Cardiovascular Revascularization Medicine最新文献

{"title":"Acute mitral regurgitation: The role of transcatheter edge-to-edge repair","authors":"Antonio Sisinni ,&nbsp;Alexandra M. Rojas Sanchez ,&nbsp;Maurizio Tusa ,&nbsp;Francesco Bedogni ,&nbsp;Luca Testa","doi":"10.1016/j.carrev.2026.01.013","DOIUrl":"10.1016/j.carrev.2026.01.013","url":null,"abstract":"<div><div>Acute mitral regurgitation (MR) is a critical condition arising from diverse etiologies, including infective endocarditis, ischemic heart disease, stress-induced cardiomyopathy, and iatrogenic injury. While surgical repair or replacement has traditionally served as the standard of care, particularly in emergent cases, the evolution of transcatheter mitral valve therapies offers viable alternatives for patients deemed high-risk for conventional surgery. This review examines the pathophysiological mechanisms underlying acute MR in specific clinical contexts, and explores the expanding role of transcatheter edge-to-edge repair.</div></div>","PeriodicalId":47657,"journal":{"name":"Cardiovascular Revascularization Medicine","volume":"86 ","pages":"Pages 112-118"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146107892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Epicardial-only left atrial appendage closure: Insights from seven years of first-in-human experience","authors":"Mehmet Cilingiroglu,&nbsp;Ibrahim Inanc","doi":"10.1016/j.carrev.2026.02.009","DOIUrl":"10.1016/j.carrev.2026.02.009","url":null,"abstract":"","PeriodicalId":47657,"journal":{"name":"Cardiovascular Revascularization Medicine","volume":"86 ","pages":"Pages 17-18"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147357148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sharing the knowledge","authors":"Spencer B. King III","doi":"10.1016/j.carrev.2026.04.005","DOIUrl":"10.1016/j.carrev.2026.04.005","url":null,"abstract":"","PeriodicalId":47657,"journal":{"name":"Cardiovascular Revascularization Medicine","volume":"86 ","pages":"Pages 119-120"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147640228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hybrid (DES + DCB) strategy for chronic total occlusions: Development of the GLOW risk stratification score","authors":"Ehab Cherif,&nbsp;Husam Abdulaziz Noor","doi":"10.1016/j.carrev.2025.12.024","DOIUrl":"10.1016/j.carrev.2025.12.024","url":null,"abstract":"<div><h3>Background</h3><div>Hybrid drug-eluting stent/drug-coated balloon percutaneous coronary intervention (DES-DCB PCI) aims to minimize stent burden while maintaining patency in chronic total occlusion lesions.</div></div><div><h3>Methods</h3><div>We prospectively studied 19 consecutive CTO patients treated with a hybrid DES–DCB strategy; primary endpoint was late lumen loss (LLL) at 3–4 months, with secondary clinical outcomes at six months.</div></div><div><h3>Results</h3><div>Technical success was 89.5 %; mean LLL was 0.10 ± 0.83 mm; late lumen gain occurred in ~53 % of patients completing angiographic follow-up; binary restenosis was 10.5 %. Residual stenosis strongly predicted LLL, while optimal DCB sizing and inflation ≥180 s were protective; residual stenosis remained the independent predictor in multivariable regression. IVUS guidance was associated with 0 % restenosis.</div></div><div><h3>Conclusions</h3><div>Hybrid DES–DCB PCI for CTOs was feasible with low LLL. Outcomes hinged on lesion preparation, sizing, and inflation duration. The six-component GLOW score provides intra-procedural risk stratification and warrants multicenter validation.</div></div>","PeriodicalId":47657,"journal":{"name":"Cardiovascular Revascularization Medicine","volume":"86 ","pages":"Pages 60-66"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145949376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to letter by Aphale et al.: Long-term outcomes of coronary angiography in patients with and without diabetes","authors":"Tobias Schupp ,&nbsp;Michael Behnes ,&nbsp;Ibrahim Akin","doi":"10.1016/j.carrev.2026.03.001","DOIUrl":"10.1016/j.carrev.2026.03.001","url":null,"abstract":"","PeriodicalId":47657,"journal":{"name":"Cardiovascular Revascularization Medicine","volume":"86 ","pages":"Pages 100-101"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147436694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcatheter interventions in adult patients with transposition of the great arteries","authors":"Raquel Luna-López ,&nbsp;Eduardo Flores-Umanzor ,&nbsp;Pedro Cepas-Guillén ,&nbsp;Andrea Ruberti ,&nbsp;Sílvia Montserrat ,&nbsp;Lusine Abrahamyan ,&nbsp;Juan M. Carretero Bellón ,&nbsp;Leyre Álvarez Rodriguez ,&nbsp;Lore Schrutka ,&nbsp;Igor Morr-Verenzuela ,&nbsp;Susanna Prat-González ,&nbsp;Daniel Pereda ,&nbsp;Xavier Freixa ,&nbsp;Ricardo Sanz-Ruiz ,&nbsp;Josep Rodés-Cabau ,&nbsp;Matthew J. Gillespie ,&nbsp;Jamil A. Aboulhosn ,&nbsp;Lee Benson ,&nbsp;Mark Osten ,&nbsp;Rafael Alonso-Gonzalez ,&nbsp;Eric Horlick","doi":"10.1016/j.carrev.2025.12.002","DOIUrl":"10.1016/j.carrev.2025.12.002","url":null,"abstract":"<div><div>Transposition of the great arteries (TGA) is a complex congenital heart defect with two primary anatomical subtypes: dextro-TGA and levo-TGA. Advances in neonatal surgical techniques, particularly the arterial switch operation, have significantly improved survival rates. However, as this population ages, late complications such as heart failure and valve dysfunction present new clinical challenges. Transcatheter interventions have emerged as valid alternatives to surgical reintervention for these patients, providing effective symptom relief and improved quality of life, reducing the need for repeated sternotomies. As more adults with repaired TGA reach advanced ages, long-term studies are needed to assess the durability and safety of transcatheter therapies. Expanding the indications, refining procedural techniques, and developing specialized devices will be essential in optimizing outcomes for this growing patient population.</div></div>","PeriodicalId":47657,"journal":{"name":"Cardiovascular Revascularization Medicine","volume":"86 ","pages":"Pages 102-111"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145752309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel lipid-lowering therapies versus statins in primary prevention of cardiovascular disease.","authors":"Ramzi Ibrahim, Todd A Laffaye, Abdul Hakim Almakadma, Mohi Hamze, Hoang Nhat Pham, Ahmed K Mahmoud, Kamal Awad, Mahmoud Abdelnabi, Luke Dreher, Juan Maria Farina, Balaji Tamarappoo, Dan Sorajja, Steven J Lester, Eugene Yang, Kwan Lee, Chadi Ayoub, Mamas A Mamas, Reza Arsanjani","doi":"10.1016/j.carrev.2026.04.027","DOIUrl":"https://doi.org/10.1016/j.carrev.2026.04.027","url":null,"abstract":"<p><strong>Background: </strong>Scarce evidence exists comparing clinical outcomes of novel lipid-lowering monotherapy with standard statin therapy for primary prevention. We compared clinical outcomes among primary prevention patients treated with novel lipid-lowering monotherapy versus statin monotherapy.</p><p><strong>Methods: </strong>We performed a retrospective matched cohort study using the TriNetX network comprising 107 predominantly U.S. healthcare organizations. Adults with LDL-C > 100 mg/dL, between 2015 and 2024, and no prior ischemic heart disease, heart failure, cerebral infarction, or peripheral vascular disease were included. Exposure was treatment with evolocumab, alirocumab, or inclisiran without concomitant statins within 1 year of the qualifying LDL-C, compared with initiation of statin monotherapy. Propensity score matching was performed 1:1 across 28 covariates. Follow-up began 7 days after treatment initiation and extended to 2 years. Primary outcomes were all-cause mortality and acute myocardial infarction (AMI). Secondary outcomes included hospitalization, acute heart failure, ventricular tachycardia, atrial fibrillation, cerebral infarction, and MACE.</p><p><strong>Results: </strong>After matching, 5844 patients remained in each cohort. Median follow-up was 675 days. All-cause mortality (0.8% vs 1.1%; HR 0.79, 95% CI 0.54-1.15) and AMI (0.3% vs 0.3%; HR 1.31, 95% CI 0.65-2.62) were similar between novel therapy and statin cohorts. Hospitalizations, stroke, atrial fibrillation, ventricular tachycardia, and MACE did not differ significantly. Novel therapies were associated with lower acute heart failure events (0.7% vs 1.2%; HR 0.63, 95% CI 0.42-0.93).</p><p><strong>Conclusions: </strong>Among patients without prior ASCVD, novel lipid-lowering monotherapy achieved comparable short-term outcomes to statin monotherapy, with fewer acute heart failure events, complementing the VESALIUS trial.</p>","PeriodicalId":47657,"journal":{"name":"Cardiovascular Revascularization Medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147844586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Racial and ethnic differences and temporal changes in outcomes following transcatheter aortic valve replacement in urban hospitals.","authors":"Rezwan Munshi, Sahil Ghay, Ralph Daher, Koushik Sanku, Christos G Mihos, Rachel Shatanof, Mohamed H Raafat, Ahmad Kassar, Marissa Donatelle, Francisco Ujueta, Priscilla Wessly, Francine K Welty, Abdulhamied Alfaddagh, Tarec K Elajami, Amr E Abbas, Andres Palomo","doi":"10.1016/j.carrev.2026.04.018","DOIUrl":"https://doi.org/10.1016/j.carrev.2026.04.018","url":null,"abstract":"<p><strong>Introduction: </strong>Transcatheter aortic valve replacement (TAVR) is an established treatment for severe aortic stenosis. Although TAVR has improved clinical outcomes, data on racial and ethnic differences in in-hospital clinical outcomes and their temporal trends, particularly within urban hospital settings, remain limited. Accordingly, we examined racial and ethnic differences in in-hospital outcomes and their temporal trends among patients undergoing TAVR in urban hospitals.</p><p><strong>Methods: </strong>We utilized the National Inpatient Sample from 2016 through 2022 and identified TAVR-related hospitalizations in urban hospitals. Patients were classified by race and ethnicity, with White patients serving as the reference group. Primary endpoints included in-hospital mortality and major adverse cardiovascular events. Secondary endpoints included acute myocardial infarction, stroke, cardiac arrest, acute kidney injury, need for transfusion, mechanical ventilation, and other in-hospital complications. Survey-weighted multivariable analyses were performed.</p><p><strong>Results: </strong>We identified a weighted total of 469,175 hospitalizations for TAVR in urban hospitals. Overall, 87.1% of patients were White, and 12.9% were racial and ethnic minority patients. Compared with White patients, Black and Hispanic patients had higher adjusted odds of major adverse cardiovascular events, driven in part by acute myocardial infarction, while Hispanic patients also had higher in-hospital mortality. Rates of ischemic and hemorrhagic stroke did not differ significantly across groups. Significant race-by-year interactions were observed for in-hospital mortality and blood transfusion.</p><p><strong>Conclusions: </strong>Our findings highlight persistent racial and ethnic disparities in in-hospital outcomes following TAVR, emphasizing the need for targeted efforts to address inequities in care delivery.</p>","PeriodicalId":47657,"journal":{"name":"Cardiovascular Revascularization Medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147844610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Stagnation before the storm: The post-2010 AMI mortality plateau and the COVID-19 pandemic.","authors":"Ori Waksman, Brian Case","doi":"10.1016/j.carrev.2026.04.025","DOIUrl":"https://doi.org/10.1016/j.carrev.2026.04.025","url":null,"abstract":"","PeriodicalId":47657,"journal":{"name":"Cardiovascular Revascularization Medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147844568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the comment on our paper \"Post-procedural ultrasound findings linked to symptomatic radial artery occlusion following transradial coronary intervention\".","authors":"Sven M Piepenburg, Dennis Bünte, Derek Hazard, Julia Schlosser, Mariya Maslarska, Christian Weber, Alexandra Lindau, Benedikt Hammerich, Dirk Westermann, Christoph Hehrlein","doi":"10.1016/j.carrev.2026.04.023","DOIUrl":"https://doi.org/10.1016/j.carrev.2026.04.023","url":null,"abstract":"","PeriodicalId":47657,"journal":{"name":"Cardiovascular Revascularization Medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}