Efort Open Reviews最新文献

{"title":"Comprehensive arthroscopic management versus total shoulder arthroplasty and hemiarthroplasty in patients with primary glenohumeral arthritis younger than 50 years old.","authors":"Marko Nabergoj, Patrick J Denard, Philippe Collin, Alexandre Lädermann","doi":"10.1530/EOR-2023-0156","DOIUrl":"10.1530/EOR-2023-0156","url":null,"abstract":"<p><p>Glenohumeral osteoarthritis (OA) is a disabling disease that leads to poor shoulder function and pain. Primary or idiopathic osteoarthritis occurs in previously intact joints without any inciting agent. Its precise incidence is not known. If conservative treatment fails, there are a variety of surgical procedures described in the literature. Total shoulder arthroplasty (TSA) is primarily indicated in patients above 60 years old with symptomatic glenohumeral OA and intact rotator cuff and failed conservative treatment. However, it is rarely recommended to young or active patients under the age of 50 due to its increased morbidity, limited lifespan, potential for revision surgeries, and difficulty achieving the same preoperative activity level, particularly in patients with high preoperative level of activity. Comprehensive arthroscopic management (CAM), hemiarthroplasty (HA), and TSA provide good results even in the long term for treatment of primary OA in properly selected young patients. A CAM procedure seems to be a reasonable option in case of conservative treatment failure, localized cartilage defect, tendinopathy of the long head of the biceps, stiffness, inferior osteophytes, and humeral head congruity. However, in case of humeral head incongruity, large anterior osteophytes, and an intact rotator cuff, an HA or a TSA is a feasible option.</p>","PeriodicalId":48598,"journal":{"name":"Efort Open Reviews","volume":"11 4","pages":"328-337"},"PeriodicalIF":4.0,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13087880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence in the diagnostic imaging of developmental dysplasia of the hip: a systematic review.","authors":"Abith Ganesh Kamath, Saran Singh Gill, Hussayn Shinwari, Kapil Sugand","doi":"10.1530/EOR-2024-0165","DOIUrl":"10.1530/EOR-2024-0165","url":null,"abstract":"<p><strong>Purpose: </strong>With the increased challenges in diagnosing DDH using traditional ultrasound imaging methods, accurate diagnosis is essential. This study assesses the effectiveness of AI in the imaging-based diagnosis of DDH through a systematic review.</p><p><strong>Methods: </strong>This review was conducted in accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines and registered in Prospero (registration ID: CRD42024563606). A comprehensive search was conducted across Ovid MEDLINE, PubMed, Embase, the Cochrane Central Register of Controlled Trials, and the Cochrane Database of Systematic Reviews. Studies were screened using selection criteria, and quality was assessed using standardised tools. Thematic content analysis was also performed. Of the 32 studies identified, 19 were included, with 15 undergoing quantitative analysis. The main outcome measures were sensitivity, specificity, accuracy, AUROC, PPV, and NPV. Median, median absolute deviation, Bonett-Price 95% confidence intervals, maximum, minimum, and interquartile ranges were calculated and presented in a box-and-whisker diagram.</p><p><strong>Results: </strong>In the 19 included studies, the median sensitivity was 90.0% and specificity was 93.2% across 36,907 patients. Fifteen studies reported diagnostic accuracy, with a median of 92.6%. Accuracy rates ranged from 79.2 to 99%. The most common model architecture was mask R-CNN. Four studies (21%) were judged to have a high risk of bias using the QUADAS-2 tool.</p><p><strong>Conclusions: </strong>AI technologies hold significant potential for enhancing the diagnostic accuracy of DDH. However, existing variability and bias across studies highlight the need for further standardisation and validation.</p>","PeriodicalId":48598,"journal":{"name":"Efort Open Reviews","volume":"11 4","pages":"290-298"},"PeriodicalIF":4.0,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13087869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biopsychosocial needs and complementary treatments for patients undergoing management for periprosthetic joint infection following hip or knee arthroplasty: a systematic review.","authors":"Amarins Koster, Gesine H Seeber, Sjoukje van der Werf, Max Ettinger, Inge van den Akker-Scheek, Martin Stevens","doi":"10.1530/EOR-2025-0107","DOIUrl":"10.1530/EOR-2025-0107","url":null,"abstract":"<p><strong>Purpose: </strong>A periprosthetic joint infection (PJI) is considered the most drastic complication after hip/knee arthroplasty. Despite extensive research into PJI treatment, insights into patients' biopsychosocial needs are sparse. The aim of the current review is to provide an overview of patients' biopsychosocial needs and interventions aimed at these needs.</p><p><strong>Methods: </strong>A systematic review incorporating a comprehensive database search of seven major scientific databases. Articles were included if they reported on the biopsychosocial needs of patients with PJI and on interventions aimed at these needs. Quality of the included studies was assessed by two reviewers with the Mixed Methods Appraisal Tool. Characteristics of included studies and the associated results were extracted.</p><p><strong>Results: </strong>Of the 9,745 identified research articles, 20 were included in the review. All of the included articles reported about biopsychosocial needs, but only two (10%) of them also reported on interventions focused on these needs. Psychological needs were reported most often (n = 19, 95%), followed by physical (n = 14, 70%) and social needs (n = 8, 40%). Improving mental health was the most frequently reported psychological need (n = 13, 65%). Functional improvement emerged as the most common identified physical need (n = 12, 60%), while social support from healthcare professionals (n = 5, 25%) was the most reported social need.</p><p><strong>Conclusion: </strong>The results show a clear need for interventions on top of the primary surgical treatment for patients diagnosed with PJI, especially for psychological and physical support. Interventions targeting needs were described in only two articles (10%) in the current literature. Future studies should explore patient-centered approaches and integrate psychological and physical management into PJI treatment pathways to improve outcomes.</p>","PeriodicalId":48598,"journal":{"name":"Efort Open Reviews","volume":"11 4","pages":"277-289"},"PeriodicalIF":4.0,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13087874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing the management of periprosthetic infections with artificial intelligence: current evidence and future directions.","authors":"Fanny Delaigue, Jules Descamps, David Lebeaux, Jawad Rahal, Rémy S Nizard, Pierre-Alban Bouché","doi":"10.1530/EOR-2025-0008","DOIUrl":"10.1530/EOR-2025-0008","url":null,"abstract":"<p><p>Periprosthetic joint infections (PJIs) are a serious complication in both primary arthroplasty and revision arthroplasty, posing a major challenge in orthopaedic surgery and creating a substantial financial burden. This literature review examines the current knowledge on PJI prediction, diagnosis and prognosis, with a focus on scoring systems and machine learning (ML) tools developed to improve their management. We conducted a narrative literature review by searching Medline, CENTRAL and Embase up to October 1, 2024, with independent dual-reviewer screening. Nine non-randomized studies were included, covering 297,981 prostheses and 7,190 PJIs. Two studies assessed prediction based on patient history but highlighted the need for refinement and multi-centre prospective validation. Five studies evaluated ML in diagnosis, showing promising accuracy, yet requiring broader validation in larger, more diverse clinical contexts. Two studies addressed prognosis, but models remain limited in providing individualized, treatment-specific insights. The development of ML models represents an interesting approach, given the rising prevalence of PJIs and the need for better management. However, available studies face important limitations, including small sample sizes, lack of external validation and limited transparency regarding parameters and models. To make ML tools clinically relevant, future research should prioritize external validation, larger multi-centre prospective studies and transparent reporting. Ultimately, robust ML models have the potential to enhance PJI management, improve patient outcomes and reduce healthcare costs.</p>","PeriodicalId":48598,"journal":{"name":"Efort Open Reviews","volume":"11 4","pages":"259-267"},"PeriodicalIF":4.0,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13087877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between preoperative hypoalbuminemia and clinical outcomes following total hip or knee arthroplasty: a systematic review and meta-analysis.","authors":"Chen Yue, Yapeng Li, Lanbo Yang, Feng Li, Xiaolong Wu, Maoxiao Ma, Jiayi Guo","doi":"10.1530/EOR-2025-0170","DOIUrl":"10.1530/EOR-2025-0170","url":null,"abstract":"<p><strong>Background: </strong>Preoperative hypoalbuminemia is common in patients undergoing total hip or knee arthroplasty (THA/TKA). While it has been linked with poorer postoperative outcomes, there remains a paucity of systematic reviews or meta-analyses dedicated to conducting a comprehensive evaluation of this issue.</p><p><strong>Methods: </strong>A comprehensive search was conducted across the PubMed, Embase, and Web of Science databases. Studies were selected and analyzed in adherence to the Meta-analysis of Observational Studies in Epidemiology (MOOSE) guidelines, and the quality of the evidence was evaluated using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) framework. Data were extracted and subjected to meta-analysis or qualitative synthesis for outcomes. This meta-analysis was registered in the PROSPERO database (NO. CRD42024581376).</p><p><strong>Results: </strong>Fourteen studies involving 1,194,088 patients were included. Meta-analyses showed that preoperative hypoalbuminemia was associated with a greater risk of all-cause complications (OR: 2.89, 95% CI: 1.94-4.31), sepsis (OR: 2.54, 95% CI: 1.88-3.45), septic shock (OR: 3.44, 95% CI: 1.15-10.25), pneumonia (OR: 3.83, 95% CI: 3.14-4.67), urinary tract infection (OR: 1.59, 95% CI: 1.13-2.23), myocardial infarction (OR: 2.10, 95% CI: 1.47-2.98), superficial incisional infection (OR: 2.16, 95% CI: 1.56-3.00), periprosthetic joint infection (OR: 4.03, 95% CI: 2.15-7.53), wound dehiscence (OR: 1.68, 95% CI: 1.06-2.69), transfusion (OR: 1.84, 95% CI: 1.72-1.98), unplanned reoperation (OR: 1.60, 95% CI: 1.38-1.87), and mortality (OR: 7.14, 95% CI: 5.44-9.37).</p><p><strong>Conclusion: </strong>Preoperative hypoalbuminemia is associated with an increased risk of numerous types of complications, transfusion, unplanned reoperation, and mortality after THA or TKA. Therefore, presurgical protocols formulated to deal with these unfavorable clinical outcomes may pay particular attention to this specific patient group.</p>","PeriodicalId":48598,"journal":{"name":"Efort Open Reviews","volume":"11 4","pages":"268-276"},"PeriodicalIF":4.0,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13087879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conservative vs surgical treatment of midshaft clavicular fractures: a systematic review.","authors":"Andreas Papaleontiou, Amelia Wild, Andrea Poupard, Panteleimon Tsantanis","doi":"10.1530/EOR-2025-0005","DOIUrl":"10.1530/EOR-2025-0005","url":null,"abstract":"<p><strong>Purpose: </strong>This systematic review aimed to evaluate the effectiveness of surgical versus conservative management in terms of union rates, functional outcomes and complications.</p><p><strong>Methods: </strong>A systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Randomised controlled trials published between January 2017 and November 2023 were sourced from MEDLINE, Embase, PubMed and Cochrane databases. Outcomes assessed included union rates, functional scores and complications.</p><p><strong>Results: </strong>Six trials, involving 579 patients with midshaft clavicle fractures, met the inclusion criteria. The union rate was higher in the surgical group (93.3-100%) compared to the conservative group (82-94%). Time to union was significantly shorter for surgical management in two out of three studies reporting this outcome. Shoulder scores revealed short-term improvements in surgical groups but no significant differences at 12 months or longer. Complication rates were comparable: hardware irritation was more frequent in surgical groups, while non-union was more prevalent in conservative management. Only two studies found a statistically significant difference in union rates favouring surgery.</p><p><strong>Conclusion: </strong>Surgical management offers higher union rates and faster recovery but does not demonstrate significant long-term advantages in functional outcomes compared to conservative treatment. Complication rates are similar, with distinct profiles. Clinicians should prioritise patient-centred decision-making, considering individual preferences and clinical contexts, as operative intervention may not significantly enhance long-term outcomes. Further research should perform subgroup analyses to refine management strategies.</p>","PeriodicalId":48598,"journal":{"name":"Efort Open Reviews","volume":"11 4","pages":"349-358"},"PeriodicalIF":4.0,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13087866/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The most common bone tumors of the upper extremity in childhood and adolescence and their treatment: a review of the current literature.","authors":"Dong Yu, Alexandre Kaempfen, Maximilian Burger, Kira Barlow, Andreas H Krieg","doi":"10.1530/EOR-2025-0149","DOIUrl":"10.1530/EOR-2025-0149","url":null,"abstract":"<p><p>In upper extremity bone tumors, osteochondromas and solitary bone cysts represent the predominant benign entities, with osteosarcoma accounting for the majority of malignant presentations. The proximal humeral metaphysis emerges as the most prevalent anatomical site across both tumor entities. Upper, one-sided extremity pain in children and adolescents should be followed up and diagnosed, since 'growing pain' in the upper extremities is not a common finding. Osteochondromas should be surgically addressed early if they impose a risk of development of a deformity, such as those located on the forearm and the distal tibia, where they can cause growth disorders and thus functional impairments. Reconstructions for pediatric malignant bone tumors of the upper arm or forearm should allow the spatial placement of the hand. Given the longevity of sarcoma survivors, the longevity of the reconstruction is an important planning consideration. Biological reconstructions combining autologous/vascularized bone with tendon repair and transfers appear to be the most appropriate and preferable to prosthesis whenever possible. Multidisciplinary collaboration involving plastic surgeons with hand reconstruction expertise constitutes a critical component in orthopedic oncology treatment planning.</p>","PeriodicalId":48598,"journal":{"name":"Efort Open Reviews","volume":"11 4","pages":"317-327"},"PeriodicalIF":4.0,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13087867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congenital lumbar spinal stenosis: current perspectives on diagnosis, imaging, and treatment.","authors":"Bechara El Khoury, Ahmad Assi, Mohamad Farhat, Marc Boutros, Amer Sebaaly","doi":"10.1530/EOR-2025-0159","DOIUrl":"10.1530/EOR-2025-0159","url":null,"abstract":"<p><p>Congenital lumbar stenosis (CLS) is an uncommon disorder marked by a congenitally small spinal canal, which frequently results in early-onset neurogenic symptoms. Sarpyener originally characterized CLS in 1947, and Verbiest later offered a clinical description of lumbar spinal stenosis that did not recognize the congenital nature of the condition. The frequency of absolute CLS is believed to be 2.6%; however, data are lacking. This narrative review will outline current knowledge on CLS, including its prevalence, clinical presentation, genetic implications, aspects in diagnostic imaging for the condition, and treatment options. CLS has similar clinical characteristics to acquired lumbar stenosis; however, individuals with CLS report more severe leg and back pain. Genetic factors may contribute to CLS occurrence; however, research on this aspect is scarce. CLS is usually related to cervical and thoracic stenosis, as well as diseases such disk herniation and spondylolisthesis. The diagnosis is based on imaging criteria, which are continually being refined. The treatment options vary from conservative care to surgical treatments, such as laminoplasty and stability-preserving decompression, although long-term outcome data are limited. CLS poses distinct diagnostic and treatment challenges given its early onset. Further study is needed to provide uniform diagnostic criteria, evaluate long-term treatment results, and identify specific genetic factors that contribute to CLS.</p>","PeriodicalId":48598,"journal":{"name":"Efort Open Reviews","volume":"11 4","pages":"359-365"},"PeriodicalIF":4.0,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13087876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimally invasive plate fixation of paediatric lower limb long bone fractures: a review on when and how.","authors":"Alberto Daniel Navarro Vergara, Jamil Soni, Weverley Rubele Valenza, Estefanía Birrer, Heloisa Zimmmermann Faggion","doi":"10.1530/EOR-2025-0122","DOIUrl":"10.1530/EOR-2025-0122","url":null,"abstract":"<p><p>Fractures of the lower limbs represent a common cause of hospital admission. Surgical intervention is increasingly indicated in paediatric patients. The gold standard for treating long bone fractures in the immature skeleton is intramedullary fixation with titanium elastic nails. Minimally invasive plating is considered a suitable option when elastic nailing is not feasible. The use of a plate provides adequate mechanical stability for weight-bearing and limb mobility while preserving biological bone integrity and resulting in limited scarring, generally well accepted by patients and families, although it requires a more extensive incision than intramedullary fixation. Potential drawbacks of this technique include a more extensive surgical approach, possible delay in weight-bearing, and the potential need for implant removal.</p>","PeriodicalId":48598,"journal":{"name":"Efort Open Reviews","volume":"11 4","pages":"299-306"},"PeriodicalIF":4.0,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13087883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A narrative review of our developing knowledge about paediatric spondylodiscitis based on existing literature.","authors":"Ahmer Ahmad Khan, Aikaterini Doubovina, Giacomo De Marco, Christina Steiger, Romain Dayer, Dimitri Ceroni","doi":"10.1530/EOR-2025-0224","DOIUrl":"10.1530/EOR-2025-0224","url":null,"abstract":"<p><p>Paediatric spondylodiscitis (SD) is an infection involving the vertebral bodies and adjacent intervertebral discs in populations below 16 years old. It is rarely confined to a single compartment; more often, it spreads to other areas in the spinal column and may cause other infections, such as epidural abscesses, subdural abscesses, septic arthritis of the facet joints, paravertebral abscesses and even meningitis. SD predominantly affects children from 6 to 48 months old, and the lumbar spine seems to be most at risk; no specific markers are currently available for a biological diagnosis of SD. Blood cultures are often negative, and even disc or bone biopsies show limited yields. However, recent advances in nucleic acid amplification tests have laid the foundations for developing and implementing more efficient methods of identifying pathogens in samples. Microbiologically, Kingella kingae dominates in children from 6 to 48 months old, while Staphylococcus aureus is more common in infants under 6 months and in older children. High-throughput sequencing performed on plasma samples (recognised as liquid biopsy) is a promising multi-purpose tool that can detect not only pathogens circulating in the bloodstream but also those emanating from focal infections, something particularly interesting in cases of paediatric SD, where disc sampling is strongly discouraged. Paediatric SD treatments are mainly medical; surgery is rarely indicated, except for abscess drainage, emergency neurological decompression or spinal stabilisation.</p>","PeriodicalId":48598,"journal":{"name":"Efort Open Reviews","volume":"11 4","pages":"307-316"},"PeriodicalIF":4.0,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13087878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}