Evaluation of the Effectiveness of Injectable Platelet-Rich Fibrın (i-PRF) Addition to Different Particle Sizes of Bovine Bone Grafts in Rabbit Calvaria Defects.
Oya Törün, Hüseyin Akçay, Fatma Ela Şimşek, Ayşe Yenigün
{"title":"Evaluation of the Effectiveness of Injectable Platelet-Rich Fibrın (i-PRF) Addition to Different Particle Sizes of Bovine Bone Grafts in Rabbit Calvaria Defects.","authors":"Oya Törün, Hüseyin Akçay, Fatma Ela Şimşek, Ayşe Yenigün","doi":"10.1007/s12663-025-02435-1","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Bone grafts are indispensable in augmentation procedures, and their properties influence the new bone formation. It has proved that the injectable platelet-rich fibrin has many positive effects on bone healing.</p><p><strong>Aim: </strong>It was aimed to compare the effectiveness of the injectable platelet-rich fibrin (i-PRF) addition to bovine bone graft with different particle sizes on bone formation and vascularization in this study.</p><p><strong>Materials and methods: </strong>In 18 New Zealand rabbits, critical sized defects were created in the calvarium. Bovine bone grafts of two different particle sizes, small particles (SP) (0.25-1.0 mm) and large particles (LP) (1.0-2.0 mm) were applied with injectable platelet-rich fibrin (i-PRF) and without i-PRF. Animals were killed at 4 and 10 weeks for examining early and late bone healing histomorphometrically and immunohistochemically.</p><p><strong>Results: </strong>Group SP + i-PRF had the significantly greater amount of new bone formation in both healing periods. The immunoreactivity scores of the vascular endothelial growth factor (VEGF) and osteocalcin (OCN) were found to be significantly higher in Group SP + i-PRF than the other groups. There has been detected significant relationship between i-PRF addition and OCN staining scores.</p><p><strong>Conclusion: </strong>In this study, which investigated the effectiveness of i-PRF in different particle sizes, it was concluded that i-PRF addition to small-particle bone graft increased new bone formation. There was no significant difference between two particle sizes of bone graft without i-PRF addition.</p>","PeriodicalId":47495,"journal":{"name":"Journal of Maxillofacial & Oral Surgery","volume":"24 4","pages":"1100-1107"},"PeriodicalIF":0.6000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316654/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Maxillofacial & Oral Surgery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s12663-025-02435-1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/15 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Bone grafts are indispensable in augmentation procedures, and their properties influence the new bone formation. It has proved that the injectable platelet-rich fibrin has many positive effects on bone healing.
Aim: It was aimed to compare the effectiveness of the injectable platelet-rich fibrin (i-PRF) addition to bovine bone graft with different particle sizes on bone formation and vascularization in this study.
Materials and methods: In 18 New Zealand rabbits, critical sized defects were created in the calvarium. Bovine bone grafts of two different particle sizes, small particles (SP) (0.25-1.0 mm) and large particles (LP) (1.0-2.0 mm) were applied with injectable platelet-rich fibrin (i-PRF) and without i-PRF. Animals were killed at 4 and 10 weeks for examining early and late bone healing histomorphometrically and immunohistochemically.
Results: Group SP + i-PRF had the significantly greater amount of new bone formation in both healing periods. The immunoreactivity scores of the vascular endothelial growth factor (VEGF) and osteocalcin (OCN) were found to be significantly higher in Group SP + i-PRF than the other groups. There has been detected significant relationship between i-PRF addition and OCN staining scores.
Conclusion: In this study, which investigated the effectiveness of i-PRF in different particle sizes, it was concluded that i-PRF addition to small-particle bone graft increased new bone formation. There was no significant difference between two particle sizes of bone graft without i-PRF addition.
期刊介绍：
This journal offers comprehensive coverage of new techniques, important developments and innovative ideas in Oral and Maxillofacial Surgery. Practice-applicable articles help develop the methods used to handle dentoalveolar surgery, facial injuries and deformities, TMJ disorders, oral cancer, jaw reconstruction, anesthesia and analgesia. The journal also includes specifics on new instruments, diagnostic equipment’s and modern therapeutic drugs and devices. Journal of Oral and Maxillofacial Surgery is recommended for first or priority subscription by the Dental Section of the Medical Library Association. Specific topics covered recently have included: ? distraction osteogenesis ? synthetic bone substitutes ? fibroblast growth factors ? fetal wound healing ? skull base surgery ? computer-assisted surgery ? vascularized bone grafts Benefits to authorsWe also provide many author benefits, such as free PDFs, a liberal copyright policy, special discounts on Elsevier publications and much more. Please click here for more information on our author services.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
