Rafael Boucher, Oscar Haigh, Emmanuel Racy, Corinne Bordonne, Emmanuel Barreau, Antoine Rousseau, Marc Labetoulle
{"title":"Human papilloma virus (HPV) presence in primary tumors of the lacrimal sac: a case series and review of the literature.","authors":"Rafael Boucher, Oscar Haigh, Emmanuel Racy, Corinne Bordonne, Emmanuel Barreau, Antoine Rousseau, Marc Labetoulle","doi":"10.1080/01676830.2024.2370056","DOIUrl":"10.1080/01676830.2024.2370056","url":null,"abstract":"<p><p>Primary tumors of the lacrimal sac (PTLS) are a rare subtype of ocular adnexa tumors, with potentially life-threatening clinical course. There has been growing evidence of human papilloma virus (HPV) as an etiological agent in these tumors.In this retrospective observational case series, we report three cases of PTLS. All three underwent an initial dacryocystorhinostomy revealing a tissular mass in the lacrimal sac. Histological findings were respectively epithelial papilloma, epithelial Malpighian papilloma, and undifferentiated epidermoid carcinoma. PCR evaluation identified HPV serotype 6 in the first case and 16 in the third, and high p16 expression was found in the second case.These three cases of PTLS with HPV detection complement 36 other cases identified in the literature, further incriminating HPV in the pathogenesis of these neoplasms. Ophthalmologists must remain wary of chronic lacrimal occlusion symptoms, and resort to CT scan and orbital Doppler sonography whenever first-line treatment fails.</p>","PeriodicalId":47421,"journal":{"name":"Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery","volume":" ","pages":"236-245"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141447348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M Meyers, I Vermeiren, A Dendooven, N Lauwers, J Goemaere
{"title":"Unusual orbital, scleral and choroidal findings in Erdheim-Chester disease: a case report.","authors":"M Meyers, I Vermeiren, A Dendooven, N Lauwers, J Goemaere","doi":"10.1080/01676830.2024.2373791","DOIUrl":"10.1080/01676830.2024.2373791","url":null,"abstract":"<p><p>This case report highlights a unique presentation of Erdheim-Chester Disease (ECD) with bilateral scleral lesions, choroidal infiltration, and extensive sinus involvement. It is the first case report where the diagnosis was confirmed through a scleral biopsy after an initial presentation of a unilateral nodular scleritis. There was a gradual disease progression and ocular examination later revealed bilateral subconjunctival hyperemic lesions and mild exophthalmos, ophthalmoplegia, and extensive choroidal infiltration. Infiltration of the frontal and maxillary sinus was present and extended into the nasal cavity and both orbits. The diagnostic work-up is described in detail. Current treatment options are analyzed. It is emphasized that the ophthalmologist can play a crucial role in the diagnosis of ECD, given the substantial prevalence of orbital and ocular symptoms. The overall prognosis for ECD remains unfavorable, particularly in cases with orbital involvement. This case underscores the complexity and importance of a multidisciplinary approach in managing ECD.</p>","PeriodicalId":47421,"journal":{"name":"Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery","volume":" ","pages":"246-251"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141560054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abdulmajeed S Alkharashi, Ali Yaseen, Hind M Alkatan, Mostafa M Diab, Adel H Alsuhaibani
{"title":"Orbital-centric invasive aspergillosis with infraorbital nerve enlargement in an immunocompetent patient: a case report.","authors":"Abdulmajeed S Alkharashi, Ali Yaseen, Hind M Alkatan, Mostafa M Diab, Adel H Alsuhaibani","doi":"10.1080/01676830.2025.2481930","DOIUrl":"https://doi.org/10.1080/01676830.2025.2481930","url":null,"abstract":"<p><p>Orbital aspergillosis is a rare but potentially life- and sight-threatening fungal infection that can affect both immunocompromised and healthy individuals. We present a case of orbital aspergillosis with infraorbital nerve enlargement in a healthy 30-year-old male who presented with progressive proptosis, diplopia, and vision decline. Nasal endoscopy was unremarkable. CT imaging revealed an ill-defined, infiltrative, hyperdense mass in the left inferior orbital region with presumed enlargement of the infraorbital nerve (ION) and expansion of the ION canal, along with pterygopalatine fossa involvement, while the sinuses were almost clear. MRI showed similar findings. Histopathological analysis confirmed <i>Aspergillus fumigatus</i>. Treatment with voriconazole led to significant clinical improvement. This case underscores the diagnostic challenges of orbital aspergillosis and highlights that ION enlargement should be cautiously interpreted as a specific sign of IgG4-related disease. It is crucial to maintain a high index of suspicion in cases of progressive proptosis, even in the absence of clear sinonasal involvement.</p>","PeriodicalId":47421,"journal":{"name":"Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery","volume":" ","pages":"1-5"},"PeriodicalIF":0.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Niko J Viskari, Minna H Vesaluoma, Juho O Wedenoja, Marita S Uusitalo
{"title":"Oculoplastic complications in patients with adenoviral keratoconjunctivitis.","authors":"Niko J Viskari, Minna H Vesaluoma, Juho O Wedenoja, Marita S Uusitalo","doi":"10.1080/01676830.2025.2481935","DOIUrl":"https://doi.org/10.1080/01676830.2025.2481935","url":null,"abstract":"<p><strong>Purpose: </strong>Adenoviruses and other viral superficial eye infections may cause long-lasting complications, including conjunctival scarring, synechiae, and lacrimal system obstructions. However, their incidence is not established. Here, we set out to assess possible oculoplastic complications and need for surgical procedures in patients with adenoviral conjunctivitis.</p><p><strong>Methods: </strong>This Finnish register-based retrospective study includes patients with adenoviral conjunctivitis treated at Helsinki University Hospital eye clinic, Finland, during adenoviral outbreak in the winter 2017-2018. Of these identified 168 patients, with median age of 43 years (range 0-83 years), 92 were female and 76 were male. 134 patients presented with a bilateral and 34 with a unilateral disease. Viral cell cultures revealed adenovirus serotypes 4 and 8. The medical records were reviewed in 2021-2022 to assess any oculoplastic complications and related surgical procedures.</p><p><strong>Result: </strong>After adenoviral infection, two patients presented with chronic tearing and were diagnosed with canalicular obstruction. One was primarily treated with silicone tube intubation. The canalicular obstruction of the other patient was released by lacrimal irrigation only, after which the patient remained symptom free. No other oculoplastic complications were found.</p><p><strong>Conclusions: </strong>Adenoviral conjunctivitis with even severe inflammation of the anterior segment rarely causes oculoplastic complications requiring surgical interventions.</p>","PeriodicalId":47421,"journal":{"name":"Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery","volume":" ","pages":"1-5"},"PeriodicalIF":0.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comment on the innovation of surgery for recurrent naso-orbital mucous cysts.","authors":"Ran Xiong, Long Chen","doi":"10.1080/01676830.2025.2479743","DOIUrl":"https://doi.org/10.1080/01676830.2025.2479743","url":null,"abstract":"","PeriodicalId":47421,"journal":{"name":"Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery","volume":" ","pages":"1"},"PeriodicalIF":0.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A case of bilateral orbital haemorrhages following periocular acupuncture.","authors":"Amelia E Davidson, Haya Al-Ani, Richard Hart","doi":"10.1080/01676830.2025.2479745","DOIUrl":"https://doi.org/10.1080/01676830.2025.2479745","url":null,"abstract":"<p><p>Acupuncture has been practised for more than 2500 years in the Western Pacific Region and has become an important component of complementary medicine. Acupuncture technique involves the insertion of fine needles into the body at specific points to affect functional changes in internal organ systems. Periocular acupuncture is increasingly used to treat ophthalmologic and non-ophthalmologic conditions. Although there are reported benefits, there is a lack of high-quality evidence supporting its efficacy. There are also increasing reports of complications, including orbital haemorrhage, globe perforation, retinal detachment and endophthalmitis. Here, we present a case of bilateral orbital haemorrhages from periocular acupuncture, highlighting the potential dangers of this practice.</p>","PeriodicalId":47421,"journal":{"name":"Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery","volume":" ","pages":"1-5"},"PeriodicalIF":0.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Modupe O Adetunji, Nishita T Sheth, Irene T Lee, Emily T Smith, Jessica L Houk, Julie A Woodward, Thomas J Cummings, Christopher R Dermarkarian
{"title":"Hybrid neurofibroma-schwannoma of the orbit: a case report and review of the literature.","authors":"Modupe O Adetunji, Nishita T Sheth, Irene T Lee, Emily T Smith, Jessica L Houk, Julie A Woodward, Thomas J Cummings, Christopher R Dermarkarian","doi":"10.1080/01676830.2025.2475828","DOIUrl":"https://doi.org/10.1080/01676830.2025.2475828","url":null,"abstract":"<p><p>Hybrid peripheral nerve sheath tumor is a rare tumor subtype that infrequently occurs within the orbit. A 50-year-old male presented with a 6-year history of worsening left-sided proptosis and hypoglobus. Magnetic resonance imaging of the orbits revealed a left superior extraconal, muti-lobulated orbital lesion with extension into the left orbital apex originating from the left frontal nerve. The patient underwent surgical resection of the mass via a left orbito-cranial approach. Histopathologic examination was positive for orbital hybrid neurofibroma-schwannoma. Postoperatively, the patient had improvement in proptosis, resolution of symptoms, and improved cosmesis. This case represents the eleventh reported occurrence of orbital hybrid neurofibroma-schwannoma.</p>","PeriodicalId":47421,"journal":{"name":"Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery","volume":" ","pages":"1-6"},"PeriodicalIF":0.9,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniel B Azzam, Alicia Casella, Yi Ling Dai, M Reza Vagefi
{"title":"Nationwide orbital decompression volume, surgical approach, and subspecialty distribution patterns within the center for medicare and medicaid services population in the era of teprotumumab.","authors":"Daniel B Azzam, Alicia Casella, Yi Ling Dai, M Reza Vagefi","doi":"10.1080/01676830.2025.2475844","DOIUrl":"https://doi.org/10.1080/01676830.2025.2475844","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate nationwide practice patterns in orbital decompression surgery for thyroid eye disease (TED) after approval of teprotumumab in January 2020.</p><p><strong>Methods: </strong>This retrospective study analyzed the Centers for Medicare and Medicaid Services (CMS) database before (2016-2019) and after teprotumumab approval (2020-2023). External (CPT codes 67414 and 67445) and endoscopic (CPT 31292 and 31293) approaches were included. Controls were cataract surgery (CPT 66984) and upper blepharoplasty (CPT 15822 and 15823). Main outcomes were orbital decompression volume, surgical approach, and subspecialty distribution.</p><p><strong>Results: </strong>In total 4,534 orbital decompressions were billed to CMS from 2016 to 2023. Nationwide orbital decompression volume significantly declined (-37%, <i>p</i> < 0.001) in the post-teprotumumab period, even when controlling relative to cataract surgery (<i>p</i> < 0.001) or upper blepharoplasty (<i>p</i> = 0.010). This was attributed to decreased external orbital decompressions (-41%, <i>p</i> < 0.001), while endoscopic approach was less impacted (-28%, <i>p</i> = 0.007). Specialty distribution trended away from oculofacial plastic surgeons (-10%) toward otolaryngologists (+18%) (<i>p</i> < 0.001). The proportion of endoscopic approach significantly grew (+13%, <i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>A nationwide evolution in surgical patterns for TED was observed after teprotumumab approval. Notable trends included decreased orbital decompressions, otolaryngologists performing proportionately more decompressions, and increased endoscopic approaches.</p>","PeriodicalId":47421,"journal":{"name":"Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery","volume":" ","pages":"1-8"},"PeriodicalIF":0.9,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Total meibomian gland loss in Parkinson's disease.","authors":"Prajakta Dandekar, Swati Singh","doi":"10.1080/01676830.2025.2475840","DOIUrl":"https://doi.org/10.1080/01676830.2025.2475840","url":null,"abstract":"<p><p>Parkinson's disease is characterized by motor dysfunction, affecting blink frequency in the eyes. Reduced blinking and use of anticholinergic medications result in dry eye disease (DED) in these patients. This unique case had complete meibomian gland loss seen on meibography with reduced blinking and lacrimal gland function as well attributed to Parkinson's and its treatment. The autoimmune workup was negative, and the final diagnosis of drug-induced DED was made. The patient was managed with ocular lubricants and anti-inflammatory eye drops.</p>","PeriodicalId":47421,"journal":{"name":"Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery","volume":" ","pages":"1-3"},"PeriodicalIF":0.9,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Corneal perforation secondary to medial canthal fistula in cocaine-induced midline destructive lesions.","authors":"Simerdip Kaur, Meydan Ben Ishai, Saul Rajak, Huw Oliphant, Mayank Nanavaty","doi":"10.1080/01676830.2025.2477637","DOIUrl":"https://doi.org/10.1080/01676830.2025.2477637","url":null,"abstract":"<p><p>To report a rare case of corneal perforation precipitated by an abnormally positioned globe, lagophthalmos and exposure keratopathy secondary to medial canthal fistula in cocaine induced midline destructive lesions (CIMDL). We describe the clinical presentation of a middle-aged man who developed a corneal perforation secondary to medial canthal fistula and enophthalmos and adduction caused by CIMDL. He underwent combined strabismus surgery, cornea patch grafting and tarsorrhaphy, but ultimately required evisceration. Thereafter, his medial canthal fistula was closed with a double layered skin flap. Destructive medial canthal and orbital vasculitis can compromise the protection of the ocular surface and result in corneal perforation. Subsequent management of residual medial canthal fistulas can be challenging and risks failure in the future, especially if there is ongoing aggressive tissue destruction.</p>","PeriodicalId":47421,"journal":{"name":"Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery","volume":" ","pages":"1-5"},"PeriodicalIF":0.9,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}