Biochemistry (Moscow)最新文献

{"title":"The Double Toxic MPTP+CBE Presymptomatic Parkinson-Like Phenotype in Mice","authors":"Sofya N. Pchelina,&nbsp;Anastasia I. Bezrukova,&nbsp;Margarita M. Rudenok,&nbsp;Alexander S. Zhuravlev,&nbsp;Ivan N. Rybolovlev,&nbsp;Anna O. Lavrinova,&nbsp;Galina V. Baydakova,&nbsp;Mikhail A. Nikolaev,&nbsp;Maxim S. Nesterov,&nbsp;Denis A. Abaimov,&nbsp;Victoria N. Pidurchina,&nbsp;Suzanna A. Partevyan,&nbsp;Ekaterina I. Semenova,&nbsp;Tatiana S. Usenko,&nbsp;Ekaterina Y. Zakharova,&nbsp;Anton K. Emelyanov,&nbsp;Maria I. Shadrina,&nbsp;Petr A. Slominsky","doi":"10.1134/S000629792560070X","DOIUrl":"10.1134/S000629792560070X","url":null,"abstract":"<p>The deficiency of glucocerebrosidase (GCase) encoded by the <i>GBA1</i> gene, leads to the autosomal recessive Gaucher disease and highly increased risk of developing Parkinson’s disease (PD). In order to study the effect of GCase dysfunction on neurodegeneration, we evaluated the GCase activity, lysosphingolipid content, extent of dopaminergic neuron degeneration in the substantia nigra (SN), and levels of dopamine (DA) and total and oligomeric α-synuclein (α-Syn) in the brain of mice with the presymptomatic stage of parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in combination with a single injection of the GCase selective inhibitor conduritol-β-epoxide (CBE) (100 mg/kg body weight). A single injection of CBE led to a ~50% decrease in the GCase activity, significant increase in the lysosphingolipid content, and striatal accumulation of oligomeric α-Syn in the mouse brain. Assessment of the DA neuron degeneration in the SN 14 days after injection by immunohistochemical staining for tyrosine hydroxylase (TH) demonstrated a twice more pronounced reduction in the number of TH+ neurons in MPTP+CBE mice compared to MPTP only-treated animals (14% vs. 29%, respectively; <i>p</i> &lt; 0.0001). The double neurotoxic (MPTP+CBE) model was also characterized by a decrease in the DA content and more pronounced accumulation of total α-Syn in the striatum. Overall, we demonstrated that inhibition of the GCase activity leads to the α-Syn accumulation and further exacerbation of the MPTP-induced pathology. The described double toxic MPTP+CBE mouse model can be used for the screening of neuroprotective drugs in approaches aimed at increasing the GCase activity.</p>","PeriodicalId":483,"journal":{"name":"Biochemistry (Moscow)","volume":"90 8","pages":"1049 - 1063"},"PeriodicalIF":2.2,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concept of Human Aging Biomarkers","authors":"Anastasia A. Kobelyatskaya,&nbsp;Aleksey A. Moskalev","doi":"10.1134/S0006297925601704","DOIUrl":"10.1134/S0006297925601704","url":null,"abstract":"<p>Aging biomarkers could potentially facilitate assessment of the rate of aging, age-related diseases, and allow monitoring of the effectiveness of preventive interventions such as diet, physical activity, and geroprotectors. This article examines key criteria for the aging biomarkers, including their association with age, prognostic value regarding mortality, ability to detect early stages of age-related pathologies, and minimal invasiveness. Comprehensive classification of the markers (clinical, functional, molecular, omics, digital) and evolution of “aging clocks” – from epigenetic models to causal systems based on Mendelian randomization – is presented. Special attention is given to the explainable artificial intelligence technologies that allow for interpretation of the algorithms, as well as practical use of the biomarkers in clinical studies in the manner understandable to humans. Prospects for the development of the comprehensive panels of biomarkers and personalized approaches to aging assessment are discussed.</p>","PeriodicalId":483,"journal":{"name":"Biochemistry (Moscow)","volume":"90 8","pages":"1018 - 1026"},"PeriodicalIF":2.2,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ribosome in Baker’s Yeast Mitochondria are Heterogeneous","authors":"Rinat A. Khannanov,&nbsp;Ivan V. Chicherin,&nbsp;Mariya V. Baleva,&nbsp;Sergey A. Levitskii,&nbsp;Ruslan A. Vasilev,&nbsp;Ulyana E. Piunova,&nbsp;Petr A. Kamenski","doi":"10.1134/S0006297925602047","DOIUrl":"10.1134/S0006297925602047","url":null,"abstract":"<p>Ribosomes are macromolecular machines of conveyor type, which move along the mRNA from triplet to triplet and polymerize cognate amino acids. They are regarded as uniform entities with constant molecular composition bearing no regulatory capacity. However, their ability to interact with multiple proteins involved in translation suggests existence of specialized ribosomes dedicated to biosynthesis of particular proteins. This can be easily imagined in yeast mitochondria, whose genomes encode eight polypeptides, and where protein-specific translation is already represented by translational activators – a group of proteins each regulating a single mRNA translation. Despite this, the subject remains poorly investigated. We report an exploratory approach to search for distinct populations of ribosomes in the yeast mitochondria. Affinity tags were added to mitochondrial ribosomal proteins, ribosomes were isolated by immunoprecipitation and their protein and RNA content was characterized. It was shown that the mitochondrial ribosomes isolated from yeast strains bearing affinity tags on different ribosomal proteins recover different sets of components. The differences were rather quantitative than qualitative, because almost full sets of mitochondrial ribosomal proteins were identified in each sample, but the ratios demonstrated variance ranging from 10 to less than 0.05 molecules per ribosome. In addition, we explored the power of translational activators as a bait to recover ribosomes translating specific mRNAs in yeast mitochondria.</p>","PeriodicalId":483,"journal":{"name":"Biochemistry (Moscow)","volume":"90 8","pages":"1099 - 1115"},"PeriodicalIF":2.2,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Human Leukocyte Antigen Alleles and Endocrine Disorders in a Cohort of 895 Patients from Russian Clinical Population","authors":"Anton A. Buzdin,&nbsp;Polina A. Pugacheva,&nbsp;Daniil V. Luppov,&nbsp;Marianna A. Zolotovskaia,&nbsp;Maxim I. Sorokin,&nbsp;Sergey A. Roumiantsev,&nbsp;Aleksandra G. Emelyanova,&nbsp;Olga O. Golounina,&nbsp;Arseniya O. Alexeeva,&nbsp;Anna A. Emelianova,&nbsp;Aleksey L. Novoselov,&nbsp;Anna Y. Khristichenko,&nbsp;Alina V. Matrosova,&nbsp;Sergey V. Popov,&nbsp;Evgeniya V. Plaksina,&nbsp;Vasiliy M. Petrov,&nbsp;Anastasia R. Guselnikova,&nbsp;Zhanna E. Belaya,&nbsp;Mary Woroncow,&nbsp;Galina A. Melnichenko,&nbsp;Ekaterina A. Troshina,&nbsp;Marina V. Shestakova,&nbsp;Olga B. Bezlepkina,&nbsp;Valentina A. Peterkova,&nbsp;Natalia G. Mokrysheva,&nbsp;Vladimir P. Chekhonin,&nbsp;Ivan I. Dedov","doi":"10.1134/S000629792460460X","DOIUrl":"10.1134/S000629792460460X","url":null,"abstract":"<p>Endocrine disorders represent a serious public health problem and frequently can be caused by genetic factors or their combination with environmental and lifestyle factors. Assessment of relevant genetic factors is important to estimate the risk of endocrine pathologies in an individual before their manifestation. Identification of genetic variations in proteins of the major histocompatibility complex is important with regard to the autoimmune nature of many endocrine pathologies, including type 1 diabetes. In this study, we investigated the relationship between human leukocyte antigen (HLA) genes and 13 endocrine disorders by using experimental whole-exome sequencing profiles obtained for 895 patients from the National Medical Research Center for Endocrinology, Moscow. In addition, the linkage disequilibrium of the identified alleles in the context of the respective diagnoses was assessed. We identified totally 45 statistically significant associations between HLA alleles and specific diagnoses of endocrine pathologies. Among them, 33 were described for the first time and 12 have been previously reported for type 1 diabetes. Overall, 17 alleles were associated with type 1 diabetes and four alleles – with other forms of diabetes. Furthermore, three alleles were associated with obesity, five – with adrenogenital diseases, three – with hypoglycemia, and three – with precocious puberty. Single alleles were found to be associated with congenital hypothyroidism without goiter, hyperfunction of pituitary gland, adrenomedullary hyperfunction, and short stature due to endocrine disorder. The study shows that early HLA typing can help in detecting genetic risk factors of endocrine disorders. In addition, identification of disease associations with specific HLA alleles can broaden our understanding of the mechanisms involved in the pathogenesis of relevant endocrine disorders.</p>","PeriodicalId":483,"journal":{"name":"Biochemistry (Moscow)","volume":"90 8","pages":"1126 - 1139"},"PeriodicalIF":2.2,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Branched Polyamine-Modified Chlorin with a Photoinduced Antimicrobial Activity","authors":"Nikita V. Suvorov,&nbsp;Galina M. Gamenyuk,&nbsp;Ekaterina A. Safonova,&nbsp;Margarita A. Shagabaeva,&nbsp;Viktoria V. Shchelkova,&nbsp;Sergey I. Tikhonov,&nbsp;Dmitriy A. Minakov,&nbsp;Nadezhda V. Konovalova,&nbsp;Yuri L. Vasil’ev,&nbsp;Mikhail A. Grin","doi":"10.1134/S0006297925601431","DOIUrl":"10.1134/S0006297925601431","url":null,"abstract":"<p>Multiple drug resistance is one of the major threats to global health. One of the approaches to solving this problem is antimicrobial photodynamic therapy, however, currently used photosensitizers are not sufficiently effective against pathogens. Polycationic molecular constructs enhance the binding and penetration of photosensitizers into poorly permeable gram-negative bacteria. Such conjugates can be obtained by introducing polyethyleneimines into a photosensitizer molecule. In this study, we synthesized a branched tetraamine and introduced it into the pyrrole ring A of the natural chlorin molecule and assessed <i>in vitro</i> the photoinduced toxicity of the new photosensitizer against <i>Staphylococcus aureus</i>, <i>Enterococcus faecalis</i>, <i>Pseudomonas aeruginosa</i>, and <i>Escherichia coli</i> bacteria. Compared to its structural precursor, the obtained chlorin with a branched polyamine residue demonstrated an increased bactericidal effect when irradiated with light.</p>","PeriodicalId":483,"journal":{"name":"Biochemistry (Moscow)","volume":"90 )\nGuest","pages":"975 - 983"},"PeriodicalIF":2.2,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1134/S0006297925601431.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective Role of Plastoquinone in the Early Stages of Second-Degree Thermal Skin Burn","authors":"Nadezhda I. Pashkevich,&nbsp;Ekaterina S. Pykhova,&nbsp;Alexander A. Ashikhmin,&nbsp;Daria V. Vetoshkina,&nbsp;Sergey S. Osochuk,&nbsp;Maria M. Borisova-Mubarakshina","doi":"10.1134/S0006297925601297","DOIUrl":"10.1134/S0006297925601297","url":null,"abstract":"<p>Thermal burns of the skin are associated not only with local tissue alterations but also with the development of systemic disorders, which promote generalization of inflammatory processes. In particular, burn injury leads to an overproduction of reactive oxygen species, activation of free-radical oxidation, and lipid peroxidation. This study investigated the protective role of plastoquinone, a natural plant antioxidant, on the morphological condition of the skin and on the shape and aggregation of erythrocytes in rats with second-degree thermal burns. Thermal burn resulted in the decrease in epidermis thickness, increase in the number of hyperemic vessels, damaged hair follicles and sebaceous glands. Application of plastoquinone, incorporated into liposomes, onto the damaged skin had a protective effect on the skin structures; in the case of liposomes applied without plastoquinone, the protective effect was less pronounced. In addition, thermal burn altered the state of erythrocytes, leading to their deformation and aggregation. Plastoquinone in liposomes applied topically or administered intravenously showed a protective effect on erythrocytes comparable to that of ubiquinone, preventing the development of burn-induced erythrocyte shape alterations. However, only plastoquinone administered intravenously completely prevented erythrocyte aggregation, thus eliminating negative effects of the burn injury on the functional activity of erythrocytes, indicating the potential of plant-derived plastoquinone as an effective agent in burn injury management.</p>","PeriodicalId":483,"journal":{"name":"Biochemistry (Moscow)","volume":"90 )\nGuest","pages":"956 - 974"},"PeriodicalIF":2.2,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of Electron Transfer in Photosystem I Using High-Frequency EPR Spectroscopy. In Memory of Professor Klaus Möbius (1936-2024)","authors":"Vasily V. Ptushenko,&nbsp;Alexey Y. Semenov","doi":"10.1134/S0006297925601091","DOIUrl":"10.1134/S0006297925601091","url":null,"abstract":"<p>Klaus Möbius, Professor at the Free University of Berlin, was an outstanding physical chemist and biophysicist. He was a pioneer in the development of high-field/high-frequency EPR spectroscopy methods and their application in the study of photosynthesis. Among the most essential are the applications in studying the charge transfer kinetics and properties of the ion-radical pairs in photosynthetic reaction centers (RC). Under his leadership and with his direct participation a unique setup allowing registration of the kinetics of the electron transfer between the (bacterio)chlorophyll dimer and quinone in the bacterial photosynthetic RC and plant photosystem I (PSI) was created. This setup also allowed precise determining of the distance between separated charges based on measuring the frequencies of the Electron Spin Echo Envelope Modulation (ESEEM). This setup made it possible to prove that electron transfer in PSI occurs mainly along the <i>A</i> branch of redox cofactors. The kinetics of backward electron transfer reaction (reoxidation of the phyllosemiquinone anion A₁⁻ and reduction of the photooxidized chlorophyll dimer P₇₀₀⁺) in PSI were measured under the same conditions. The essential data on the bioprotective effect of the disaccharide trehalose on the kinetics of forward and backward electron transfer in PSI complexes were obtained. A significant slowdown in the kinetics of electron transfer due to the restriction of protein conformational mobility, as well as long-term maintaining of functional activity of PSI dried in a vitreous trehalose matrix at room temperature (i.e., subjected to a reversible anhydrobiosis) was demonstrated. These results obtained in collaboration with Prof. Möbius and Prof. Venturoli (Bologna) allowed elucidating the role of hydrogen bond network and the conformational mobility of the protein subunits in facilitating electron transfer in the photosynthetic RC.</p>","PeriodicalId":483,"journal":{"name":"Biochemistry (Moscow)","volume":"90 )\nGuest","pages":"830 - 839"},"PeriodicalIF":2.2,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Hydrogen Peroxide on the Redistribution of Antenna Complexes Between Photosystems in Higher Plants","authors":"Nikolai V. Balashov,&nbsp;Maria M. Borisova-Mubarakshina,&nbsp;Daria V. Vetoshkina","doi":"10.1134/S0006297925601443","DOIUrl":"10.1134/S0006297925601443","url":null,"abstract":"<p>One of the adaptive mechanisms used by photosynthetic organisms in response to changing light conditions is redistribution of antenna complexes between the photosystems, a process known as state transitions (ST). This mechanism allows to regulate the amount of light energy absorbed by the photosystems. Numerous studies have reported inhibition of ST at the elevated light intensity; however, the mechanism underlying this process is still debated. We evaluated the effect of H₂O₂ at various concentrations on the ST process in functionally active thylakoids isolated from <i>Arabidopsis thaliana</i> leaves and investigated which stage of this process is affected by H₂O₂. To assess the extent of ST, we measured low-temperature chlorophyll <i>a</i> fluorescence spectra (650-780 nm) and calculated the F745/F685 ratio, whose changes can serve as an indicator of ST progression. H₂O₂ inhibited ST under the low-intensity light conditions and, furthermore, led to a decrease in the accumulation of phosphorylated Lhcb1 and Lhcb2 proteins involved in ST. This suggests that the observed ST inhibition resulted from the suppression of STN7 kinase activity. Importantly, H₂O₂ in the tested concentrations did not affect the electron transport rate, indicating that the inhibition of STN7 kinase activity was not associated with suppression of the photosynthetic electron transport chain (PETC) activity. The treatment with H₂O₂ did not reduce the level of phosphorylated D1 protein (a product of phosphorylation by the thylakoid STN8 kinase). Taken together, these results demonstrate for the first time the mechanism by which H₂O₂ inhibits STN7 kinase activity and, consequently, the process of ST.</p>","PeriodicalId":483,"journal":{"name":"Biochemistry (Moscow)","volume":"90 )\nGuest","pages":"943 - 955"},"PeriodicalIF":2.2,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preface to the Special Issue “New Advances in Photobiochemistry and Photobiophysics”","authors":"Vladimir S. Sukhov,&nbsp;Maria M. Borisova-Mubarakshina,&nbsp;Alexey Yu. Semenov","doi":"10.1134/S000629792560200X","DOIUrl":"10.1134/S000629792560200X","url":null,"abstract":"","PeriodicalId":483,"journal":{"name":"Biochemistry (Moscow)","volume":"90 )\nGuest","pages":"829 - 829"},"PeriodicalIF":2.2,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between the Photosystem II Regulation Mechanisms and Hydrogen Production in Chlamydomonas reinhardtii under Nitrogen or Sulfur Deprivation","authors":"Vera I. Grechanik,&nbsp;Maksim A. Bol’shakov,&nbsp;Anatoly A. Tsygankov","doi":"10.1134/S0006297925600929","DOIUrl":"10.1134/S0006297925600929","url":null,"abstract":"<p>Some microalgae are capable of light-dependent hydrogen production after a period of anaerobic adaptation, thus performing biophotolysis of water. The rate of hydrogen production the start of illumination has the rate equal to the maximum rate of photosynthesis. However, this process is short-lived: oxygen produced during photosynthesis quickly inactivates the key enzyme of biophotolysis, hydrogenase, and inhibits its expression. To date, approaches have been developed to achieve sustained hydrogen production by microalgae. The most studied are those based on transferring microalgae to nutrient-deficient conditions. However, it is known that hydrogen production under nutrient deficiency is always accompanied by the decrease in activity of photosystem II (PSII). Several mechanisms for suppression of PSII activity have been described in the literature, and there is no consensus on which mechanism is the determining one. The aim of this work was to test the hypothesis that realization of a particular mechanism of PSII suppression depends not only on the type of stress but also on the growth conditions. For this purpose, the photoautotrophic culture of the microalga <i>Chlamydomonas reinhardtii</i> was grown under nitrogen or sulfur deficiency under different light regimes, and realization of the following mechanisms of PSII activity suppression was analyzed: over-reduction of the plastoquinone pool (coupled with over-reduction of the entire photosynthetic electron transport chain), decoupling of PSII (based on the kinetics of ascorbate accumulation and the JIP test) with water-oxidizing complex, violaxanthin cycle, anaerobic stress associated with the creation of a reducing redox potential of the culture suspension. It was found that the key mechanism determining hydrogen production is the over-reduction of the plastoquinone pool. Other mechanisms are also realized under various conditions but do not show clear correlation with hydrogen production. The obtained results indicate that induction of stress through starvation of cultures is a convenient approach for studying hydrogen production by microalgae, but due to the low activity of PSII, it is impractical. New approaches are required to create industrial systems based on microalgae, allowing full realization of their photosynthetic potential.</p>","PeriodicalId":483,"journal":{"name":"Biochemistry (Moscow)","volume":"90 )\nGuest","pages":"921 - 933"},"PeriodicalIF":2.2,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}