{"title":"Editorial: The resistance movement in coronary physiology","authors":"H.V. (Skip) Anderson","doi":"10.1016/j.carrev.2024.12.003","DOIUrl":"10.1016/j.carrev.2024.12.003","url":null,"abstract":"","PeriodicalId":47657,"journal":{"name":"Cardiovascular Revascularization Medicine","volume":"72 ","pages":"Pages 52-53"},"PeriodicalIF":1.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Measured responses","authors":"Spencer B. King III","doi":"10.1016/j.carrev.2025.02.016","DOIUrl":"10.1016/j.carrev.2025.02.016","url":null,"abstract":"","PeriodicalId":47657,"journal":{"name":"Cardiovascular Revascularization Medicine","volume":"72 ","pages":"Pages 86-87"},"PeriodicalIF":1.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Manual compression hemostasis using a hemostatic pad for the distal radial artery approach","authors":"Kenji Sadamatsu , Tadahiro Kugai , Yoshiko Eto , Makoto Muta , Takanobu Maeda , Takashi Ishimatsu , Miwako Shihara , Yoshihiro Fukumoto","doi":"10.1016/j.carrev.2024.05.028","DOIUrl":"10.1016/j.carrev.2024.05.028","url":null,"abstract":"<div><h3>Background</h3><div><span>The method of hemostasis<span><span> for the distal radial approach has not been standardized, although this approach has become increasingly popular due to its advantages. In this study, we investigated the feasibility of manual compression hemostasis using a </span>calcium alginate pad after </span></span>coronary angiography via the distal radial approach.</div></div><div><h3>Methods</h3><div><span><span>We retrospectively collected 150 consecutive patients (mean age, 74.9 ± 8.0 years; male, 75 %) who underwent coronary angiography via the distal radial artery with a predominantly 4 Fr sheath from April 2021 to December 2022 and were </span>hemostatic<span><span> according to the following methods. After sheath removal, hemostasis was achieved by manual compression for 10 min using a </span>hemostatic<span><span> pad containing calcium alginate. When hemostasis was confirmed, a small log-shaped gauze was placed over the pad and fixed using a self-adhesive </span>elastic bandage for 2 h. </span></span></span><em>All procedures were performed by four fellows just beginning the distal radial approach</em>.</div></div><div><h3>Results</h3><div><span>The mean compression time was 12.4 ± 4.8 min, and hemostasis was successfully achieved in all patients, allowing the release of the elastic bandage after 2 h, with only one patient oozing the next morning. There were no major complications, while one patient had a >10 cm hematoma. Compared to that of the first 15 patients, for each fellow, the compression time of the subsequent patients was significantly shorter (14.5 ± 6.7 vs 11.1 ± 2.1 min, </span><em>p</em> < 0.01).</div></div><div><h3>Conclusions</h3><div>Manual compression hemostasis using calcium alginate pads for the distal radial artery approach appears feasible with a simple learning.</div></div>","PeriodicalId":47657,"journal":{"name":"Cardiovascular Revascularization Medicine","volume":"72 ","pages":"Pages 54-57"},"PeriodicalIF":1.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141145154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Twenty-year trend of mortality from concomitant sepsis and acute myocardial infarction (Type 1 or Type 2) in the United States","authors":"Ashish Kumar , Rama Ellauzi , Nandan S. Anavekar , Ankur Kalra","doi":"10.1016/j.carrev.2024.10.003","DOIUrl":"10.1016/j.carrev.2024.10.003","url":null,"abstract":"","PeriodicalId":47657,"journal":{"name":"Cardiovascular Revascularization Medicine","volume":"72 ","pages":"Pages 61-63"},"PeriodicalIF":1.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Robert F Storey, Kambiz Hassan, Anna L Meyer, Thomas Eberle, Nikolaas deNeve, Matthias Thielmann, Martin H Bernardi, Nandor Marczin, Ulf Guenther, Bernd Panholzer, Heinrich Maechler, Steven Hunter, Marijana Matejic-Spasic, Daniel Wendt, Efthymios N Deliargyris, Michael Schmoeckel
{"title":"Early CABG with intraoperative hemoadsorption in patients on ticagrelor: Real world data from the international Safe and Timely Antithrombotic Removal (STAR) registry.","authors":"Robert F Storey, Kambiz Hassan, Anna L Meyer, Thomas Eberle, Nikolaas deNeve, Matthias Thielmann, Martin H Bernardi, Nandor Marczin, Ulf Guenther, Bernd Panholzer, Heinrich Maechler, Steven Hunter, Marijana Matejic-Spasic, Daniel Wendt, Efthymios N Deliargyris, Michael Schmoeckel","doi":"10.1016/j.carrev.2025.02.015","DOIUrl":"https://doi.org/10.1016/j.carrev.2025.02.015","url":null,"abstract":"<p><strong>Objectives: </strong>Severe perioperative bleeding occurs in over 30 % of patients on ticagrelor undergoing isolated coronary artery bypass grafting (i-CABG) before completing the recommended 3-day washout. Intraoperative ticagrelor removal with a polymer bead hemoadsorption device is an approved therapy that may reduce perioperative bleeding.</p><p><strong>Methods: </strong>The current analysis from the international Safe and Timely Antithrombotic Removal (STAR) registry reports outcomes with intraoperative hemoadsorption in patients on ticagrelor undergoing i-CABG before completing the recommended washout. Bleeding was assessed by the Universal Definition of Perioperative Bleeding (UDPB) definition.</p><p><strong>Results: </strong>102 patients (63.8 ± 10.1 years, 81.2 % male) underwent i-CABG at mean time from last dose (TLD) of 22.8 ± 14.6 h. Groups were created based on TLD to CABG: Group-1 (G1): <24 h (n = 61; TLD 12.6 ± 6.5 h); Group-2 (G2): 24-72 h (n = 41; 37.2 ± 10.1 h). G1 was higher risk than G2 based on EuroSCORE-II (median: 4.2 % vs. 1.7 %, p = 0.006) and emergency indication (66.1 % vs. 12.2 %, p < 0.001). Operation and cardiopulmonary bypass durations were similar (G1: 4.3 ± 1.5 h and 94.9 ± 37.1 min vs. G2: 4.4 ± 1 h and 94.7 ± 36.1 min, p = ns). Severe bleeding (UDPB≥3) and re-operations for bleeding were more frequent in G1 vs. G2 (14.8 % vs. 2.4 %, p = 0.047, and 8.2 % vs. 0 %, p = 0.08, respectively). Any transfusion of red blood cells or platelets was also more frequent in G1 vs. G2 (45.9 % vs. 26.8 %, p = 0.05 and 59.0 % vs. 34.1 %, p = 0.014, respectively).</p><p><strong>Conclusions: </strong>Intraoperative ticagrelor removal may help reduce ticagrelor-related bleeding in patients undergoing i-CABG before completing the 3-day washout. High risk emergency procedures within the first 24 h of last ticagrelor dose have an increased bleeding risk.</p><p><strong>Clinical trial registry number: </strong>ClinicalTrials.gov: NCT05077124.</p>","PeriodicalId":47657,"journal":{"name":"Cardiovascular Revascularization Medicine","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Paclitaxel crystal visualization by intravascular imaging following drug-coated balloon angioplasty: A report of 2 cases.","authors":"Rajesh Vijayvergiya, Arghadip Bose, Nikhil Sharma, Basant Kumar, Bhupinder K Sihag, Ankush Gupta","doi":"10.1016/j.carrev.2025.02.013","DOIUrl":"https://doi.org/10.1016/j.carrev.2025.02.013","url":null,"abstract":"<p><p>Drug-coated balloons (DCB) have evolved as an alternative to drug-eluting stents in coronary interventions without the addition of an extra metal layer while delivering antiproliferative drugs. However, the delivery of the drug at the target site cannot be objectively assessed in routine practice. Hence, the success of a DCB angioplasty is limited to luminal gain alone. We report a novel finding of tiny paclitaxel crystals detected on the intimal surface by intravascular ultrasound (IVUS) and optical coherence tomography (OCT) in two cases treated with DCB angioplasty.</p>","PeriodicalId":47657,"journal":{"name":"Cardiovascular Revascularization Medicine","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
António Rocha de Almeida, Rafael Viana, Kisa Congo, Manuel Trinca, Lino Patrício
{"title":"Complete revascularization in elderly patients with multi-vessel disease following acute coronary syndrome: A multicenter retrospective study.","authors":"António Rocha de Almeida, Rafael Viana, Kisa Congo, Manuel Trinca, Lino Patrício","doi":"10.1016/j.carrev.2025.02.009","DOIUrl":"https://doi.org/10.1016/j.carrev.2025.02.009","url":null,"abstract":"<p><strong>Background: </strong>In the elderly, acute coronary syndromes (ACS) are particularly challenging, especially with multivessel disease (MVD). Concerns about outcomes and limited evidence often lead to conservative treatment. While complete revascularization benefits in younger patients are well established, uncertainties persist for older individuals.</p><p><strong>Methods: </strong>A national multicenter, retrospective cohort study of 629 patients older than 75 with ACS and MVD was divided into two groups: complete revascularization (CR) and culprit-only (CO) revascularization. The in-hospital composite outcome of death and major adverse cardiovascular events (MACE) and the follow-up composite outcome of death and cardiovascular hospital admission were assessed.</p><p><strong>Results: </strong>Of 629 patients, 383 (66 %) were successfully revascularized: 254 (66 %) with CO revascularization and 129 (34 %) with CR. The mean age between groups was similar; in the CO group, it was 82 ± 5 years, while in the CR group, it was 81 ± 5 years (p = 0.4). The proportion of females was similar (42 % vs. 39 %). There was a higher ST-segment elevation myocardial infarction rate in the CO group (62 % vs 38 %, p < 0.01). CR was associated with a lower rate of in-hospital events (35 % vs 51 %, p = 0.025; OR 0.62 95 %CI [0.4-0.9]). Not only was there an association between CR and a lower number of in-hospital deaths (6 % vs. 19 %, p < 0.01; OR 0.3 95 %CI [0.15-0.67]) but also with lower in-hospital MACE (34 % vs. 49 % p = 0.02; OR 0.6 95 %CI [0.4-0.9]). During follow-up, complete revascularization was non-significantly associated with lower mortality (14 % vs. 15 %, p = 0.4), hospital admissions (22 % vs. 25 %, p = 0.2), and the composite outcome (35 % vs. 40 %, p = 0.2) compared with the culprit-only cohort. The survival curves of both groups were statistically similar (p = 0.16).</p><p><strong>Conclusion: </strong>In older patients with ACS and MVD, the ideal revascularization strategy is still to be determined. However, CR was associated with lower in-hospital deaths and MACE without significant difference in follow-up events, deaths, and hospital admissions. The choice of revascularization strategy should be carefully individualized and tailored considering patient-specific factors, clinical presentation, and overall risk profile.</p>","PeriodicalId":47657,"journal":{"name":"Cardiovascular Revascularization Medicine","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pierfrancesco Agostoni, Jan-Peter Van Kuijk, Paul Knaapen, Farhat Fouladvand, Martin Hudec, Antonino Nicosia, Kari Kervinen, Salvatore Davide Tomasello, Ramesh Singh Arjan Singh, Girish N Vishwanathan, Béla Merkely, Houng Bang Liew, Khalid Al Faraidy, Clive Corbett, Saleem Dawood, Anirban Choudhury, Imad Abdelhafiz Alhaddad, Azfar Zaman, Adriaan O Kraaijeveld, Martino Pepe
{"title":"Clinical outcomes of the BioMime™ morph coronary stent system for long (30 to ≤56 mm length) coronary lesions: Three-year follow-up of the Morpheus Global Registry.","authors":"Pierfrancesco Agostoni, Jan-Peter Van Kuijk, Paul Knaapen, Farhat Fouladvand, Martin Hudec, Antonino Nicosia, Kari Kervinen, Salvatore Davide Tomasello, Ramesh Singh Arjan Singh, Girish N Vishwanathan, Béla Merkely, Houng Bang Liew, Khalid Al Faraidy, Clive Corbett, Saleem Dawood, Anirban Choudhury, Imad Abdelhafiz Alhaddad, Azfar Zaman, Adriaan O Kraaijeveld, Martino Pepe","doi":"10.1016/j.carrev.2025.02.010","DOIUrl":"https://doi.org/10.1016/j.carrev.2025.02.010","url":null,"abstract":"<p><strong>Background: </strong>Percutaneous coronary intervention (PCI) of long coronary artery lesions (CAL) presents a puzzle, often requiring multiple stents. As the arteries twist and narrow, this becomes even more challenging with issues like potential distal overexpansion and proximal under expansion, and edge dissections. The study aims to assess the safety and performance of BioMime™ Morph sirolimus-eluting stent (SES) in individuals with long CAL.</p><p><strong>Methods: </strong>This prospective, single-arm, multi-center, observational, real-world registry, included 565 patients with long CAL (length 30 to ≤56 mm) in native coronary arteries (reference vessel diameters: 2.25 mm to 3.50 mm). Based on lesion length, patients were implanted with 30 mm, 40 mm, 50 mm, or 60 mm BioMime™ Morph SES. Primary endpoint was freedom of target lesion failure (TLF) at 6-month and up to 36-month.</p><p><strong>Results: </strong>Over 65 % of patients had lesions requiring 50 mm and 60 mm stents. The follow-up length was up to 24-month for the whole cohort and up to 36-month only for 211 patients from seven selected centers. The freedom from TLF rate was 97.86 %, 97.26 %, 96.27 %, and 95.15 % at 6-, 12-, 24-, and 36-month follow-ups, respectively. The cumulative rates of major adverse cardiac events (MACE) were 2.74 % at 12-month, 3.73 % at 24-month and 4.85 % at 36-month. Additionally, the rates of ischemia-driven target lesion revascularization were 2.01 % at 12-month, 2.16 % at 24-month, and 3.88 % at 36-month. Lastly, stent thrombosis (ST) was reported in only 2 cases (0.97 %) at 36-month.</p><p><strong>Conclusion: </strong>The lower incidences of MACE and ST up to three-year follow-up indicate BioMime™ Morph SES is an effective and safe option for PCI in long CAL.</p>","PeriodicalId":47657,"journal":{"name":"Cardiovascular Revascularization Medicine","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}