Anushka R. Patel , Nuwan Jayawickreme , Vanessa Visquerra , Kelly Dixon , Vikram Patel
{"title":"Empirically supported treatments for all: Realizing equitable coverage of care for trauma survivors globally","authors":"Anushka R. Patel , Nuwan Jayawickreme , Vanessa Visquerra , Kelly Dixon , Vikram Patel","doi":"10.1016/j.brat.2025.104757","DOIUrl":"10.1016/j.brat.2025.104757","url":null,"abstract":"<div><div>Global mental health is focused on reducing inequities in treatment access for mental health disorders. A core social determinant of mental health is trauma (e.g., violence, disasters, wars), contributing to myriad psychosocial outcomes such as posttraumatic stress disorder (PTSD), depression, anxiety, and functional impairment. Despite the development of numerous efficacious empirically supported treatments (ESTs), trauma survivors remain a particularly vulnerable group and rarely receive quality trauma-informed treatment. In this paper, we argue that in order to reduce global inequities in mental health treatment access, we need to <em>fully</em> embrace Chambless and Hollon's (1998) criteria for ESTs – that they be efficacious, effective in routine clinical contexts, feasible to deploy and scale up, and cost-effective. While the field of clinical science has made impressive strides in developing efficacious treatments, we argue that we ought to place greater emphasis on an EST being effective across contexts, feasible for delivery by a wide cadre of providers, and cost-effective to scale to improve equity. We discuss efforts in the field of global mental health that use innovative paradigms to fully realize the latter criteria, which have been under-appreciated in clinical science. We conclude with recommendations to improve EST access by applying an equity lens <em>within and between contexts</em>.</div></div>","PeriodicalId":48457,"journal":{"name":"Behaviour Research and Therapy","volume":"190 ","pages":"Article 104757"},"PeriodicalIF":4.2,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143892189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nicholas P. Otis , Alexander C. Kline , Lisa H. Glassman , W. Michael Hunt , Kristen H. Walter
{"title":"Sudden gains in cognitive processing therapy with and without behavioral activation among service members with comorbid PTSD and MDD","authors":"Nicholas P. Otis , Alexander C. Kline , Lisa H. Glassman , W. Michael Hunt , Kristen H. Walter","doi":"10.1016/j.brat.2025.104753","DOIUrl":"10.1016/j.brat.2025.104753","url":null,"abstract":"<div><div>Sudden gains—large, rapid, and stable symptom reductions during treatment—are associated with better patient outcomes. Little is known about sudden gains among patients with co-occurring posttraumatic stress disorder (PTSD) and major depressive disorder (MDD), yet better understanding of sudden gains in this population may improve treatment of this comorbidity. This study evaluated sudden gains in PTSD and depression symptoms and their association with treatment outcomes among active duty service members with comorbid PTSD and MDD (<em>N</em> = 94) who were randomized to behavioral activation-enhanced cognitive processing therapy (BA + CPT) or CPT alone. Outcomes were interviewer-rated PTSD and depression severity at posttreatment and 3-month follow-up. PTSD and depression sudden gains occurred in 19 % and 27 % of the sample, respectively. Multilevel modeling showed sudden gains in depression symptoms were associated with clinically and statistically significant improvements in PTSD (<em>p</em> < .001) and depression severity (<em>p</em> < .001) outcomes. PTSD sudden gains were not associated with PTSD (<em>p</em> = .137) or depression (<em>p</em> = .187) outcomes. Improvements in both PTSD and depression outcomes following sudden depression gains may highlight the importance of depression symptom change during treatment as a prognostic marker of outcomes in this comorbid population.</div></div><div><h3>Clinicaltrials gov identifier</h3><div>NCT02874131.</div></div>","PeriodicalId":48457,"journal":{"name":"Behaviour Research and Therapy","volume":"190 ","pages":"Article 104753"},"PeriodicalIF":4.2,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tracey D. Wade , Neophytos Georgiou , Ella Keegan , Mia L. Pellizzer , Glenn Waller
{"title":"Indicators of early change in cognitive behaviour therapy that predict eating disorder remission","authors":"Tracey D. Wade , Neophytos Georgiou , Ella Keegan , Mia L. Pellizzer , Glenn Waller","doi":"10.1016/j.brat.2025.104754","DOIUrl":"10.1016/j.brat.2025.104754","url":null,"abstract":"<div><div>We examined the utility of three definitions of rapid response to treatment for predicting remission in a transdiagnostic sample receiving 10-session cognitive behaviour therapy (CBT) for an eating disorder. Both efficiency (categorising the greatest number of people as rapid responders) and predictiveness (performs best in predicting outcomes) were compared. The participants (<em>N</em> = 176, 93 % female, 89 % white, mean age 26.65 years) completed measures at baseline and before session 4 of CBT which was used to calculate rapid response. Remission was achieved by 64 participants (36 %) at the end of therapy. A multivariable logistic regression analysis was used to examine the contribution of rapid response, as well as baseline disordered eating, impairment, general negative emotion, to remission status. Two of the rapid response definitions were associated with participants being 2.5 times more likely to achieve remission at end of treatment. In both cases, remission was also associated with a lower level of baseline eating disorder psychopathology. The preferred definition (a reduction of ≥1.13 points on the Eating Disorder Examination Questionnaire) categorised 58 % of participants as rapid responders. These findings can be used to inform clinicians of meaningful early change that predicts positive outcomes in brief CBT for eating disorders. Early change indicators can inform collaborative consideration of barriers to progress and approaches to tackle these, making CBT more effective for more people. The conclusions should be interpreted with caution given remission was only examined at end of treatment and not over longer-term follow-up.</div></div>","PeriodicalId":48457,"journal":{"name":"Behaviour Research and Therapy","volume":"190 ","pages":"Article 104754"},"PeriodicalIF":4.2,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143864856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brian Schwartz , Julia Giesemann , Jaime Delgadillo , Jana Schaffrath , Miriam I. Hehlmann , Danilo Moggia , Christopher Baumann , Wolfgang Lutz
{"title":"Comparing three neural networks to predict depression treatment outcomes in psychological therapies","authors":"Brian Schwartz , Julia Giesemann , Jaime Delgadillo , Jana Schaffrath , Miriam I. Hehlmann , Danilo Moggia , Christopher Baumann , Wolfgang Lutz","doi":"10.1016/j.brat.2025.104752","DOIUrl":"10.1016/j.brat.2025.104752","url":null,"abstract":"<div><h3>Objective</h3><div>Artificial neural networks have been used in various fields to solve classification and prediction tasks. However, it is unclear if these may be adequate methods to predict psychological treatment outcomes. This study aimed to evaluate the prognostic accuracy of neural networks using psychological treatment outcomes data.</div></div><div><h3>Method</h3><div>Three neural network models (TensorFlow, nnet, and monmlp) and a generalised linear regression model were compared in their ability to predict post-treatment remission of depression symptoms in a large naturalistic sample (<em>n</em> = 69,489) of patients accessing low intensity cognitive behavioural therapy. Prognostic accuracy was evaluated using the area under the curve (AUC) in an external cross-validation design.</div></div><div><h3>Results</h3><div>The AUC of the neural networks in an external test sample ranged from 0.64 to 0.65 and the AUC of the linear regression model was 0.63.</div></div><div><h3>Conclusion</h3><div>Neural networks can help predict symptom remission in new samples with moderate accuracy, although these models were no more accurate than a simpler inferential statistical linear regression model.</div></div>","PeriodicalId":48457,"journal":{"name":"Behaviour Research and Therapy","volume":"190 ","pages":"Article 104752"},"PeriodicalIF":4.2,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143870486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zoe McClure , Christopher J. Greenwood , Matthew Fuller-Tyszkiewicz , Mariel Messer , Jake Linardon
{"title":"Predicting responsiveness to a dialectical behaviour therapy skills training app for recurrent binge eating: A machine learning approach","authors":"Zoe McClure , Christopher J. Greenwood , Matthew Fuller-Tyszkiewicz , Mariel Messer , Jake Linardon","doi":"10.1016/j.brat.2025.104755","DOIUrl":"10.1016/j.brat.2025.104755","url":null,"abstract":"<div><h3>Objective</h3><div>Smartphone applications (apps) show promise as an effective and scalable intervention modality for disordered eating, yet responsiveness varies considerably. The ability to predict user responses to app-based interventions is currently limited. Machine learning (ML) techniques have shown potential to improve prediction of complex clinical outcomes. We applied ML techniques to predict responsiveness to a dialectical behaviour therapy-based smartphone app for recurrent binge eating.</div></div><div><h3>Method</h3><div>Data were collected as part of a randomised controlled trial (RCT). The present sample was based on data from 576 participants with recurrent binge eating. 10 common classification and regression approaches were used to predict outcomes that represent key stages of the user experience, including initial intervention uptake, app adherence, study drop-out, and symptom change. Models were developed using 69 self-reported baseline variables (i.e., demographic, clinical, psychological) and several app usage variables (i.e., number of modules completed) as predictors.</div></div><div><h3>Results</h3><div>All models, using only baseline predictors, performed sub-optimally at predicting engagement (AUCs = 0.48–0.61; R<sup>2</sup> = 0.00–0.04) and symptom level change (R<sup>2</sup> = 0.00–0.07). Incorporating usage data improved prediction of study dropout (AUC = 0.69–0.76).</div></div><div><h3>Conclusion</h3><div>ML models were unable to accurately predict responsiveness using self-reported baseline predictors alone. Predicting outcomes with greater precision may require consideration of how predictors change over time and interact with a user's context. Modelling usage pattern data appears to improve prediction of dropout, highlighting the potential value of tracking intervention usage to identify individuals at risk of disengagement.</div></div>","PeriodicalId":48457,"journal":{"name":"Behaviour Research and Therapy","volume":"190 ","pages":"Article 104755"},"PeriodicalIF":4.2,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143870487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Generalization of exposure therapy: Systematic review and recommendations for future research","authors":"Iris Kodzaga, Jan Heistermann, Armin Zlomuzica","doi":"10.1016/j.brat.2025.104751","DOIUrl":"10.1016/j.brat.2025.104751","url":null,"abstract":"<div><div>Limited generalization of exposure therapy effects from treatment-related to treatment-unrelated contexts and/or stimuli is a potential factor contributing to relapse after successful exposure treatment. Investigating the processes underlying exposure therapy generalization (ETG) and developing strategies to promote ETG has become a significant research area. This systematic review provides an overview of the current state of ETG research, outlining its operationalization and the methodological diversity used to detect changes in ETG. We also summarize and discuss findings from studies aimed at enhancing ETG through pharmacological and behavioral interventions.</div><div>A total of 34 studies were identified, investigating ETG across therapy-related and unrelated contexts and fear stimuli. These studies primarily used physical and/or social context/stimuli manipulations to investigate ETG. Multiple response systems (subjective, psychophysiological, behavioral) were used as indices of diminished ETG, but most studies found increased subjective fear in treatment-unrelated contexts/stimuli compared to treatment-related ones.</div><div>We conclude that clear definitions and criteria for assessing ETG are urgently needed. Behavioral interventions, such as multiple context exposure or sleep after exposure, seem effective in promoting ETG across different contexts/stimuli. In contrast, findings from pharmacological approaches are less encouraging, but more research is needed. We identify research gaps that require further investigation to better understand the mechanisms governing and promoting ETG. Experimental paradigms offer a clear advantage for this purpose and for screening novel strategies to maximize ETG.</div></div>","PeriodicalId":48457,"journal":{"name":"Behaviour Research and Therapy","volume":"190 ","pages":"Article 104751"},"PeriodicalIF":4.2,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143864855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Recognition of dynamic angry expressions in socially anxious individuals: An ERP study","authors":"Jing Yuan , Yuchen Zhang , Chenwei Zhao , Zejun Liu , Xiaoping Yin","doi":"10.1016/j.brat.2025.104750","DOIUrl":"10.1016/j.brat.2025.104750","url":null,"abstract":"<div><div>Dynamic facial expressions provide temporal information and ecological validity. In this study, participants with high and low social anxiety were instructed to recognise dynamic expressions of anger at different intensities (15 %, 21 %, 27 %, 33 %, 39 %, 45 %). At the same time, their brain electrical activity was recorded. In terms of behavioural results, the high socially anxious (HSA) group had higher accuracy in recognising dynamic angry facial expressions than the low socially anxious (LSA) group. Compared to the lower anger intensities, participants identified the higher anger intensities with increased accuracy and decreased reaction time (RT). In the electrophysiological results, the HSA group showed increased P3 and LPP amplitudes at intensities of 15 %, 21 %, 27 %, 33 % compared to the LSA group. However, there were no significant differences between the two groups at 39 % and 45 % intensity. The differences between the groups in P1 and P2 amplitudes were not significant. Our findings suggest that when dynamic angry expressions are ambiguous, high socially anxious individuals are more deeply encoded than low socially anxious individuals, which has important implications for the development of interventions.</div></div>","PeriodicalId":48457,"journal":{"name":"Behaviour Research and Therapy","volume":"189 ","pages":"Article 104750"},"PeriodicalIF":4.2,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143855650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tabea Kloos , Fernando Blanco , Winfried Rief , Ann Meulders , Jenny Riecke
{"title":"Visualizing one's Best Possible Self increases positive future expectancies, but does not boost selective learning in fibromyalgia","authors":"Tabea Kloos , Fernando Blanco , Winfried Rief , Ann Meulders , Jenny Riecke","doi":"10.1016/j.brat.2025.104748","DOIUrl":"10.1016/j.brat.2025.104748","url":null,"abstract":"<div><div>Compromised learning is considered to contribute importantly to the development and maintenance of chronic pain disability. More specifically, predictive learning is impaired in people with chronic pain. Therefore, learning mechanisms have been identified as treatment targets. A widely neglected, but relevant question is whether resilience factors can enhance selective learning. This online study combined a selective learning task with a positive psychology intervention in participants with fibromyalgia (FM). The Best Possible Self group (BPS) described and visualized a future in which everything had gone well, which is shown to increase optimism and positive affect, while the active control group described and visualized their Typical Day (TD). Subsequently, selective learning was tested within a contingency learning scenario task using a blocking procedure and pain expectancies as main outcome. We successfully manipulated positive future expectancies (a proxy for state optimism), but not positive affect within a single-session intervention. In contrast with our expectations, the positive psychology intervention did not increase selective learning in the BPS group compared to the TD group, but a small blocking effect was observed in the merged sample. However, because no healthy control group was included, no conclusions can be drawn as to whether the selective learning effect is reduced compared to a non-clinical population. To conclude, there was partial evidence for selective learning in people with fibromyalgia, but manipulated resilience factors did not modulate the selective learning effect.</div></div>","PeriodicalId":48457,"journal":{"name":"Behaviour Research and Therapy","volume":"190 ","pages":"Article 104748"},"PeriodicalIF":4.2,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143864787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Janice R. Kuo , Katherine E. Christensen , Rachel Liebman , Skye Fitzpatrick , Alexander Chapman , Shelley McMain
{"title":"Which one impacts the other?: The relationship between change in borderline personality disorder severity and change in posttraumatic stress disorder severity among individuals in dialectical behavior therapy","authors":"Janice R. Kuo , Katherine E. Christensen , Rachel Liebman , Skye Fitzpatrick , Alexander Chapman , Shelley McMain","doi":"10.1016/j.brat.2025.104747","DOIUrl":"10.1016/j.brat.2025.104747","url":null,"abstract":"<div><div>Borderline personality disorder (BPD) and posttraumatic stress disorder (PTSD) commonly co-occur. Limited research, however, has examined the association between fluctuations in the severity of one disorder with fluctuations in the severity of the other disorder. In a sample of N = 240 self-harming individuals with BPD undergoing 6 or 12 months of Dialectical Behavior Therapy (DBT), we used a cross-lagged panel model with 3-month intervals to evaluate the temporal relationship between BPD severity and PTSD severity during DBT and throughout follow-up. We similarly examined the relationship in the sub-sample meeting criteria for both disorders (BPD + PTSD; N = 81). Results indicated that decreases in PTSD severity at one timepoint corresponded with decreases in BPD severity at the subsequent timepoint, and that there was minimal evidence for the reverse relationship. Findings were consistent across our analyses in both the full BPD sample and the BPD + PTSD subsample. In the context of DBT, addressing PTSD might help reduce subsequent BPD severity, but addressing BPD features might not have similar effects on PTSD severity.</div></div>","PeriodicalId":48457,"journal":{"name":"Behaviour Research and Therapy","volume":"190 ","pages":"Article 104747"},"PeriodicalIF":4.2,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143878506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The influence of (social) anxiety and visual exploration on threat responding and generalization","authors":"Mario Reutter , Janna Teigeler , Matthias Gamer","doi":"10.1016/j.brat.2025.104746","DOIUrl":"10.1016/j.brat.2025.104746","url":null,"abstract":"<div><div>Fear generalization has been identified as an important mechanism that might contribute to the etiology and maintenance of anxiety disorders. It is, however, yet unclear to what degree attentional processes contribute to overgeneralization of fear in clinical samples. To address this issue, we utilized a set of facial photographs that was meticulously created such that pairs of faces could either be distinguished by looking into the eyes or the region around mouth and nose, respectively. These pairs were then employed as CS+ and CS− in a differential fear conditioning paradigm followed by a generalization test with morphs in steps of 20 %, creating a continuum between CS+ and CS−. In a sample with diverse levels of social and general anxiety (<em>N</em> = 87), we demonstrated that the amount of fear generalization depends on attentional orienting towards diagnostic facial features. While social anxiety did not affect the shape of generalization gradients, we observed altered visual exploration patterns and a distinct multi-phasic heart rate modulation in participants with higher social anxiety. General anxiety symptomatology was also related to these characteristics of visual exploration and additionally predicted a broad elevation of threat ratings. In summary, fear generalization depends on attentional deployment. Future work should build on these findings to further explore these processes in clinical populations.</div></div>","PeriodicalId":48457,"journal":{"name":"Behaviour Research and Therapy","volume":"189 ","pages":"Article 104746"},"PeriodicalIF":4.2,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143837936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}