Journal of Maxillofacial & Oral Surgery最新文献

{"title":"Tie and Tucker: A Technical Note from Surgeons View.","authors":"V Venugopalan, R Sathyanarayanan, S Duraimurugan","doi":"10.1007/s12663-023-01930-7","DOIUrl":"10.1007/s12663-023-01930-7","url":null,"abstract":"<p><p>Intermaxillary fixation using erich arch bars is a common treatment in maxillofacial trauma. The arch bars are stabilized and fixed to maxillary and mandibular arches with interdental wires which are twisted, cut and bent to make loops. Wire twisters and artery forceps are used to bend and make loops of cut twisted wires with difficulty. The orthodontic tie and tucker can be incorporated in oral surgery to bend the cut end of the twisted interdental arch bar wires to make consistent loops.</p>","PeriodicalId":47495,"journal":{"name":"Journal of Maxillofacial & Oral Surgery","volume":"1 1","pages":"407-408"},"PeriodicalIF":0.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13066047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41376568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting Distant Metastasis in Head and Neck Squamous Cell Carcinoma: A Machine Learning Analysis of 31,060 Patients from the SEER Database.","authors":"Changping Ma, Xinyi Xu, Yaoqi Chen, Jingjing Mao, Jiawen Xue, Zhongwei Zhou","doi":"10.1007/s12663-025-02683-1","DOIUrl":"https://doi.org/10.1007/s12663-025-02683-1","url":null,"abstract":"<p><strong>Background: </strong>Accurate assessment of the risk of distant metastasis of head and neck squamous cell carcinoma (HNSCC) is important for the development of personalized treatment and prognosis. The purpose of this study was to explore the risk factors for distant metastasis of HNSCC and to establish a predictive model using machine learning methods.</p><p><strong>Materials and methods: </strong>We designed a retrospective cross-sectional study with a cohort from the SEER database (affiliated with the National Cancer Institute). A total of 31,060 cases of head and neck cancer were included by our inclusion criteria. We constructed four machine learning models-logistic regression, decision tree, XGBoost, and neural network-to predict the risk of distant metastasis in HNSCC patients and compared the performance of the four models. Accuracy, precision, recall, and F1-score were used to evaluate the performance of the model. The evaluation ability and clinical practicability of the model were verified by comparing the area under the curve and the receiver operating characteristic curve.</p><p><strong>Results: </strong>The receiver operating characteristic of the four models ranged from 0.681 to 0.847. The average accuracy of all algorithms was 77%, and XGBoost had the highest accuracy of 85.119%. Among the four models, XGBoost and logistic regression had the highest precision, both with precision greater than 79. Neural network had the highest recall and F1-score. Decision tree had the lowest accuracy and recall. Among the four models, XGBoost achieved the highest AUC (0.846) and accuracy (85.1%), outperforming neural networks (AUC: 0.837) and logistic regression (AUC: 0.838).</p><p><strong>Conclusion: </strong>XGBoost had the highest classification accuracy, so this machine learning method could be used to predict distant metastasis of HNSCC. The application of machine learning algorithms can stratify patients with HNSCC in clinic, which is conducive to the development of personalized treatment plans.</p><p><strong>Clinical relevance: </strong>The findings of this study have significant implications clinical management of HMSCC. The model's top predictors were surgical treatment (OR: 0.33) and lymph node involvement (OR: 3.37), suggests that this machine learning algorithm could be effectively integrated into clinical practice to predict distant metastasis in HMSCC patients. This has the potential to enhance the accuracy of prognostic assessments, thereby facilitating more informed treatment planning and personalized care.</p>","PeriodicalId":47495,"journal":{"name":"Journal of Maxillofacial & Oral Surgery","volume":"25 2","pages":"370-377"},"PeriodicalIF":0.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13066069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-Specific Implants as a Treatment of Oral Manifestations of Aggressive Periodontitis Accompanying Papillon-Lefèvre Syndrome. A Case Report.","authors":"Hesham El-Hawary, Ammar Yasser Oun, Yomna Ahmed AbouMousa, Mohamed Shawky","doi":"10.1007/s12663-025-02499-z","DOIUrl":"https://doi.org/10.1007/s12663-025-02499-z","url":null,"abstract":"<p><strong>Objectives: </strong>A case report of aggressive periodontitis that accompanied Papillon-Lefèvre syndrome in a 19-year-old female patient. It demonstrates a full workflow for full mouth rehabilitation of this case using patient-specific subperiosteal implants (SPIs) with modifications in the designing and surgical installation protocol to enhance its adaptation, stability, and long-term prognosis.</p><p><strong>Methods: </strong>A complete virtual planning was performed. Virtual extraction of teeth was done. SPIs were designed to rest on the basal bone crestally with extended prosthetic posts where implant platforms were equigingival to allow seating of the prosthesis. Surgical guides were 3D printed, and the plan was then surgically implemented. Digital design and construction of a fixed prosthesis were performed to restore teeth, gingiva, and alveolar bone.</p><p><strong>Conclusions: </strong>The modification in the design of the SPIs performed allows for better retention and stability in addition to the fixation of a screw-retained fixed-retained prosthesis for the patient. This approach offers a predictable and efficient alternative to traditional implant therapy, particularly in cases where bone grafting is contraindicated or unlikely to succeed.</p>","PeriodicalId":47495,"journal":{"name":"Journal of Maxillofacial & Oral Surgery","volume":"25 2","pages":"475-484"},"PeriodicalIF":0.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13065927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Evaluation of Erich Arch Bars with Hybrid Arch Bars for Maxillomandibular Fixation in the Treatment of Mandibular Fractures: A Prospective Clinical Study.","authors":"Saumya Kapoor, Parimala Sagar, Kavitha Prasad","doi":"10.1007/s12663-025-02763-2","DOIUrl":"https://doi.org/10.1007/s12663-025-02763-2","url":null,"abstract":"<p><strong>Aim: </strong>To compare the effectiveness of hybrid arch bars with Erich arch bars for intermaxillary fixation in mandibular fracture treatment.</p><p><strong>Materials and methods: </strong>The study consisted of 22 patients presenting with mandibular fractures. Patients undergoing IMF using Erich arch bars were allocated to group 1 and hybrid arch bars to group 2, with an equal number of patients being allocated in each group. Patients were recalled for a follow-up at three-week intervals to evaluate the gingival health, patient satisfaction and operator satisfaction.</p><p><strong>Results: </strong>Twenty-two patients were enrolled in this study; <i>p</i> value of the gingival index was recorded in both the groups at pre-, mid- and postoperative periods, which were 0.947, 0.858 and 0.338, respectively. The mean value of the Hospital Anxiety and Depression Scale was 3.90 for Erich arch bar and 4.63 for the hybrid arch bar. The depression component did not have much variation. The mean Visual Analog Scale values for Erich arch bar and hybrid arch bar were 3.36 and 2.45, respectively. Patient satisfaction values were not statistically significant in both groups. Operator satisfaction for the Erich and hybrid arch bar groups was 5.36 and 5.54, respectively.</p><p><strong>Conclusion: </strong>Hybrid arch bars are as effective as Erich arch bars in mandibular fractures, requiring closed reduction and intermaxillary fixation but with an inherent set of complications.</p>","PeriodicalId":47495,"journal":{"name":"Journal of Maxillofacial & Oral Surgery","volume":"25 2","pages":"394-400"},"PeriodicalIF":0.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13066049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Versatility of Lateral Orbitotomy Approach for Intra-orbital Lesions-A Retrospective Study.","authors":"Arunkumar Kamalakaran, Balaji Jayaraman, Rohini Thirunavukarasu, Kamalakannan Padmanaban, Priyadharshini Raghavan","doi":"10.1007/s12663-025-02589-y","DOIUrl":"https://doi.org/10.1007/s12663-025-02589-y","url":null,"abstract":"<p><strong>Background: </strong>Orbital tumors can occur in any part of the orbit. The safest and the most direct approach should be chosen based on the location and the extension of the tumor. The lateral orbitotomy was first described by Kronlein in 1889.</p><p><strong>Methods: </strong>This retrospective study evaluates the effectiveness of lateral orbitotomy in accessing pathologies within the lateral orbit. 10 patients underwent lateral orbitotomy to treat lesions lateral to the optic nerve. The patients' mean follow-up period ranged from 2 to 3 years.</p><p><strong>Results: </strong>Preoperatively, all patients presented with proptosis, while 80% had decreased visual acuity, 40% experienced diplopia, and 40% had restricted extraocular movements. Postoperatively, all patients showed significant improvement in proptosis, while 100% of those with diplopia and 100% of those with restricted extraocular movements experienced complete resolution of their symptoms. However, one patient developed ophthalmoplegia as a post-operative complication. Definitive surgical outcomes were graded as good, when postoperatively the visual acuity and ocular mobility were normal and the proptosis remitted partially or completely, fair, when the visual acuity remained unchanged but the proptosis reduced significantly and poor, when post-operative permanent visual impairment and irreversible proptosis were observed. Good surgical outcome was seen in eight patients, fair in one patient and poor in one patient.</p><p><strong>Conclusion: </strong>Our study demonstrates that lateral orbitotomy is a safe and effective approach for accessing lesions in the lateral and superolateral compartments of the orbital cavity, offering good aesthetic outcomes and minimal morbidities compared to transcranial approaches.</p>","PeriodicalId":47495,"journal":{"name":"Journal of Maxillofacial & Oral Surgery","volume":"25 2","pages":"544-548"},"PeriodicalIF":0.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13066075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Dilemma: Intracanal Schwannoma of Inferior Alveolar Nerve: A Rare Case Presentation.","authors":"Paramjit Kajla, Rachana Galinde, S P S Sooch, Sharad Gowda, Manpreet Kaur","doi":"10.1007/s12663-025-02518-z","DOIUrl":"https://doi.org/10.1007/s12663-025-02518-z","url":null,"abstract":"<p><p>An intraosseous schwannoma is an infrequent benign tumour originating from Schwann cells. It can present at any age, but is more prevalent in the 2nd-3rd decade of life. They can be seen as large single unilocular or multilocular radiolucency resembling other intraosseous benign lesions of the jaw. This case report presents an intraosseous schwannoma in the posterior mandibular region of 34 years aged male patient with the chief complaint of paraesthesia and radiographic presentation with fusiform expansion of inferior alveolar nerve canal. The tumour was managed by complete excision and curettage along with resection of entrapped inferior alveolar nerve fibre, leaving most of nerve bundle unblemished. Patient was followed up regularly for any signs of recurrence and resolution of paraesthesia.</p>","PeriodicalId":47495,"journal":{"name":"Journal of Maxillofacial & Oral Surgery","volume":"25 2","pages":"558-562"},"PeriodicalIF":0.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13066083/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does the Use of Transcutaneous Electrical Nerve Stimulation Improve Temporomandibular Disorders After Orthognathic Surgeries?","authors":"Majid Nemati, Shakila Peimani, Ensiyeh Cheraghchibashi Astaneh, Samir Aboul Hosn Centenero, Reza Tabrizi","doi":"10.1007/s12663-025-02697-9","DOIUrl":"https://doi.org/10.1007/s12663-025-02697-9","url":null,"abstract":"<p><strong>Background: </strong>Temporomandibular disorders (TMD) occur in a small number of patients who undergo orthognathic surgery. Transcutaneous electrical nerve stimulation (TENS) is a treatment modality used to manage TMD.</p><p><strong>Objective: </strong>This study aimed to assess the effects of TENS on reducing symptoms following orthognathic surgery.</p><p><strong>Methodology: </strong>This was a pre-protocol randomized clinical trial. Patients with retrognathia and myogenic temporomandibular joint disorders following mandibular advancement were studied. The subjects were randomly divided into two groups: the treatment group, which received TENS, and the control group. This study was conducted at Shahid Beheshti University of Medical Science. Patients in the treatment group underwent 10 sessions of TENS two months after surgery, which were repeated 1 month later. The main outcomes of the study were pain severity measured using a visual analog scale and maximum mouth opening (MMO). Pain and MMO were assessed 1, 3, 6 months after the intervention.</p><p><strong>Results: </strong>A total of 29 patients were included in group I (TENS) and 31 in group II (control). Pain was significantly different between the treatment and control groups 3 and 6 months after the intervention (p = 0.001, p < 0.001 retrospectively). MMO was significantly different between the treatment and control groups at 1, 3, and 6 months after the intervention (<i>p</i> = 0.032, <i>p</i> = 0.007, <i>p</i> = 0.013 retrospectively).</p><p><strong>Conclusion: </strong>TENS appears that TENS is effective for pain relief and improvement in maximum mouth opening (MMO) in patients with temporomandibular disorder (TMD) following orthognathic surgery.</p>","PeriodicalId":47495,"journal":{"name":"Journal of Maxillofacial & Oral Surgery","volume":"25 2","pages":"430-437"},"PeriodicalIF":0.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13066068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147676682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"End to Side Microvascular Anastomosis in External Carotid Artery in Vessel Depleted Neck: A Case Series.","authors":"Himanshu Koyani, Prashant Vanzar, Darshan Patel, Hardik Mehta, Hemal Sejani, Ravirajsinh Gohil, Imtiyaz Dodhiya","doi":"10.1007/s12663-025-02765-0","DOIUrl":"https://doi.org/10.1007/s12663-025-02765-0","url":null,"abstract":"<p><strong>Introduction: </strong>Overtime, there have been significant changes in reconstructive techniques. The effectiveness of free flap reconstruction has increased with improved surgical technique as well as technological refinement in vessel selection and flap monitoring.</p><p><strong>Material and method: </strong>Twenty-five patients were included into this study, and surgeries were performed during the period of 3 months from January to March 2025 at our tertiary care center.</p><p><strong>Results: </strong>Only 8% of total n = 25 patient had complication in microvascular surgery and needed re-exploration but no flap failure was noted.</p><p><strong>Discussion: </strong>End-to-side anastomosis to the ECA is particularly beneficial in challenging clinical scenarios such as previously irradiated necks, infected or contaminated surgical fields, or when the distal branches of the ECA are atherosclerotic and unsuitable for end-to-end anastomosis.</p><p><strong>Conclusion: </strong>This technique ensures more stable and laminar arterial flow, which, in turn, reduces the risk of arterial thrombosis and improves overall flap survival.</p>","PeriodicalId":47495,"journal":{"name":"Journal of Maxillofacial & Oral Surgery","volume":"25 2","pages":"365-369"},"PeriodicalIF":0.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13065915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perineural Invasion in Head and Neck Malignancies: Clinical, Radiological and Pathological Correlation.","authors":"Veena B Ganga, Krishnappa","doi":"10.1007/s12663-025-02748-1","DOIUrl":"https://doi.org/10.1007/s12663-025-02748-1","url":null,"abstract":"<p><strong>Background: </strong>Perineural invasion (PNI) is a significant prognostic factor in head and neck malignancies, influencing treatment decisions and survival outcomes. This study aims to evaluate the prevalence of PNI across different subsites and its correlation with clinical, radiological, and pathological indicators.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 216 patients who underwent surgical management with or without adjuvant therapy between 2016 and 2019. The prevalence of PNI was assessed across different anatomical subsites, and the correlation between radiological and pathological indicators was statistically analyzed using the chi-square test.</p><p><strong>Results: </strong>Oral cavity squamous cell carcinoma was the most common malignancy (61%), followed by tumors of the larynx, hypopharynx, maxilla, salivary glands, and skin. Radiological indicators of PNI were detected in 17.2% of oral cavity tumors, 11.1% of laryngeal and hypopharyngeal tumors, 71.1% of maxillary tumors, and 80% of salivary gland malignancies. Pathological confirmation of PNI was noted in 20.3% of oral cavity tumors, 28.9% of laryngeal and hypopharyngeal tumors, 57.1% of maxillary tumors, and 80% of salivary gland malignancies. A significant association was observed between tumor subsite and PNI detection (<i>p</i><0.001), highlighting variability in diagnostic accuracy.</p><p><strong>Conclusion: </strong>PNI is a critical factor across multiple head and neck subsites, with maxillary and salivary gland malignancies exhibiting the highest prevalence. The discrepancy between radiological and pathological detection underscores the need for improved imaging protocols and molecular characterization of PNI. Further research is warranted to explore the biological mechanisms underlying PNI and its potential role as a therapeutic target.</p>","PeriodicalId":47495,"journal":{"name":"Journal of Maxillofacial & Oral Surgery","volume":"25 2","pages":"359-364"},"PeriodicalIF":0.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13066148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Treating Myofascial Pain by Injecting Masseter and Temporalis Muscles with Botulinum Toxin.","authors":"Ahmed M Abdul Rahman, Zahraa M Al-Hawwaz, Sarah A Haji","doi":"10.1007/s12663-025-02895-5","DOIUrl":"https://doi.org/10.1007/s12663-025-02895-5","url":null,"abstract":"<p><strong>Aims and objectives: </strong>Botulinum toxin (BTX) injections have gained great attention for the management of myofascial pain involving the masticatory muscles as alternative or complementary to other treatments. The objective is to evaluate how effective the botulinum toxin injections in reducing myofascial pain of the masseter and temporalis muscles through assessing pain changes over time and factors influencing treatment outcomes.</p><p><strong>Methods: </strong>A prospective clinical study was conducted between January 2019 and November 2024 in Basrah, Iraq. The number of patients to be enrolled was the 320 patients who had myofascial pain and 200 patients had completed the follow-up. Pain intensity was measured on a pain scale at baseline and structural follow-ups on an interval of several follow-ups following botulinum toxin injection on masseter and temporalis muscle tender points.</p><p><strong>Results: </strong>The mean pain scores were lower at two years of follow up as compared to the baseline of 7.99 with a standard deviation of 0.79, which had reduced to 3.87 with a standard deviation of 1.53. The highest reduction of pain was experienced during the early follow up but it was sustained. At 8 weeks, younger patients (2635 years) had lower pain scores. There was a small difference in genders and more pain reduction was experienced by married patients. The increased income and education level was correlated with a low score of pain in the early follow-up. But the differences decreased by the two year assessment.</p><p><strong>Conclusion: </strong>The effects of Botulinum toxin injections are a large and long-lasting decrease in myofacial pains of the masseter and temporalis muscles. Early pain reaction may depend on demographic and socio-economic factors, but the long-term results seem to be similar.</p>","PeriodicalId":47495,"journal":{"name":"Journal of Maxillofacial & Oral Surgery","volume":"25 2","pages":"501-508"},"PeriodicalIF":0.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13066046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}