International Journal of Clinical and Health Psychology最新文献

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Using network analysis to model associations between psychological symptoms, sexual function, and sexual distress in women 利用网络分析建立女性心理症状、性功能和性困扰之间的关联模型
IF 5.3 1区 心理学
International Journal of Clinical and Health Psychology Pub Date : 2024-07-01 DOI: 10.1016/j.ijchp.2024.100479
Marta T. Kolbuszewska , Inês M. Tavares , Pedro J. Nobre , Samantha J. Dawson
{"title":"Using network analysis to model associations between psychological symptoms, sexual function, and sexual distress in women","authors":"Marta T. Kolbuszewska ,&nbsp;Inês M. Tavares ,&nbsp;Pedro J. Nobre ,&nbsp;Samantha J. Dawson","doi":"10.1016/j.ijchp.2024.100479","DOIUrl":"https://doi.org/10.1016/j.ijchp.2024.100479","url":null,"abstract":"<div><h3>Background</h3><p>Psychological difficulties, including depression, anxiety, and somatization, are among the most important predictors for women's sexual function (i.e., arousal, desire, lubrication, pain, and satisfaction) and sexual distress. These associations have largely been studied at the construct level, with little research examining which specific symptoms might be most important for maintaining links between psychological difficulties and domains of sexual function. The present research sought to establish and characterize networks of women's psychological symptoms, sexual function, and sexual distress, and identify potential bridge symptoms that connect them.</p></div><div><h3>Methods</h3><p>In a cross–sectional study, 725 women reported on their sexual function, sexual distress, and depressive, anxiety, and somatization symptoms. A series of network analyses was used to identify central symptoms and connections between psychological symptoms, sexual function domains, and sexual distress.</p></div><div><h3>Results</h3><p>Across the modeled networks, sexual distress and pain during sex were consistent bridges between other sexual function domains and psychological symptoms.</p></div><div><h3>Discussion</h3><p>Overall, our models revealed sexual distress as an important potential mediator between sexual function problems and psychological symptoms that might contribute to the development and maintenance of comorbid sexual function and psychological problems.</p></div>","PeriodicalId":47673,"journal":{"name":"International Journal of Clinical and Health Psychology","volume":"24 3","pages":"Article 100479"},"PeriodicalIF":5.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1697260024000449/pdfft?md5=cd44d2e6aa66446362ea6e6adf0c15ab&pid=1-s2.0-S1697260024000449-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141482837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding sexual distress related to sexual function (SDRSF): A preliminary framework based on a qualitative study with clinical sexologists 了解与性功能相关的性困扰(SDRSF):基于临床性学家定性研究的初步框架
IF 5.3 1区 心理学
International Journal of Clinical and Health Psychology Pub Date : 2024-07-01 DOI: 10.1016/j.ijchp.2024.100473
Catarina F. Raposo , Pedro J. Nobre , Andreia A. Manão , Patrícia M. Pascoal
{"title":"Understanding sexual distress related to sexual function (SDRSF): A preliminary framework based on a qualitative study with clinical sexologists","authors":"Catarina F. Raposo ,&nbsp;Pedro J. Nobre ,&nbsp;Andreia A. Manão ,&nbsp;Patrícia M. Pascoal","doi":"10.1016/j.ijchp.2024.100473","DOIUrl":"https://doi.org/10.1016/j.ijchp.2024.100473","url":null,"abstract":"<div><h3>Introduction</h3><p>Sexual distress related to sexual function (SDRSF) is pivotal in diagnosing sexual dysfunction. However, there is a lack of theoretical models for its comprehension and of knowledge concerning how to address it in clinical practice.</p></div><div><h3>Aim</h3><p>To contribute to theory building and clinical practice about SDRSF by collecting clinicians' accounts, aiming to inform a preliminary framework to study and intervene in SDRSF.</p></div><div><h3>Method</h3><p>Reflexive thematic analysis was used to analyze the data from 16 semi-structured interviews with clinical sexologists. <em>Results:</em> Three main themes were created: (1) Burning from the inside, (2) Wicked games, and (3) Running up that hill. Participants revealed a multidimensional understanding of SDRSF in clinical settings that integrates individual, sociocultural, interpersonal and situational factors. This underscores the interconnected nature of SDRSF, revealing its links to different facets of overall distress in clinical settings. We present a preliminary framework that may be analytically generalized to enhance the comprehension of the specificities of SDRSF.</p></div><div><h3>Conclusion</h3><p>These insights frame a comprehensive conceptualization of SDRSF in clinical settings that goes beyond sexual activity and implies that interpersonal and societal factors need to be considered in research and intervention in this field.</p></div>","PeriodicalId":47673,"journal":{"name":"International Journal of Clinical and Health Psychology","volume":"24 3","pages":"Article 100473"},"PeriodicalIF":5.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1697260024000383/pdfft?md5=8e28061974e83103bf5589ca4b843c4b&pid=1-s2.0-S1697260024000383-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141482838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is religion beneficial for mental health? A 9-year longitudinal study 宗教有益于心理健康吗?一项为期 9 年的纵向研究
IF 5.3 1区 心理学
International Journal of Clinical and Health Psychology Pub Date : 2024-07-01 DOI: 10.1016/j.ijchp.2024.100491
Gabriele Prati
{"title":"Is religion beneficial for mental health? A 9-year longitudinal study","authors":"Gabriele Prati","doi":"10.1016/j.ijchp.2024.100491","DOIUrl":"10.1016/j.ijchp.2024.100491","url":null,"abstract":"<div><h3>Background/Objective</h3><p>This study aimed to investigate the within-person and between-person effects of religious variables on mental health and vice versa.</p></div><div><h3>Method</h3><p>Using a large sample of adults residing in Germany from the GESIS Panel study (<em>N</em> = 8146), the random intercept cross-lagged panel model was used. Data on six dimensions of religion (i.e., membership in a religious community; attendance at a place of worship; frequency of prayers; importance of religion in life; and participation in a religious organization) and three indicators of mental health (i.e., depression symptoms, happiness, and life satisfaction) were collected.</p></div><div><h3>Results</h3><p>The findings revealed that there is almost no evidence of lagged effects of religion on mental health and limited evidence regarding the role of mental health in influencing the dimensions of religion. Moreover, at the between-person level, there was some evidence of significant covariance between the trait-like components, indicating stable, trait-like differences between persons on religion and mental health.</p></div><div><h3>Conclusions</h3><p>The beneficial effect of religion on mental health may have been exaggerated in previous research.</p></div>","PeriodicalId":47673,"journal":{"name":"International Journal of Clinical and Health Psychology","volume":"24 3","pages":"Article 100491"},"PeriodicalIF":5.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1697260024000565/pdfft?md5=dbd9e03e9a949ca69b7084beb2b41ae7&pid=1-s2.0-S1697260024000565-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141941171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reduction mammoplasty, self-esteem, and sexual desire: A pre-post intervention study 乳房缩小整形术、自尊和性欲:干预前-干预后研究
IF 5.3 1区 心理学
International Journal of Clinical and Health Psychology Pub Date : 2024-06-21 DOI: 10.1016/j.ijchp.2024.100477
Ana Isabel Berenguel-Pérez , Alda Elena Cortés-Rodríguez
{"title":"Reduction mammoplasty, self-esteem, and sexual desire: A pre-post intervention study","authors":"Ana Isabel Berenguel-Pérez ,&nbsp;Alda Elena Cortés-Rodríguez","doi":"10.1016/j.ijchp.2024.100477","DOIUrl":"https://doi.org/10.1016/j.ijchp.2024.100477","url":null,"abstract":"<div><h3>Background/objective</h3><p>Sexuality plays a significant role in social relationships and overall development. For women, the breasts hold considerable importance in sexual expression. Deviation from societal norms regarding breast size can lead to mental and sexual health issues. This study aimed to examine the impact of breast reduction surgery on self-esteem, body image, and sexual desire in women undergoing the procedure.</p></div><div><h3>Methods</h3><p>A descriptive correlational study was conducted, involving 50 women who underwent reduction mammoplasty.</p></div><div><h3>Results</h3><p>Regarding pre- and post-surgical measurements, breast reduction surgery was associated with improvements in body image perception, as indicated by the BREASTQ reduction module, and both dyadic and solitary sexual desire. However, self-esteem remained unaffected by the intervention. Correlational analysis demonstrated a positive relationship between psychosocial well-being and other dimensions of body image, as well as sexual desire. Sexual well-being also correlated with breast and nipple satisfaction, along with dyadic sexual desire. Notably, age and self-esteem did not exhibit significant correlations with the variables studied.</p></div><div><h3>Conclusion</h3><p>These findings suggest that breast reduction surgery can improve body image and sexual desire in women, but further research is needed to explore the long-term effects and the specific factors that contribute to these outcomes.</p></div>","PeriodicalId":47673,"journal":{"name":"International Journal of Clinical and Health Psychology","volume":"24 3","pages":"Article 100477"},"PeriodicalIF":5.3,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1697260024000425/pdfft?md5=4fb99bce32f9c23ba61c6164c29aeb3c&pid=1-s2.0-S1697260024000425-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141438855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The experimental study of consciousness: Is psychology travelling back to the future? 意识的实验研究:心理学正在回到未来吗?
IF 5.3 1区 心理学
International Journal of Clinical and Health Psychology Pub Date : 2024-06-21 DOI: 10.1016/j.ijchp.2024.100475
Óscar F. Gonçalves , Joana Sayal, Fábio Lisboa, Pedro Palhares
{"title":"The experimental study of consciousness: Is psychology travelling back to the future?","authors":"Óscar F. Gonçalves ,&nbsp;Joana Sayal,&nbsp;Fábio Lisboa,&nbsp;Pedro Palhares","doi":"10.1016/j.ijchp.2024.100475","DOIUrl":"https://doi.org/10.1016/j.ijchp.2024.100475","url":null,"abstract":"<div><p>It was with the promise of rendering an experimental approach to consciousness that psychology started its trajectory as an independent science more than 150 years ago. Here, we will posit that the neurosciences were instrumental in leading psychology to resume the study of consciousness by projecting an empirical agenda for the future. First, we will start by showing how scientists were able to venture into the consciousness of supposedly unconscious patients, opening the door for the identification of important neural correlates of distinct consciousness states. Then, we will describe how different technological advances and elegant experimental paradigms helped in establishing important neuronal correlates of global consciousness (i.e., being conscious at all), perceptual consciousness (i.e., being conscious of something), and self-consciousness (i.e., being conscious of itself). Finally, we will illustrate how the study of complex consciousness experiences may contribute to the clarification of the mechanisms associated with global consciousness, the relationship between perceptual and self-consciousness, and the interface among distinct self-consciousness domains. In closing, we will elaborate on the road ahead of us for re-establishing psychology as a science of consciousness.</p></div>","PeriodicalId":47673,"journal":{"name":"International Journal of Clinical and Health Psychology","volume":"24 3","pages":"Article 100475"},"PeriodicalIF":5.3,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1697260024000401/pdfft?md5=f84e66355034ee668a1d60a4ef4491c8&pid=1-s2.0-S1697260024000401-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141438854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phenomenological memory characteristics and impact of near-death experience in critically ill survivors: Observations at discharge and after a 1-year follow-up 危重病幸存者濒死体验的现象记忆特征及其影响:出院时和一年随访后的观察结果
IF 8.8 1区 心理学
International Journal of Clinical and Health Psychology Pub Date : 2024-06-18 DOI: 10.1016/j.ijchp.2024.100478
Charlotte Martial , Pauline Fritz , Helena Cassol , Olivia Gosseries , Bernard Lambermont , Benoit Misset , Anne-Françoise Rousseau
{"title":"Phenomenological memory characteristics and impact of near-death experience in critically ill survivors: Observations at discharge and after a 1-year follow-up","authors":"Charlotte Martial ,&nbsp;Pauline Fritz ,&nbsp;Helena Cassol ,&nbsp;Olivia Gosseries ,&nbsp;Bernard Lambermont ,&nbsp;Benoit Misset ,&nbsp;Anne-Françoise Rousseau","doi":"10.1016/j.ijchp.2024.100478","DOIUrl":"https://doi.org/10.1016/j.ijchp.2024.100478","url":null,"abstract":"<div><h3>Background</h3><p>It is not rare that intensive care unit (ICU) patients report unusual subjective experiences, ranging from a feeling of harmony with the environment to complex phenomena such as near-death experience (NDE). This 1-year follow-up study investigates the characteristics and potential global impact of the NDE memories recalled by ICU survivors.</p></div><div><h3>Method</h3><p>We prospectively enrolled 126 adult survivors of a prolonged (&gt;7days) ICU stay (all etiologies), including 19 (15 %) who reported a NDE as identified by the Greyson NDE scale. The NDE group underwent a semi-structured interview one month later evaluating their memory characteristics and the associated life-threatening situation. One year after inclusion, all patients (regardless of whether they recalled an NDE) were contacted for a follow-up Greyson NDE scale assessment and questions about their ICU experience and opinions on death since discharge.</p></div><div><h3>Results</h3><p>The Greyson NDE scale revealed that the most frequently reported features were altered time perception, heightened senses and life review, and the Greyson total scores did not evolve over time. NDE memories persisted, with a consequent number of phenomenological characteristics (e.g., visual details, emotions). One year post-ICU, two patients (18 %) of the NDE group and 12 (24 %) of the non-NDE group were less afraid of death.</p></div><div><h3>Conclusions</h3><p>Results emphasize the clinical importance of interviewing all ICU patients to explore any memory after an ICU stay.</p></div>","PeriodicalId":47673,"journal":{"name":"International Journal of Clinical and Health Psychology","volume":"24 3","pages":"Article 100478"},"PeriodicalIF":8.8,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1697260024000437/pdfft?md5=097b918039c72d9df8ab4bdcedadd3b2&pid=1-s2.0-S1697260024000437-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141423031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A quantitative study on peripersonal space in anorexia nervosa and healthy subjects: Role of social variables and association with psychopathology 关于神经性厌食症患者和健康受试者周身空间的定量研究:社会变量的作用以及与精神病理学的关联
IF 8.8 1区 心理学
International Journal of Clinical and Health Psychology Pub Date : 2024-06-18 DOI: 10.1016/j.ijchp.2024.100476
Paola Longo , Eugenio Scaliti , Matteo Panero , Federica Toppino , Annalisa Brustolin , Benedetta Salis , Maria Carla Lacidogna , Giovanni Abbate-Daga , Matteo Martini
{"title":"A quantitative study on peripersonal space in anorexia nervosa and healthy subjects: Role of social variables and association with psychopathology","authors":"Paola Longo ,&nbsp;Eugenio Scaliti ,&nbsp;Matteo Panero ,&nbsp;Federica Toppino ,&nbsp;Annalisa Brustolin ,&nbsp;Benedetta Salis ,&nbsp;Maria Carla Lacidogna ,&nbsp;Giovanni Abbate-Daga ,&nbsp;Matteo Martini","doi":"10.1016/j.ijchp.2024.100476","DOIUrl":"https://doi.org/10.1016/j.ijchp.2024.100476","url":null,"abstract":"<div><h3>Objectives</h3><p>This study investigates peripersonal space (PPS) modulation in patients with anorexia nervosa (AN) versus healthy controls (HCs) and explores associations between PPS, eating-related, and general psychopathology.</p></div><div><h3>Method</h3><p>Forty-six patients and 42 HCs completed a computer-based task observing videos of an approaching actor (male or female) displaying different facial expressions along with a non-social condition. Then, participants completed self-report questionnaires assessing eating-related and general psychopathology.</p></div><div><h3>Results</h3><p>Mixed-models revealed that both groups adjusted PPS based on task conditions, with a gender effect favoring closer proximity to female actor. HCs reduced PPS amplitude progressively during the task, while patients did not show this effect. In patients, wider PPS correlated with lower self-esteem and facial expression identification accuracy, while in HCs, PPS was associated to body dissatisfaction and anxiety symptoms.</p></div><div><h3>Conclusion</h3><p>These findings enhance understanding of bodily self-consciousness, suggesting PPS consideration in therapeutic interactions with patients with AN and as a potential target in treatments addressing social impairment.</p></div>","PeriodicalId":47673,"journal":{"name":"International Journal of Clinical and Health Psychology","volume":"24 3","pages":"Article 100476"},"PeriodicalIF":8.8,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1697260024000413/pdfft?md5=e392a983d712aff2d6c3ce6901927797&pid=1-s2.0-S1697260024000413-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141423030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psychological characteristics associated with chemsex among men who have sex with men: Internalized homophobia, conscientiousness and serostatus as predictive factors 与男男性行为者的化学性行为有关的心理特征:作为预测因素的内化恐同症、自觉性和血清状况
IF 8.8 1区 心理学
International Journal of Clinical and Health Psychology Pub Date : 2024-04-01 DOI: 10.1016/j.ijchp.2024.100465
Benjamín Rodríguez-Expósito , Jennifer A. Rieker , Sara Uceda , Ana Isabel Beltrán-Velasco , Víctor Echeverry-Alzate , Manuel Gómez-Ortega , Apoyo Positivo , Manuel Reiriz
{"title":"Psychological characteristics associated with chemsex among men who have sex with men: Internalized homophobia, conscientiousness and serostatus as predictive factors","authors":"Benjamín Rodríguez-Expósito ,&nbsp;Jennifer A. Rieker ,&nbsp;Sara Uceda ,&nbsp;Ana Isabel Beltrán-Velasco ,&nbsp;Víctor Echeverry-Alzate ,&nbsp;Manuel Gómez-Ortega ,&nbsp;Apoyo Positivo ,&nbsp;Manuel Reiriz","doi":"10.1016/j.ijchp.2024.100465","DOIUrl":"https://doi.org/10.1016/j.ijchp.2024.100465","url":null,"abstract":"<div><h3>Background</h3><p>Although significant progress has been made in the rights of the LGBTQ+ community, even today this population still faces stigma and discrimination that impacts their mental health. In the case of men who have sex with men, it has been demonstrated that the use of drugs in a sexual context (chemsex) is one of the coping mechanisms and means of escape to deal with these situations.</p></div><div><h3>Method</h3><p>We assessed 284 native Spanish speakers’ participants, 45,4 % were not engaged in sexualised drug use (<em>n</em> = 129) while 54,6 % were chemsex users (<em>n</em> = 155) using 18,7 % of them the injected via. The participants completed six questionnaires about life and sexual satisfaction, depression, anxiety, internalised homophobia and personality. Bivariate and multivariable logistic regression were performed to assess the associations between sexual behaviour-related and psychological variables. Kruskal-Wallis H test was used to analysed the impact on mental health of the administration via.</p></div><div><h3>Results</h3><p>Aged, unprotected sexual relationships, positive serostatus, homonegativity and conscientiousness predicted the chemsex engagement. Furthermore, we found differences regarding the administration via.</p></div><div><h3>Conclusions</h3><p>We conclude that mental health significantly correlates with the practice of chemsex, highlighting the importance of integrating mental health considerations into the prevention of risky sexual behaviors.</p></div>","PeriodicalId":47673,"journal":{"name":"International Journal of Clinical and Health Psychology","volume":"24 2","pages":"Article 100465"},"PeriodicalIF":8.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1697260024000309/pdfft?md5=1d33cb55319f580b10bc90f5f72b6e6b&pid=1-s2.0-S1697260024000309-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140824678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MIR137 polygenic risk for schizophrenia and ephrin-regulated pathway: Role in lateral ventricles and corpus callosum volume MIR137 导致精神分裂症的多基因风险和ephrin 调节通路:在侧脑室和胼胝体体积中的作用
IF 8.8 1区 心理学
International Journal of Clinical and Health Psychology Pub Date : 2024-04-01 DOI: 10.1016/j.ijchp.2024.100458
G.A.M. Blokland , N. Maleki , J. Jovicich , R.I. Mesholam-Gately , L.E. DeLisi , J.A. Turner , M.E. Shenton , A.N. Voineskos , R.S. Kahn , J.L. Roffman , D.J. Holt , S. Ehrlich , Z. Kikinis , P. Dazzan , R.M. Murray , J. Lee , K. Sim , M. Lam , S.M.C. de Zwarte , E. Walton , E.C. del Re
{"title":"MIR137 polygenic risk for schizophrenia and ephrin-regulated pathway: Role in lateral ventricles and corpus callosum volume","authors":"G.A.M. Blokland ,&nbsp;N. Maleki ,&nbsp;J. Jovicich ,&nbsp;R.I. Mesholam-Gately ,&nbsp;L.E. DeLisi ,&nbsp;J.A. Turner ,&nbsp;M.E. Shenton ,&nbsp;A.N. Voineskos ,&nbsp;R.S. Kahn ,&nbsp;J.L. Roffman ,&nbsp;D.J. Holt ,&nbsp;S. Ehrlich ,&nbsp;Z. Kikinis ,&nbsp;P. Dazzan ,&nbsp;R.M. Murray ,&nbsp;J. Lee ,&nbsp;K. Sim ,&nbsp;M. Lam ,&nbsp;S.M.C. de Zwarte ,&nbsp;E. Walton ,&nbsp;E.C. del Re","doi":"10.1016/j.ijchp.2024.100458","DOIUrl":"https://doi.org/10.1016/j.ijchp.2024.100458","url":null,"abstract":"<div><p><em>Background/Objective.</em> Enlarged lateral ventricle (LV) volume and decreased volume in the corpus callosum (CC) are hallmarks of schizophrenia (SZ). We previously showed an inverse correlation between LV and CC volumes in SZ, with global functioning decreasing with increased LV volume. This study investigates the relationship between LV volume, CC abnormalities, and the microRNA MIR137 and its regulated genes in SZ, because of MIR137’s essential role in neurodevelopment. <em>Methods</em>. Participants were 1224 SZ probands and 1466 unaffected controls from the GENUS Consortium. Brain MRI scans, genotype, and clinical data were harmonized across cohorts and employed in the analyses. <em>Results.</em> Increased LV volumes and decreased CC central, mid-anterior, and mid-posterior volumes were observed in SZ probands. The MIR137-regulated ephrin pathway was significantly associated with CC:LV ratio, explaining a significant proportion (3.42 %) of CC:LV variance, and more than for LV and CC separately. Other pathways explained variance in either CC or LV, but not both. CC:LV ratio was also positively correlated with Global Assessment of Functioning, supporting previous subsample findings. SNP-based heritability estimates were higher for CC central:LV ratio (0.79) compared to CC or LV separately. <em>Discussion.</em> Our results indicate that the CC:LV ratio is highly heritable, influenced in part by variation in the MIR137-regulated ephrin pathway. Findings suggest that the CC:LV ratio may be a risk indicator in SZ that correlates with global functioning.</p></div>","PeriodicalId":47673,"journal":{"name":"International Journal of Clinical and Health Psychology","volume":"24 2","pages":"Article 100458"},"PeriodicalIF":8.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1697260024000231/pdfft?md5=b52de252ec1cfaf7528915eebfab4f7a&pid=1-s2.0-S1697260024000231-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140539827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mindfulness-based intervention reduce interference of negative stimuli to working memory in individuals with subclinical depression: A randomized controlled fMRI study 正念干预可减少亚临床抑郁症患者工作记忆中负面刺激的干扰:随机对照 fMRI 研究
IF 8.8 1区 心理学
International Journal of Clinical and Health Psychology Pub Date : 2024-04-01 DOI: 10.1016/j.ijchp.2024.100459
Chengjin Hong , Cody Ding , Yiwen Chen , Shiyue Cao , Yi Hou , Weiyu Hu , Dong Yang
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