Journal of Maxillofacial & Oral Surgery最新文献

{"title":"Resection of Midfacial Tumors Assisted by Virtual Planning Based on CT/MRI Multimodal Image Fusion: A Cohort Study.","authors":"Lei-Hao Hu, Wei Zhou, Wen-Bo Zhang, Yao Yu, Zhi-Peng Sun, Xin Peng","doi":"10.1007/s12663-025-02441-3","DOIUrl":"10.1007/s12663-025-02441-3","url":null,"abstract":"<p><strong>Objective: </strong>This cohort study aimed to preliminarily explore the effect of midfacial tumor resection procedure with assistance of virtual planning based on CT/MRI multimodal image fusion.</p><p><strong>Methods: </strong>For the experimental cohort, patients with midfacial tumors receiving treatment from February 2019 to March 2021 were enrolled. Virtual planning was completed preoperatively based on CT/MRI multimodal image fusion. Tumor resection was performed under virtual planning-based surgical navigation, and intraoperative frozen sections were taken to determine resection margin status. For the control cohort, patients with midfacial tumors treated by the same surgical team were enrolled according to the same criteria. Patients underwent surgery assisted by virtual planning based on single-modality CT images. Resection margin and survival status were compared between groups during follow-up.</p><p><strong>Results: </strong>Altogether twenty-nine patients were enrolled. The resection margin status was significantly different between groups at the per-margin level (experimental group: 100% [66/66] negative; control group: 90.9% negative [70/77]; <i>P</i> = 0.014). During follow-up period, two patients in experimental cohort and seven patients in control cohort confirmed local recurrence.</p><p><strong>Conclusions: </strong>Patients with midfacial tumor who underwent virtual planning based on CT/MRI multimodal image fusion were more likely to have tumor-free resection margins. The use of the image fusion procedure may improve treatment outcomes in such patients.</p>","PeriodicalId":47495,"journal":{"name":"Journal of Maxillofacial & Oral Surgery","volume":"24 3","pages":"674-684"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122973/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Ideal Patient-Specific Implant: An Eight Step Design Checklist for Mandibular Class I,II Brown Defects.","authors":"Sanjay Kumar Roy Chowdhury, Karan Padha, Sneha Singh, Pradeep Yadav, Ravi Prajapati","doi":"10.1007/s12663-025-02502-7","DOIUrl":"10.1007/s12663-025-02502-7","url":null,"abstract":"<p><strong>Objectives: </strong>Patient-specific implants (PSI) are the next frontier in maxillofacial reconstruction, and though autogenous reconstruction of Brown I,II mandibulectomy defects is still the gold standard, the advantages of patient-specific implants, namely being reduced duration of surgery, prediction of failure due to biomechanical accuracy and FEA analysis, make it the prime alternative. However, the lack of standardisation in design leads to complications like wound dehiscence, poor dimensional accuracy and unoptimised biomechanics thus impeding its widespread acceptance among the scientific community.</p><p><strong>Methods: </strong>The authors aimed to address this lacunae in literature and answer the question whether PSI's can be designed through a standardised set of protocols? Through this study, the authors present an eight step checklist to be followed for designing of an ideal standardised patient-specific implant in a Brown I,II mandibular defect not involving the condyle which can serve as a go to guide for the operating and designing team.</p><p><strong>Conclusion: </strong>PSI's through an optimised designing and manufacturing process can serve as an exciting new treatment modality and an alternative to the gold standard autogenous reconstruction.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s12663-025-02502-7.</p>","PeriodicalId":47495,"journal":{"name":"Journal of Maxillofacial & Oral Surgery","volume":"24 3","pages":"707-715"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prognosis Predictive Value of Tumor Depth of Invasion on the Clinical Outcomes of Oral Squamous Cell Carcinoma Patients.","authors":"Talal Mohamed Ahmed Eltayib Mohamed, Yousif Idris Eltohami","doi":"10.1007/s12663-025-02524-1","DOIUrl":"10.1007/s12663-025-02524-1","url":null,"abstract":"<p><strong>Objectives: </strong>This study was conducted for the first time in the Sudan that aimed to assess whether the tumor depth of invasion (DOI) in oral squamous cell carcinoma (OSCC) is a prognosticator for regional nodal metastasis, locoregional recurrence, survival and identify the cutoff point for metastasis.</p><p><strong>Methods: </strong>Descriptive retrospective cross-sectional hospital based study carried out at Khartoum Teaching Dental Hospital (KTDH) and histopathology laboratory, University of Khartoum. Records of patients were retrieved from the archives of KTDH and the histopathological records were retrieved from archival specimens of Oral Pathology laboratory, University of Khartoum. Data of patients who underwent primary radical surgery for OSCC and neck dissection at KTDH were reviewed.</p><p><strong>Results: </strong>A total of 127 cases, 84 were males and 43 were females.Sixty-seven were snuff dippers.Thirty-six of the total number of snuff dippers favored the lower labial vestibule. Lower gingivolabial area was the favorite site for OSCC that encountered in 52 patients. In the present study, 93 of patients presented with stage IV and the predominant grade was well differentiated squamous cell carcinoma that found in 67 patients. There is a high significant association between depth of invasion and recurrence. Among 60 patients who developed recurrence, 55 of them had DOI ≥ 4 mm. From total of 24 patients with DOI > 4 mm, six patients died, and from total of 101 patients with DOI ≥ 4 mm, 62 patients died that indicated a high significant association between depth of invasion and death with a survival period 27.05 ± 23.08 months in patients with DOI ≥ 4 mm and 44.77 ± 19.20 months in patients with DOI < 4 mm. Patients with positive surgical margins were 9.9 timed more likely to develop recurrence.</p><p><strong>Conclusions: </strong>DOI of OSCC is a reliable histological parameter to predict nodal metastasis, locoregional recurrence and survival with 4 mm cutoff point.</p>","PeriodicalId":47495,"journal":{"name":"Journal of Maxillofacial & Oral Surgery","volume":"24 3","pages":"699-706"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) Expression and Its Prognostic Significance in Oral Cancer Patients.","authors":"Jyoti Saini, Jaimanti Bakshi, Maryada Sharma, Ahmad K Alnemare, Turki Bin Mahfoz, Atul Kumar Goyal","doi":"10.1007/s12663-025-02517-0","DOIUrl":"10.1007/s12663-025-02517-0","url":null,"abstract":"<p><strong>Background: </strong>Tissue inhibitors of matrix metalloproteinases (TIMPs) are natural inhibitors of matrix metalloproteinases (MMPs) that inhibit the action of MMPs in 1:1 stoichiometry. TIMP-1 inhibits MMP-9 and MMP-13 and keeps them in an inactive stage. The imbalance between the MMPs and TIMPs disturbs the integrity of the extracellular matrix, which leads to disease progression and metastasis.</p><p><strong>Objective: </strong>The aim of the present study is to analyze the expression of TIMP-1 in oral cancer patients and compare it with a healthy control. We also analyze the TIMP-1 expression in patients over a two-year follow-up. Moreover, the present study also correlated the TIMP-1 expression with the survival duration, recurrence, and mortality rate. Additionally, predictive accuracy of TIMP-1 for survival outcomes was evaluated.</p><p><strong>Methodology: </strong>A total 60 subjects enrolled in this study among which 46 were oral cancer patients and 14 were healthy controls. TIMP-1 expression was analyzed in serum samples of healthy controls and patients using the ELISA. Immunohistochemical analysis of IHC was also done for tissue samples of patients. After two years of follow-up, TIMP-1 was again analyzed using ELISA in serum samples of oral cancer patients. TIMP-1 concentration was compared between controls and patients and in patients after two years of follow-up. TIMP-1 expression level was correlated with the overall survival, disease-free survival, mortality, and recurrence rates.</p><p><strong>Results: </strong>The mean concentration of TIMP-1 was found to be significantly higher in the oral cancer patients (487.4 ± 459.4 ng/ml) as compared to the healthy control (205.1 ± 109.3 ng/ml). TIMP-1 levels were also found to be significantly higher in oral cancer patients after two years of follow-up (487.4 ± 459.4 ng/ml) as compared to the baseline values. The mean TIMP-1 concentration was found to be higher in mortality cases (566.89 ± 493.11 ng/ml) as compared to the survival cases (469.31 ± 465.59 ng/ml); however, the difference was not statistically significant. TIMP-1 concentration exhibits a nonsignificant weak negative correlation with overall survival, whereas it exhibits a nonsignificant but strong negative correlation with disease-free survival. TIMP-1 was found to be 54% accurate in predicting mortality and 38% accurate in predicting the recurrence.</p><p><strong>Conclusion: </strong>This study underscores the potential of TIMP-1 as a prognostic marker in oral cancer. A high expression of TIMP-1 was found to be correlated with poor treatment outcomes in the patients. A possible reason for this could be an additional intracellular FAK signaling pathway that led to cell proliferation or TIMP-1 may have found to be rise in response to higher MMPs in the cancer cases. Further studies need to investigate the network of interconnected molecular pathways playing a role in disease progression.</p>","PeriodicalId":47495,"journal":{"name":"Journal of Maxillofacial & Oral Surgery","volume":"24 3","pages":"690-698"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Clinico-Radiological Study to Evaluate the Risk of Inferior Alveolar Nerve Damage in Impacted Mandibular Third Molar Removal.","authors":"Akash Sehgal, Vivek Saxena, H Rangarajan, V Gopalakrishnan, Kritika Dewan","doi":"10.1007/s12663-025-02498-0","DOIUrl":"10.1007/s12663-025-02498-0","url":null,"abstract":"<p><strong>Introduction: </strong>Impacted mandibular third molar (IMTM) extraction, is the most commonly performed surgical procedure in oral and maxillofacial surgery, which may present with post-op complications like Inferior Alveolar neurosensory deficit (IANSD). Risk factor assessment by correlating pre-op OPG, CBCT findings with intra-op parameters provides a comprehensive tool for predicting nerve injury which forms the basis of this clinico-radiological study.</p><p><strong>Materials and method: </strong>Hundred patients with IMTM taken up for transalveolar extraction secondary to varied etiologies, were evaluated for post-op IANSD while comparing pre-op OPG and CBCT association with Intra-op parameters like hemorrhage, odontectomy, bone removal and physical observation of the canal. Affected patients on the 7th day were then followed up for 14th day, 01 month and 6 months for evaluating resolution of neurosensory deficit.</p><p><strong>Results: </strong>A total of <i>n</i> = 9 out of 100 patients presented with post-surgical IANSD. Pre-op OPG findings of loss of white lines, deflection of roots and CBCT findings of inferior and lingual canal position were predominant attributable factors (<i>p</i> = 0.017). Intra-operatively, hemorrhage (<i>p</i> = 0.001), bone removal (<i>p</i> = 0.016) and odontectomy (<i>p</i> = 0.427) were associated with deficit in decreasing order while canal observation was definitely associated with IANSD (<i>p</i> = 0.007). All the patients recovered at 06 month follow up depicting only transient neurosensory deficit in our study sample.</p><p><strong>Conclusion: </strong>Varied anatomic orientation of IMTM and its intimate association with IANC may pose as an indicator of post-op IANSD causing both surgeon and patient dissatisfaction. It is, thus, important to assess tooth and canal complex thoroughly and educate the patients about possible IANSD complication after correlating them with intra-op findings to avoid undue clinical surprises.</p>","PeriodicalId":47495,"journal":{"name":"Journal of Maxillofacial & Oral Surgery","volume":"24 3","pages":"775-784"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adenomatoid Odontogenic Tumor: Histomorphological Evidence of Its Origin from the Cystic Component and Literature Review.","authors":"Ana Terezinha Marques Mesquita, Gabriela Fonseca Rocha, Karina Helen Martins, Camila de Oliveira Barbeiro, Heitor Albergoni Silveira, Jorge Esquiche León","doi":"10.1007/s12663-025-02503-6","DOIUrl":"10.1007/s12663-025-02503-6","url":null,"abstract":"<p><strong>Objectives: </strong>Adenomatoid odontogenic tumor (AOT) is a distinct benign odontogenic tumor, with relevant studies indicating that a cystic component can be found in about half of cases; however, controversy still exists regarding its true nature.</p><p><strong>Methods: </strong>Here, we show an interesting case of follicular AOT affecting the maxilla of a 13-year-old girl, which was predominantly cystic with intraepithelial calcified deposits, including histomorphological changes of its basal and parabasal layers, in close connection with typical AOT nests, the same ones that looked like detach or originate from this cystic component.</p><p><strong>Conclusion: </strong>Our findings suggest the that the cystic component is part of the tumor in an AOT subgroup, which should also be considered.</p>","PeriodicalId":47495,"journal":{"name":"Journal of Maxillofacial & Oral Surgery","volume":"24 3","pages":"826-829"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tunneled Tongue-Lip Adhesion-Method Redefined: A Technical Note.","authors":"Saruchi Agarwal, Pushkar P Waknis, Samkit V Sakhariya, Kannan Balaraman","doi":"10.1007/s12663-025-02539-8","DOIUrl":"10.1007/s12663-025-02539-8","url":null,"abstract":"","PeriodicalId":47495,"journal":{"name":"Journal of Maxillofacial & Oral Surgery","volume":"24 3","pages":"758-759"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Kidney-Shaped Innovative Pectoralis Major Myocutaneous (PMMC) Flap for Reconstruction of Bite Resection Defect: A Case Report.","authors":"Pushkar P Waknis, Bhushan R Bhagat, Mehek Oswal, Ria Raghavan, Lakshmi Shetty","doi":"10.1007/s12663-025-02545-w","DOIUrl":"10.1007/s12663-025-02545-w","url":null,"abstract":"<p><p>The case presentation involves a 51-year-old male with a diagnosis of moderately differentiated keratinizing squamous cell carcinoma located in the right gingivobuccal mucosa and sulcus. Following extensive surgical resection, including right partial mandibulectomy, partial maxillectomy, and modified radical neck dissection, reconstruction was performed using kidney-shaped pectoralis major myocutaneous (PMMC) flap. This method aims to overcome the shortcomings of conventional flap designs by offering a reconstruction that is more customized and practical.</p>","PeriodicalId":47495,"journal":{"name":"Journal of Maxillofacial & Oral Surgery","volume":"24 3","pages":"716-719"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing Analgesic Efficacy of Intranasal Fentanyl Using Mucosal Atomization Device Versus Intravenous Fentanyl for Management of Breakthrough Pain in Head and Neck Cancer Patients: A Randomized Clinical Trial.","authors":"Tanya Takkar, S Gidean Arularasan, R Ramsesh Manohar, Murugesan Krishnan, M P Santhosh Kumar","doi":"10.1007/s12663-025-02506-3","DOIUrl":"10.1007/s12663-025-02506-3","url":null,"abstract":"<p><strong>Aim: </strong>The purpose of this study is to compare the analgesic efficacy of intranasal fentanyl versus intravenous fentanyl and their role in reducing the pain intensity in breakthrough pain in patients with head and neck cancer.</p><p><strong>Material and methods: </strong>This study includes 30 patients who were diagnosed with head and neck cancer and underwent surgery for the same. Patients were divided into 2 groups: group A receiving intranasal fentanyl 1 mcg/kg using mucosal atomization device and group B receiving intravenous fentanyl 1 mcg/kg when the patient complained of the breakthrough pain postoperatively; both the groups received 1 g paracetamol IV every 8 hourly. The primary outcome pain was assessed using FLACC scale.</p><p><strong>Results: </strong>Onset of action of drug was an average of 5 min in group A and 15 min in group B. No incidence of bradycardia, hypotension was seen in both the groups.</p><p><strong>Conclusions: </strong>We concluded that intranasal administration of fentanyl provides better postoperative breakthrough pain relief and opioids are the rescue medication of choice for breakthrough pain and it should be individually titrated as needed to achieve adequate pain relief while minimizing the risk of side effects.</p>","PeriodicalId":47495,"journal":{"name":"Journal of Maxillofacial & Oral Surgery","volume":"24 3","pages":"685-689"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to \"Proactive Customized Protocol for Oral Management in Head and Neck Cancer Patients Planned for Radiotherapy\".","authors":"Efsun Somay, Erkan Topkan, Ugur Selek","doi":"10.1007/s12663-025-02509-0","DOIUrl":"10.1007/s12663-025-02509-0","url":null,"abstract":"","PeriodicalId":47495,"journal":{"name":"Journal of Maxillofacial & Oral Surgery","volume":"24 3","pages":"723-724"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}