World Journal of Orthopedics最新文献

{"title":"Correlation between Kellgren-Lawrence classification of osteoarthritis and Knee Injury and Osteoarthritis Outcome Score.","authors":"Ali Saad Alshahrani, Abdullah Bader Aljaffar, Baqir Jafar Albin Ahmed, Mohammad Waleed Altabash, Zaid A Dajani, Ali Hussein Alamer, Abdulaziz Jamal Alzawad, Fawaz Alanii, Mohammad M Alzahrani","doi":"10.5312/wjo.v16.i11.111953","DOIUrl":"10.5312/wjo.v16.i11.111953","url":null,"abstract":"<p><strong>Background: </strong>Osteoarthritis (OA) is a common degenerative joint disease that considerably affects the quality of life (QoL) of individuals, especially the elderly. The Kellgren-Lawrence (KL) grading system assesses the severity of OA through radiographic evaluation, whereas the Knee Injury and Osteoarthritis Outcome Score (KOOS) measures clinical symptoms and functional status.</p><p><strong>Aim: </strong>To analyze the relationship between KL grades and KOOS to elucidate the association between radiographic severity and clinical manifestations of knee OA.</p><p><strong>Methods: </strong>A cross-sectional study was performed at King Fahd Hospital of the University, involving 164 adult patients diagnosed with knee OA. Patients were evaluated using the KL system, based on standing knee X-rays performed within the last six months. The KOOS questionnaire was utilised for clinical assessment, evaluating five domains: (1) Pain; (2) Symptoms; (3) Activities of daily living; (4) Sport and recreation function; and (5) Knee-related QoL. Analysis of variance was utilised to examine variations in KOOS domain scores among different patient variables. The correlations between KOOS domains were determined using Pearson's correlation.</p><p><strong>Results: </strong>KOOS scores demonstrated a significant decline in patients with elevated KL grades, with Grade 4 exhibiting the lowest scores and grade 1 the highest (<i>P</i> < 0.001). The correlation between pain and activities of daily living was strong (<i>r</i> = 0.871, <i>P</i> < 0.001), as was the correlation with knee-related QoL (<i>r</i> = 0.754, <i>P</i> < 0.001). Notable age-related disparities were observed, as older patients (≥ 60 years) indicated poorer pain and functional outcomes. Gender differences were noted exclusively in symptoms, with females exhibiting lower scores than males (<i>P</i> = 0.022).</p><p><strong>Conclusion: </strong>The association between radiographic severity and clinical impact is shown by the substantial correlation between KL grading and KOOS results, especially in later stages of OA. The results highlight the necessity for thorough assessments that integrate radiographic and clinical evaluations for individualized therapy choices for OA patients.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"16 11","pages":"111953"},"PeriodicalIF":2.3,"publicationDate":"2025-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12679146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145702589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional Chinese bone-setting combined with percutaneous screw fixation for comminuted calcaneal fractures: A case report and review of literature.","authors":"Hui-Chun Huang, Yong-Feng Che, He Sun, Yi-Sheng Xu, Hua-Yin Gao, Xiu-Shu Tang","doi":"10.5312/wjo.v16.i11.111052","DOIUrl":"10.5312/wjo.v16.i11.111052","url":null,"abstract":"<p><strong>Background: </strong>Comminuted calcaneal fractures present significant treatment challenges. Open reduction and internal fixation carries risks such as infection and skin necrosis, while minimally invasive techniques may compromise reduction stability. Conservative management is generally limited to minimally displaced fractures. Traditional Chinese manual bone-setting has a long history in fracture treatment and is renowned globally for achieving functional reduction. It offers distinct advantages including lower cost, minimal soft tissue trauma, and the avoidance of expensive reduction equipment or internal fixation materials.</p><p><strong>Case summary: </strong>A 60-year-old female presented with left foot pain and limited mobility following a fall. Computed tomography scan revealed a Sanders type IV calcaneal fracture with a Böhler angle of 0°. A standardized, stepwise Traditional Chinese manual bone-setting was initially performed, followed by percutaneous screw fixation through several mini-incisions after satisfactory alignment was confirmed under fluoroscopy. The Visual Analog Scale score decreased from 5 on postoperative day 1 to 3 by day 3. The American Orthopaedic Foot and Ankle Society score improved from 73 at 6 weeks to 90 at 3 months, indicating rapid functional recovery and high patient satisfaction. At 7 months postoperatively, the American Orthopaedic Foot and Ankle Society score reached 95, prompting removal of internal fixation. At the 6-year follow-up, reduction remained well maintained, with the Böhler angle preserved at 22°.</p><p><strong>Conclusion: </strong>The combination of Traditional Chinese manual bone-setting and percutaneous screw fixation achieved satisfactory functional reduction for comminuted calcaneal fractures.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"16 11","pages":"111052"},"PeriodicalIF":2.3,"publicationDate":"2025-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12679086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145702655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alginate-based biomaterials in orthopedics: What are the prospects for bacterial alginate?","authors":"Andrei A Dudun, Garina A Bonartseva, Anton P Bonartsev","doi":"10.5312/wjo.v16.i10.110562","DOIUrl":"10.5312/wjo.v16.i10.110562","url":null,"abstract":"<p><p>The mini-review explores the potential use of alginates produced biotechnologically by bacteria for the development of various implantable biomaterials intended for bone and cartilage tissue regeneration in orthopedics: the recent studies on the use of algal alginate-based biomaterials in the form of hydrogels, scaffolds, and microparticles for medical applications are considered as a potential opportunity to use bacterial alginate for these applications, taking into account the advantages of biotechnological production of a polymer with desired properties. The methods of producing different alginate-based biomaterials, the manufacturing of implantable medical devices using them, and the surgical techniques for bone and cartilage tissue regeneration using these materials for orthopedic purposes are discussed.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"16 10","pages":"110562"},"PeriodicalIF":2.3,"publicationDate":"2025-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12576728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145432547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early diagnosis and targeted intervention based on the pathogenesis of rapidly progressive osteoarthritis of the hip.","authors":"Tadashi Yasuda","doi":"10.5312/wjo.v16.i10.108992","DOIUrl":"10.5312/wjo.v16.i10.108992","url":null,"abstract":"<p><p>Early diagnosis of rapidly progressive osteoarthritis of the hip (RPOH) remains clinically challenging due to the lack of unified guidelines and standardized diagnostic criteria. Current diagnostic criteria (chondrolysis > 2 mm/year) require follow-up for at least 12 months. This review characterizes two types of early-stage RPOH progression: Chondrolysis with or without subsequent femoral head destruction within 12 months of onset. Based on their association with early disease progression in RPOH, elevated serum matrix metalloproteinase-3 levels and spinopelvic malalignment may serve as predictive factors for subsequent bone destruction when only joint space narrowing is observed. This review also proposes potential mechanisms of pathogenesis and intervention strategies for RPOH at its initial stage. Cartilage matrix fragments generated by stress concentrations on the hip joint, resulting from spinopelvic malalignment, may trigger inflammatory pathways involving proinflammatory cytokines and inflammasome activation, ultimately leading to joint destruction in the initial phase of RPOH. Suppression of these early pathological events may prevent joint destruction caused by RPOH. However, further elucidation of the cellular and molecular pathways involved in rapid joint destruction is necessary to identify specific biomarkers for early diagnosis and to facilitate the development of targeted therapies in the initial phase of RPOH.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"16 10","pages":"108992"},"PeriodicalIF":2.3,"publicationDate":"2025-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12576752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145432678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of surgical skin preparation solutions in orthopaedic surgery: A systematic review of the current comparative literature.","authors":"Troy B Puga, McKenna W Box, Tanner Haechten, Ibraheem Qureshi, John T Riehl","doi":"10.5312/wjo.v16.i10.110741","DOIUrl":"10.5312/wjo.v16.i10.110741","url":null,"abstract":"<p><strong>Background: </strong>Surgical site infection (SSI) is a major concern in orthopaedic surgery procedures as they can have devastating consequences for patients and their outcomes. Many infection prevention measures are routinely taken in order to prevent infection during surgery, the main one being surgical skin preparation prior to any incision.</p><p><strong>Aim: </strong>To investigate the efficacy of different perioperative surgical skin preparation products commonly used in orthopaedic surgery.</p><p><strong>Methods: </strong>Seven databases were searched from inception to January 25, 2025, using a combination of keywords and medical subject headings terms, specifically for studies comparing any two surgical skin preparation products used at any point prior to skin incision for orthopaedic procedures. Titles and abstracts were screened and full texts reviewed based on inclusion criteria. Data was extracted on study design, interventions, and outcomes from studies that met inclusion criteria. Meta-analysis was not completed due to heterogeneity.</p><p><strong>Results: </strong>Thirty-two studies met the inclusion criteria in this systematic review. In extremity fracture surgery, evidence was mixed on whether iodine or chlorhexidine-based solutions are more effective at preventing SSI. No significant difference was found between iodine and chlorhexidine-based solutions in total joint arthroplasty, spine surgery, foot and ankle surgery, or upper extremity surgery. No tested preparation method was superior in reducing positive <i>Cutibacterium acnes</i> culture rates in upper extremity (shoulder) surgery. Adding adjuncts to iodine and chlorhexidine methods, such as isopropyl alcohol, hydrogen peroxide, or benzoyl peroxide showed no significant changes to SSI or bacterial cultures.</p><p><strong>Conclusion: </strong>Current literature shows no significant difference between chlorhexidine-based and iodine-based skin preparation solutions in orthopaedic extremity or spine surgery regarding SSI prevention or culture results. Likewise, adding other antiseptic agents provided no clear benefit. While skin antisepsis is important, many different factors contribute to SSI risk outside of the skin preparation solution.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"16 10","pages":"110741"},"PeriodicalIF":2.3,"publicationDate":"2025-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12576735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145432692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Open reduction can be a reasonable, safe and effective choice in complex paediatric supracondylar humeral fractures operative treatment.","authors":"Efstratios D Athanaselis, Nikolaos Metaxiotis, Nikolaos Rigopoulos, Michael Hantes, Zoe H Dailiana, Theofilos Karachalios, Sokratis Varitimidis","doi":"10.5312/wjo.v16.i10.110461","DOIUrl":"10.5312/wjo.v16.i10.110461","url":null,"abstract":"<p><strong>Background: </strong>Supracondylar humeral fractures are among the most common paediatric injuries. Displacement and consequent need for reduction impose operative treatment. Restoration of the anatomy of the distal part of the humerus prevents deformities and functional disorders of the elbow and upper limb. Stable K-wire fixation can be succeeded either by closed or open reduction method.</p><p><strong>Aim: </strong>To investigate the safety and efficacy of open reduction method in the operative treatment of Gartland type III and IV supracondylar humeral fractures in children.</p><p><strong>Methods: </strong>We retrospectively studied 131 cases of paediatric supracondylar humerus fractures of Gartland type III-IV treated operatively by open reduction and pinning between 2001 and 2023 in our department. All patients underwent clinical and radiological examination recording elbow range of motion, function and deformity.</p><p><strong>Results: </strong>The standard lateral approach was carried out in all patients while in 47 cases (35.9%) additional medial approach was used. Average follow-up time was 5.4 years (1-14 years). Fracture healing was completed at 4-6 weeks. The average operative time was 50 min (range: 37-75 minutes, SD: 11.307) and the average duration of radiation exposure based on image intensifier usage time was 20 seconds (range: 7-45 seconds, SD: 9.864). No infections or iatrogenic neurovascular complications were recorded and the functional outcome regarding range of motion, Patient-Reported Outcome Measures (Disabilities of the Arm, Shoulder, and Hand questionnaire, Mayo Elbow Performance Scores) at 2-year follow-up was satisfying.</p><p><strong>Conclusion: </strong>Open reduction and K-wire fixation provide very satisfactory outcome in supracondylar fractures of the humerus in children with reduced radiation burden. Moreover, the risk of neurovascular injuries due to manipulations of closed reduction, is minimized while complications related to surgical approaches are insignificant provided there is expertise.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"16 10","pages":"110461"},"PeriodicalIF":2.3,"publicationDate":"2025-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12576745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145432821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanotechnology for pain management in orthopedic surgery.","authors":"Emerito Carlos Rodriguez-Merchan, Javier De Andres-Ares, Alberto D Delgado-Martinez, William J Ribbans","doi":"10.5312/wjo.v16.i10.110009","DOIUrl":"10.5312/wjo.v16.i10.110009","url":null,"abstract":"<p><p>This narrative review evaluated the potential of nanotechnology platforms (DepoFoam bupivacaine^®, DepoDur^®, Exparel^®, Zynrelef^®, NeuroCuple^™) in the control of postoperative pain following orthopedic procedures. In individuals experiencing bunionectomy DepoFoam bupivacaine^® 120 mg and placebo <i>via</i> wound infiltration before wound closure was compared. The area under the curve for numeric rating scale scores was substantially less in individuals treated with DepoFoam bupivacaine^® <i>vs</i> individuals receiving placebo at 24 h and 36 h. In individuals undergoing total hip arthroplasty, a single dose of 15 mg, 20 mg, or 25 mg DepoDur^® [extended-release epidural morphine (EREM)] and placebo were compared. All EREM dosages diminished the mean fentanyl usage <i>vs</i> placebo and delayed the median time to first dose of fentanyl. All EREM cohorts had substantially improved pain control at rest for up to 48 h post-surgery compared with placebo. No supplementary analgesia was required in 25% of individuals treated with EREM and 2% of individuals treated with placebo at 48 h. In individuals undergoing total knee arthroplasty, iPACK (local anesthetic infiltration of the interspace between the popliteal artery and the posterior knee capsule) adductor canal block was compared to adductor canal block with Exparel^®. Individuals in the Exparel^® cohort experienced an improvement in numeric rating scale pain scores at all postsurgical time points. These individuals also utilized a lower dose of inpatient opioids. In individuals undergoing bunionectomy a single intraoperative dose of Zynrelef^® prolonged release (PR) was compared to bupivacaine HCl 0.5% <i>via</i> wound infiltration before wound closure. Zynrelef^® PR diminished pain intensity by 18% compared with bupivacaine HCl. Opioid consumption was reduced by 37% in the Zynrelef^® PR cohort <i>vs</i> 25% in the bupivacaine HCl cohort. In individuals experiencing total knee arthroplasty and total hip arthroplasty, the use of a nanotechnology-based NeuroCuple^TM device diminished postoperative pain at rest by 34% and reduced pain with movement by 18%.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"16 10","pages":"110009"},"PeriodicalIF":2.3,"publicationDate":"2025-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12576718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145432840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of introducing custom-made articulating spacers: A retrospective cohort study on two protocols for two-stage hip revision.","authors":"Marijn H Stelwagen, Jakob Van Oldenrijk, Peter D Croughs, Erlangga Yusuf, P Koen Bos, Ewout S Veltman","doi":"10.5312/wjo.v16.i10.111955","DOIUrl":"10.5312/wjo.v16.i10.111955","url":null,"abstract":"<p><strong>Background: </strong>Two-stage revision is the most common treatment for chronic periprosthetic joint infection of the hip, involving a resection arthroplasty with or without placement of an antibiotic-loaded spacer, followed by antibiotic therapy before reimplantation.</p><p><strong>Aim: </strong>To compare the outcomes and complications of two consecutive treatment protocols for two-stage revision arthroplasty of the infected hip: One using Girdlestone with an antibiotic holiday, the other using custom-made articulating spacers (CUMARS) without an antibiotic holiday.</p><p><strong>Methods: </strong>In this retrospective study, two consecutive cohorts were compared. Group A (2017-2020) underwent two-stage revision with a Girdlestone and an antibiotic holiday before reimplantation, while Group B (2020-2023) received CUMARS whenever possible, and no antibiotic holiday, or a Girdlestone if indicated. The primary outcome was successful infection eradication after one year. Secondary outcomes included surgical duration, length of hospital stay, weight-bearing allowance, discharge destination, and complications.</p><p><strong>Results: </strong>A total of 98 patients were included: 39 patients in Group A and 59 patients in Group B. Successful infection eradication after one year was achieved in 69% of Group A and 83% of Group B (<i>P</i> = 0.164). Patients in Group B were more frequently allowed to bear weight (64% <i>vs</i> 18%, <i>P</i> < 0.001), had a shorter in-hospital stay (9 <i>vs</i> 16 days, <i>P</i> < 0.001), and were more often discharged home after the first surgery (48% <i>vs</i> 24%, <i>P</i> = 0.048). No significant differences were found in (mechanical) complications.</p><p><strong>Conclusion: </strong>A protocol including CUMARS is a safe and effective treatment, offering faster recovery, shorter length of hospital stay, and enabling more patients to return home during the interval. This reduces strain on patients and the healthcare system, potentially saving costs, without compromising infection control or increasing (mechanical) complications.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"16 10","pages":"111955"},"PeriodicalIF":2.3,"publicationDate":"2025-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12576732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145432614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dutch translation and cross-cultural adaptation of the LIMB-Q Kids questionnaire.","authors":"Lea M Kessling, Veronique M Voorn, Johannes Hjm Bessems, Anthony P Cooper, Harpreet Chhina, Jaap J Tolk","doi":"10.5312/wjo.v16.i10.109822","DOIUrl":"10.5312/wjo.v16.i10.109822","url":null,"abstract":"<p><strong>Background: </strong>We aimed to translate and culturally adapt the LIMB-Q Kids questionnaire for use in the Netherlands. The LIMB-Q Kids is a patient-reported outcome measure designed to assess functional, psychosocial, and aesthetic aspects of living with a limb difference in paediatric populations.</p><p><strong>Aim: </strong>To investigate the feasibility of a questionnaire in the Netherlands, which was translated into Dutch after having already been successfully translated and validated in several other languages.</p><p><strong>Methods: </strong>The translation and adaptation process followed best practice guidelines, including forward and backward translation, expert panel review, and cognitive debriefing interviews with patients. The interviews focused on the clarity and comprehensibility of the instructions, response options, and questionnaire items.</p><p><strong>Results: </strong>The rigorous process resulted in a linguistically and conceptually equivalent Dutch version of the LIMB-Q Kids questionnaire. While some challenges were encountered, no major difficulties were reported. The constructs and cultural relevance were found to be relatable to the Dutch context. Minor adjustments were made based on patient feedback, such as clarifying questions and modifying translations for technical terms.</p><p><strong>Conclusion: </strong>We demonstrated the successful translation and cultural adaptation of the LIMB-Q Kids questionnaire for use in the Netherlands. By following best practices, the researchers have developed a version that is conceptually and linguistically equivalent to the original English version. The availability of this Dutch version will facilitate the assessment of outcomes in paediatric populations with limb differences, and potentially enable cross-cultural comparisons.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"16 10","pages":"109822"},"PeriodicalIF":2.3,"publicationDate":"2025-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12576746/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145432622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metagenomic analysis of gut microbiome and spondyloarthropathy: A systematic review.","authors":"Madhan Jeyaraman, Easwar Balasubramanian, Naveen Jeyaraman, Arulkumar Nallakumarasamy, Sathish Muthu","doi":"10.5312/wjo.v16.i10.108374","DOIUrl":"10.5312/wjo.v16.i10.108374","url":null,"abstract":"<p><strong>Background: </strong>Spondyloarthritis (SpA), a prevalent chronic inflammatory disorder, predominantly impacts the axial skeleton, including the spine and sacroiliac joints. Emerging evidence implicates gut dysbiosis in the pathogenesis of SpA.</p><p><strong>Aim: </strong>To evaluate the association between gut microbiome alterations and SpA through metagenomic sequencing analyses.</p><p><strong>Methods: </strong>A systematic review was conducted by querying English-language databases, including PubMed, EMBASE, and Google Scholar, spanning 2000 to 2023. From an initial pool of 150 studies, four articles meeting stringent inclusion and exclusion criteria were selected for analysis.</p><p><strong>Results: </strong>The reviewed studies identified an enrichment of opportunistic pathogenic bacterial species, such as <i>Clostridium spp.</i>, <i>Prevotella spp.</i>, and <i>Bacteroides spp.</i>, alongside viral families including <i>Gratiaviridae</i> and <i>Quimbyviridae</i>, in individuals with ankylosing spondylitis compared to healthy controls. Dysregulated metabolic pathways were highlighted as potential mediators of chronic inflammation and arthritic manifestations. Notably, treatment with tumor necrosis factor inhibitors demonstrated efficacy in mitigating SpA symptoms and restoring gut microbial balance.</p><p><strong>Conclusion: </strong>The findings underscore a significant presence of pathogenic gut microbiota in SpA patients, suggesting a pivotal role in disease progression. Future investigations should focus on species-specific microbial targets to develop innovative therapies for preventing and managing SpA and associated gut dysbiosis.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"16 10","pages":"108374"},"PeriodicalIF":2.3,"publicationDate":"2025-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12576755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145432743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}