Journal of Maxillofacial & Oral Surgery最新文献

{"title":"Radioguided Surgery for the Localisation of Specific Adenopathies in the Head and Neck Area.","authors":"Miren de Las Fuentes Monreal, Valentina Castillo Morales, Isabel Hernández Pérez, Isabel Lopez Villar, Verónica Escorial Hernández, Mario Fernando Muñoz-Guerra","doi":"10.1007/s12663-023-01991-8","DOIUrl":"10.1007/s12663-023-01991-8","url":null,"abstract":"<p><strong>Purpose: </strong>Intraoperative identification and excision of specific lymphadenopathies is not always easy; it is, therefore, important to have complementary techniques that help us in the identification of these structures intraoperatively. The aim of this study is to present preliminary results of the use of ROLL technique (radioguided occult lesion localisation) as a method of excisional biopsy in the head and neck territory.</p><p><strong>Material and methods: </strong>We present 10 cases of patients with difficult to localise lymphadenopathies in the head and neck territory that underwent the ROLL technique. The radiotracer was only injected in the nodes that we wanted to study; in this way, all of them were correctly identified and extracted without resecting those that had no signs of pathology avoiding removing healthy lymphatic tissue and reducing morbidity.</p><p><strong>Results: </strong>The ROLL technique is a useful technique, since in all of the patients, the previously marked adenopathy was accurately identified and excised; we reduced the intraoperative time and avoided the complications derived from more aggressive cervical exploratory surgeries.</p>","PeriodicalId":47495,"journal":{"name":"Journal of Maxillofacial & Oral Surgery","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11455826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49553936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Can Perioperative Intravenous Lidocaine Decrease Postoperative Pain After Oral and Maxillofacial Surgeries?\": A Randomized Clinical Trial.","authors":"Vivek Kumar Mahato, Ashok Dongol, Pradeep Acharya, Anjani Kumar Yadav, Asish Subedi, Mehul R Jaisani","doi":"10.1007/s12663-022-01831-1","DOIUrl":"10.1007/s12663-022-01831-1","url":null,"abstract":"<p><strong>Purpose: </strong>To determine the efficacy of perioperative intravenous lidocaine in decreasing postoperative pain after oral and maxillofacial surgeries.</p><p><strong>Methods: </strong>Forty patients undergoing various oral and maxillofacial surgeries under general anesthesia were recruited in this prospective, randomized, double blinded controlled trial. Lidocaine group received Lidocaine 2.0%, whereas the control group received Normal saline 0.9% infusion. Pain intensity, sedation, vitals and side effects were assessed at 2 h, 4 h, 6 h, 12 h and 24 h postoperatively.</p><p><strong>Results: </strong>Twenty patients were assigned to each group. There were no significant differences between the groups for the study variables at baseline. The median Numeric Rating Scale (NRS) pain scores were higher in normal saline group than lidocaine group at 2 h, 4 h and 6 h and same at 12and 24 h; however, the differences were not statistically significant. Mean (± SD) analgesic consumed in lidocaine group was 47.37 (± 42.80) mg and 69.47(± 36.13) mg in saline group, which was not significant either. Similarly, no statically significant difference was observed for sedation and vitals at all the time intervals.</p><p><strong>Conclusion: </strong>Perioperative infusion of low dose lidocaine does not have significant effect on reduction in postoperative pain intensity and analgesic consumption, in patients undergoing oral and maxillofacial surgeries. <i>Trail registered at clinicaltrials</i>.gov (NCT03479320).</p>","PeriodicalId":47495,"journal":{"name":"Journal of Maxillofacial & Oral Surgery","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11455827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42377787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment Patterns of Oral and Maxillofacial Surgery: A 3-Year Retrospective Study in Major Industrial Region in Eastern India.","authors":"Ramashankar Choudhary, Ballamudi Sarat Ravi Kiran","doi":"10.1007/s12663-023-01870-2","DOIUrl":"10.1007/s12663-023-01870-2","url":null,"abstract":"<p><strong>Introduction: </strong>This study is designed to outline the likely patterns of treatment modalities based on patient demographics and mechanism of injury in eastern region of India (industrial area).</p><p><strong>Objective: </strong>To evaluate the various treatment patterns in eastern region of India and for better understanding of providing patient care.</p><p><strong>Materials and methods: </strong>We conducted a retrospective study by collecting data from the records of the patients who reported at our institution from 2018 to 2020. The types of the major procedures done at the department were classified based on the type and the area of the trauma. The data were tabulated using Excel sheet and projected in percentages. Later with statistical analysis by one-way ANOVA, the different groups were compared with SPSS version 20.0.</p><p><strong>Results: </strong>The total number of patients observed were 197. The gender distribution was M/F = 1.31:1. Comminuted mandibular fracture had the highest incidence with RTA (road traffic accident) being the most prevalent etiology, whereas no significant difference was found between the types of procedures performed and demography of the patients.</p><p><strong>Conclusion: </strong>Being a dominant industrial area (Jharkhand), it can be concluded that facial trauma is seen predominant in this part of eastern India due to road traffic accidents with heavy, high-speed vehicles and lack of awareness in using protective safety accessories. This study helped us evaluate the various major surgical procedures performed in the department of Oral and Maxillofacial Surgery. Such data would also act as an educational tool for trainees and for enhancing multidisciplinary meets.</p>","PeriodicalId":47495,"journal":{"name":"Journal of Maxillofacial & Oral Surgery","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11455998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45106473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IS Intra-masseteric Dexamethasone Better than Intra-deltoid Injection in Reducing Post-operative Sequelae Following Impacted Third Molar Surgery?: A Randomized Clinical Study.","authors":"Arpit Gupta, Sujata Mohanty, Pankaj Sharma, Zainab Chaudhary, Anjali Verma, S Hemavathy","doi":"10.1007/s12663-024-02308-z","DOIUrl":"https://doi.org/10.1007/s12663-024-02308-z","url":null,"abstract":"<p><strong>Aim: </strong>The post-operative sequelae of third molar surgical extractions need to be controlled in order to reduce patient morbidity. Dexamethasone is a well-researched drug which has established its merit as an anti-inflammatory agent. The aim of this randomized clinical study was to compare the patient-centric outcomes after pre-emptive intramuscular injection of dexamethasone into the masseter and deltoid, respectively.</p><p><strong>Materials and methods: </strong>The outcomes measured were pain, facial swelling and mouth-opening postoperatively on Day 1, 3 and 7. The subjects were randomly divided into two groups. Group 1 received an intra-oral injection of 8 mg of dexamethasone into the masseter muscle and a placebo injection of distilled-water into the deltoid muscle 2 h before surgical removal of impacted mandibular third molar. Group 2 received an intra-oral placebo injection of distilled-water into masseter muscle and an 8 mg injection of dexamethasone into deltoid muscle.</p><p><strong>Results: </strong>On comparison, Group 1 patients experienced statistically significant less pain (VAS score on day 1, 3, and 7), facial swelling (day 1, 3), and restricted mouth-opening (day 1, 3).</p><p><strong>Conclusion: </strong>The study concluded that pre-emptive dexamethasone injection, at masseter or deltoid, is helpful in reducing post-operative sequelae of mandibular third molar extraction. However, the immediate post-operative outcomes were found to be better mitigated when the injection was administered locally into masseter muscle.</p>","PeriodicalId":47495,"journal":{"name":"Journal of Maxillofacial & Oral Surgery","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11455738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142394247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Unusual Case of Dacryocystitis After Dacryocystectomy: Is It Still Possible to Perform a Dacryocystorhinostomy?","authors":"Paola Bonavolontà, Simona Barone, Giovanna Norino, Vincenzo Abbate, Antonio Romano, Giorgio Iaconetta, Riccardo Villari, Luigi Califano","doi":"10.1007/s12663-023-01940-5","DOIUrl":"10.1007/s12663-023-01940-5","url":null,"abstract":"<p><p>This is a rare case of a patient who developed a relapse of dacryocystitis and maxillary sinusitis although previous dacryocystectomy. We decided to perform an external dacryocystorhinostomy to remove the scar and the residual part of the lacrimal sac combined with endoscopic sinus surgery (ESS) to solve the symptoms.</p>","PeriodicalId":47495,"journal":{"name":"Journal of Maxillofacial & Oral Surgery","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11455758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41631558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Prehabilitation With Preoperative Swallowing Exercises on Postoperative Swallowing Morbidity in Oral Cavity Cancer: Randomized Controlled Trial.","authors":"Subbiah Shanmugam, R R Pravenkumar","doi":"10.1007/s12663-024-02324-z","DOIUrl":"https://doi.org/10.1007/s12663-024-02324-z","url":null,"abstract":"<p><strong>Background and objective: </strong>Oral cancer surgery and the associated reconstructive procedures cause mechanical and neurological impairment of swallowing. Despite postoperative rehabilitation, functional impairment of swallowing remains a concern. This study is to investigate the potential benefits of prehabilitation with preoperative swallowing exercises to patients undergoing composite resections and compartmental tongue resections so that it results in better swallowing outcomes and improved quality of life after surgery.</p><p><strong>Materials and methods: </strong>Sixty patients included in the study were randomized into an exercise and control group of 30 each. Patients with squamous cell carcinoma of the oral cavity undergoing composite resection or compartmental tongue resections were included, and patients with severe trismus at presentation were excluded. Patients in the exercise group were instructed on a set of six active exercises to be followed strictly for a period of at least 1 week before surgery. Preoperative swallowing exercises comprised of evidence-based exercises targeting the muscle groups involved in swallowing. Postoperative swallowing rehabilitation was the same as that of the control group. Patients were assessed after 6 months of surgery. Outcomes were assessed both subjectively and objectively. Objective assessment was done by inexpensive, novel clinical methods of repetitive saliva swallow test (RSST), water swallow test (WST) and food swallow test (FST) to and graded using dysphagia severity scale (1-7).</p><p><strong>Results: </strong>Average oral intake scale (1-Oral solids, 2-Oral semisolids/easy to chew foods, 3-Oral liquids only and 4-Non-oral, orogastric tube dependent) assessed subjectively was significantly lower in exercise arm, and the control arm had a significantly higher OIS score. Exercise arm had higher number of patients in DSS scores of 5, 6 and 7. The control arm had a higher number of patients in DSS scores of 3 and 4. The differences between the two groups were found to be statistically significant taking into consideration the confounding factors of radiation, wound morbidity and tongue resections.</p><p><strong>Conclusion: </strong>Preoperative swallowing exercises have shown a positive impact on postoperative swallowing ability. This is the first randomized trial to assess the effect of PSE in postoperative oral cancer patients. Our exercise protocol needs standardization, and clinical objective method of dysphagia assessment requires further validation. However, prehabilitation with PSE has the potential to improve the quality of life in oral cancer patients.</p>","PeriodicalId":47495,"journal":{"name":"Journal of Maxillofacial & Oral Surgery","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11456139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142394246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrence and Prognosticators of Recurrence in Odontogenic Keratocyst of the Jaws.","authors":"Rathindra Nath Bera, Sapna Tandon, Preeti Tiwari, Madan Mishra","doi":"10.1007/s12663-022-01846-8","DOIUrl":"10.1007/s12663-022-01846-8","url":null,"abstract":"<p><strong>Introduction: </strong>The incidence of recurrence of OKC varied from 2.5 to 62%. Studies have linked recurrence to treatment methods and also clinical and pathological features. The aim of this study was to evaluate the 5-year recurrence and the factors associated with recurrence in odontogenic keratocysts of the jaws.</p><p><strong>Methods: </strong>A retrospective review of records was done from the Institute's Medical Records Directory from 2010 to 2021. The following data were obtained of the lesion; age at presentation, gender, site, subsite, radiographic presentation (locularity), radiographic borders, presence or absence of satellite cysts, inflammatory infiltrate, and treatment rendered presence or absence of cortical perforation and soft-tissue extension and presence or absence of recurrence. Kaplan Meir estimator was used to evaluate recurrence rate and log rank test was used to compare the survival amongst groups. Cox regression analysis was used to evaluate the odds ratio to find out the possible factors influencing risk of recurrence. A <i>p</i> value of < 0.05 was considered statistically significant at 95% confidence interval.</p><p><strong>Results: </strong>In our study cohort, 27.2% of patients had recurrence. Posterior maxillary lesions, multilocular lesions, lesions with scalloped borders, presence of soft-tissue extension and cortical perforation, presence of satellite cysts and inflammatory infiltrate and enucleation with peripheral ostectomy were significantly associated with recurrence. However, soft-tissue extension, cortical perforation, multilocular lesions and presence of satellite cysts were independent risk factors.</p><p><strong>Conclusion: </strong>There is still debate on the best treatment modality for the management of OKCs. More studies are required to quantify the results.</p>","PeriodicalId":47495,"journal":{"name":"Journal of Maxillofacial & Oral Surgery","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11455759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41844524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shame and Stigma Over Long-Term Survival in Postoperative Cases of Head and Neck Cancer.","authors":"Atul Kumar Goyal, Jaimanti Bakshi, Naresh K Panda, Rakesh Kapoor, Dharam Vir, Krishan Kumar, Pankaj Aneja","doi":"10.1007/s12663-023-01931-6","DOIUrl":"10.1007/s12663-023-01931-6","url":null,"abstract":"<p><strong>Background: </strong>Surgical excision of the tumor remains the primary choice for the treatment of head and neck cancer patients, but it often leads to facial disfigurement, which further causes mutilation in the patients. Mutilation causes shame and stigma, which imparts significant psychological strain on patients, and tends to impair their quality of life.</p><p><strong>Objective: </strong>The present study aimed to assess the shame and stigma over long-term postoperative survival duration in head and neck cancer patients.</p><p><strong>Methodology: </strong>Total 100 postoperative patients of head and neck cancer were recruited from the outpatient department of the host institute, and shame and stigma was assessed using the Hindi version of the shame and stigma scale.</p><p><strong>Results: </strong>The global shame and stigma score was 22.67 ± 16.22, with the highest perceived stigma due to changes in appearance (11.94 ± 8.805), followed by impaired speech (4.490 ± 3.243), feeling of regret (3.950 ± 3.313), and feeling of stigma (4.490 ± 3.243). The shame and stigma was found to be significantly higher in maxillary cancer patients (33.22 ± 16.60), followed by larynx cancer patients (22.06 ± 13.41) and oral cancer patients (21.53 ± 16.49). Patients with stage III and stage IV of cancer were found to perceive higher shame and stigma (35.91 ± 22.23 and 27.36 ± 14.71, respectively) compared to the patients having stage I and stage II cancer (9.583 ± 9.709 and 16.44 ± 11.82, respectively). A significantly declining linear trend was found between shame and stigma and postoperative survival duration.</p><p><strong>Conclusion: </strong>We concluded that shame and stigma act as important determinants of quality of life over long-term survival in head and neck cancer patients, and should be considered while designing psychological interventions and surgical reconstruction protocols. The present study will help clinicians to assess the mutilation among head and neck cancer patients in a better way and will help in devising new psychological strategies to manage psychological aspects associated with mutilation, which will ultimately enhance the quality of life of patients.</p>","PeriodicalId":47495,"journal":{"name":"Journal of Maxillofacial & Oral Surgery","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11456006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42322560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparative Study of Efficacy for Extra-Oral vs. Intra-Oral Mandibular Nerve Block in Arch Bar Fixation for Management of Mandibular Fractures.","authors":"Monika Gupta, Aaquib Nazir, Atul Sharma, Amit Bali","doi":"10.1007/s12663-024-02306-1","DOIUrl":"https://doi.org/10.1007/s12663-024-02306-1","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of the study was to evaluate and compare the efficacy of extra-oral mandibular nerve block (infra-zygomatic approach/lateral approach) vs. intra-oral (Gow-Gates) mandibular nerve block in arch bar fixation for management of mandibular fractures.</p><p><strong>Methodology: </strong>A total of 200 patients reported with maxillofacial fractures. Out of them, 50 patients who required arch bar fixation for management of mandibular fractures were divided into two groups: Group I: Extra-oral and Group II: Intra-oral mandibular nerve blocks. The intra-operative pain, time of onset of anaesthesia, volume of drug administered, depth of needle insertion, repetition of injections and postoperative complications were analysed.</p><p><strong>Results: </strong>In Group I (Extra-oral nerve block), the time of onset of anaesthesia, volume of anaesthesia administered, needle depth, number of repetition of injections and postoperative complications were more as compared to Group II. No significant difference was observed in intra-operative pain score between two groups.</p><p><strong>Conclusion: </strong>Intra-oral approach with Gow-Gates technique seemed to be efficient and easy to operate as compared to extra-oral approach, for arch bar fixation of mandibular fractures in an output door setting, as extra-oral approach is more technique-sensitive and may lead to certain complications which require operation theatre setting with medical attention.</p>","PeriodicalId":47495,"journal":{"name":"Journal of Maxillofacial & Oral Surgery","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11456107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142394233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Bone Formation Potential of Collagen/ß-TCP/Ginger Extract Scaffold Loaded with Mesenchymal Stem Cells in Rat Animal model: A Stereological Study.","authors":"Nader Tanideh, Afsoon Bordbar, Hossein Bordbar, Mohammad Saleh Khaghaninejad, Sajad Daneshi, Shima Torabi Ardekani, Aida Iraji, Shahrokh Zare, Zahra Khodabandeh, Najmeh Sarafraz, Romina Tanideh, Moein Zarei, Cambyz Irajie","doi":"10.1007/s12663-022-01829-9","DOIUrl":"10.1007/s12663-022-01829-9","url":null,"abstract":"<p><p>Tissue engineering offers a new horizon for restoring the function of damaged tissues and organs. Here, bone regeneration potential of three-dimensional (3D) scaffold made of collagen/beta-tricalcium phosphate/ginger hydroalcoholic extract (COL-ß-TCP-GIN) loaded with stem cells was evaluated. The scaffolds with different component ratios were fabricated using a freeze dryer to obtain the optimum composition. The scaffolds' chemical, physical, and biological characteristics were evaluated using scanning electron microscope, fourier transform infrared spectroscopy, tensile testing machine, and cytotoxicity assay. The optimum scaffold's bone repairing potential was assessed with loaded synovial membrane mesenchymal stem cells (SM-MSCs) in mandibular bone defect of a rat animal model after two months. The ß-TCP component up to 30% could increase the tensile strength of the freeze-dried scaffold. In comparison, the GIN up to 5% was selected as a sufficient amount to be incorporated with the scaffolds. The morphology of scaffolds showed a suitable porosity for cells to proliferate and migrate. In vitro cytotoxicity results showed that GIN increased the cell viability up to 7 days. Regarding in vivo bone regeneration study, histopathology and stereology assessments showed the mandibular bone formation in COL/β-TCP/GIN scaffolds with SM-MSCs group significantly increased compared to COL/β-TCP/GIN without cells and sham groups. These results demonstrated the effectiveness of COL/β-TCP/GIN scaffold with SM-MSCs to induce bone formation, and this composite can be applied in dental and reconstructive surgery.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s12663-022-01829-9.</p>","PeriodicalId":47495,"journal":{"name":"Journal of Maxillofacial & Oral Surgery","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11455761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42486654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}