Cardiovascular Revascularization Medicine最新文献

{"title":"Reply to \"DK-crush versus Mini-crush: Beyond the P value\".","authors":"Sunny Goel, Andy Moyal","doi":"10.1016/j.carrev.2026.08.016","DOIUrl":"https://doi.org/10.1016/j.carrev.2026.08.016","url":null,"abstract":"","PeriodicalId":47657,"journal":{"name":"Cardiovascular Revascularization Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148898129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of predicted post-PCI FFR derived from coronary computed tomography angiography versus observed angiographic FFR: emerging concept of wireless end-to-end physiology-guided PCI","authors":"Pedro E.P. Carvalho,&nbsp;João L. Cavalcante,&nbsp;John Lesser,&nbsp;Victor Cheng,&nbsp;Dimitrios Strepkos,&nbsp;Michaella Alexandrou,&nbsp;Olga Mastrodemos,&nbsp;Bavana V. Rangan,&nbsp;Emmanouil S. Brilakis,&nbsp;Yader Sandoval","doi":"10.1016/j.carrev.2025.12.019","DOIUrl":"10.1016/j.carrev.2025.12.019","url":null,"abstract":"<div><h3>Background</h3><div>Fractional flow reserve (FFR) derived from coronary computed tomography angiography (FFR_CT) facilitates virtual PCI planning and informs stent length selection based on predicted post-PCI FFR_CT. This approach was previously validated against pressure-wire based FFR. Whether angiographic FFR can be used to ascertain the target post-PCI FFR_CT predicted from CCTA is uncertain.</div></div><div><h3>Methods</h3><div>Observational cohort study of patients undergoing coronary computed tomography angiography (CCTA) with an FFR_CT ≤ 0.80 that were referred to CCTA-guided PCI using the FFR_CT-based virtual planner (HeartFlow Inc.) for pre-procedural guidance and FFR_angio (CathWorks Ltd.) for intra- and post-procedural assessment. Virtual FFR pullbacks (FFR measurements every 1 mm across the vessel length) were analyzed and compared for both FFR_CT and FFR_angio modalities. We evaluated the agreement between pre- and post-PCI FFR_CT and FFR_angio at matched locations using the Pearson correlation coefficient and Bland-Altman analysis. Virtual FFR pullbacks (FFR measurements every 1 mm across the vessel length) were analyzed and compared for both FFR_CT and FFR_angio modalities.</div></div><div><h3>Results</h3><div>A total of 2290 post-PCI FFR values were derived from 20 vessels that underwent CCTA-guided PCI virtual PCI followed by post-PCI FFR_angio. FFR values were matched across FFR pullback tracings that allowed the comparison of predicted post-PCI FFR_CT to observed post PCI FFR_angio results. The left anterior descending artery (LAD) (45 %) was the most common target vessel. A strong correlation was observed between FFR_CT and FFR_angio (<em>R</em> = 0.74; <em>p</em> &lt; 0.001). The mean difference at matched locations was −0. 01 FFR units, with a standard deviation of 0.04 and limits of agreement ranging from −0.10 to 0.07.</div></div><div><h3>Conclusion</h3><div>Predicted post-PCI FFR_CT values derived from CCTA-based virtual PCI have an excellent correlation with observed post-PCI FFRangio values derived from invasive coronary angiography after stenting. These findings highlight the novel concept of wireless end-to-end physiology guided PCI, integrating pre-PCI FFR_CT and post-PCI angiographic FFR as complementary tools.</div></div>","PeriodicalId":47657,"journal":{"name":"Cardiovascular Revascularization Medicine","volume":"90 ","pages":"Pages 31-37"},"PeriodicalIF":2.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145896993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative outcomes of intracardiac versus transesophageal echocardiography for left atrial appendage occlusion","authors":"Hasaan Ahmed,&nbsp;Mahmoud Ismayl,&nbsp;Ali Bin Abdul Jabbar,&nbsp;Andrew Michael Goldsweig,&nbsp;Ahmed Aboeata","doi":"10.1016/j.carrev.2025.12.018","DOIUrl":"10.1016/j.carrev.2025.12.018","url":null,"abstract":"","PeriodicalId":47657,"journal":{"name":"Cardiovascular Revascularization Medicine","volume":"90 ","pages":"Pages 63-65"},"PeriodicalIF":2.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146020062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Females are underrepresented in randomized controlled trials of mechanical circulatory support in cardiogenic shock","authors":"John E. Connolly,&nbsp;Anushka V. Desai,&nbsp;Robert M. Weinstein,&nbsp;Craig Cronin,&nbsp;Emily Joseph,&nbsp;Steven Hsu,&nbsp;Faisal Rahman","doi":"10.1016/j.carrev.2026.01.005","DOIUrl":"10.1016/j.carrev.2026.01.005","url":null,"abstract":"","PeriodicalId":47657,"journal":{"name":"Cardiovascular Revascularization Medicine","volume":"90 ","pages":"Pages 54-56"},"PeriodicalIF":2.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146020146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative flow ratio and non-hyperemic pressure ratio in patients with intermediate coronary lesions","authors":"Simone Finocchiaro,&nbsp;Maria Sara Mauro,&nbsp;Davide Sclofani,&nbsp;Marco Spagnolo,&nbsp;Antonio Greco,&nbsp;Davide Capodanno","doi":"10.1016/j.carrev.2025.12.021","DOIUrl":"10.1016/j.carrev.2025.12.021","url":null,"abstract":"<div><h3>Background</h3><div>Quantitative flow ratio (QFR) is a recent, non-invasive method for functional coronary assessment, providing estimates of lesion-specific ischemia without the need for pressure wires or hyperemic agents. While its diagnostic concordance with fractional flow reserve (FFR) has been previously explored, data comparing QFR to non-hyperemic pressure ratios (NHPRs), such as instantaneous wave-free ratio (iwFR) and resting full-cycle ratio (RFR), remain limited.</div></div><div><h3>Objectives</h3><div>This study aimed to evaluate the diagnostic agreement between QFR and NHPRs in real-world patients undergoing physiological assessment for intermediate coronary stenoses.</div></div><div><h3>Methods</h3><div>Lesions from the CAST registry with available iwFR or RFR and analyzable angiograms for QFR computation were included. Ischemia was defined as NHPRs ≤0.89 or QFR ≤0.80. Diagnostic performance was assessed using sensitivity, specificity, predictive values, and ROC analysis (AUC via DeLong's method). Agreement was evaluated with Cohen's kappa and Bland-Altman analysis. McNemar's test assessed asymmetry in discordant pairs. Spearman's correlation and logistic univariate and multivariable regressions identified predictors of QFR-NHPRs discordance.</div></div><div><h3>Results</h3><div>A total of 174 lesions from 142 patients were included in the final analysis. QFR demonstrated a diagnostic accuracy of 79 %, with a sensitivity of 90 % and a negative predictive value of 82 %, in respect of NHPRs. Specificity and positive predictive value were 63 % and 78 %, respectively. The area under the ROC curve was 0.80 (95 % CI, 0.733–0.867). QFR underestimated ischemia in 14.9 % of lesions (false negatives), and overall diagnostic discordance with NHPRs occurred in 20.7 % of cases. Longer lesion length was independently associated with higher concordance (OR 0.95, 95 % CI 0.91–0.99, <em>p</em> = 0.012), while bifurcation lesions were predictors of discordance (OR 4.81, 95 % CI 1.30–21.12, <em>p</em> = 0.024).</div></div><div><h3>Conclusions</h3><div>QFR shows moderate concordance with NHPRs and may serve as a useful, wire-free alternative for excluding functionally significant stenoses. While it demonstrated high sensitivity, the risk of false negatives in certain anatomical subsets highlights the value of a cautious, individualized approach, possibly integrating QFR with invasive indices or imaging modalities in selected cases.</div></div>","PeriodicalId":47657,"journal":{"name":"Cardiovascular Revascularization Medicine","volume":"90 ","pages":"Pages 38-46"},"PeriodicalIF":2.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145897033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suture-based vs plug-based vascular access closure in patients undergoing transcatheter transfemoral aortic valve implantation","authors":"Luca Paolucci,&nbsp;Andrea Buono,&nbsp;Michele Colucci,&nbsp;Mattia Basile,&nbsp;Michele Galasso,&nbsp;Ludovica Lenci,&nbsp;Angelo Giuseppe Marino,&nbsp;Diego Maffeo,&nbsp;Mario Scarpelli,&nbsp;Amelia Focaccio,&nbsp;Daniele Maselli,&nbsp;Carlo Briguori","doi":"10.1016/j.carrev.2025.12.016","DOIUrl":"10.1016/j.carrev.2025.12.016","url":null,"abstract":"<div><h3>Background and aims</h3><div>Suture-based vascular closure devices (S-VCD) plus the liberal use of an additional small plug-based VCD have been demonstrated to be superior to “pure” plug-based VCD (P-VCD) in patients treated with transcatheter aortic valve implantation (TAVI). Preliminary data suggests that the systematic use of the arteriotomy-site ballooning plus concomitant manual compression following P-VCD (MANTA, Teleflex) delivery may optimize the device apposition and should be adopted to improve the final hemostatic efficacy.</div></div><div><h3>Methods</h3><div>Consecutive patients undergoing transfemoral TAVI at two Italian centers were included. Patients treated with S-VCD and balloon assisted P-VCD were matched for major variables. The primary outcome was the occurrence of any in-hospital vascular complication. All outcomes were defined according to the Valve Academic Research Consortium (VARC)-3 statement.</div></div><div><h3>Results</h3><div>Overall, 799 patients were included (S-VCD: 451; balloon-assisted P-VCD: 348). Patients in the S-VCD group received 2 ProGlides (Abbott Vascular Inc.) plus the liberal use of an additional small plug-based VCD. Patients in the P-VCD group received the systematic use of the arteriotomy-site ballooning plus concomitant manual compression. After matching, 123 pairs of subjects were selected. The primary outcome occurred in 11.4 % of patients in the S-VCD group and 6.5 % in the balloon assisted P-VCD group (OR 0.56, 95 % CI (0.22–1.40); <em>p</em> = 0.217). Major VARC-3 vascular complications were more frequent in the S-VCD cohort (OR 0.12, 95 % CI (0.01–0.96); <em>p</em> = 0.048). No differences were found for the composite of major vascular complications and in-hospital death (OR 0.59, 95 % CI (0.19–1.88); <em>p</em> = 0.377). Any VARC-3 access related bleedings were slightly more frequent in the S-VCD group (OR 0.27, 95 % CI (0.07–0.99); <em>p</em> = 0.048), while no differences were evident for major bleedings (OR 0.28, 95 % CI (0.06–1.40); <em>p</em> = 0.122).</div></div><div><h3>Conclusions</h3><div>The balloon-assisted P-VCD showed similar vascular outcomes compared to traditional S-VCD in patients undergoing transfemoral TAVI.</div></div>","PeriodicalId":47657,"journal":{"name":"Cardiovascular Revascularization Medicine","volume":"90 ","pages":"Pages 11-15"},"PeriodicalIF":2.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145896988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The current and future in transcatheter treatment of aortic stenosis: from the ‘Beyond the Guidelines’ session at Cardiovascular Research Technologies 2026","authors":"Edward T. Ha,&nbsp;Holger Thiele,&nbsp;Michael Joner,&nbsp;Howard C. Herrmann,&nbsp;Hasanian A. Jilaihawi,&nbsp;Gilbert H.L. Tang,&nbsp;Isaac George,&nbsp;Thomas E. MacGillivray,&nbsp;Ron Waksman","doi":"10.1016/j.carrev.2026.07.018","DOIUrl":"10.1016/j.carrev.2026.07.018","url":null,"abstract":"<div><div>The introduction of transcatheter aortic valve replacement (TAVR) over two decades ago has fundamentally reshaped the management and treatment landscape for the treatment of severe aortic stenosis by introducing a less invasive approach compared to a surgical aortic valve replacement (SAVR). The field continues to rapidly evolve as clinical studies expand the indications for TAVR across all surgical risk strata. However, it is unclear whether TAVR can be safely applied to patients with complex aortic valve and root pathologies as well as match the long-term durability demonstrated by SAVR. Thus, optimizing patient selection to maximize net clinical benefit, by defining the indications and limitations of TAVR, continue to be areas of active research and discourse. To this end, the annual ‘Beyond the Guidelines’ session at the 2026 Cardiovascular Research Technologies (CRT) convened an expert panel to highlight the current state of evidence, summarize the accumulated evidence in current domains of clinical equipoise where investigative efforts are focused, and identify key areas of clinical unmet need. This article summarizes the expert panel discussions of current evidence supporting the latest societal guidelines on management of severe aortic stenosis, the accumulation of investigative evidence in established clinical domains of equipoise including TAVR for aortic stenosis in asymptomatic patients; those with bicuspid aortic valves, treatment of transcatheter aortic valve failure, and expert opinions on emerging areas of unmet need where future investigative efforts may need to be focused.</div></div>","PeriodicalId":47657,"journal":{"name":"Cardiovascular Revascularization Medicine","volume":"90 ","pages":"Pages 1-10"},"PeriodicalIF":2.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148686424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of chronic kidney disease on in-hospital outcomes among patients undergoing percutaneous coronary intervention for chronic total occlusions","authors":"David Šarenac,&nbsp;Ilija Doknić,&nbsp;Ronald K. Binder,&nbsp;Marko Banović","doi":"10.1016/j.carrev.2025.12.022","DOIUrl":"10.1016/j.carrev.2025.12.022","url":null,"abstract":"<div><h3>Background</h3><div>Approximately one-tenth of patients undergoing percutaneous coronary intervention (PCI) of a chronic total occlusion(CTO) have chronic kidney disease (CKD). There are limited data on outcomes in patients with CKD undergoing elective CTO PCI and our aim was to investigate the short-term outcomes of these patients.</div></div><div><h3>Methods</h3><div>We utilized Nationwide Inpatient Sample (NIS) database (years 2010–11) to identify all hospitalizations associated with elective single-vessel CTO PCI. Afterwards, patients were categorized into two groups according to CKD status, with the CKD group further stratified by stage. Primary outcome was in-hospital mortality and secondary outcomes were periprocedural complications. We also investigated the length of hospital stay and costs. Discharge weights were used to produce national estimates.</div></div><div><h3>Results</h3><div>We identified 6164 adult patients who underwent single-vessel CTO PCI. There were 604 patients (9.85 %) with CKD. They were older, with higher prevalence of hypertension, diabetes mellitus, atrial fibrillation, peripheral artery disease and chronic obstructive pulmonary disease. CKD was independently associated with higher in-hospital mortality, demonstrating a 74 % increase in odds per category (non-CKD, moderate-severe CKD [encompassing CKD stage 3–5] and end-stage renal disease requiring chronic dialysis). Patients with CKD had significantly higher rates of periprocedural myocardial infarction, acute kidney injury (AKI) and need for initiation of dialysis, as well as composite outcome of periprocedural complications. Consequently, this resulted in longer hospital stay and higher hospitalization costs.</div></div><div><h3>Conclusion</h3><div>CKD is independently associated with higher in-hospital mortality among patients undergoing elective single-vessel CTO PCI, demonstrating increasing odds with worsening CKD. Presence of CKD is associated with a higher rate of periprocedural complications, prolonged hospital stay and increased hospitalization costs.</div></div>","PeriodicalId":47657,"journal":{"name":"Cardiovascular Revascularization Medicine","volume":"90 ","pages":"Pages 47-53"},"PeriodicalIF":2.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145913425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term causes of death in patients who underwent mitral transcatheter edge-to-edge repair","authors":"Antonio Popolo Rubbio,&nbsp;Mihail Celeski,&nbsp;Antonio Sisinni,&nbsp;Marco Guerrini,&nbsp;Marta Barletta,&nbsp;Chiara Mainardi,&nbsp;Gaspare Cannone,&nbsp;Pietro Desimone,&nbsp;Antonino A. Nicodemo,&nbsp;Nedy Brambilla,&nbsp;Maurizio Tusa,&nbsp;Francesco Bedogni,&nbsp;Luca Testa","doi":"10.1016/j.carrev.2026.01.011","DOIUrl":"10.1016/j.carrev.2026.01.011","url":null,"abstract":"<div><h3>Background</h3><div>Transcatheter mitral edge-to-edge repair (M-TEER) has transformed the management of patients with severe mitral regurgitation (MR) at high or prohibitive surgical risk. However, data on long-term survival and causes of death after M-TEER remain limited.</div></div><div><h3>Methods and results</h3><div>This single-center registry included consecutive patients undergoing M-TEER with the MitraClip device for severe MR between February 2016 and June 2020. The primary objective was long-term mortality trends and causes of death. Over a median follow-up of 3.3 years (IQR 1.3–5.1; maximum 8.5 years), 130 of 218 patients (59.6%) died, with 55.4% due to cardiovascular (CV) causes, mainly heart failure (HF, 34.6%). Non-CV deaths were attributed to sepsis (15.4%), malignancy (10.8%), trauma (3.8%), and multi-organ failure (1.5%). CV mortality accounted for 55% of deaths within 1 year and 68.4% beyond 5 years, with no significant change in the CV/non-CV mortality ratio over time. Among 88 survivors, non-fatal CV events were infrequent: 12.5% were rehospitalized for HF and 2.3% underwent repeat M-TEER. Non-CV hospitalizations occurred in 9.1%, mainly due to fractures or pneumonia.</div><div>Independent predictors of all-cause mortality included ischemic secondary MR etiology, prior HF, TAPSE/sPAP ≤0.36, and ≥moderate tricuspid regurgitation, while a low MitraScore predicted better survival. A low MitraScore risk was associated with a significantly lower all-cause and CV mortality compared to a high Mitrascore risk (48.6% vs 83.9%, <em>p</em> &lt; 0.001; 21.0% vs 64.4%, <em>p</em> ≤ 0.001).</div></div><div><h3>Conclusion</h3><div>Long-term mortality after M-TEER remains influenced by extra-mitral cardiac involvement and non-cardiac comorbidities. The MitraScore preserves its prognostic accuracy during extended follow-up.</div></div>","PeriodicalId":47657,"journal":{"name":"Cardiovascular Revascularization Medicine","volume":"90 ","pages":"Pages 23-30"},"PeriodicalIF":2.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146114474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reperfusion therapy for older patients with acute myocardial infarction and cardiogenic shock","authors":"Yuko Kiyohara,&nbsp;Kota Minami,&nbsp;Lina Freeman,&nbsp;Wai Hong Wilson Tang,&nbsp;Sean P. Pinney,&nbsp;Yuichiro Yano,&nbsp;Toshio Naito,&nbsp;Satoshi Miyashita","doi":"10.1016/j.carrev.2026.01.008","DOIUrl":"10.1016/j.carrev.2026.01.008","url":null,"abstract":"<div><h3>Background</h3><div>Reperfusion therapy is the cornerstone of treatment for acute myocardial infarction (AMI) complicated by cardiogenic shock (CS). However, older adults with AMI and CS face higher risks of adverse outcomes and procedure-related complications. Since this population is under-represented in clinical trials, the efficacy of reperfusion therapy remains unclear. We performed a meta-analysis to evaluate the impact of reperfusion therapy on mortality in older adults with AMI and CS.</div></div><div><h3>Methods</h3><div>We searched PUBMED and EMBASE through 4/1/2025 for studies comparing reperfusion therapy with percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG) and non-reperfusion therapy for AMI and CS in patients aged ≥75 years. We included prospective and retrospective observational trials reporting clinical outcomes. The primary outcome was set as short-term mortality, and the secondary outcome was long-term mortality. We performed subgroup analysis of the primary outcome for patients with ST-segment elevation myocardial infarction and those without.</div></div><div><h3>Results</h3><div>Our search identified 14 eligible studies in a total of 4583 patients. Reperfusion therapy was associated with significantly reduced short-term mortality, compared with non-reperfusion therapy with high heterogeneity (odds ratio (OR): 0.47; 95% confidence interval (CI): 0.30–0.73, <em>I</em>^<em>2</em> = 76.8%). There was no significant difference in long-term all-cause mortality between reperfusion and non-reperfusion therapy (OR: 0.66; 95% CI: 0.34–1.26, <em>I</em>^<em>2</em> = 79.7%). The subgroup analyses were largely consistent with the main findings.</div></div><div><h3>Conclusions</h3><div>Reperfusion therapy was associated with reduced short-term mortality, compared to non-reperfusion therapy for older patients with AMI and CS. Reperfusion therapy showed a tendency towards reduced long-term mortality.</div></div>","PeriodicalId":47657,"journal":{"name":"Cardiovascular Revascularization Medicine","volume":"90 ","pages":"Pages 57-62"},"PeriodicalIF":2.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146094457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}