"abstract":"","PeriodicalId":48605,"journal":{"name":"Journal of Eating Disorders","volume":"13 1","pages":"136"},"PeriodicalIF":4.5,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12247242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144620940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measurement invariance of a brief disordered eating scale in a large sample of secondary school students in Canada.","authors":"Lin Zheng, William Pickett, Jian Liu, Scott T Leatherdale, Karen A Patte","doi":"10.1186/s40337-025-01332-9","DOIUrl":"10.1186/s40337-025-01332-9","url":null,"abstract":"<p><strong>Background: </strong>For use in population-level surveys, there is a need for brief measures of disordered eating (DE) that demonstrate validity among diverse adolescents. This study aimed to (1) assess the measurement invariance of a short DE scale among high school students in Canada, and (2) estimate differences in scale scores across student sociodemographic subgroups.</p><p><strong>Methods: </strong>We used student-level survey data collected during the 2021/2022 school year in the COMPASS study. The sample included 24,639 students in grades 9-12 from 69 secondary schools in Alberta, British Columbia, and Ontario, Canada. Multi-group confirmatory factor analysis was applied to assess measurement invariance (i.e., configural, metric, scalar, and strict invariance) of the 6-item DE scale, and one-way ANOVA and mixed linear regression were implemented to estimate scale score differences across population subgroups (by grade, gender, race and ethnicity, family affluence, and weight status).</p><p><strong>Results: </strong>Results demonstrated full measurement invariance of the DE scale across student sociodemographic subgroups. Higher sum scale scores indicated greater engagement in DE thoughts or behaviours. Students in higher school grade (e.g., grade 12), transgender and gender diverse youth, and cisgender girls reported higher DE scores compared to their grade 9 and cisgender boy peers. Elevated DE scores were also observed among adolescents of Middle Eastern and Another or Multiethnic identity, students with less affluent households, and those with higher body weights, relative to their White, more affluent, and relatively lower weight peers, respectively.</p><p><strong>Conclusions: </strong>Results indicate the DE scale measures the same construct across various subgroups of adolescents, providing confidence that differences in scale scores found by grade, gender, race and ethnicity, affluence, and weight reflect actual differences in DE rather than artifactual differences in scale interpretation. This scale warrants additional psychometric testing as a promising brief DE measure suitable for large population-level youth surveys. Our results provide important new evidence from a large contemporary sample of adolescents demonstrating elevated risk of DE among specific subgroups and emphasizing the need for targeted interventions.</p>","PeriodicalId":48605,"journal":{"name":"Journal of Eating Disorders","volume":"13 1","pages":"132"},"PeriodicalIF":3.5,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12243181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between dietary intake, eating attitudes, and premenstrual syndrome severity among Iranian women: insights from a cross-sectional study.","authors":"Sara Mighani, Fatemeh Taghizadeh Shivyari, Alireza Razzaghi, Mohammad Amerzadeh, Maryam Javadi","doi":"10.1186/s40337-025-01326-7","DOIUrl":"10.1186/s40337-025-01326-7","url":null,"abstract":"<p><strong>Background: </strong>Premenstrual syndrome (PMS) is a common issue that impacts many women, and a well-balanced diet can help alleviate PMS symptoms. Evidence suggests that dietary factors and eating disorders may influence PMS severity, yet the specific relationships remain unclear. This study aimed to evaluate the association of specific dietary components and eating behaviors with PMS symptoms.</p><p><strong>Methods: </strong>This cross-sectional study was conducted on 252 women with PMS who were referred to healthcare centers in Qazvin province. Data concerning PMS, dietary factors, and eating disorders were collected using online questionnaires, including the premenstrual symptoms screening tool (PSST), 3-day dietary recall, and Eating Attitudes Test-26 (EAT-26) questionnaires. Statistical analysis utilized ANOVA and chi-square tests. The adequacy of the sample was evaluated using the Kaiser-Meyer-Olkin (KMO) test. To examine the relationship between eating disorders, dietary factors, and PMS symptoms, multivariable linear regression analysis was conducted. Statistical significance was set at p < 0.05.</p><p><strong>Results: </strong>According to the PSST, 28.7% of individuals reported mild severity, 21.9% reported moderate severity, and 49.4% reported severe severity. The study revealed that higher sodium (p = 0.003, OR = 1.000, 95% CI = [1.000, 1.001]), vitamin D (p = 0.044, OR = 1.298, 95% CI = [1.007, 1.674]), and vitamin C intake were positively linked to increased psychological PMS symptoms, (p = 0.036, OR = 1.006, 95% CI = [1.000, 1.012]) while magnesium showed a negative association with these symptoms. Also, sodium and vitamin D intake were significantly associated with increased physical symptoms (p < 0.05). Individuals with eating disorders showed higher rates of severe PMS symptoms, though differences were not statistically significant (p > 0.05).</p><p><strong>Conclusion: </strong>These findings highlight the potential influence of specific nutrients on PMS severity. This insight could inform dietary recommendations for managing PMS symptoms, providing young women with potential non-pharmacological options to relieve discomfort.</p>","PeriodicalId":48605,"journal":{"name":"Journal of Eating Disorders","volume":"13 1","pages":"131"},"PeriodicalIF":3.5,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12243156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social rejection sensitivity and its role in anorexia nervosa: a systematic review of experimental literature.","authors":"Senan Coughlan-Hopkins, Cristina Martinelli","doi":"10.1186/s40337-025-01261-7","DOIUrl":"10.1186/s40337-025-01261-7","url":null,"abstract":"<p><strong>Objective: </strong>Social rejection sensitivity (SRS) is characterised by anxious expectations of rejection, and the increased tendency to readily perceive and react intensely to rejection-based cues. It has been suggested SRS may play a role in anorexia nervosa (AN). Our review investigates whether SRS is exhibited in AN, and the cognitive mechanisms that underly this disposition.</p><p><strong>Method: </strong>We included experimental studies if they used social threat or rejection-based stimuli, reported on measures related to either cognitive, emotional, and/or behavioural responses, and compared patients with a diagnosis of AN and/or those who have recovered from the illness with healthy controls.</p><p><strong>Results: </strong>This article identified 47 eligible studies, with risk of bias assessment indicating the research was of good quality. Main findings showed patients with AN exhibit attentional bias towards social rejection cues, negative interpretation bias during ambiguous social scenarios, and heightened negative affect during and following rejection-based experiences. Physiological blunting during and following rejection-based experiences was observed in AN with some evidence to suggest this remediates during the process of weight-restoration. demonstrating an incongruence between affective and somatic experience in active illness.</p><p><strong>Discussion: </strong>Our results suggest females with AN display a cognitive profile that could lead to a tendency to expect rejection, readily perceive rejection and react with more intense negative affect to rejection-based cues, with limited evidence to suggest this cognitive profile persists in recovery. Our results can be interpreted through theoretical models that postulate drive for thinness may partially function to cope with anticipated or experienced rejection.</p>","PeriodicalId":48605,"journal":{"name":"Journal of Eating Disorders","volume":"13 1","pages":"134"},"PeriodicalIF":3.5,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12247325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personalised and precision mental health in eating disorders: why routine outcome measurement is key.","authors":"Amelia Austin, Karina L Allen","doi":"10.1186/s40337-025-01290-2","DOIUrl":"10.1186/s40337-025-01290-2","url":null,"abstract":"<p><p>For over a decade, the mental health field has been interested in precision treatment using psychopharmacological interventions. More recently, this interest has expanded to include psychotherapy, which is the primary treatment modality for eating disorders. Personalised medicine and precision treatment are also seen as priorities for the eating disorder field by those with lived experience and carers, clinicians and researchers. However, precision treatment necessitates the collection of large amounts of clinical data. Three frameworks exist or have been proposed for the purpose of gathering large-scale routine clinical outcomes in eating disorder services: The International Consortium for Health Outcomes Measurement (ICHOM) eating disorder set, the Australia national minimum dataset, and the Eating Disorders Clinical Research Network. Despite the emergence of these frameworks, challenges exist with implementation. This paper outlines the rationale for the collection of routine outcome data in eating disorder treatment settings, the three existing frameworks proposed, and considerations for implementation and scaling. These include clinical and practice applications, technical aspects, statistics, and contextual factors. We invite attention to our recommendations and collaborative approaches to facilitate progress towards precision treatment in eating disorders.</p>","PeriodicalId":48605,"journal":{"name":"Journal of Eating Disorders","volume":"13 1","pages":"135"},"PeriodicalIF":3.5,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12247249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acceptability of a personalised single-session feedback intervention for eating disorders: a qualitative content analysis.","authors":"Laura Lapadat, Samantha Wilson, Lisa Y Zhu, Sarah E Racine","doi":"10.1186/s40337-025-01333-8","DOIUrl":"10.1186/s40337-025-01333-8","url":null,"abstract":"","PeriodicalId":48605,"journal":{"name":"Journal of Eating Disorders","volume":"13 1","pages":"133"},"PeriodicalIF":3.5,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12247479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the relationship between peer attachment, and disordered eating behaviours and body dissatisfaction in adolescence: a systematic review.","authors":"Clarice Chan, Cecily Donnelly, Aphrodite Eshetu, Dasha Nicholls","doi":"10.1186/s40337-025-01273-3","DOIUrl":"10.1186/s40337-025-01273-3","url":null,"abstract":"<p><strong>Objective: </strong>Adolescence is a critical period in the development of eating disorders (ED) and the influence of peers becomes increasingly evident in shaping behaviour. Insecure attachment to parents is associated with higher ED risk, but the impact of attachment to peers is unknown. This systematic review aims to ascertain the role of peer attachment in ED symptoms and body dissatisfaction in adolescents.</p><p><strong>Methods: </strong>Electronic databases Medline, Embase, PsychINFO, and Scopus were searched using the search terms related to adolescents, eating disorders, peers, and attachment.</p><p><strong>Results: </strong>Out of the 19 included studies (n = 15 cross-sectional, n = 4 Longitudinal), most (n = 17) used the Peer subscale of the 'Inventory of Parent and Peer Attachment (IPPA)' to measure peer attachment. The prevalence of insecure attachment was higher in populations with ED symptoms compared to those without. Lower attachment scores were associated with higher ED symptomology and body dissatisfaction. Out of the 3 subscales of the IPPA, alienation emerged as the most significant predictor of symptomology.</p><p><strong>Discussion: </strong>Insecure attachment to peers may be a risk factor in the development of ED symptoms and body dissatisfaction, but the protective role of secure attachment remains unclear. More longitudinal research is required to disentangle this relationship and ascertain the clinical significance of peer attachment in prognosis or intervention.</p>","PeriodicalId":48605,"journal":{"name":"Journal of Eating Disorders","volume":"13 1","pages":"130"},"PeriodicalIF":3.5,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12235894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From childhood to adolescence: Development of binge eating and the prospective role of self-regulation.","authors":"Nele Westermann, Annette M Klein, Robert Busching, Petra Warschburger","doi":"10.1186/s40337-025-01330-x","DOIUrl":"10.1186/s40337-025-01330-x","url":null,"abstract":"<p><strong>Background: </strong>Research shows that binge eating often starts in childhood or adolescence, but its development remains largely unexplored. Additionally, while cross-sectional studies link self-regulation to binge eating, longitudinal research is lacking. Therefore, this study examined the development of binge eating and self-regulation as a potential predictor for this development in a community sample.</p><p><strong>Methods: </strong>A total of N = 1660 children were assessed at four time points spanning ages 6-11, 7-11, 9-13, and 16-21. The assessment of self-regulation encompassed emotional reactivity, working memory updating, cognitive flexibility, inhibition, inhibitory control, planning behavior, affective decision-making, anger regulation, and as appetite self-regulation, satiety responsiveness, emotional overeating, food responsiveness, and external eating, using computerized tasks, teacher- and parent-reports. Binge eating was modeled by child-reported loss of control eating, overeating, and eating in the absence of hunger. A latent change score model was used to evaluate intra- and interindividual differences in binge eating across middle childhood and adolescence. Self-regulation facets were regressed on changes in binge eating.</p><p><strong>Results: </strong>Results indicated a decrease in binge eating at the beginning of middle childhood, followed by a stagnation and then an increase during adolescence, with significant interindividual differences in these changes. Higher planning behavior, inhibitory control, and cognitive flexibility predicted decreases in binge eating during middle childhood, while higher satiety responsiveness unexpectedly predicted an increase in binge eating during adolescence. Results remained the same after controlling for body weight.</p><p><strong>Conclusions: </strong>Our findings highlight adolescence as a critical period for binge eating prevention, with planning behavior, inhibitory control, and cognitive flexibility acting as protective factors in middle childhood. The longitudinal data underscore the importance of self-regulation in the development of binge eating.</p>","PeriodicalId":48605,"journal":{"name":"Journal of Eating Disorders","volume":"13 1","pages":"129"},"PeriodicalIF":3.5,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12232867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}