Journal of Case Reports and Medical History最新文献

{"title":"Thrombotic Recurrence Under New Oral Anticoagulants Revealing Antiphospholipid Antibody Syndrome: Case Report","authors":"","doi":"10.54289/jcrmh2400103","DOIUrl":"https://doi.org/10.54289/jcrmh2400103","url":null,"abstract":"Introduction and importance: Non-vitamin K antagonist Oral Anti-Coagulants (NOACs) have emerged as an effective treatment for thromboembolic events with a reduced bleeding risk compared to traditional anti-vitamin K drugs. However, their role in managing antiphospholipid antibody syndrome remains a subject of debate. Case presentation: We present the case of a 48-year-old man with a history of pulmonary embolism and a right cavitary thrombus, who was receiving treatment with a new-generation anticoagulant. Despite this treatment, he exhibited resistance, prompting further investigation that led to the diagnosis of antiphospholipid antibody syndrome. Clinical discussion: Our clinical case highlights the importance of routinely screening for antiphospholipid syndrome, especially when it coexists with lupus, due to the potential ineffectiveness of NOACs. Conclusion: This case underscores the necessity of considering alternative treatment strategies in individuals with antiphospholipid antibody syndrome, particularly when traditional anticoagulants prove inadequate, even when lupus is concurrent.","PeriodicalId":484263,"journal":{"name":"Journal of Case Reports and Medical History","volume":"2 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139439494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Failed Regenerative Endodontic Treatment of a Necrotic Immature Molar: A Case Report With 12-Month Follow Up","authors":"","doi":"10.54289/jcrmh2400102","DOIUrl":"https://doi.org/10.54289/jcrmh2400102","url":null,"abstract":"Introduction: Management of necrotic immature permanent teeth has always posed a challenge to clinicians. Regenerative endodontic procedures (REPs) have been proposed as an alternative to apexification to treat necrotic immature teeth. However, few failed cases of REPs have been presented in the literature with different successful retreatment approaches. Case presentation: An eight-year-old boy reported spontaneous pain in the right permanent mandibular first molar. Regenerative endodontic treatment using platelet-rich fibrin (PRF) was the treatment method due to the open apices. At the 9-month follow-up, there was a periapical lesion around the distal root. Hence, apexification with Mineral trioxide aggregate (MTA) was carried out. In the twelve-month follow-up, the periapical lesion healed radiographically. Conclusions: MTA and bioceramic-based root canal sealers yielded satisfactory outcomes in lesion healing. Little is known about the biological and clinical aspects of regenerative endodontic treatment. Moreover, there are still unknown factors that govern the success of REPs.","PeriodicalId":484263,"journal":{"name":"Journal of Case Reports and Medical History","volume":"48 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139446532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Sarcoidosis and Primary Biliary Cirrhosis: A New Observation","authors":"","doi":"10.54289/jcrmh2300143","DOIUrl":"https://doi.org/10.54289/jcrmh2300143","url":null,"abstract":"Sarcoidosis is a systemic disease of unknown etiology. It is characterized by the presence of noncaseating granulomatous lesions in the affected organs. Primary biliary cirrhosis (PBC) is a chronic autoimmune cholestatic hepatopathy characterized by destruction of the bile ducts and the presence of M2-type anti-mitochondrial antibodies [1]. The association of sarcoidosis and primary biliary cirrhosis reported here is rare. It poses a problem of histological differential diagnosis and raises the hypothesis of an etiopathogenic link between the two conditions [2]. We report the clinical case of a patient hospitalized in the internal medicine department of chu ibno rochd casablanca, who was diagnosed with a combination of sarcoidosis and primary biliary cirrhosis.","PeriodicalId":484263,"journal":{"name":"Journal of Case Reports and Medical History","volume":"46 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138967384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laparoscopic Surgery of an Isolated Splenic Hydatid Cyst in a 43- Year- Old Man: A Case Report","authors":"","doi":"10.54289/jcrmh2300145","DOIUrl":"https://doi.org/10.54289/jcrmh2300145","url":null,"abstract":"Introduction: Hydatid disease is a type of parasitic disease mainly affect the lungs and the liver and splenic hydatid cyst is a rare disease. We hereby present a rare case of splenic hydatid disease. Case report: A 43-years-old man with a history of left upper quadrant pain (LUQ) pain, anorexia, weakness, and weight loss was admitted to the surgery department in Iran. The imaging studies showed a cystic mass in the gastro-splenic ligament extending up to below the left diaphragm with adhesion to the spleen capsule and the fundus of the stomach caused focal elevation of this part of the diaphragm. A laparoscopic surgery was performed and splenic hydatid cyst with adhesion to the stomach and the left lobe of the liver and with penetration into the left hemi thorax was observed. Splenectomy, hepatectomy of the left segment of the liver, repair of diaphragmatic defect and stomach release was done. Conclusion: Splenic hydatid cyst surgery can be difficult and requires appropriate diagnostic evaluations and examination for adhesions and invasion to other organs.","PeriodicalId":484263,"journal":{"name":"Journal of Case Reports and Medical History","volume":"21 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138967718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neoplastic Pericardial Effusion in Malignant Solid Tumors: Clinical Features, Diagnosis and Management","authors":"","doi":"10.54289/jcrmh2300144","DOIUrl":"https://doi.org/10.54289/jcrmh2300144","url":null,"abstract":"Introduction: Neoplastic pericardial effusion (NPE) poses a significant challenge in medical pathology, particularly due to its association with secondary involvement by malignancies originating in various organs. Timely management of NPE is pivotal for both overall survival and the patients' quality of life. However, there is a scarcity of data on NPE in our country. This study aims to provide a comprehensive description of the clinical, diagnostic, and therapeutic characteristics of consecutive Moroccan patients with NPE. Methods: A retrospective cohort study was conducted at Ibn Rochd Cardiology Department and Oncology Unit in Casablanca, covering a period of three years (January 2020 to December 2022). The study included patients diagnosed with NPE based on clinical, biological, histological, and echocardiographic criteria. Data collection encompassed sociodemographic information, performance status, clinical manifestations, ECG and echocardiography findings, grade of pericardial effusion, cytology of pericardial fluid, and details of therapeutic protocols administered. Results: Between 2020 and 2022, 49 NPE patients were admitted, with a gender distribution of 51% men and 49% women. The median age was 42 years. Most patients presented with symptomatic pericardial effusion (81%), and 61.2% had NPE at the first diagnosis of metastatic disease. Lung, breast, and other solid tumors were common etiologies. Cytology of pericardial fluid was positive in 23 patients. Clinical examination and diagnostic imaging revealed diverse presentations, including signs of right heart failure, ECG abnormalities, and echocardiographic findings indicative of significant pericardial effusion. Pericardiocentesis and drainage were performed in the majority of patients, often combined with pleuropericardial window placement. Systemic treatments, tailored to the primary tumor type, were administered, with a 60% overall mortality rate, rising to 88% in lung cancer cases. Conclusion: This study provides crucial insights into the clinical spectrum and management of NPE in Moroccan patients. The high mortality rate, particularly in lung cancers, underscores the importance of early detection and targeted therapeutic interventions in improving outcomes for patients with NPE.","PeriodicalId":484263,"journal":{"name":"Journal of Case Reports and Medical History","volume":"91 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138999493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidental Postmortem Diagnosis of Anterior Communicating Artery Aneurysm After Successful Treatment of Double Aneurysms of the Superior Cerebellar and Paraclinoid Internal Carotid Arteries","authors":"","doi":"10.54289/jcrmh2300140","DOIUrl":"https://doi.org/10.54289/jcrmh2300140","url":null,"abstract":"Intracranial aneurysm diagnosis uses several tools, of which digital subtraction angiography is still the gold standard. Computed tomography angiography is widely used for its specificity and sensibility. The 3D slicer software is an interesting diagnosis tool that provides high-quality 3D modeling. It facilitates diagnosis and improves aneurysm assessment. However, it is still not approved for clinical tasks. We present a case of a woman treated for a ruptured paraclinoid and superior cerebellar artery aneurysms, and who succumbed to a post-procedural rebleeding. During a research routine, we realized a computed tomography angiography-based 3D slicer modeling that detected an incidental anterior communicating artery aneurysm. This case illustrates an unusual association of two rare intracranial aneurysm locations and the usefulness of the 3D slicer modeling tool in the diagnosis of intracranial aneurysms. Through this report, we recommend using this tool worldwide for clinical tasks.","PeriodicalId":484263,"journal":{"name":"Journal of Case Reports and Medical History","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138979497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breast Cancer and Autoimmune Hemolytic Anemia: A Rare Paraneoplastic Syndrome","authors":"","doi":"10.54289/jcrmh2300142","DOIUrl":"https://doi.org/10.54289/jcrmh2300142","url":null,"abstract":"Autoimmune hemolytic anemia (AIHA) is a pathological process involving the destruction of red blood cells by the humoral immune system. Although there is a well-established relationship between the presence of AIHA and lymphoproliferative malignancies, AIHA rarely presents in association with solid malignancies. Few cases of solid cancer associated with AIHA have been reported. AIHA rarely presents as a paraneoplastic syndrome indicative of solid cancer. We report a case of breast cancer revealed by AIHA.","PeriodicalId":484263,"journal":{"name":"Journal of Case Reports and Medical History","volume":"8 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138598590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Learning to Play the Piano Can Greatly Improve the Lives of Children on the Autism Spectrum","authors":"","doi":"10.54289/jcrmh2300141","DOIUrl":"https://doi.org/10.54289/jcrmh2300141","url":null,"abstract":"","PeriodicalId":484263,"journal":{"name":"Journal of Case Reports and Medical History","volume":"143 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138598816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Special Role of JAK/STAT, and Notch Signaling Pathways in Cancer Pathogenesis","authors":"","doi":"10.54289/jcrmh2300135","DOIUrl":"https://doi.org/10.54289/jcrmh2300135","url":null,"abstract":"Cancer is essentially a genetic disease, characterized by unclear etiology in many cases, complex pathogenic mechanisms, since in the majority of cancer cases only risk or predisposing factors have been recognized, and unclarified observations concerning organs that are not often affected by malignant tumors such as the small intestine, spleen, heart, and the neurons of the Central Nervous System. A tumor’s appearance and progression presupposes a series of genetic and non-genetic alterations that characterize tumor cells, and are related to self-sufficiency in growth stimuli, insensitivity to anti-growth signals, unlimited replicative potential, angiogenesis promotion, ability to infiltrate surrounding tissues and induce distant metastases, and resistance to apoptosis. The mentioned characteristics are associated with signaling pathways that are involved in cell survival, cell death, cell growth and division, cell motility, and can be considered in the context of abnormalities of wider signaling networks that support cancer progression, such as tumor microenvironment alterations, angiogenesis, and inflammation. Among others, two signaling pathways, JAK/STAT and Notch, seem to play essential roles in tumorigenesis, despite the fact that are implicated in diverse cellular functions such as tissue formation and cell differentiation, proliferation, apoptosis, inflammation, self-renewal, antitumor immune response suppression, motility, stress response and other responses depending on the target tissue. Hyperactivation of those signaling pathways caused by mutations are able to transform cellular proto-oncogenes to oncogenes, whereas inactivation of tumor suppressor genes eradicates crucial negative regulators of signaling. Various anticancer agents target those signaling pathways in an attempt to inhibit those pathways including monoclonal antibodies and other agents in the context of targeted cancer therapy.","PeriodicalId":484263,"journal":{"name":"Journal of Case Reports and Medical History","volume":"105 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135513026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facial Tumors Revealing Systemic Sarcoidosis: About a Case Report","authors":"","doi":"10.54289/jcrmh2300134","DOIUrl":"https://doi.org/10.54289/jcrmh2300134","url":null,"abstract":"Cutaneous involvement in sarcoidosis is highly variable, occurring in 9 to 37% of cases, and can be classified into specific and non-specific lesions. The specific lesions are essentially sarcoids with small and large nodules, plaques and annular lesions. However, the tumoral form is still very rare, and has only been reported in a handful of cases in the literature. We report the case of a 33-year-old female patient diagnosed with systemic sarcoidosis, revealed by a 5-year history of atypical skin lesions on the face, the largest of which measured 7 cm long. Skin biopsy was consistent with sarcoidosic granuloma, and workup for other localizations revealed ocular, respiratory, salivary gland and joint involvement. The originality of our observation lies in the extreme rarity of the tumoral form in cutaneous sarcoidosis.","PeriodicalId":484263,"journal":{"name":"Journal of Case Reports and Medical History","volume":"112 9","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135512301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}