International Journal of Clinical and Health Psychology最新文献

{"title":"The impact of transcranial direct current stimulation combined with virtual reality-based mindfulness on attention and inhibitory control in healthy individuals","authors":"Filipa Freire-Santos ,&nbsp;Dicle Karacadag ,&nbsp;Yasmin Vieira ,&nbsp;Mónica Sobral ,&nbsp;Vera Mateus ,&nbsp;Raquel Guiomar ,&nbsp;Perianen Ramasawmy ,&nbsp;Andrea Antal ,&nbsp;Ana Ganho-Ávila","doi":"10.1016/j.ijchp.2025.100631","DOIUrl":"10.1016/j.ijchp.2025.100631","url":null,"abstract":"<div><div>Combining virtual reality-focused mindfulness (VR-FM) and transcranial direct current stimulation (tDCS) can enhance cognitive performance, offering new insights for scientific research and clinical applications. We aimed to examine the effects of a single session of VR-FM, a single session of tDCS, and their combination on sustained attention, attention control, and inhibitory control.</div><div>We conducted a double-blind, controlled, randomized study (<em>N</em> = 107) with five groups: VR-FM or VR-mind wandering, paired with active (2 mA for 20 min) or sham tDCS with the anode over F3 and cathode over F4, and a no-intervention control group. Non-specific skin conductance response (nsSCR) was collected during virtual reality, and cognitive performance was measured with Sustained Attention to Response Task (SART) and the Emotional Stroop (EST) after intervention. Differences between groups were not statistically significant in cognitive tasks (all <em>p</em>&gt;.05) but we found a main effect of group in nsSCR (<em>F</em> (3, 66) = 4.07, <em>p</em> = .010, η² = 0.156), with significant differences between VR-FM + tDCS active and VR-MW + tDCS sham (<em>p</em> = .014).</div><div>Single sessions of VR-FM and tDCS did not significantly impact cognitive performance. However, reduced autonomic activation might be associated with mindfulness. Future studies should include several sessions and consider other individual conditions to understand the factors involved.</div></div>","PeriodicalId":47673,"journal":{"name":"International Journal of Clinical and Health Psychology","volume":"25 4","pages":"Article 100631"},"PeriodicalIF":4.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145270089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What comes first: Heart rate variability changes or insomnia? A causal investigation using Mendelian randomization","authors":"Bing Yan ,&nbsp;Xin Cui ,&nbsp;Lei Chen ,&nbsp;Xiangzhen Miao ,&nbsp;Hailin Jiang ,&nbsp;Yu Wang ,&nbsp;Fuchun Wang","doi":"10.1016/j.ijchp.2025.100656","DOIUrl":"10.1016/j.ijchp.2025.100656","url":null,"abstract":"<div><h3>Background</h3><div>Heart rate variability (HRV), a vital indicator of autonomic nervous system function, is frequently altered in patients with insomnia. While substantial evidence suggests a link between HRV changes and insomnia, previous studies have been limited by small sample sizes and cross-sectional designs, making it impossible to determine whether HRV changes are a cause or consequence of insomnia. Understanding this causal relationship is crucial for developing targeted interventions for sleep disorders.</div></div><div><h3>Objective</h3><div>To investigate the potential bidirectional causal relationship between HRV and insomnia using two-sample Mendelian randomization (MR) analysis.</div></div><div><h3>Method</h3><div>We obtained genome-wide association study (GWAS) summary statistics for three HRV traits (pvRSA/HF, RMSSD, and SDNN) from IEU Open GWAS database and insomnia data from FinnGen database (5763 cases and 445,483 controls). Bidirectional MR analyses were performed using multiple methods including inverse variance weighted (IVW), MR-Egger, weighted median, and mode-based approaches. Sensitivity analyses were conducted to assess heterogeneity and horizontal pleiotropy.</div></div><div><h3>Results</h3><div>MR analysis of HRV on insomnia revealed significant causal effects, specifically for pvRSA/HF (OR = 1.437, 95 % CI: 1.147–1.801, <em>p</em> = 0.002) and SDNN (OR = 1.910, 95 % CI: 1.092–3.342, <em>p</em> = 0.022). These associations remained robust across multiple MR methods and sensitivity analyses. In the reverse direction, MR analysis of insomnia on HRV found no significant causal effects on any HRV traits, suggesting unidirectional causality from HRV to insomnia.</div></div><div><h3>Conclusions</h3><div>This study provides genetic evidence that altered HRV may causally increase insomnia risk, while insomnia does not appear to causally affect HRV. These findings suggest that regulating HRV might help alleviate insomnia symptoms and improve sleep quality, and highlight the potential of HRV as a therapeutic target in sleep disorders.</div></div>","PeriodicalId":47673,"journal":{"name":"International Journal of Clinical and Health Psychology","volume":"25 4","pages":"Article 100656"},"PeriodicalIF":4.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145736101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural brain changes in people with dementia receiving Cognitive Stimulation Therapy: Preliminary findings","authors":"Lucas M. Loureiro ,&nbsp;Elodie Bertrand ,&nbsp;Eelco van Duinkerken ,&nbsp;Jerson Laks ,&nbsp;Valeska Marinho ,&nbsp;Iris Bomilcar ,&nbsp;Renata Naylor ,&nbsp;Gloria Wong ,&nbsp;Aimee Spector ,&nbsp;Daniel C. Mograbi","doi":"10.1016/j.ijchp.2025.100643","DOIUrl":"10.1016/j.ijchp.2025.100643","url":null,"abstract":"<div><h3>Background</h3><div>There are growing numbers of people with dementia (PwD) globally, a syndrome with well documented impact on brain structure and connectivity that lead to cognitive impairment. Cognitive Stimulation Therapy (CST) is a non-pharmacological intervention for dementia with a strong evidence-base indicating positive effects on cognition and mood. There is, however, a lack of data on the effects of CST on brain structural and functional changes. This study aimed to analyze the impact of CST on brain cortical differences through the symmetrized percentage change (SPC) of surface area, thickness and volume measured through magnetic resonance imaging (MRI).</div></div><div><h3>Methods</h3><div>Structural MRI was collected from 17 PwD who received CST and 11 treatment as usual (TAU) controls pre- and pos-intervention. The SPC of cortical structure was calculated for each participant. Freesurfer’s general linear model was used, and the resulting statistical maps were thresholded at <em>p</em> &lt; .01. The maps were then corrected for multiple comparisons using Monte Carlo Z simulation with 10.000 iterations. The family wise error cluster-level correction for multiple comparisons threshold was set at <em>p</em> &lt; .05 and p-values were further corrected using the Bonferroni method to correct for both hemispheres.</div></div><div><h3>Results</h3><div>There were no statistically significant differences between CST and TAU groups regarding age, sex or years of education. Relative to TAU, the CST group exhibited a decrease in surface area in the left rostral middle frontal region (P_FWE = 0.019, Cohen’s δ of 1.764), in addition to an increase in thickness in the right supramarginal (P_FWE = 0.012, Cohen’s δ of -2.063) and postcentral regions (P_FWE = 0.038, Cohen’s δ of -2.11). No differences in volume SPC were found between groups. A statistically significant correlation was also found between cognition and the right supramarginal gyrus thickness (<em>p</em> = .017).</div></div><div><h3>Conclusion</h3><div>This is the first study on the effects of CST on brain surface area, thickness, and volume. Our results indicate a change in cortical structure associated with CST. Reduced cortical thickness in the rostral middle frontal region may be related to the effects of CST on mood and stress. Increased thickness in the right supramarginal and postcentral regions may be due to increased abilities of phonological processing, verbal working memory, and somatosensory processing. More data, with larger samples, are needed to support these findings.</div></div>","PeriodicalId":47673,"journal":{"name":"International Journal of Clinical and Health Psychology","volume":"25 4","pages":"Article 100643"},"PeriodicalIF":4.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145364127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel brain functional-structural hybrid analysis to explain the effect of a 6-month psychosocial intervention on resilience in breast cancer","authors":"Muzi Liang ,&nbsp;Jin Zhou ,&nbsp;Peng Chen ,&nbsp;Wenjing Wu ,&nbsp;Yalan Song ,&nbsp;Guangyun Hu ,&nbsp;Qu Hu ,&nbsp;Zhe Sun ,&nbsp;Yuanliang Yu ,&nbsp;Yuyan Liang ,&nbsp;Alex Molassiotis ,&nbsp;M. Tish Knobf ,&nbsp;Zengjie Ye","doi":"10.1016/j.ijchp.2025.100639","DOIUrl":"10.1016/j.ijchp.2025.100639","url":null,"abstract":"<div><h3>Purposes</h3><div>To explore if pretreatment brain function/structure connectome could explain the response to a psychosocial intervention on resilience in breast cancer.</div></div><div><h3>Methods</h3><div>Between February 2018 and October 2021, women newly diagnosed with breast cancer were retrospectively enrolled from the <em>Be Resilient to Breast Cancer</em> (BRBC) trial and received a supportive-expressive therapy intervention. Baseline Resting-state Functional Magnetic Resonance Imaging (rs-fMRI) combined with Diffusion Tensor Imaging (DTI) were administered and resilience was scored by 10-item Resilience Scale specific to Cancer (RS-SC-10) at baseline and after the intervention (6 months). Response to the supportive intervention on resilience was defined as &gt; 0.5 standard deviation (SD) improvement at 6 months compared to baseline mean resilience score.</div></div><div><h3>Results</h3><div>A total of 105 patients received intervention. At 6 months, the resilience score improved in 62.9 % (<em>N</em> = 66), defined as the Response group. Amygdala (53 %) and Hippocampus (15 %) in rs-fMRI and CorpusCallosum_ForcepsMinor (96 %) in DTI were recognized as the main significant brain regions associated with treatment response.</div></div><div><h3>Conclusion</h3><div>These preliminary data suggest that neuro-markers of brain function/structure connectome from MR imaging might be useful in evaluating response to behavioral interventions on resilience.</div></div>","PeriodicalId":47673,"journal":{"name":"International Journal of Clinical and Health Psychology","volume":"25 4","pages":"Article 100639"},"PeriodicalIF":4.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145325955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral pro-inflammatory cytokine levels are associated with brain structural atrophies in patients with anxious depression","authors":"Zhihui Lan ,&nbsp;Ji-Tao Li ,&nbsp;Lin-lin Zhu,&nbsp;Yankun Wu,&nbsp;Tian Shen,&nbsp;Youran Dai,&nbsp;Yun-Ai Su,&nbsp;Tianmei Si","doi":"10.1016/j.ijchp.2025.100629","DOIUrl":"10.1016/j.ijchp.2025.100629","url":null,"abstract":"<div><h3>Background</h3><div>Anxious depression (AD), a common neurophysiological subtype of major depressive disorder (MDD), is often accompanied by immune dysregulation and volumetric alterations in brain structures. However, the intrinsic relationships between inflammatory markers and brain structural changes in AD patients remain unclear.</div></div><div><h3>Methods</h3><div>Participants were categorized into three groups: the AD group (<em>n</em> = 43), the non-anxious depression group (NAD, <em>n</em> = 68), and healthy controls (HC, <em>n</em> = 53), matched for age, sex, and education level. Serum levels of interleukin-1 beta (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-α) were measured across the groups. All participants underwent T1-weighted magnetic resonance imaging (MRI) scans, and voxel-based morphometry (VBM) analysis was performed to assess gray matter volume (GMV). Correlation analyses were conducted to investigate potential associations between inflammatory markers and GMV in the AD group.</div></div><div><h3>Results</h3><div>Compared to HCs, patients with MDD exhibited significantly elevated serum IL-6 levels. Additionally, AD patients demonstrated reduced GMV in the right putamen, right superior temporal gyrus (STG), and right cuneus compared to both NAD and HC groups. Notably, reduced GMV in the right STG was significantly correlated with serum IL-1β levels and depression severity within the AD group.</div></div><div><h3>Conclusions</h3><div>These findings provide preliminary psychoradiological evidence for the pathophysiological mechanisms underlying this MDD subtype and possible explanations for the differences in clinical features and prognosis between AD and NAD.</div></div>","PeriodicalId":47673,"journal":{"name":"International Journal of Clinical and Health Psychology","volume":"25 4","pages":"Article 100629"},"PeriodicalIF":4.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145222891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of resistance exercise on attentional bias toward food in overweight female college students: An event-related potential study","authors":"Jifu Wang ,&nbsp;Feng Ding ,&nbsp;Shuailei Lian ,&nbsp;Lin Yu","doi":"10.1016/j.ijchp.2025.100632","DOIUrl":"10.1016/j.ijchp.2025.100632","url":null,"abstract":"<div><h3>Background</h3><div>Attentional bias toward high-energy foods may increase appetite, leading to overconsumption and overweight. Physical exercise has been shown to reduce such bias, however, limited research has investigated its effects and underlying mechanisms.</div><div>The present study aimed to explore whether acute resistance exercise modulates attentional bias toward food-related stimuli among young overweight women.</div></div><div><h3>Methods</h3><div>Forty-three overweight female college students were randomly assigned to either an experimental group (<em>n</em> = 20; BMI = 25.25 ± 0.84) that performed 41 min of moderate-intensity resistance exercise or a control group (<em>n</em> = 23; BMI = 25.52 ± 1.01) that completed a reading task. Attentional bias was assessed using a dot-probe task with high- and low-energy food images after the exercise or control session, with the behavioral (reaction time, accuracy, attentional engagement/disengagement index) and neurophysiological (N2, P3) measures.</div></div><div><h3>Results</h3><div>Compared to the control group, the exercise group had a significantly lower attentional engagement index for the low-energy food cues and significantly shorter peak latency of N2 and P3 during the dot probe task. Within the experimental group, the N2 peak amplitude was significantly lower in the high-energy vs. low-energy condition when there were incongruent food cues.</div></div><div><h3>Conclusion</h3><div>These results indicate that the onset of attentional engagement and attentional orientation toward food cues occurred significantly earlier after resistance exercise. This study provides novel insights into the neurocognitive mechanisms underlying resistance exercise-induced modulations of attentional processing of food-related stimuli in overweight females, offering both theoretical contributions to exercise cognition and practical implications for weight management interventions.</div></div>","PeriodicalId":47673,"journal":{"name":"International Journal of Clinical and Health Psychology","volume":"25 4","pages":"Article 100632"},"PeriodicalIF":4.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145270091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the bidirectional within-subject relationship between sleep and affective wellbeing: Insights from an intensive longitudinal study","authors":"Justin Hachenberger ,&nbsp;Maia ten Brink ,&nbsp;Denny Kerkhoff ,&nbsp;Sebastian Baron ,&nbsp;Manuel Schabus ,&nbsp;Sakari Lemola","doi":"10.1016/j.ijchp.2025.100648","DOIUrl":"10.1016/j.ijchp.2025.100648","url":null,"abstract":"<div><div>This study aimed to investigate the bidirectional relationships between affective wellbeing and sleep, and to explore the moderating effects of depressive and insomnia symptoms. Data from two studies, involving 178 participants in total aged 18–29 years, were analyzed. Over 14 days, participants completed daily surveys assessing affective wellbeing and wore ECG chest belts for heart rate variability monitoring to derive objective sleep indices. Multilevel models were used to examine within-subject associations between affective states and subsequent sleep, and vice versa, while considering depressive and insomnia symptoms as moderators. Higher positive affect than usual in the evening was associated with shorter total sleep time, shorter rapid eye movement sleep, and lower number of awakenings and stage shifts than usual in the following night. Regarding sleep predicting morning’s affective wellbeing, longer slow-wave sleep was linked to higher positive affect than usual, while longer rapid eye movement sleep and higher sleep efficiency than usual predicted lower negative affect than usual. Also, higher subjective sleep quality than usual was associated with higher positive and lower negative affect than usual the next morning. No evidence for moderation effects of insomnia and depressive symptoms for the bidirectional within-subject associations between sleep and affect was found. The findings underscore the complex interplay between sleep and affective wellbeing, particularly highlighting that the subjective perception of one’s sleep appears to be relevant for the next morning’s affective states.</div></div>","PeriodicalId":47673,"journal":{"name":"International Journal of Clinical and Health Psychology","volume":"25 4","pages":"Article 100648"},"PeriodicalIF":4.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145520114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuous sleep tracking in digital CBT-I: Efficacy and insights from a naturalistic-environment study","authors":"Alexandra Hinterberger ,&nbsp;Esther-Sevil Eigl ,&nbsp;Aniko Szeko ,&nbsp;Pavlos I Topalidis ,&nbsp;Manuel Schabus","doi":"10.1016/j.ijchp.2025.100646","DOIUrl":"10.1016/j.ijchp.2025.100646","url":null,"abstract":"<div><h3>Background</h3><div>Insomnia is highly prevalent, yet few receive cognitive behavioral therapy for insomnia (CBT-I) due to limited treatment availability. Unguided digital CBT-I offers an accessible alternative to traditional face-to-face therapy. Research in this area often relies on either subjective sleep measurements (e.g., sleep diaries) or controlled single-night lab studies. This study examines the effectiveness of a novel app-based CBT-I program combining therapy with continuous subjective and objective sleep tracking via a heart rate (HR) sensor in a naturalistic setting.</div></div><div><h3>Methods</h3><div>Eighty-eight participants (56.8 % female) aged 20–85 years (M = 49.9 ± 13.10) completed an 8-week app-based CBT-I intervention with continuous sleep tracking (sleep diaries and HR sensor), followed by a 2-week follow-up. Assessments at baseline, post-intervention, and follow-up included sleep related problems, psychological strain, quality of life, and dysfunctional beliefs.</div></div><div><h3>Results</h3><div>Insomnia prevalence dropped from 92 % at pre-intervention to 67 % at follow-up. Improvements were observed in subjective sleep quality (p &lt; .001, r = 0.59), dysfunctional beliefs (p &lt; .001, r = 0.48), quality of life (p’s &lt; .002, r’s &gt; 0.33), psychological strain (p &lt; .001, r = 0.43), depression (p = .010, r = 0.27), and anxiety (p = .003, r = 0.32). While sleep diary data showed improvements in various sleep parameters, objective data revealed statistical trends towards a reduced total sleep time (TST; p = .083, r = 0.19), driven by sleep restriction, and light sleep (p = .089, r = 0.18). Using continuous sleep monitoring we additionally found relevant changes during the intervention levels for subjective wake after sleep onset, sleep efficiency as well as objective TST.</div></div><div><h3>Conclusion</h3><div>Findings support the effectiveness of app-based CBT-I and suggest that continuous objective sleep tracking over weeks can reveal previously undetected sleep and well-being improvements in real-world settings.</div></div>","PeriodicalId":47673,"journal":{"name":"International Journal of Clinical and Health Psychology","volume":"25 4","pages":"Article 100646"},"PeriodicalIF":4.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145467337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of eating disorder specific and unspecific symptoms with suicidal ideation in patients with anorexia nervosa","authors":"Evelina Marie Stender ,&nbsp;René Freichel ,&nbsp;Arne Doose ,&nbsp;Inger Hellerhoff ,&nbsp;Clara Marie Breier ,&nbsp;Ute Lewitzka ,&nbsp;Klara Schacht ,&nbsp;Daniel Geisler ,&nbsp;Joseph A. King ,&nbsp;Veit Rössner ,&nbsp;Stefan Ehrlich","doi":"10.1016/j.ijchp.2025.100633","DOIUrl":"10.1016/j.ijchp.2025.100633","url":null,"abstract":"<div><h3>Background</h3><div>Anorexia nervosa is a serious eating disorder with a high mortality rate, ranking among the most lethal mental health conditions. This is not only due to sequelae of cachexia, but also due to suicidality. The present study employs a network analysis approach to determine whether there are unique associations between suicidal ideation and eating disorder-specific symptoms in anorexia nervosa, or if suicidal ideation is more influenced by other symptoms such as those more loosely related to eating disorders or general internalizing symptoms, as well as biological factors. Additionally, we examined the potentially changing impact of symptoms after intensive treatment. <em>Methods:</em> The study involved female patients with anorexia nervosa admitted to intensive inpatient treatment. Eating disorder-specific and -related symptoms, depressive, anxiety, obsessive-compulsive symptoms, nutritional data as well as suicidal ideation were assessed at two points: immediately after admission (<em>n</em> = 313) and following partial weight gain (<em>n</em> = 217) and were examined together in a network analysis model. <em>Results:</em> The nodes that were most strongly related to suicidal ideation at both timepoints were feelings of ineffectiveness, as well as depressive and anxiety symptoms. Eating disorder-specific symptoms were found to be not significantly related to suicidal ideation. <em>Conclusions:</em> The results indicate that suicidal ideation in anorexia nervosa is primarily related to broader psychological symptoms rather than eating disorder-specific symptoms. The prominence of feelings of ineffectiveness within the network highlights the need for clinical interventions that focus on the enhancement of self-efficacy in anorexia nervosa.</div></div>","PeriodicalId":47673,"journal":{"name":"International Journal of Clinical and Health Psychology","volume":"25 4","pages":"Article 100633"},"PeriodicalIF":4.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145325495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between glymphatic system, multi-level stress response, and psychological resilience","authors":"Rachel R. Jin ,&nbsp;Li Liang ,&nbsp;Horace Tong ,&nbsp;Menglu Chen ,&nbsp;Tatia M.C. Lee","doi":"10.1016/j.ijchp.2025.100645","DOIUrl":"10.1016/j.ijchp.2025.100645","url":null,"abstract":"<div><h3>Background</h3><div>Stress promotes affective, neural, endocrine, and immune responses. The glymphatic system, essential for waste clearance and immune homeostasis, protects the brain against adverse neurobiological changes. However, it remains unclear how the glymphatic system changes during acute stress, coordinates with multi-level stress responses, and relates to psychological resilience in humans.</div></div><div><h3>Methods</h3><div>We recruited 84 healthy middle-aged adults (mean age 29.26 ± 2.91, 50 males) without major physical, neurological, or psychological conditions. Glymphatic system function was assessed via the coupling between global blood-oxygen-level-dependent and cerebrospinal fluid signals (gBOLD-CSF coupling) before, immediately after, and 60 min after the Montreal Imaging Stress Task. Mood states, neural responses (BOLD signal changes), acute and awakening cortisol responses, and psychological resilience (Connor-Davidson Resilience Scale) were measured. We compared gBOLD-CSF coupling changes over time using repeated-measures ANOVA, and investigated their associations with affective, neural, endocrine responses, and resilience with linear models and network analysis.</div></div><div><h3>Results</h3><div>gBOLD-CSF coupling was stronger at baseline and after recovery compared to immediately after stress. Changes in gBOLD-CSF coupling were associated with stress-related negative affect and prefrontal neural response. The cortisol response to acute stress was related to gBOLD-CSF coupling response to stress, depending on the level of the cortisol awakening response. The glymphatic system emerged as a central mediator of multi-organ stress response. Finally, post- to pre-stress changes in gBOLD-CSF coupling were associated with psychological resilience.</div></div><div><h3>Conclusions</h3><div>The glymphatic system transiently fluctuates during acute stress, synergizing with affective, neural, and endocrine networks, playing significant roles in stress response and psychological resilience.</div></div>","PeriodicalId":47673,"journal":{"name":"International Journal of Clinical and Health Psychology","volume":"25 4","pages":"Article 100645"},"PeriodicalIF":4.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145467336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}