Journal of Eating Disorders最新文献

{"title":"Exercise addiction and disordered eating in young Lebanese regular sport practitioners: the indirect role of body appreciation and body dysmorphic concerns.","authors":"Michelle Abi Karam, Rana El Khoury, Carla Hokayem, Nada Akiki, Sahar Obeid, Feten Fekih-Romdhane, Souheil Hallit, Marie Hokayem","doi":"10.1186/s40337-025-01269-z","DOIUrl":"https://doi.org/10.1186/s40337-025-01269-z","url":null,"abstract":"<p><strong>Background: </strong>Disordered eating, encompassing behaviors like restrictive dieting, binge eating, and purging, is a prevalent issue with significant psychological and physical consequences. Among athletes, it is often exacerbated by sociocultural pressures and performance demands, making it a critical area of study. Exercise addiction is characterized by compulsive exercise behaviors and is frequently associated with disordered eating; however, the underlying mechanisms of this relationship remain unclear. Limited research has explored the factors that may contribute to the risk of both exercise addiction and disordered eating, particularly in athletes. This study aims to investigate the relationship between exercise addiction and disordered eating in regular sport practitioners and explore the potential indirect roles of body appreciation and body dysmorphic concerns. Examining these constructs is particularly important, as sociocultural pressures and limited mental health resources may uniquely influence their risk factors and experiences.</p><p><strong>Methods: </strong>This was a cross-sectional study enrolling 321 Lebanese regular sport practitioners (mean age of 21.09 years with 51.2% males) currently residing in Lebanon.. The questionnaire consisted of four scales, validated in Arabic: the Eating Attitudes Test, the Body Appreciation Scale, Exercise Addiction Inventory-Youth, and the Dysmorphic Concern Questionnaire.</p><p><strong>Results: </strong>Body appreciation explained a significant amount of the variance in the association between exercise addiction and disordered eating; higher exercise addiction was significantly associated with lower body appreciation and directly associated with more disordered eating. Moreover, higher body appreciation was significantly associated with less disordered eating. Furthermore, body dysmorphic concerns explained a significant amount of variance in the association between exercise addiction and disordered eating; higher exercise addiction was significantly associated with more body dysmorphic concerns and directly associated with more disordered eating. Additionally, higher body dysmorphic concerns were significantly associated with more disordered eating.</p><p><strong>Conclusion: </strong>The study examines the significant indirect role of body dysmorphic concerns and body appreciation between exercise addiction and disordered eating in young adult athletes. These findings underscore the need for interventions targeting body dysmorphic concerns and body appreciation in addressing exercise addiction and disordered eating. By fostering a positive body image and reducing maladaptive behaviors, this can guide coaches and trainers in creating supportive, body positive environments that prioritize athletes' mental and physical well-being.</p>","PeriodicalId":48605,"journal":{"name":"Journal of Eating Disorders","volume":"13 1","pages":"93"},"PeriodicalIF":3.5,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A call for a trauma-informed approach during compulsory care for enduring anorexia nervosa with combined PTSD - an autoethnographic perspective.","authors":"Jennie Moberg","doi":"10.1186/s40337-025-01283-1","DOIUrl":"https://doi.org/10.1186/s40337-025-01283-1","url":null,"abstract":"<p><strong>Background: </strong>Individuals with both anorexia nervosa (AN) and post-traumatic stress disorder (PTSD) often experience significant challenges in psychiatric inpatient care, particularly when coercive measures are used. While the comorbidity of AN and PTSD is well-documented, their interplay in the context of compulsory care and from a lived experience and trauma-informed perspective remains underexplored, despite its critical impact on treatment outcomes. This autoethnographic study aims to shed light on how coercion is experienced in this context, highlighting the need for a trauma-informed approach that acknowledges patients' histories rather than solely viewing their behaviors as pathological. The Power Threat Meaning Framework (PTMF) provides a theoretical lens for understanding how trauma affects individuals with AN and PTSD, emphasizing the importance of viewing these conditions not just as symptoms to be treated but as survival strategies linked to broader trauma histories.</p><p><strong>Methods: </strong>An autoethnographic approach was used to analyze blog posts, clinical notes, and diary entries from 2010 to 2019, focusing on experiences of AN, coercion, and trauma.</p><p><strong>Results: </strong>One overarching theme, 'Life in inpatient care', and four subthemes emerged: (1) 'Being sucked into the vortex of hunger', (2) 'Relapse no. 5 and admission procedure - state of emergency', (3) 'Encountering coercion and losing control - living in constant fear', and (4) 'Managing the aftermaths of eating'.</p><p><strong>Conclusions: </strong>This autoethnography highlights the interplay between AN and PTSD in compulsory inpatient care, showing how AN served as a coping mechanism for trauma, with starvation as emotional avoidance. The PTMF framework challenges diagnostic-based models, viewing these behaviors as survival strategies rather than pathology. Key findings highlight the impact of coercive treatments such as forced feeding and restraint, which can intensify fear and retraumatization. A trauma-informed approach prioritizing trust, autonomy, and trauma acknowledgment is essential for effective, compassionate care. Recovery should go beyond renourishment to include psychological healing and body-self reintegration, emphasizing a holistic, patient-centered approach for improved treatment outcomes.</p>","PeriodicalId":48605,"journal":{"name":"Journal of Eating Disorders","volume":"13 1","pages":"92"},"PeriodicalIF":3.5,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144162872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic emergence of dissociated traumatic memories during psilocybin treatment for anorexia nervosa.","authors":"Stephanie Knatz Peck, Timothy D Brewerton, Hannah Fisher, Julie Trim, Samantha Shao, Nadav Liam Modlin, Jessie Kim, Daphna M Finn, Walter H Kaye","doi":"10.1186/s40337-025-01274-2","DOIUrl":"10.1186/s40337-025-01274-2","url":null,"abstract":"<p><strong>Background: </strong>Psychedelic treatment is a rapidly emerging therapeutic approach for a host of chronic, difficult to treat psychiatric disorders, including anorexia nervosa (AN). Trauma and its sequelae, such as dissociation, often contribute to comorbidity and treatment refractoriness.</p><p><strong>Aims: </strong>In this report, we describe the therapeutic emergence of previously dissociated traumatic memories of sexual assault in 2 of 10 research participants with AN while receiving psilocybin treatment.</p><p><strong>Methods: </strong>Ten female adults who met DSM-5 criteria for AN or pAN (partial remission) participated in an open pilot study evaluating the safety, tolerability and preliminary efficacy of psilocybin-assisted psychotherapy. Participants received a 25-mg dose of investigational drug COMP360, a proprietary pharmaceutical-grade synthetic psilocybin formulation developed by COMPASS Pathfinder Ltd. administered in conjunction with psychological support. Participants also received two integration therapy sessions on days 1 and 7 after dosing, and they were reassessed at 1 and 3 months. Participants were interviewed using a semi-structured interview to understand qualitative perspectives of treatment and its effect on AN.</p><p><strong>Results/outcomes: </strong>Both patients described in this report significantly benefited from the emergence and processing of previously dissociated information (dissociative amnesia), and both patients subsequently attained remission of their AN psychopathology at 3-month follow-up as determined by global scores on the Eating Disorder Examination Questionnaire (EDE-Q) and clinically meaningful weight gain.</p><p><strong>Conclusions/interpretation: </strong>PT may hold promise not only in the treatment of eating disorders but also trauma-related disorders, including PTSD and dissociative amnesia. Potential mechanisms of psilocybin's facilitation of remembering and processing traumatic material is reviewed.</p>","PeriodicalId":48605,"journal":{"name":"Journal of Eating Disorders","volume":"13 1","pages":"89"},"PeriodicalIF":3.5,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A way of relating to life; myself and others - a thematic analysis of patients' experience of having an eating disorder.","authors":"Malin Bäck, Sanna Aila Gustafsson, Karin Jacobson, Theresia Ljung, Rolf Holmqvist, Gerhard Andersson","doi":"10.1186/s40337-025-01291-1","DOIUrl":"10.1186/s40337-025-01291-1","url":null,"abstract":"<p><strong>Background: </strong>Eating disorders are psychiatric conditions that extend beyond concerns with weight, body and shape, encompassing complex issues related to self-esteem, emotion regulation and interpersonal functioning. Moreover, co-occurring depression, often undiagnosed, is a common complicating factor. Gaining an in-depth understanding of living with an eating disorder is vital both theoretically and for identifying factors that maintain or inhibit recovery. Patient-centred studies offer valuable insights into the lived experience of eating disorders, highlighting their impact and interaction with various life phenomena.</p><p><strong>Methods: </strong>This qualitative study aimed to capture the meaning and experience of living with an eating disorder from a patient perspective. Semi-structured interviews were conducted with 15 women suffering from eating disorders and comorbid depressive symptoms, prior to the start of treatment. Data were analysed using reflexive thematic analysis.</p><p><strong>Results: </strong>Two dimensions of relating to the eating disorder emerged. The first dimension, \"Relating to the eating disorder over time\", followed a temporal trajectory with four themes: \"The eating disorder as a way to handle other difficulties\", \"From control to a consistent loss of control\", \"The whole existence revolves around the eating disorder\" and \"Hard to see a life without the eating disorder\". The second dimension, \"Having an eating disorder- a relentless relating\", focused on the present experience and was divided into two themes: \"The eating disorder's impact on relating to myself\" and \"The eating disorder's impact on relating to others\".</p><p><strong>Conclusions: </strong>Living with an eating disorder involves a constant, entangled and conflicted relationship with the disorder, leading to alienation from significant others and one's own body. This pervasive presence of disordered thoughts and behaviours makes it challenging to relate to oneself and the external world without their influence. Over time, the disorder becomes increasingly ego-syntonic, rendering it difficult to envisage a life without it. Treatment should, therefore, aim to externalise the disorder-to foster new life goals, enhance social engagement, and improve interpersonal skills. Further research is needed to elucidate how co-occurring depressive symptomatology influences an individual's relationship with their eating disorder, as these factors may be crucial in tailoring effective interventions.</p>","PeriodicalId":48605,"journal":{"name":"Journal of Eating Disorders","volume":"13 1","pages":"88"},"PeriodicalIF":3.5,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the burden of anorexia nervosa and bulimia nervosa in Mexico, 1990-2021.","authors":"Jesús Alberto Pérez-Hernández, Itzel Alejandra Téllez-Castillo, Liliana Giraldo-Rodríguez, Marcela Agudelo-Botero","doi":"10.1186/s40337-025-01288-w","DOIUrl":"10.1186/s40337-025-01288-w","url":null,"abstract":"<p><strong>Background: </strong>Eating disorders (ED) have been on the rise in both high-income and middle-income countries. The objective of this study is to analyze the burden of eating disorders (ED) due anorexia nervosa (AN) and bulimia nervosa (BN) in Mexico at the national and subnational levels between 1990 and 2021 and to measure the correlation between disability-adjusted life years (DALY) with the socio-demographic index (SDI) and with the healthcare access and quality index (HAQI) for both 1990 and 2021.</p><p><strong>Methods: </strong>This was a secondary analysis of the GBD 2021. The DALY number and age-standardized rate (ASR) were analyzed for 1990, 2005, 2019, and 2021. The data were disaggregated by sex, age groups, and subcauses (AN and BN) at national and subnational levels.</p><p><strong>Results: </strong>In Mexico, the ASR DALY due to ED increased by 50.2% and 49.6% between 1990 and 2021. In all states and for all years, women had higher ASR DALY due to ED than men. The ASR DALY was also higher for BN than for AN. A positive and significant correlation existed between ASR DALY due to ED and the SDI and HAQI.</p><p><strong>Conclusions: </strong>ED due AN and BN represents a significant burden for individuals under 50 years old in Mexico. There are wide disparities between states and heterogeneous patterns by sex, age groups, and subcauses. Prioritizing this issue on the country's public policy agenda is crucial.</p>","PeriodicalId":48605,"journal":{"name":"Journal of Eating Disorders","volume":"13 1","pages":"90"},"PeriodicalIF":3.5,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12107798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Family-based treatment with metacognitive therapy for adolescents with anorexia nervosa: findings from a phase II trial.","authors":"Beate Østgård, Gunn Julie D Nordahl, Arve Strandheim, Hans M Nordahl","doi":"10.1186/s40337-025-01272-4","DOIUrl":"10.1186/s40337-025-01272-4","url":null,"abstract":"<p><strong>Background: </strong>The incidence of anorexia nervosa (AN) has increased over the past decade, particularly among school-aged children. Family-based therapy (FBT), which focuses on parental management and control, is the recommended and standard treatment for adolescents with AN. While FBT promotes weight gain and improved parent‒child interactions, it does not directly address the adolescents' cognitive change, which could make them vulnerable to relapse. Metacognitive therapy is scarcely studied in AN, and this trial tested its feasibility and long-term effects for adolescents with AN.</p><p><strong>Methods: </strong>This phase II trial included 14 adolescents with AN in an A‒B design. Medical tests and diagnostic assessments were conducted before and after treatment. Assessments were conducted before treatment, by end of treatment and at 12 months after end of treatment. We integrated family-based treatment and metacognitive therapy for patient intervention and parental guidance.</p><p><strong>Results: </strong>At posttreatment, 13 of the 14 patients no longer met the diagnostic criteria for AN. There were significant increases in percentage expected body weight and reductions in emotional and cognitive symptoms. One patient continued to have eating disorder symptoms at posttreatment and withdrew before follow-up. No significant changes were observed in areas of family conflict or parent‒child communication. The treatment was well tolerated and deemed meaningful by both parents and patients. No adverse events or rehospitalization occurred during the 12 month follow-up period. Data collection was challenging, especially with respect to patients' disclosure of family interactions and symptoms.</p><p><strong>Conclusions: </strong>The trial revealed positive effects posttreatment at the 12 month follow-up for 13 of 14 participants with AN. The treatment was well tolerated with no adverse effects. Despite the small sample size and lack of control, the results suggest that larger-scale trials of this intervention are warranted.</p><p><strong>Trial registration: </strong>The study has been approved as a clinical and quality audit of the delivered clinical service registered by the institutional research board at Levanger Hospital HF (IRB-13672).</p>","PeriodicalId":48605,"journal":{"name":"Journal of Eating Disorders","volume":"13 1","pages":"91"},"PeriodicalIF":3.5,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12107747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can bioelectrical impedance analysis be used to identify water loading in patients with anorexia nervosa?- Implications from experimental measurements in young, healthy, and normal weight women.","authors":"Nadja Knoll-Pientka, Dorina Schils, Katrin Pasternak, Sandra Czarnetzky, Christoph Jansen, Gertraud Gradl-Dietsch, Jochen Seitz, Eva-Maria Skoda, Lars Libuda, Adam Schweda, Martin Teufel","doi":"10.1186/s40337-025-01285-z","DOIUrl":"10.1186/s40337-025-01285-z","url":null,"abstract":"<p><p>Anorexia nervosa (AN) is a severe mental disorder, and patients with AN are characterized by a low body weight and a fear of gaining weight. Restoration of body weight to the normal range is one major treatment aim, which can be a challenging process for the patients. Hence, as a psychopathological symptom of AN, weight manipulations such as water loading before weighing are commonly observed in clinical routine. Biological impedance analysis (BIA) is a helpful tool in routinely visualizing changes in body composition during the refeeding process. Here, we targeted the question whether BIA could potentially detect water loading in healthy, young and normal weight women serving as a preclinical model for patients with AN.Sixty-one women (mean ± SD, 22.2 ± 2.2 years, 20.4 ± 1.0 kg/m²) were included in the analyses. We used a full experimental setting with a cross-over design on two consecutive days. On both days, all participants underwent a baseline BIA in the fasting state (t₀). Directly thereafter, participants either consumed 1000 ml of tap water (intervention-condition) or waited for the second BIA measurement 20 min (t₁) after baseline (control-condition), and vice versa the subsequent day. Two further BIA measurements took place at 40 (t₂) and 60 min (t₃) after baseline.After water consumption, we found increases in derived fat mass (FM) and phase angle at t₁ to t₃, decreases at t₁ and subsequent increases at t₂ and t₃ in extracellular water (ECW) and total body water (TBW). In contrast, skeletal muscle mass (SMM) and ECW/TBW remained rather stable. In the control-condition, most parameters remained constant.Our study provided insight into the changes of impedance raw data and derived body compartments after water consumption among young, healthy and normal weight women. Although the considerable increase of FM in combination with a rather stable course of SMM, as found in our experiment after the consumption of water, could be a potential hint for water loading, further investigation considering the limitations of the present study as for instance the different metabolisms of patients with AN vs. healthy women is required, before transferability to the clinical setting will be given.</p>","PeriodicalId":48605,"journal":{"name":"Journal of Eating Disorders","volume":"13 1","pages":"87"},"PeriodicalIF":3.5,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Service models in eating disorders: a scoping review.","authors":"Rachel Knight, Karen Stagnitti, Genevieve Pepin","doi":"10.1186/s40337-025-01252-8","DOIUrl":"10.1186/s40337-025-01252-8","url":null,"abstract":"<p><strong>Background: </strong>The complexity of eating disorders can be reflected in the different diagnoses, varied clinical presentations and diverse personal circumstances of people living with an eating disorder. Given this complexity, adaptable and flexible service models are essential for effective care. Service models outline a structure for health care delivery that targets the health-related needs of people. The characteristics of existing service models providing assessment and treatment for eating disorders are not well described or understood.</p><p><strong>Objective: </strong>The purpose of this scoping review was to map and describe the different types of service models for eating disorders and their characteristics.</p><p><strong>Method: </strong>The JBI methodology for scoping reviews was used. A search of four databases (MEDLINE Complete, EMBASE, PsychINFO, and CINAHL) and grey literature was conducted. Sources describing service models supporting individuals with eating disorders were included.</p><p><strong>Results: </strong>After duplicates were removed, the remaining sources were screened and read in full, and 30 sources were included in the review. Most service models were eating disorder specialist, located in metropolitan areas and based in community settings. Key characteristics of eating disorder service models included person-centred care, involvement of family and carers, co-design and lived experience contribution, multidisciplinary team, accessibility, identification and management of co-occurring conditions and integration with broader service systems.</p><p><strong>Conclusion: </strong>Findings indicate vast differences between service models for eating disorders. However, there are examples of innovative and effective service models that show promise. The characteristics of service models for eating disorders identified in this review provided insight into what constitutes an effective and high-quality service model in the sector.</p>","PeriodicalId":48605,"journal":{"name":"Journal of Eating Disorders","volume":"13 1","pages":"85"},"PeriodicalIF":3.5,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lymphocyte subsets and the increased risk for opportunistic infections in severe restrictive anorexia nervosa.","authors":"Petra Vidmar, Josje Altenburg, Ester M van Leeuwen, Annemarie C M van Bellegem, Chantal Verhoef, Godelieve J de Bree, Maarten R Soeters","doi":"10.1186/s40337-025-01235-9","DOIUrl":"10.1186/s40337-025-01235-9","url":null,"abstract":"<p><p>Restrictive anorexia nervosa (AN-R) is characterized not only by psychiatric manifestations but also by significant medical complications. Patients commonly exhibit immune alterations, potentially increasing their susceptibility to infections. While direct evidence linking AN-R to heightened rates of opportunistic infections remains inconclusive, clinical observations suggest a higher incidence of complications and delayed febrile response in patients with infections. Concurrently, malnutrition, a frequent cause of secondary immunodeficiencies, exacerbates this susceptibility by compromising immune function. This paper investigates the immunological profiles of two patients with long-term AN-R who developed severe infections: one with disseminated Mycobacterium kansasii and the other with a co-infection of pulmonary Aspergillus fumigatus and Mycobacterium celatum. These cases, alongside data collected from previously published case reports summarized in this study, highlight the impact of altered immune function associated with mentioned population. The paper aims to explain the underlying mechanisms of immune dysfunction. Proactive monitoring of immune status and incorporating such assays into clinical practice may benefit early detection, effective management, and ultimately, improved outcomes.</p>","PeriodicalId":48605,"journal":{"name":"Journal of Eating Disorders","volume":"13 1","pages":"84"},"PeriodicalIF":3.5,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monitoring neutrophil-to-lymphocyte ratio dynamics for personalized treatment in adolescent eating disorders: a retrospective cohort study.","authors":"Yuta Inagawa, Kazumi Kurata, Seiji Obi, Yoshiyuki Onuki, Yukifumi Monden, Koyuru Kurane, Rieko Furukawa, Tadahiro Mitani, Hirotaka Nakamura, Shiro Suda, Tatsuhiko Yagihashi","doi":"10.1186/s40337-025-01282-2","DOIUrl":"10.1186/s40337-025-01282-2","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the dynamics of the neutrophil-to-lymphocyte ratio (NLR) during the initial hospitalization of patients with eating disorders (EDs) and to assess its potential as a biomarker for monitoring disease severity and treatment response.</p><p><strong>Methods: </strong>A retrospective chart review was conducted with 55 patients aged ≤ 16 years diagnosed with anorexia nervosa or avoidant/restrictive food intake disorder and admitted to Jichi Medical University Hospital between 2015 and 2021. Sociodemographic and clinical characteristics including sex, age, rate of weight gain, percentage of ideal body weight (%IBW), tube feeding treatment, and NLR were obtained. Statistical analyses used a mixed model for repeated measures to assess NLR changes regarding %IBW and other clinical factors.</p><p><strong>Results: </strong>The NLR at admission was lower in the malnourished state but increased with weight recovery. MMRM revealed that tube feeding treatment (β = 0.538) and restoration of %IBW (β = 0.029) significantly predicted an increase in the NLR. The interaction between tube feeding and the quadratic term of %IBW was also significant, indicating distinct patterns of NLR changes: without tube feeding, NLR increased linearly with weight recovery, whereas with tube feeding, NLR exhibited a non-linear, upward-convex parabolic trend.</p><p><strong>Discussion: </strong>These findings suggest that NLR may offer an objective recovery marker less influenced by patient self-report. Monitoring NLR before and after tube feeding may help distinguish true physiological recovery from transient stress responses, providing complementary information to conventional assessments. Further research is warranted to establish its clinical relevance.</p>","PeriodicalId":48605,"journal":{"name":"Journal of Eating Disorders","volume":"13 1","pages":"86"},"PeriodicalIF":3.5,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}