Biochemistry (Moscow)最新文献

{"title":"Role of MMP-2 and MMP-9 in the Relationship between Inflammation, Fibrosis, and Apoptosis during Progression of Non-Alcoholic Fatty Liver Disease and Diagnostic Significance of Plasma Levels of Their Active Forms.","authors":"Irina V Kurbatova, Lyudmila V Topchieva, Olga P Dudanova, Anastasia A Shipovskaya","doi":"10.1134/S0006297924110130","DOIUrl":"https://doi.org/10.1134/S0006297924110130","url":null,"abstract":"<p><p>MMP-2 and MMP-9 play an important role in pathogenesis of chronic liver diseases, participating in the processes of inflammation and fibrosis. Their role in progression of non-alcoholic fatty liver disease (NAFLD) is poorly understood. Analysis of MMP-2, -9 levels in the blood plasma of patients with different forms of NAFLD [liver steatosis (LS) and non-alcoholic steatohepatitis (NASH) of weak (-WA), moderate (MA), high (-HA) activity without pronounced fibrosis] was performed. Correlations between the levels of MMP-2, -9 and mRNA of the genes <i>MMP2</i>, <i>MMP9</i>, <i>ADAM17</i>, <i>NLRP3</i>, caspase 3 activity in peripheral blood leukocytes (PBL), TNFα, IL-6, sIL-6R, cytokeratin-18 fragments in plasma were assessed. In steatosis, the levels of <i>MMP2</i> gene mRNA in PBL and MMP-2 in plasma are lower than in the control, and expression of the <i>NLRP3</i> gene in PBL is increased relative to other groups. In the NASH-WA, the level of MMP-9 is higher than in the control, in LS, and in NASH-MA, which could be associated with activation of inflammation during transformation of LS into NASH. The plasma level of MMP-9 over 389.50 pg/ml has been shown to be diagnostically significant for identification of NASH-WA among the patients with steatosis (<i>AUC ROC</i> = 0.818, 95% CI = 0.689-0.948, <i>p</i> &lt; 0.001). In NAFLD, the level of MMP-9 could be associated not only with inflammation, but also with apoptosis. ADAM17 probably plays a certain role in this regard. In the advanced NASH, hepatocyte apoptosis is increased, the level of caspase 3 activity in PBL is increased, the level of MMP-9 in the blood is reduced to the level of the control and LS. In the NASH-HA, the level of mRNA of the <i>ADAM17</i> gene in PBL is increased compared to the control, NASH-WA, and NASH-MA. Thus, MMP-2 and MMP-9 are involved in pathogenesis of NAFLD already at the early stages and their level in blood could be associated with the presence and severity of inflammation in the liver parenchyma.</p>","PeriodicalId":483,"journal":{"name":"Biochemistry (Moscow)","volume":"89 11","pages":"1998-2022"},"PeriodicalIF":2.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of Neuroinflammation in the Rat Hippocampus during Ethanol Exposure and Pharmacological Correction with Azithromycin: New Data and Future Perspectives.","authors":"Marat I Airapetov, Sergei O Eresko, Sofiia A Shamaeva, Evgenii R Bychkov, Andrei A Lebedev, Petr D Shabanov","doi":"10.1134/S0006297924110051","DOIUrl":"https://doi.org/10.1134/S0006297924110051","url":null,"abstract":"<p><p>With prolonged ethanol ingestion, disturbances in the emotional spectrum develop, and memory problems are noted. These symptoms could be mediated by the development of neurochemical changes in the hippocampus of the brain. Although there is evidence that hippocampus is vulnerable to chronic alcohol intoxication and that neuroinflammation and neurodegeneration develop in this brain region, the key molecular mechanisms have not been identified. The aim of the study was to investigate changes in the immune system in the periphery as well as in the hippocampus of rat brain during ethanol exposure and during pharmacological correction with azithromycin (AZM). Long-term ethanol exposure was modeled by injecting rats with a 20% ethanol solution (4 g/kg) for 4 weeks. General biochemical and clinical blood analysis was performed in animals. Expression levels of the cytokine genes (<i>Il1β</i>, <i>Ccl2</i>, <i>Il6</i>, <i>Il11</i>, <i>Il13</i>, <i>Tnfα</i>, <i>Tgfβ</i>), Toll-like receptor system genes (<i>Tlr3</i>, <i>Tl4</i>, <i>Tlr7</i>, <i>Nfkb1</i>, <i>Hmgb1</i>), and TLR system-related microRNA molecules (miR-182, miR-155-5p, miR-96-5p, miR-let-7b) were evaluated in the hippocampus. IL-1β protein content was also assessed in the hippocampus. Prolonged exposure to alcohol caused increase in the mRNA and protein levels of IL-1β, and decrease in the mRNA levels of <i>Tnfα</i>, <i>Il11</i>, <i>Tlr3</i>, and <i>Tlr7</i>. The contents of miRlet7b, miR96, and miR155 were downregulated in the hippocampus after long-term alcohol exposure. Elevated levels of THE <i>Il1β</i> mRNA and protein and <i>Hmgb1</i> mRNA were maintained under conditions of ethanol abstinence. The <i>Tlr3</i> mRNA levels were decreased after abstinence. Administration of AZM reduced the IL1β, TLR3, and HMGB1 mRNA levels under conditions of ethanol abstinence; and at higher doses of the drug decrease in the IL-1β protein levels in the hippocampus of rat brain was observed. Thus, the study provided new insights into the mechanisms of neuroinflammation in the hippocampus during prolonged exposure to ethanol and upon abstinence. The obtained results allowed us to suggest a number of tasks for further studies in this direction.</p>","PeriodicalId":483,"journal":{"name":"Biochemistry (Moscow)","volume":"89 11","pages":"1911-1921"},"PeriodicalIF":2.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol-Induced Activation of Chemokine System and Neuroinflammation Development.","authors":"Ekaterina V Mikhalitskaya, Natalya M Vyalova, Nikolay A Bokhan, Svetlana A Ivanova","doi":"10.1134/S0006297924110038","DOIUrl":"10.1134/S0006297924110038","url":null,"abstract":"<p><p>Chemokines are immunoregulatory proteins with pleiotropic functions involved in neuromodulation, neurogenesis, and neurotransmission. The way chemokines affect the CNS plays an important role in modulating various conditions that could have negative impact on CNS functions, including development of alcohol use disorders. In this review, we analyzed the literature data available on the problem of chemokine participation in pathogenesis, clinical presentation, and remission of alcohol use disorders both in animal models and in the study of patients with alcoholism. The presented information confirms the hypothesis that the alcohol-induced chemokine production could modulate chronic neuroinflammation. Thus, the data summarized and shown in this review are focused on the relevant direction of research in the field of psychiatry, which is in demand by both scientists and clinical specialists.</p>","PeriodicalId":483,"journal":{"name":"Biochemistry (Moscow)","volume":"89 11","pages":"1889-1903"},"PeriodicalIF":2.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracellular Vesicles as Potential Biomarkers in Addictive Disorders.","authors":"Vsevolod V Severtsev, Margarita A Pavkina, Nikolay N Ivanets, Maria A Vinnikova, Alexander A Yakovlev","doi":"10.1134/S0006297924110117","DOIUrl":"10.1134/S0006297924110117","url":null,"abstract":"<p><p>Small extracellular vesicles (sEVs) and their role in mental and addictive disorders are extremely promising research areas. Because of their small size, sEVs can pass through the blood-brain barrier. The membrane of sEVs contain proteins that protect them against destruction by the organism's immune system. Due to these properties, sEVs circulating in the blood can be used as potential biomarkers of processes occurring in the brain. Exposure to psychoactive substances <i>in</i> <i>vitro</i> and <i>in vivo</i> affects sEV biogenesis and significantly alters the amount of sEVs and chemical composition of their cargo. Based on the published reports, sEVs carry numerous potential biomarkers of addictive pathologies, although the diagnostic significance of these markers still has to be evaluated. A large body of evidence indicates that psychoactive substances influence Rab family GTPases, Toll-like receptors, complement system components, and cytokines. In some studies, the effect of psychoactive substances on sEVs was found to be sex-dependent. It has become commonly accepted that sEVs are involved in the regulation of neuroinflammation and interaction between glial cells and neurons, as well as between peripheral cells and cells of the central nervous system. Here, we formulated a hypothesis on the existence of two mechanisms/stages involved in the effect of psychoactive substances on sEVs: the \"fast\" mechanism that provides neuroplasticity, and the \"slow\" one, resulting from the impaired biogenesis of sEVs and formation of aberrant vesicles.</p>","PeriodicalId":483,"journal":{"name":"Biochemistry (Moscow)","volume":"89 11","pages":"1970-1984"},"PeriodicalIF":2.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Peripheral Markers of Oxidative Stress with Clinical Parameters and Inflammatory Factors in Alcoholic Patients.","authors":"Valentina D Prokopieva, Tamara P Vetlugina, Elena V Epimakhova, Anastasiya S Boiko, Nikolay A Bokhan","doi":"10.1134/S000629792411004X","DOIUrl":"https://doi.org/10.1134/S000629792411004X","url":null,"abstract":"<p><p>One of the fundamental problems in studying addiction is elucidation of mechanisms of alcohol dependence (AD) development. Disturbances of cellular redox balance and inflammation play an important role in AD pathogenesis. Deciphering associations between biological and clinical indicators can elucidate molecular mechanisms of disease pathogenesis. The aim of the work was to study peripheral markers of oxidative stress in patients with AD during early abstinence period and to identify their relationship with clinical parameters of the disease and inflammatory factors. In total, 84 patients with AD were studied (average age, 44.3 ± 8.2 years). The analyzed clinical parameters included patient's age, age of alcohol withdrawal syndrome (AWS) formation, disease duration, and AWS duration. The markers of oxidative stress determined in the blood plasma were oxidation products of proteins (protein carbonyls, PCs), lipids (thiobarbituric acid-reactive products, TBA-RPs), and DNA (8-hydroxy-2'-deoxyguanosine, 8-OH-dG). The content of inflammatory mediators, such as proinflammatory cytokines (IFNγ, IL-1β, IL-6, IL-8, IL-17A, TNFα) was determined in the blood serum. Blood samples of 80 conditionally healthy men (average age, 40.9 ± 9.6 years) were used as a control. Patients with AD demonstrated an increase in the content of PCs, TBA-RPs, and all analyzed cytokines (but not 8-OH-dG) compared to the control individuals. There was a direct correlation between the TBA-RP content and disease duration and inverse correlation of the PC content with the age of AWS formation and AWS duration. The content of PCs demonstrated an inverse correlation with the IL-6 concentration in the blood plasma. We also observed a positive correlation between 8-OH-dG and IL-6, TBA-RPs and IL-8, and TBA-RPs and TNFα. Therefore, the early abstinence period in patients with AD was characterized by a pronounced oxidative stress and inflammation. The obtained results expand the knowledge on the integrative contribution of oxidative stress and inflammatory factors to the AD pathogenesis and can be used in the development of new therapies.</p>","PeriodicalId":483,"journal":{"name":"Biochemistry (Moscow)","volume":"89 11","pages":"1904-1910"},"PeriodicalIF":2.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of Structural Properties and Antimicrobial Activity of the C3f Peptide of Complement System.","authors":"Ilia A Krenev, Ekaterina V Egorova, Maria M Khaydukova, Anna D Mikushina, Yana A Zabrodskaya, Aleksey S Komlev, Igor E Eliseev, Olga V Shamova, Mikhail N Berlov","doi":"10.1134/S000629792411018X","DOIUrl":"https://doi.org/10.1134/S000629792411018X","url":null,"abstract":"<p><p>The C3f peptide is a by-product of regulation of the activated complement system with no firmly established function of its own. We have previously shown that C3f exhibits moderate antimicrobial activity against some Gram-positive bacteria <i>in vitro</i>. Presence of two histidine residues in the amino acid sequence of the peptide suggests enhancement of its antimicrobial activity at lower pH and in the presence of metal cations, particularly zinc cations. Since such conditions could be realized in inflammatory foci, the study of dependence of C3f activity on pH and presence of metal cations could provide an opportunity to assess biological significance of antimicrobial properties of the peptide. The peptide C3f and its analogs with histidine residues substituted by lysines or serines, C3f[H/K] and C3f[H/S], were prepared by solid-phase synthesis. Using CD spectroscopy, we found that C3f contained a β-hairpin and unstructured regions; presence of Zn²⁺ did not affect conformation of the peptide. In the present work, it was shown that C3f could also exhibit antimicrobial activity against Gram-negative bacteria, in particular, <i>Pseudomonas aeruginosa</i> ATCC 27583. Exposure of <i>P. aeruginosa</i> and <i>Listeria monocytogenes</i> EGD to the peptide was accompanied by disruption of the barrier function of bacterial membranes. Zn²⁺ ions, unlike Cu²⁺ ions, enhanced antimicrobial activity of C3f against <i>L. monocytogenes</i>, with 4- and 8-fold molar excess of Zn²⁺ being no more effective than a 20% excess. Activity of the C3f analogs was also enhanced to some extent by the zinc ions. Thus, we hypothesize existence of the histidine-independent formation of C3f-Zn²⁺ complexes leading to increase in the total charge and antimicrobial activity of the peptide. In the presence of 0.15 M NaCl, C3f lost its antimicrobial activity regardless of the presence of Zn²⁺, indicating an insignificant role of C3f as an endogenous antimicrobial peptide. Presence of C3f eliminated bactericidal effect of Zn²⁺ against the zinc-sensitive <i>Escherichia coli</i> strain ESBL 521/17, indirectly confirming interaction of the peptide with Zn²⁺. Activity of C3f against <i>Micrococcus luteus</i> A270 increased with decreasing pH, while effect of pH on the C3f activity against <i>L. monocytogenesis</i> was more complex. In this work, we show significance of the factors such as pH and metal cations in realization of antimicrobial activity of peptides based on the example of C3f.</p>","PeriodicalId":483,"journal":{"name":"Biochemistry (Moscow)","volume":"89 11","pages":"2069-2082"},"PeriodicalIF":2.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behavioral Features and Blood Enzyme Activity in Offspring of Rats Conceived from an Alcohol-Intoxicated Father.","authors":"Sergey K Sudakov, Natalya G Bogdanova, Galina A Nazarova, Nikolai N Zolotov","doi":"10.1134/S0006297924110075","DOIUrl":"https://doi.org/10.1134/S0006297924110075","url":null,"abstract":"<p><p>Quite often, conception of a child occurs after consuming small doses of alcohol. However, effect of this factor on offspring has not been studied at all. The aim of this study was to examine the level of motor activity, anxiety-like and depressive-like behavior, sensitivity to analgesic effect of ethanol, as well as activity of the enzymes DPP-IV, PEP, and ADG in the blood of rats whose fathers received ethanol immediately before mating. As a result of the conducted experiments, it was found that the males conceived by the intoxicated fathers have significant differences in behavior compared to control animals. Thus, motor activity in the rats conceived by males under the influence of alcohol was 2-2.5 times less intense; they exhibited decreased severity of the anxiety-like and depressive-like behavior. In such animals, activity of DPP-IV and ADG was increased and activity of PEP in the blood was reduced. In the rats conceived by the fathers under the influence of alcohol, analgesic effect of ethanol was decreased, and there was also reduction in response of the activities of ADG, DPP-IV, and PEP enzymes to ethanol administration. It is assumed that a single use of ethanol by male rats immediately before mating leads to the decrease in methylation of the paternal inherited genes in offspring. As a result, activity of a number of enzymes could change, which leads to the change in the balance of neuropeptides involved in mediation of animal behavior.</p>","PeriodicalId":483,"journal":{"name":"Biochemistry (Moscow)","volume":"89 11","pages":"1930-1937"},"PeriodicalIF":2.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-Molecular Neurotrophin-3 Mimetics with Different Patterns of Postreceptor Signaling Activation Attenuate Differentially Morphine Withdrawal in Rats.","authors":"Larisa G Kolik, Mark A Konstantinipolsky, Sergey V Nikolaev, Ilya O Logvinov, Tatyana A Antipova, Tatiana A Gudasheva","doi":"10.1134/S0006297924110105","DOIUrl":"https://doi.org/10.1134/S0006297924110105","url":null,"abstract":"<p><p>The accumulated evidence suggests that varying levels of tyrosine kinase receptor signaling pathway activity may regulate opiate-associated neuroadaptation of noradrenergic system. Neurotrophin-3 (NT-3) interacts with tropomyosin receptor kinases (TRKs), binding mainly to TRKC receptors, which are expressed within noradrenergic neurons in the blue spot (<i>locus coeruleus</i>, LC). Considering the difficulties in delivering full-length neurotrophins to the CNS after systemic administration, low-molecular mimetics of loop 4 in NT-3, hexamethylenediamide bis-(N-monosuccinyl-L-asparaginyl-L-asparagine) (GTS-301), and hexamethylenediamide bis-(N-γ-oxybutyryl-L-glutamyl-L-asparagine) (GTS-302), activating TRKC and TRKB receptors, were synthesized. The aim of the study is comparative examination of the effects of NT-3 dipeptide mimetics on the signs of morphine withdrawal in outbred white rats with opiate dependence, as well as investigation of activation of postreceptor signaling pathways by the mimetics. Dipeptides GTS-301 and GTS-302 after acute administration at doses of 0.1, 1.0, and 10.0 mg/kg (i.p., intraperitoneal) had a dose-dependent effect on the specific morphine withdrawal symptoms with the most effective dose being 1.0 mg/kg. Maximum decrease in the total index of morphine withdrawal syndrome for GTS-301 was 31.3% and for GTS-302 - 41.4%. Unlike GTS-301, GTS-302 weakened mechanical allodynia induced by morphine withdrawal, reducing tactile sensitivity. When studying activation of the postreceptor signaling pathways by the NT-3 mimetics in the HT-22 hippocampal cell culture, a different pattern of postreceptor signaling was shown: GTS-302 (10^-6 M), similar to NT-3, activates all three MAPK/ERK, PI3K/AKT/mTOR, and PLCγ1 pathways, while GTS-301 (10^-6 M) triggers only MAPK/ERK and PLCγ1 pathways. Thus, the identified features of attenuation of the morphine withdrawal syndrome in the rats under GTS-301 and GTS-302 effects could be associated with different activation pattern of the postreceptor pathways.</p>","PeriodicalId":483,"journal":{"name":"Biochemistry (Moscow)","volume":"89 11","pages":"1961-1969"},"PeriodicalIF":2.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroimmune Characteristics of Animals with Prenatal Alcohol Intoxication.","authors":"Inna Yu Shamakina, Petr K Anokhin, Ruslan A Ageldinov, Viktor S Kokhan","doi":"10.1134/S0006297924110063","DOIUrl":"https://doi.org/10.1134/S0006297924110063","url":null,"abstract":"<p><p>Neuroinflammation can be an important factor of many disorders in central nervous system (CNS) including cognitive dysfunction, affective disorders, and addictive behavior associated with prenatal alcohol exposure and presented in early adulthood. In this study we used an experimental rodent model of prenatal alcohol (PA) exposure (consumption of a 10% ethanol solution by female Wistar rats throughout pregnancy), multiplex immunofluorescence analysis of interleukins (IL-1α, IL-1β, IL-3, IL-6, IL-9, and IL-12), tumor necrosis factor (TNF-α), and chemokine CCL5, as well as quantitative real-time PCR to assess the level of cytokine mRNAs in the prefrontal cortex of the sexually mature (PND60) offspring - male and female rats with prenatal alcohol intoxication and control animals. Significant decrease in the content of TNF-α and interleukins IL-1β, IL-3, IL-6, IL-9 was detected in the prefrontal cortex of male, but not in the female PA offspring. Importantly, PA males also showed decrease in the level of TNF-α mRNA in the prefrontal cortex by 45% compared to the control males, which may underlie the detected decrease in its content. Taken together, our study demonstrates that a number of neuroimmune factors are regulated in a sex-specific manner in the prefrontal cortex and are differentially affected in males and females by the prenatal exposure to alcohol. Sex factor must be taken into account when conducting further translational studies of the fetal alcohol spectrum disorders and developing new methods for prevention and therapy.</p>","PeriodicalId":483,"journal":{"name":"Biochemistry (Moscow)","volume":"89 11","pages":"1922-1929"},"PeriodicalIF":2.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contribution of Visceral Systems to the Development of Substance Use Disorders: Translational Aspects of Interaction between Central and Peripheral Mechanisms.","authors":"Danil I Peregud, Natalia V Gulyaeva","doi":"10.1134/S0006297924110026","DOIUrl":"10.1134/S0006297924110026","url":null,"abstract":"<p><p>Substance use disorders are associated with structural and functional changes in the neuroendocrine, neuromediator, and neuromodulator systems in brain areas involved in the reward and stress response circuits. Chronic intoxication provokes emergence of somatic diseases and aggravates existing pathologies. Substance use disorders and somatic diseases often exacerbate the clinical courses of each other. Elucidation of biochemical pathways common for comorbidities may serve as a basis for the development of new effective pharmacotherapy agents, as well as drug repurposing. Here, we discussed molecular mechanisms underlying integration of visceral systems into the central mechanisms of drug dependence.</p>","PeriodicalId":483,"journal":{"name":"Biochemistry (Moscow)","volume":"89 11","pages":"1868-1888"},"PeriodicalIF":2.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}