Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery最新文献_第2页

Primary orbital and adnexal rhabdomyosarcoma: a study of 54 Asian Indian patients. 原发性眼眶和附件横纹肌肉瘤：对 54 名亚洲印度患者的研究。

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Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery Pub Date : 2025-06-01 Epub Date: 2024-10-29 DOI: 10.1080/01676830.2024.2419058

Ayushi Agarwal, Vijitha S Vempuluru, Faraz Ali Mohammad, Mohammed Hasnat Ali, Vijay Anand Reddy Palkonda, Swathi Kaliki

{"title":"Primary orbital and adnexal rhabdomyosarcoma: a study of 54 Asian Indian patients.","authors":"Ayushi Agarwal, Vijitha S Vempuluru, Faraz Ali Mohammad, Mohammed Hasnat Ali, Vijay Anand Reddy Palkonda, Swathi Kaliki","doi":"10.1080/01676830.2024.2419058","DOIUrl":"10.1080/01676830.2024.2419058","url":null,"abstract":"Purpose: To describe the clinical presentation, management, and outcomes of orbital and adnexal rhabdomyosarcoma (RMS) in an Asian-Indian cohort and analyze the factors predictive of outcomes.Methods: Retrospective interventional case series of 54 patients of histopathology-proven RMS.Results: The mean age of presentation with RMS was 10 years (median, 7 years; range, <1-54 years). The most common tumor location was the superonasal quadrant (n = 21, 39%). Extensions beyond the orbit into the sinuses, temporal fossa, and brain were seen in 15 (28%), 3 (6%), and 8 (15%), respectively. First-line treatment modalities included a combination of surgical debulking, chemotherapy, and external beam radiotherapy in 20 (37%) patients; chemotherapy and radiation in 20 (37%); complete surgical excision and chemotherapy in 3 (6%); orbital exenteration, chemotherapy, and external beam radiotherapy in 1 (2%); chemotherapy alone in 1 (2%) patient, and 9 (17%) patients were lost to follow up. By Intergroup Rhabdomyosarcoma Study Group (IRSG) grouping, tumors belonged to groups I (n = 2,4%), II (n = 13, 29%), and III (n = 30, 67%). Kaplan-Meier survival estimates for tumor recurrence, lymph node metastasis, systemic metastasis, and death (n = 45) were 84%, 82%, 95%, and 95% at 1 year, 69%, 76%, 81%, and 77% at 5 years, 69%, 76%, 81%, and 77% at 10 years, respectively. On multivariate regression, age >18 years was found to have a significantly increased risk of locoregional LN metastasis (p = 0.005).Conclusion: Despite aggressive treatment modalities, the 5-year disease-specific survival rate was 77% in Asian-Indian cohort. Age > 18 years at presentation was associated with a poorer prognosis.","PeriodicalId":47421,"journal":{"name":"Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery","volume":" ","pages":"257-266"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142548283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Solitary neurofibroma confined to inferior rectus muscle tendon: a case report. 局限于下直肌肌腱的孤立性神经纤维瘤：病例报告。

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Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery Pub Date : 2025-06-01 Epub Date: 2024-07-17 DOI: 10.1080/01676830.2024.2377248

Reza Jafari, Ali Shushtari, Hanie Ahmadi, Ahmad Ahmadzade Amiri, Amir Veisi

引用次数: 0

Tumor versus bland thrombus: diffuse large B-cell lymphoma presenting as cavernous sinus and left superior ophthalmic vein thrombosis. 肿瘤与单纯血栓：弥漫大 B 细胞淋巴瘤表现为海绵窦和左眼上静脉血栓。

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Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery Pub Date : 2025-06-01 Epub Date: 2024-08-28 DOI: 10.1080/01676830.2024.2393416

Hays T Cape, Lalita Gupta, Cody C Blanchard, Flavius D Raslau, Peter J Timoney

{"title":"Tumor versus bland thrombus: diffuse large B-cell lymphoma presenting as cavernous sinus and left superior ophthalmic vein thrombosis.","authors":"Hays T Cape, Lalita Gupta, Cody C Blanchard, Flavius D Raslau, Peter J Timoney","doi":"10.1080/01676830.2024.2393416","DOIUrl":"10.1080/01676830.2024.2393416","url":null,"abstract":"A 66-year-old female with a history of sinusitis presented with persistent diplopia and worsening eyelid swelling. Examination revealed bilateral vision loss, cranial nerve palsies, left-sided chemosis, proptosis, and edema. Initial imaging showed sphenoid sinus opacification, bilateral ethmoid disease, lack of filling of bilateral cavernous sinuses, and partial thrombosis of the left superior ophthalmic vein. The sinus findings were evaluated with endoscopic sinus surgery, which was unremarkable. Subsequent orbital imaging suggested the lesions were in keeping with tumor thrombus as opposed to bland thrombus. CT scans revealed a large mass in the right axilla, which was biopsied and confirmed the diagnosis of diffuse large B-cell lymphoma (DLBCL). The patient was treated with anticoagulation, steroids, and chemotherapy resulting in marked improvement. Our report highlights a rare case of tumor thrombus from DLBCL causing bilateral cavernous sinus thrombosis and, to the best of our knowledge, the first documented case of superior ophthalmic vein thrombosis from tumor thrombus.","PeriodicalId":47421,"journal":{"name":"Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery","volume":" ","pages":"348-352"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142082182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of eyelid function following frontalis suspension and levator dissection-resection in congenital ptosis with poor levator function. 额肌悬吊术和上睑提肌解剖-切除术治疗上睑提肌功能不佳的先天性上睑下垂后的眼睑功能比较。

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Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery Pub Date : 2025-06-01 Epub Date: 2024-09-12 DOI: 10.1080/01676830.2024.2399665

Hesham A Ibrahim, Eman M Salem, Ibrahim Y Allam, Heba N Sabry

{"title":"Comparison of eyelid function following frontalis suspension and levator dissection-resection in congenital ptosis with poor levator function.","authors":"Hesham A Ibrahim, Eman M Salem, Ibrahim Y Allam, Heba N Sabry","doi":"10.1080/01676830.2024.2399665","DOIUrl":"10.1080/01676830.2024.2399665","url":null,"abstract":"Purpose: A levator dissection-resection technique (LDR) in which the levator is dissected free from all fibrous attachments including Whitnall's ligament was compared to two commonly used frontalis-based procedures in the management of congenital ptosis with poor levator function.Methods: Thirty patients having congenital ptosis with poor levator function were randomized to one of the three surgical groups (ten patients for each group), namely, frontalis sling (FS), frontalis advancement flap (FAF), and (LDR) technique. Marginal reflex distance-one (MRD-1), levator function, symmetry in different levels of vertical gaze, lagophthalmos, and any other surgical complications were assessed 6 months following the intervention.Results: Patients in the three groups achieved statistically significant improvement in MRD-1 in the primary position of gaze (p = 0.001 for FS, 0.003 for FAF, 0.001 for LDR). Patients who underwent a frontalis-based procedure acquired an additional ability to elevate the upper eyelid by using their eyebrows. Patients who underwent LDR technique have acquired an additional mean of 5.79 ± 1 mm improvement in levator function with better symmetry during up and down gaze in unilateral cases. Patients from all groups had an equal degree of lagophthalmos with forced eyelid closure, and during sleep.Conclusion: Patients with ptosis and poor levator function who were managed with LDR technique achieved a similar degree of eyelid elevation in the primary gaze to that of frontalis-based procedures, acquired additional levator function, achieved more symmetry in up and down gaze in unilateral cases, and had no additional risk to the cornea.","PeriodicalId":47421,"journal":{"name":"Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery","volume":" ","pages":"299-305"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142298554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ocular adnexal sebaceous carcinoma in a patient with Li-Fraumeni syndrome. 一名李-弗劳米尼综合征患者的眼附件皮脂腺癌。

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Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery Pub Date : 2025-06-01 Epub Date: 2024-07-29 DOI: 10.1080/01676830.2024.2382268

Chia W Hsu, Cornelia W Peterson, Charles G Eberhart, Christian F Meyer, Deborah K Armstrong, Katie Fiallos, Ashley A Campbell

{"title":"Ocular adnexal sebaceous carcinoma in a patient with Li-Fraumeni syndrome.","authors":"Chia W Hsu, Cornelia W Peterson, Charles G Eberhart, Christian F Meyer, Deborah K Armstrong, Katie Fiallos, Ashley A Campbell","doi":"10.1080/01676830.2024.2382268","DOIUrl":"10.1080/01676830.2024.2382268","url":null,"abstract":"Li-Fraumeni syndrome (LFS) is caused by a pathogenic germline variant at the TP53 locus and is associated with an increased predisposition to a variety of cancers. The neoplasms most frequently associated with LFS are sarcomas, breast cancer, brain tumors, and adrenocortical carcinomas. In this case report, we present a 43-year-old male diagnosed with an ocular adnexal sebaceous carcinoma of the right upper eyelid who was confirmed to have LFS with subsequent genetic testing. The mutational profile of both the patient's genetic screen and tumor sequencing were congruent, demonstrating the same pathogenic loss-of-function TP53 variant. This case report highlights the importance of pursuing genetic testing in patients with a history of multiple tumor types, particularly those with uncommon diagnoses. In this case, confirmation of LFS had important implications for personalized patient care, including identification of contraindicated treatment interventions and the imaging modalities necessary for vigilant follow-up screening.","PeriodicalId":47421,"journal":{"name":"Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery","volume":" ","pages":"321-325"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Orbital necrobiotic xanthogranuloma with necrotizing scleritis and absent cutaneous manifestations. 眼眶坏死性黄疽瘤伴有坏死性巩膜炎，无皮肤表现。

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Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery Pub Date : 2025-06-01 Epub Date: 2024-08-07 DOI: 10.1080/01676830.2024.2387105

Josefina Herrera, Gerard Reid, Peter McCluskey, Krishna Tumuluri

引用次数: 0

Canalicular obstructions after monkeypox infection. 猴痘感染后的输液管阻塞。

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Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery Pub Date : 2025-06-01 Epub Date: 2024-08-01 DOI: 10.1080/01676830.2024.2384049

Óscar Felguera-García, Marina Dotti-Boada, Sara Labay-Tejado, Eduard Millán-Valbuena, Silvia Feu-Basilio, Sara Marín-Martínez, Marta Pazos, Jessica Matas Fassi

引用次数: 0

Congenital orbital respiratory epithelial cyst with anomalous maxillary antrum in the absence of bony defect. 先天性眼眶呼吸道上皮囊肿，上颌窦异常，无骨缺损。

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Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery Pub Date : 2025-06-01 Epub Date: 2024-07-02 DOI: 10.1080/01676830.2024.2373811

Anthony Yao, Sepideh Amin, Raman Malhotra

引用次数: 0

Impact of phenylephrine-induced Hering's response on Müller's muscle-conjunctival resection outcomes. 苯肾上腺素诱发的赫林氏反应对 Müller 肌肉结膜切除术结果的影响。

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Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery Pub Date : 2025-06-01 Epub Date: 2024-12-16 DOI: 10.1080/01676830.2024.2435928

Niloufar Bineshfar, Leo Meller, Benjamin I Meyer, Wendy W Lee

{"title":"Impact of phenylephrine-induced Hering's response on Müller's muscle-conjunctival resection outcomes.","authors":"Niloufar Bineshfar, Leo Meller, Benjamin I Meyer, Wendy W Lee","doi":"10.1080/01676830.2024.2435928","DOIUrl":"10.1080/01676830.2024.2435928","url":null,"abstract":"Purpose: To evaluate the impact of preoperative phenylephrine (PE)-induced Hering's response on postoperative outcomes in patients undergoing unilateral Müller's muscle-conjunctival resection (MMCR) for blepharoptosis correction.Methods: Sixty-five consecutive patients (65 eyes) undergoing unilateral MMCR between January 2016 and December 2023 were included in this retrospective single-surgeon study. The main outcome measure was the margin-reflex distance 1 (MRD1) at postoperative month 1 visit. Logistic regression analysis was conducted to identify factors influencing postoperative Hering's response.Results: A preoperative post-PE Hering's response was observed in 40.0% of patients. At 1 week and 1 month postoperatively, Hering's response was recorded in 20.0% and 21.5% of cases, respectively. Regression analysis revealed a significant correlation between preoperative post-PE Hering's and post-MMCR Hering's response at postoperative month 1 visit (crude odds ratio (OR): 8.80, p = .003; adjusted OR: 30.43, p = .002).Conclusion: Preoperative post-PE Hering's response is a significant predictor of postoperative Hering's response in unilateral MMCR.","PeriodicalId":47421,"journal":{"name":"Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery","volume":" ","pages":"289-294"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immune checkpoint inhibitors and the orbit; two cases of reactive dacryoadenitis. 免疫检查点抑制剂与眼眶；两例反应性泪腺炎。

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Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery Pub Date : 2025-06-01 Epub Date: 2024-08-07 DOI: 10.1080/01676830.2024.2385010

Matthew Fenech, Ayodeji Ajanaku, James Hsuan, Austin McCormick, Simon Shamas, Nima Ghadiri

{"title":"Immune checkpoint inhibitors and the orbit; two cases of reactive dacryoadenitis.","authors":"Matthew Fenech, Ayodeji Ajanaku, James Hsuan, Austin McCormick, Simon Shamas, Nima Ghadiri","doi":"10.1080/01676830.2024.2385010","DOIUrl":"10.1080/01676830.2024.2385010","url":null,"abstract":"Immune checkpoints refer to mechanisms entrusted with the modulation of immune responses in peripheral tissues and are required for minimising collateral damage. Immune checkpoint inhibitors (ICPi) work through numerous pathways, including the anti-CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), anti-PD-1 (programmed cell death protein 1) and the PD-L1 (protein cell death protein-ligand-1) pathways. They are proving to be an exciting therapeutic avenue in the attempt to activate anti-tumour activity. Ipilimumab is a fully human monoclonal antibody working on the anti-CTLA-4 pathway, while nivolumab and pembrolizumab are humanised monoclonal IgG4 antibodies that work on the PD-1 pathway. Despite a growing body of research pertinent to these novel therapies, early indications show that they are limited by their side effect profile. Furthermore, their efficacy appears to be greater in cancers with a high mutational burden. We present two female patients with bilateral reactive dacryoadenitis secondary to ICPi therapy, a finding that to the best of our knowledge was not previously described in the literature.","PeriodicalId":47421,"journal":{"name":"Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery","volume":" ","pages":"335-339"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141898646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0