Current Indian Science最新文献

{"title":"Moisture Determination in CO2 Gas Cylinders for Application in Annulus Gas\u0000Monitoring Systems of Pressurized Heavy Water Reactors (PHWRs)","authors":"N. Raje, S. Kolay","doi":"10.2174/012210299x254766231115104920","DOIUrl":"https://doi.org/10.2174/012210299x254766231115104920","url":null,"abstract":"\u0000\u0000Critical monitoring of moisture content in annulus gas is required due to its detrimental effect on the pressure tube, leading to surface corrosion and\u0000finally the rupture of the pressure tube.\u0000\u0000\u0000\u0000The present work describes a simple and reliable thermo-analytical method for the quantitative determination of moisture in CO2 gas cylinders,\u0000using anhydrous barium chloride as the novel adsorbent material and simultaneous.\u0000\u0000\u0000\u0000Thermogravimetry - Differential Thermal Analysis - Evolved Gas Analysis (Fourier Transformed InfraRed Spectroscopy) [TG-DTA-EGA(FTIR)]\u0000as determination techniques.\u0000\u0000\u0000\u0000Differential Scanning Calorimetry (DSC) coupled with Microscopy has been used to see the surface morphological variations during the heat\u0000treatment. The results of these studies are being discussed here.\u0000","PeriodicalId":479738,"journal":{"name":"Current Indian Science","volume":"55 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139003704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Therapeutic Role of Cannabinoid System in Alzheimer’s Disease: A\u0000Review","authors":"Abrar Ahmad Zargar, Ranjeet Kumar, Arvind Kumar, Ruby Gangwar, Amit Sharma","doi":"10.2174/012210299x256030231114114815","DOIUrl":"https://doi.org/10.2174/012210299x256030231114114815","url":null,"abstract":"\u0000\u0000The purpose of the study was to investigate the role of the endocannabinoid system and the therapeutic potential benefits of cannabinoids in\u0000Alzheimer’s disease. The most frequent form of dementia in older individuals is Alzheimer's disease (AD), a progressive neurological ailment that\u0000gradually deprives people of their memory, cognitive abilities, and, ultimately, their ability to perform daily tasks. Alzheimer's disease is\u0000distinguished by a progressive deterioration in cognitive function, which includes a decline in memory, learning capacity, and thinking power. The\u0000human body's endocannabinoid system functions as a channel for cell communication. It is a neurotransmission system that is present in various\u0000regions of the body and tissues as well as assists in the control of a number of metabolic processes. Endocannabinoids, enzymes, and cannabinoid\u0000receptors all play a role in managing a variety of biological functions. In this review, we aimed to summarize the endocannabinoid system, the\u0000effect of beta-amyloid, tau-protein accumulation and neuroinflammation, potential therapeutic benefits of cannabinoids, current pre-clinical and\u0000clinical evidence for the potential therapeutic benefits, limitations, and challenges, and potential future research in the field. Emerging scientific\u0000data suggests that the ECS (Endocannabinoid system) is linked to neurodegenerative illnesses and that altering its tone may be a useful\u0000therapeutic strategy for the treatment of AD (Alzheimer’s disease).\u0000","PeriodicalId":479738,"journal":{"name":"Current Indian Science","volume":"57 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139005944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nano Lipid Carriers: A Novel Approach for Nose to Brain Drug Delivery","authors":"Bhavishya Tyagi, Madhu Verma","doi":"10.2174/012210299x260333231120025251","DOIUrl":"https://doi.org/10.2174/012210299x260333231120025251","url":null,"abstract":"\u0000\u0000A nanostructured lipid carrier (NLC) is a nanoparticulate carrier system consisting of solid lipids, liquid lipids, surfactants, and water. NLCs are\u0000second-generation lipid nanocarriers, gained continuous significance in recent times, and possess better physical stability, increased drug loading,\u0000improved permeability, and bioavailability. They are considered superior to many other traditional lipid-based nanocarriers such as nanoemulsion,\u0000liposomes, and solid lipid nanoparticles (SLN) and have emerged as an alternative to first-generation nanoparticles (SLN). NLCs have significant\u0000potential in the pharmaceutical industry due to their extensive beneficial effects, like drug targeting, enhanced bioavailability, and their wide\u0000positive benefits.\u0000\u0000\u0000\u0000The primary aim of this review was to study and explore the Nano lipid carrier, its advantages, patent preferences, and advancement of NLCs use\u0000in nose-to-brain drug delivery\u0000\u0000\u0000\u0000The objective of this study was to conduct a literature review on the development of NLC for nose-to-brain drug delivery. The review focused on\u0000NLC, its significant role in nose-to-brain delivery, and relevant patents. To achieve this goal, different review articles searched, were studied, and\u0000summarized from various sources such as research articles, review articles, books, scientific reports, and patents.\u0000\u0000\u0000\u0000This review article discusses the potential benefits of NLCs in brain-targeting drug delivery through the intranasal route and key aspects of NLCs,\u0000including their structure composition, formulation technique, and characterization, which are crucial for developing a reliable drug delivery.\u0000","PeriodicalId":479738,"journal":{"name":"Current Indian Science","volume":"70 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139003142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digitalis Purpurea: Hope for Myocardial Infarction Induced By Obesity - A\u0000Review","authors":"Kusum Passi, Ranjeet Kumar, Dipasha Khurana, Naman Dhanda","doi":"10.2174/012210299x261528231116134608","DOIUrl":"https://doi.org/10.2174/012210299x261528231116134608","url":null,"abstract":"\u0000\u0000Digitalis purpurea L. belongs to the Scrophulariaceae family. The most significant is digitoxin, a very toxic substance that builds up in the body\u0000and is impenetrable in water. For millennia, people have utilized the medication Digitalis to treat cardiac problems induced by obesity. External\u0000triggers like strenuous exercise, emotional stress, eating, exposure to extreme weather, sexual activity, coffee and alcohol consumption, and use of\u0000cocaine or marijuana temporarily increase the risk of having a myocardial infarction. A person's genetic makeup influences disease progression, the\u0000presence of chronic risk factors, and lifestyle choices. Despite various educational programs, the fight against obesity does not appear to be\u0000successful. According to WHO (World Health Organisation) statistics, 13 percent of adults over the age of 18 are obese, and 39 percent are\u0000overweight. Being overweight or obese significantly raises the chance of developing disorders, including coronary heart disease. Digitalis is\u0000primarily used to treat heart conditions. It encourages and stimulates the action of all muscle tissues in cases of clogged heart failure. The herb\u0000improves heart nutrient absorption by forcing more blood into the coronaries. Digitalis aids in the repair and regulation of the heart's function when\u0000blood circulation is hampered.\u0000","PeriodicalId":479738,"journal":{"name":"Current Indian Science","volume":"6 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139004729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Some Versatile Medicinal Plants for Healing Wounds: A Review","authors":"Raj Kumari, Meenakshi Sharma, Abhilasha Mittal, Gauri Goel","doi":"10.2174/012210299x257271231124075042","DOIUrl":"https://doi.org/10.2174/012210299x257271231124075042","url":null,"abstract":"\u0000\u0000The cellular and biochemical stages of the wound-healing process are interrelated and work to repair the wound. The body heals wounds in stages,\u0000and each stage that is postponed raises the risk of microbial infection. The time needed for healing can be sped up, and unwanted events can be\u0000reduced to improve wound healing. To aid in the healing of the wounds, the medications are administered locally or systemically. In order to\u0000promote wound healing, antibiotics, antiseptics, desloughing agents, extracts, etc. have been employed. Due to their adverse effects, several\u0000synthetic medications are subject to restrictions. Investigation, identification, and formulation of plants or plant-derived combinations are required\u0000for the management and therapy of wound healing. Because they have fewer adverse effects and have been used to treat wounds for a longer\u0000period, medicinal plants are becoming more popular for use in wound healing. According to studies, medicinal herbs help diabetic, infected, and\u0000opened wounds heal more quickly. It has been claimed that medicinal herbs can speed up wound healing through a variety of processes. Many\u0000medicinal plants, including Allium sativum, Commiphora myrrha, Curcuma longa (L.), Rauwolfia serpentia, and Vateria indica, have\u0000demonstrated the ability to treat wounds.\u0000","PeriodicalId":479738,"journal":{"name":"Current Indian Science","volume":"81 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138586837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost-effectiveness of Dementia Medication","authors":"Nikita Khera, Rojin G Raj, Ranjeet Kumar, Megha Bajaj, Bintoo Sharma, Harsh Tyagi, Josmy Maria Job","doi":"10.2174/012210299x259911231128112915","DOIUrl":"https://doi.org/10.2174/012210299x259911231128112915","url":null,"abstract":"\u0000\u0000Aim:\u0000This review has examined and organized the available research on dementia medication care costs. Although the accessible database in this area is\u0000growing and is still quite limited, there are many clear scientific methods.\u0000Objective:\u0000The use of Memantine, a non-competitive antagonist with low to moderate affinity for the NMDA (N-methyl-D-aspartate) receptor, has been\u0000approved for the treatment of mild to moderately severe Alzheimer's disease (AD). The efficacy of cholinesterase inhibitors (ChEIs) in the\u0000treatment of dementia varies depending on the drug type and ease of administration. Numerous techniques have been employed to evaluate the\u0000quality of life (QOL) of individuals suffering from dementia. QOL data is a well-established measure of an intervention's effectiveness. Up to now,\u0000cost-effectiveness studies have concentrated on both pharmaceutical and non-pharmacological therapy. Each unit of QoL-AD improvement costs\u0000USD27.82578 at mean values.\u0000Methods:\u0000Searches were conducted to observe studies of the pharmacoeconomic impact of dementia medications with the help of previous articles published\u0000in journals and collected from Google Scholar with name search dementia or Alzheimer's cross-referenced with pharmacoeconomic or costs and\u0000effectiveness.\u0000","PeriodicalId":479738,"journal":{"name":"Current Indian Science","volume":"418 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139010938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MECHANISTIC INSIGHT OF INNOVATIVE BIOMARKERS FOR SCREENING OF TYPE II DIABETES MELLITUS","authors":"Shubhdeep Yadav, Neelam singh","doi":"10.2174/012210299x257270231127062630","DOIUrl":"https://doi.org/10.2174/012210299x257270231127062630","url":null,"abstract":"\u0000\u0000Diabetes mellitus is a complex, chronic disorder characterised by increased blood glucose levels caused by cellular resistance to insulin action, insufficient insulin production by pancreatic -cells, or both. Type 2 diabetes (T2DM), the most prevalent form of diabetes mellitus, accounts for almost 90% of all cases globally. T2DM is more common in middle-aged and older people, and its causes are multifaceted. The use of successful and cost-effective solutions for diabetes mellitus screening is critical to ensuring early identification and minimising patients' risk of acquiring life-threatening illness complications. Identifying novel biomarkers and test methods for diabetes mellitus is therefore critical in order establish robust, non-invasive, painless, highly sensitive, and precise screening procedures. This review focuses on the recent finding of new clinically validated and innovative biomarkers, as well as methods for determining them, which provide cost-effective options for T2DM screening and early detection.\u0000","PeriodicalId":479738,"journal":{"name":"Current Indian Science","volume":"387 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139010973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Regulatory Framework and Challenges for the Approval of Complex\u0000Generics in the US and the EU","authors":"Sharvari Patil, Sandeep Kumar, Dasari Mallikarjuna Rao, Kishore Rewatkar","doi":"10.2174/012210299x269535231203164108","DOIUrl":"https://doi.org/10.2174/012210299x269535231203164108","url":null,"abstract":"\u0000\u0000The pharmaceutical industry is witnessing a growing demand for complex generic products, which are generic versions of drugs that possess\u0000complex formulations, delivery systems, or active ingredients. However, the approval process for these complex generic products poses unique\u0000challenges compared to traditional generics. There is no specific regulatory procedure available for the approval of complex generics, unlike smallmolecule\u0000generics and biosimilars. This led to controversial arguments in the past about the scientific evidence needed for applications, which led\u0000to lengthy approval processes. The regulatory frameworks that are currently being used for complex generics are debatable and unclear.\u0000Complexity in the molecular structure, mechanism of action, route of delivery, and complex manufacturing process makes proving bioequivalence\u0000and pharmaceutical equivalence difficult. There is a need for harmonization of the regulatory framework by the agencies to help the generic\u0000manufacturers by providing scientific advice, defining the submission requirements for complex products, and fastening the approval process.\u0000This review begins by discussing the regulatory landscape surrounding complex generic products in various regions, including the United States\u0000and Europe. It examines the specific guidelines and requirements set forth by regulatory authorities to ensure the safety, efficacy, and quality of\u0000these products. Additionally, the review explores the differences in terminology and definitions used to classify complex generics across different\u0000jurisdictions. Furthermore, it delves into the challenges faced by both regulatory agencies and pharmaceutical companies in evaluating and\u0000approving complex generic products. These challenges include establishing appropriate bioequivalence criteria, determining interchangeability\u0000with the reference product, addressing patent and exclusivity issues, and ensuring consistent quality throughout the product lifecycle. The impact of\u0000these challenges on market entry and competition is also discussed. The review highlights the need for harmonization and streamlining of\u0000regulations for complex generic products worldwide. It emphasizes the importance of clear and consistent guidelines to enable timely approvals,\u0000foster innovation, and facilitate patient access to affordable alternatives.\u0000","PeriodicalId":479738,"journal":{"name":"Current Indian Science","volume":"232 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139011036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comprehensive Review of Abroma Augusta (Devil's Cotton): Phytochemical\u0000Constituents, Ethnomedicinal Applications, and Pharmacological Properties","authors":"A. Balkrishna, Shailja Mishra, Ashish Dhyani, Priyanka Saini, V. Arya, Nidhi Sharma","doi":"10.2174/012210299x265912231130060959","DOIUrl":"https://doi.org/10.2174/012210299x265912231130060959","url":null,"abstract":"\u0000\u0000The nutritional and therapeutic potential of medicinal plants is constantly being investigated. This is especially relevant in today's world, where an\u0000increasing number of people are turning to complementary and alternative therapies to address their health-related concerns. Traditional\u0000knowledge, as a valuable resource, plays a crucial role in the development of new herbal medicines. Abroma augusta stands out as one such\u0000medicinal plant that has a rich history of use in traditional medicine. It has been employed to address a wide spectrum of health issues, including\u0000diabetes, menstrual irregularities, respiratory problems, musculoskeletal disorders, urinary ailments, and sexual dysfunctions, among others. While\u0000various parts of this plant species are believed to possess pharmacological properties, the active compounds and underlying mechanisms remain\u0000largely unexplored. To facilitate the development of innovative drugs for the benefit of individuals, this study places significant emphasis on\u0000delving into the phytochemical and ethnomedicinal attributes of A. augusta. Moreover, it seeks to bolster its findings with scientifically validated\u0000pharmacological investigations conducted through both in vivo and in vitro methodologies.\u0000","PeriodicalId":479738,"journal":{"name":"Current Indian Science","volume":"104 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139011124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review on Psoriasis Pathophysiology, Clinical Appearance, and\u0000Pharmacotherapeutic Interventions","authors":"Deepak Kumar, Sagarika Majhi, Meenakshi Sharma","doi":"10.2174/012210299x256032231127060853","DOIUrl":"https://doi.org/10.2174/012210299x256032231127060853","url":null,"abstract":"\u0000\u0000A chronic skin condition called psoriasis can manifest as plaque, flexural, guttate, pustular, and erythrodermic lesions, among other clinical\u0000symptoms. Sixty million people are believed to be affected by psoriasis worldwide. In India, the frequency ranges from 0.44 to 2.8%, with males\u0000affected two times more frequently than females in their third or fourth decade of life. An immune-mediated inflammation condition with a sizable\u0000genetic component is psoriasis. Due to its connection to psoriatic arthritis and the increased prevalence of cardiometabolic, hepatic, and psychiatric\u0000problems, a thorough and interdisciplinary strategy for treatment is required. Corticosteroids and analogs of vitamin D are examples of topical\u0000treatments for psoriasis. Phototherapy includes NB-UVB, psoralen, and ultraviolet radiation (PUVA). Standard systemic treatments include\u0000methotrexate, acitretin, and ciclosporin. This disease is useful for physicians and scientists since it might be used as a model for research into the\u0000underlying causes of chronic inflammation. It is also crucial for clinical trial scientists as a first-choice disease indication for preliminary research\u0000of new pathogenesis-based treatment approaches. This review covers both the therapeutic choices that have resulted from the analysis of the\u0000aggressive psoriatic pathways and the processes involved in the onset and progression of the disease. We start by writing regarding the important\u0000cell kinds and inflammatory mechanisms that initiate and maintain psoriatic inflammation. Next, we discuss how skin flora interacts with heredity,\u0000related epigenetic processes, and the pathogenesis of psoriasis. Finally, we provide a thorough analysis of recently targeted medications as well as\u0000well-known, extensively used treatments.\u0000","PeriodicalId":479738,"journal":{"name":"Current Indian Science","volume":"176 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139010686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}