Neuroradiology Journal最新文献

{"title":"Successful use of gadolinium contrast medium for flow-diverter stent placement in a patient with hypersensitivity to iodinated contrast: A case report.","authors":"Shoji Saito, Hitoshi Hasegawa, Hayate Takahashi, Mamoru Ichinohe, Hiroki Seto, Ryosuke Mizuta, Keita Kawabe, Masakazu Sano, Makoto Oishi","doi":"10.1177/19714009251313505","DOIUrl":"https://doi.org/10.1177/19714009251313505","url":null,"abstract":"<p><p>Gadolinium contrast medium can serve as an alternative to iodinated contrast medium when the latter is unsuitable. In this report, we describe a case of a carotid-ophthalmic aneurysm in which angiograms were obtained using gadolinium contrast medium for flow-diverter stent placement due to the patient's history of bronchial asthma and hypersensitivity reactions to iodinated contrast medium. To enhance the visibility of gadolinium contrast medium, which typically provides lower contrast compared to iodinated contrast medium, we employed a contrast-enhancing and noise-reducing protocol on our image-guided therapy system. We performed catheterization and established working angles guided by a roadmap based on previous magnetic resonance angiography, the position of which was adjusted using cone-beam computed tomography performed before the intervention. This approach helped reduce the amount of contrast medium required. The procedure was successful and did not induce hypersensitivity reactions, morbidity, or mortality. Thus, the efficacy of the contrast-enhancing imaging protocol and the magnetic resonance angiography-based roadmap was confirmed. Measures must be taken to address gadolinium contrast medium-specific adverse events, limitations on the amount of contrast medium used, and the issue of low-contrast angiograms.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"19714009251313505"},"PeriodicalIF":1.3,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11707754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unusual anatomic variation: The posterior inferior cerebellar artery arising from the middle meningeal artery.","authors":"Emilio Lozupone, Simona Scalise, Pietro Trombatore, Alfredo Pauciulo, Vita Direnzo, Francesco Signorelli, Leonardo Barbarini, Adriana Paladini","doi":"10.1177/19714009251313508","DOIUrl":"https://doi.org/10.1177/19714009251313508","url":null,"abstract":"<p><p>An adult patient was admitted to our emergency department for a first episode of generalized tonic-clonic seizure. Computed tomography scan and magnetic resonance imaging showed a temporal intracranial hemorrhage and parenchymal edema caused by a dural arteriovenous fistula (DAVF), whose angioarchitecture was better understood through the DSA which showed as intriguing and rare vascular anomaly the origin of the posterior inferior cerebellar artery (PICA) from the middle meningeal artery (MMA). The endovascular treatment of the DAVF was then successfully performed.This case describes the first case of a PICA arising from the MMA in the literature and highlights as an accurate knowledge of vascular anatomy and its variations is essential for the endovascular treatment of the cerebrovascular diseases.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"19714009251313508"},"PeriodicalIF":1.3,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11707755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overview of perianeurysmal edema following the endovascular management of cerebral aneurysms: A pooled analysis of 48 cases.","authors":"Mohammed A Azab, Hamid Abdelma'aboud Mostafa, Oday Attalah","doi":"10.1177/19714009241303130","DOIUrl":"10.1177/19714009241303130","url":null,"abstract":"<p><strong>Background: </strong>Perianeurysmal edema occurring after endovascular treatment for cerebral aneurysms is uncommon compared to surgical clipping. The clinical aspects and the exact explanation are poorly understood.</p><p><strong>Methods: </strong>We searched PubMed, Google Scholar, and Web of Science. We used the following keywords: \"endovascular management of cerebral aneurysms,\" \"perianeurysmal cerebral edema,\" \"perianeurysmal cerebral edema after endovascular treatment endovascular treatment,\" \"intracranial aneurysms with perianeurysmal edema,\" and \"vessel wall enhancement after endovascular therapy.\" For each case, demographic, clinicopathological, therapeutic, and follow-up data were gathered and analyzed.</p><p><strong>Results: </strong>Perianeurysmal edema after endovascular treatment has a clear female predilection, with a male: female ratio of 12:29 (25%; 60.41%). The average time from EVT to the onset of edema ranged from 1 day to about 8 years. The aneurysm dimension ranged from 6.8 to 25 mm as the largest size reported. Most patients were asymptomatic (18 [37.5 %]), and headache was the presenting symptom in 10 patients (20.8%). Aneurysmal wall enhancement was reported in 16 (33.3 %) patients with perianeurysmal edema. About 12 patients (25%) developed post-EVT hydrocephalus. The most common coil used was the platinum type (31 [64.58%]). Most of the patients were treated expectantly with follow-up (17 [35.41 %]), while steroids were used only in 14 (29.16%) patients. Most of the patients have their edema resolved (29 [60.41%]) or stable (9 [37.5%]).</p><p><strong>Conclusion: </strong>There is growing evidence supporting the incidence of post-embolization inflammatory reactions involving the vessel wall and the surrounding parenchyma; however, the exact clinical perspectives and the predisposing factors are not fully uncovered. This analysis highlights the possible presentations and short-term outcome of patients presenting with perianeurysmal edema after endovascular management of cerebral aneurysms.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"19714009241303130"},"PeriodicalIF":1.3,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11632708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MRI markers of idiopathic normal pressure hydrocephalus in a population study with 791 participants: Exploring reference values and associations.","authors":"Clara Constantinescu, Doerthe Ziegelitz, Carsten Wikkelsø, Silke Kern, Daniel Jaraj, Lina Rydén, Eric Westman, Ingmar Skoog, Mats Tullberg","doi":"10.1177/19714009241303132","DOIUrl":"10.1177/19714009241303132","url":null,"abstract":"<p><strong>Purpose: </strong>Epidemiological studies on idiopathic normal pressure hydrocephalus (iNPH) imaging markers and their normal values are scarce. This population-based study aimed to analyze several morphologic and volumetric iNPH-related imaging markers in a large sample, determining their distribution, diagnostic accuracy, suggested cut-offs, and associations with iNPH symptoms.</p><p><strong>Methods: </strong>This cross-sectional study included 791 70 year olds, 40 with radiologically probable iNPH (iNPH_Radiol) and 751 without iNPH features (reference). MRI measures included Evans index (EI), z-EI, brain per ventricle ratio at anterior (BVR_AC) and posterior commissures (BVR_PC), sulcal compression, Sylvian fissure enlargement, callosal angle, diameter of temporal horns, 3^rd and 4^th ventricles, midbrain, and pons. Volumes of ventricles, corpus callosum, and brainstem were computed using automated segmentation. ROC analysis determined imaging markers' cut-offs. Symptoms were evaluated clinically and through self-report.</p><p><strong>Results: </strong>In the reference group, median values (95% CI) for imaging markers were as follows: EI: 0.27 (0.26-0.27), z-EI: 0.28 (0.26-0.31), BVR_AC: 1.69 (1.48-1.90), and BVR_PC: 2.66 (2.24-3.27). Most imaging markers differed significantly between iNPH_Radiol and the reference. Lateral ventricle volumes correlated better with z-EI and BVR than EI (Rs > 0.81 vs 0.68). Optimal cut-off values for z-EI, and BVR_AC and BVR_PC for distinguishing iNPH_Radiol were 0.32, 1.36, and 1.83, respectively. Clinical symptoms correlated moderately with imaging markers (Rs < 0.49 for iNPH_Radiol, <i>p</i> < .01).</p><p><strong>Conclusions: </strong>We report population-based reference values and propose cut-offs for iNPH-related imaging markers and volumetric measurements. Z-EI and BVR are likely superior markers for assessing ventricular enlargement in iNPH. Imaging markers of iNPH correlate moderately with iNPH symptoms.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"19714009241303132"},"PeriodicalIF":1.3,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11626555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142796414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comatose vertebrobasilar occlusion patient recovering with bilateral hearing loss following full recanalization with mechanical thrombectomy.","authors":"Arsida Bajrami, Songul Senadim, Serdar Geyik","doi":"10.1177/19714009241303087","DOIUrl":"10.1177/19714009241303087","url":null,"abstract":"<p><p>Acute occlusion of vertebrobasilar artery mostly presents with severe neurologic impairment. Bilateral sensorineural hearing loss (SNHL) as the first clinical symptom on onset is a rare phenomenon. Clinical benefit of mechanical thrombectomy (MT) in terms of hearing loss in these cases is poorly understood. We describe a case of a patient with vertebrobasilar occlusion who presented with only sudden bilateral SNHL and recovered poorly in terms of hearing loss after full recanalization with MT. We describe a 52-year-old right-handed male patient with an unremarkable medical history. On admission, he was hypertensive to 200/102 mm Hg; neurological examination was significant for mild right facial palsy and bilateral SNHL, later confirmed by an audiogram. diffusion-weighted imaging (DWI) showed infarction of bilateral anterior cerebellum, cerebellar peduncles, and pons with negative flair. Computed tomography angiography showed occlusion in the level of the vertebrobasilar junction. Patients' neurological status deteriorated within hours into a comatose status with anarthria and quadriplegia. He was treated with MT and stenting and full recanalization was achieved. All neurological examination findings have completely resolved, except for the bilateral SNHL. Acute onset of sudden bilateral deafness in isolation or accompanied by vestibular, cerebellar, and/or brainstem signs may indicate large vessel occlusion. Although rapid recanalization with MT helps improve the symptoms, the specific impact over SNHL varies between patients.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"19714009241303087"},"PeriodicalIF":1.3,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11625400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative susceptibility mapping of the fear circuit: Associations with silent symptoms in relapsing-remitting multiple sclerosis.","authors":"Ibrahim Khormi, Amir Fazlollahi, Oun Al-Iedani, Rishma Vidyasagar, Scott Ayton, Abdulaziz Alshehri, Bryan Paton, Saadallah Ramadan, Jeannette Lechner-Scott","doi":"10.1177/19714009241303123","DOIUrl":"10.1177/19714009241303123","url":null,"abstract":"<p><p><b>Background:</b> Multiple sclerosis (MS) is a long-term autoimmune inflammatory disorder that affects the central nervous system leading to neurodegeneration, and can involve a variety of symptoms. These symptoms can include fatigue, anxiety, depression, and cognitive decline, which may be silent. The objective of this study was to explore changes in brain iron deposition in people with relapsing-remitting MS (pw-RRMS) compared to healthy controls (HCs), with a particular focus on regions of fear circuit. Additionally, the study aimed to evaluate relationship between iron deposition in these areas and clinical measurements. <b>Methods:</b> Pw-RRMS and HCs participants underwent brain MRI scans using quantitative susceptibility mapping (QSM) to assess iron deposition in the fear circuit between the two groups. The study analyzed correlations between brain susceptibility changes and clinical measurements. <b>Results:</b> We recruited 35 pw-RRMS (mean age = 46.7 ± 11 years; median EDSS = 2.5) and 18 HCs (mean age = 40.6 ± 17.8 years). Our research revealed significant increases in QSM signals relating to iron deposition in pw-RRMS compared to HCs, whole fear circuit (β = 5.82, <i>p</i> < 0.001), caudate (β = 21.48, <i>p</i> < 0.001), and putamen (β = 17.53, <i>p</i> = 0.03), showing the greatest difference. The whole fear circuit and particularly the caudate are strongly associated with fatigue in pw-RRMS. QSM values in the anterior cingulate cortex significantly differed between pw-RRMS with normal and abnormal depression scores (<i>p</i> = 0.007). <b>Conclusions:</b> These results strengthen the relationship between increased iron deposition in fear circuit regions and specific silent symptoms in pw-RRMS. However, further studies are required to confirm these findings and clarify the implications of iron accumulation in MS pathophysiology.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"19714009241303123"},"PeriodicalIF":1.3,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11618841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Olfactory training affects the correlation between brain structure and functional connectivity.","authors":"Abolhasan Rezaeyan, Somayeh Asadi, Seyed Kamran Kamrava, Arash Zare-Sadeghi","doi":"10.1177/19714009241303129","DOIUrl":"10.1177/19714009241303129","url":null,"abstract":"<p><strong>Purpose: </strong>and background: Neuroimaging studies have increasingly found functional connectivity (FC) changes and structural cortical abnormalities in patients with post-traumatic anosmia (PTA). Training and repeated exposure to odorants lead to enhanced olfactory capability. This study is conducted to investigate the correlations between FC and cortical thickness on the olfaction-related regions of the brain in PTA after olfactory training (OT).</p><p><strong>Methods: </strong>Twenty-five PTA patients were randomly divided in three groups: (1) 9 control patients who did not receive any training, (2) 9 patients underwent classical OT by 4 fixed odors, and (3) 7 patients underwent modified OT coming across 4 sets of 4 different odors sequentially. Before and after the training period, all patients performed olfactory function tests, and magnetic resonance imaging (MRI). Sniffin' Sticks test was used to assess olfactory function. MRI data were analyzed using functional connectivity analysis and brain morphometry.</p><p><strong>Results: </strong>Modified OT resulted in heightened activation in the medial orbitofrontal cortex and anterior cingulate cortex and increased FC between the piriform cortex (PIRC) and the caudate cortex. Conversely, classical OT induced increased activation in the insula cortex and greater FC between the PIRC and the pre-central gyrus. Furthermore, after OT, both training groups achieved significantly improved scores in the changes in brain connectivity associated with OT, which were attributable to anatomical measures.</p><p><strong>Conclusions: </strong>This study demonstrates that intensive olfactory training can enhance functional connectivity, and this improvement correlates with structural changes in the brain's olfactory processing areas.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"19714009241303129"},"PeriodicalIF":1.3,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11615909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The hypointense pulvinar sign on susceptibility weighed magnetic resonance imaging: A visual biomarker for iron deposition in epilepsy.","authors":"Victoria Martella, Riccardo Ludovichetti, Nathalie Nierobisch, Carina Obermüller, Felix Gunzer, Fabienne Maibach, Philip Heesen, Qeumars Hamie, Robert Terziev, Marian Galovic, Zsolt Kulcsar, Nicolin Hainc","doi":"10.1177/19714009241303050","DOIUrl":"10.1177/19714009241303050","url":null,"abstract":"<p><strong>Objective: </strong>Our study aimed to investigate potential alterations in iron deposition within pulvinar, using susceptibility weighted imaging (SWI) MRI in epilepsy patients through a biomarker termed the \"hypointense pulvinar sign.\"</p><p><strong>Methods: </strong>A full-text radiological information system search of radiological reports was performed for the term \"epilepsy\" between 2014 and 2022. Only patients with the diagnosis of epilepsy were included. SWI was assessed by two readers recording lateralization of an asymmetrically more hypointense pulvinar. Cohen's kappa for inter-rater reliability was calculated. Fisher's exact test was performed to assess for significance between groups.</p><p><strong>Results: </strong>Our epilepsy cohort comprised 105 patients with following diagnoses: 45 intra-axial tumor, 13 meningioma, 13 MRI negative, 12 encephalomalacia, seven siderosis, six cavernoma, five arteriovenous malformation, two acute demyelinating encephalomyelitis, one tuberous sclerosis, one giant aneurysm. The hypointense pulvinar sign was correct in 44% of cases. Notably, right hemispheric lesions exhibited a significantly higher proportion of correct hypointense pulvinar signs compared to the left hemisphere (46% vs 24%; <i>p</i> = 0.044). Inter-rater reliability was substantial at 0.62 (<i>p</i> < 0.001). Only two of 21 (10%) of healthy controls demonstrated a hypointense pulvinar sign, which was significantly different from the epilepsy cohort (<i>p</i> < 0.01).</p><p><strong>Conclusions: </strong>The hypointense pulvinar sign has proven to be a reproducible, simple to use biomarker for iron deposition in epilepsy which could be considered for inclusion into multimodal precision medicine models.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"19714009241303050"},"PeriodicalIF":1.3,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11613152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endovascular treatment for brain arteriovenous malformations via the anterior choroidal artery for casting Onyx-18.","authors":"Han Su, Jinlu Yu","doi":"10.1177/19714009241260797","DOIUrl":"10.1177/19714009241260797","url":null,"abstract":"<p><p><b>Background:</b> Few studies have investigated the safety of endovascular treatment (EVT) for brain arteriovenous malformations (BAVMs) via the anterior choroidal artery (AchA); therefore, this topic is worth studying further. <b>Materials and methods:</b> This was a retrospective study of 18 consecutive patients with BAVMs that were treated via the AchA with Onyx casting. Clinical and angiographic data were collected from the patients and analyzed. <b>Results:</b> The ages of the 18 patients ranged from 13 to 67 years (mean 39.2 ± 14.7 years), and eight patients were male (44.4%, 8/18). All patients had intracranial hemorrhages, including 2 with previous hemorrhages. All 18 BAVMs were mainly fed by the AchA and were treated via the AchA as the route for casting Onyx-18. Of the 13 single-trunk AchAs, after EVT, all proximal segments were preserved. For the 5 double-trunk AchAs, EVT was performed via the lower trunk; the proximal segments of the lower trunk were occluded for 2 of these AchAs. Among the 18 BAVMs, 16 niduses were embolized to different degrees, as were twelve associated aneurysms. Five (27.8%, 5/18) of the 18 patients experienced complications, and appropriate management was provided. During long-term follow-up, 14 (77.8%, 14/18) patients achieved good outcomes. <b>Conclusion:</b> EVT for BAVMs via the AchA has significant risks, but overall, good long-term outcomes were achieved in approximal 80% of the patients. This study highlights the potential of this technique for embolizing BAVMs via the AchA.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"723-737"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11531058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141288772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of diffusion tensor imaging in differentiating benign from malignant thyroid nodules.","authors":"Ahmed El-Morsy, Ali H Elmokadem, Ahmed Abdel Razek, Amany Ezzat Mousa, Amal Abdelsattar Sakrana, Rihame M Abdel-Wahab","doi":"10.1177/19714009241260807","DOIUrl":"10.1177/19714009241260807","url":null,"abstract":"<p><p><b>Purpose:</b> To assess diffusion tensor imaging (DTI) in differentiating benign from malignant thyroid nodules. <b>Methods:</b> A retrospective analysis was done on 55 patients with thyroid nodules who had undergone DTI. The fraction anisotropy (FA) and mean diffusivity (MD) of the thyroid nodules were measured using region of interest (ROI) by two observers. The final diagnosis was malignant and benign, as proved by pathological examination. <b>Results:</b> The mean MD of benign thyroid nodules (1.84 ± 0.42 and 1.90 ± 0.37 × 10-3mm²/s) was significantly higher (<i>p</i> < .001) than malignant nodules (0.95 ± 0.46 and 0.97 ± 0.41 × 10-3mm²/s) as scored by both observers. The cut-off values of 1.45 and 1.50 × 10-3mm²/s were used to differentiate malignant from benign thyroid nodules with the areas under the curve (AUC) of 0.926 and 0.937, respectively. The mean FA of benign thyroid nodules (0.23 ± 0.07 and 0.24 ± 0.08) was significantly lower (<i>p</i> < .001) than malignant nodules (0.48 ± 0.21 and 0.49 ± 0.18). The FA cut-off value of ≤0.32 and 0.33 was used for differentiating malignant from benign thyroid nodules with an AUC of 0.877 and 0.881, respectively. A combination of MD and FA values was used to differentiate benign from malignant thyroid nodules with an AUC of 0.932 and an accuracy of 87%. There was an excellent agreement between both observers for FA and MD (K = 0.939, 0.929). <b>Conclusion:</b> The DTI is a non-invasive, non-contrast imaging tool that can differentiate benign from malignant thyroid nodules.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"751-757"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11531045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141307104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}