Indian Journal of Urology最新文献

{"title":"The current status of miRNA in urinary bladder cancer: A minireview and strength, weakness, opportunity, and threat analysis.","authors":"Rachana Tripathy, Lalit Kumar, Sukhad Kural, Anuja Thakur, Sameer Trivedi, Satya Narayan Sankhwar","doi":"10.4103/iju.iju_442_24","DOIUrl":"https://doi.org/10.4103/iju.iju_442_24","url":null,"abstract":"<p><p>MicroRNAs, small noncoding RNA molecules, are critical in modulating gene expression and contribute substantially to the initiation and progression of urinary bladder cancer (UBCa), a major malignancy affecting people globally. UBCa is known for its high recurrence rates and significant heterogeneity. The stability of miRNAs in body fluids such as urine and blood are excellent potential noninvasive markers for early detection, monitoring treatment progress, and predicting outcomes of patients with UBCa. In addition, miRNAs could also improve the effectiveness of immunotherapy and support the development of personalized treatment strategies. Despite their significant potential, challenges such as variability in the expression of miRNAs and shortcomings in their delivery systems must be carefully addressed. This strength, weakness, opportunity, and threat (SWOT) analysis highlights the crucial role of miRNAs in UBCa and explores their potential in advancing precision oncology.</p>","PeriodicalId":47352,"journal":{"name":"Indian Journal of Urology","volume":"41 2","pages":"98-103"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12021363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modification of minced buccal mucosal graft endourethral urethroplasty: A pilot study.","authors":"Abhay Singh Gaur, Vivek Tarigopula, Swarnendu Mandal, Pavithra Ayyanar, Suvendu Purkait, Kirti Singh, C Sabique, Prasant Nayak","doi":"10.4103/iju.iju_519_24","DOIUrl":"https://doi.org/10.4103/iju.iju_519_24","url":null,"abstract":"<p><strong>Introduction: </strong>The minced buccal mucosal graft endourethral urethroplasty (MBGEU) is our novel technique of combining direct vision internal urethrotomy with buccal mucosal graft urethroplasty. We assessed success at 30-months of follow-up. Secondary objectives were to compare the changes in the American Urological Association (AUA) symptom score, peak flow rate (Qmax), and post-void residue (PVR) postoperatively.</p><p><strong>Methods: </strong>This pilot study (CTRI/2021/09/036651) was conducted at a tertiary-care center and included 30 male patients with primary, <2 cm bulbar urethral strictures. A 1 cm × 1 cm buccal mucosal graft was harvested, minced, centrifuged, and suspended in fibrin glue. After a cold knife urethrotomy, a 12-Fr Foley was placed. An 11-Fr cystourethroscope was passed by the side of the catheter, and the suspension was instilled through a 5-Fr ureteric catheter over the urethrotomy site.</p><p><strong>Results: </strong>The success rate of MBGEU was 93.33% at 12 months, 90% at 18 months, 83.3% at 24 months, and 76.6% at 30 months. The stricture recurred in seven patients. The AUA score reduced by 15, 15, 16, 16, 15.5, and 15.5 points from the baseline at 3, 6, 12, 18, 24, and 30 months (P < 0.01). There was a significant increase in the Qmax by 17 ml/s and a significant reduction in the PVR by 73.5 ml at 30 months (P < 0.01). No donor site morbidity was seen. There were no postoperative complications.</p><p><strong>Conclusion: </strong>The medium-term success of MBGEU is encouraging. However, a longer follow-up and further studies with a larger sample size and a comparative arm are required.</p>","PeriodicalId":47352,"journal":{"name":"Indian Journal of Urology","volume":"41 2","pages":"131-136"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12021355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Partial nephrectomy for a completely endophytic tumor in an allograft kidney, 14 years after transplantation.","authors":"Vivek Dadasaheb Patil, Prashanth Reddy Yensani, Vishnu Prasad, Mounish Nuthalapati, Shashank Agrawal, Arun Ramdas Menon, P Ginil Kumar","doi":"10.4103/iju.iju_135_24","DOIUrl":"https://doi.org/10.4103/iju.iju_135_24","url":null,"abstract":"<p><p>We report our experience with nephron-sparing surgery for a completely endophytic small renal mass in an allograft kidney. A 37-year-old female, 14 years post live-related renal transplant for end-stage renal disease due to crescentic glomerulonephritis, presented with a 3.6 cm renal mass. She underwent open allograft partial nephrectomy and was discharged on the 5^th postoperative day. Six months postsurgery, she showed excellent graft function with no tumor recurrence. Nephron-sparing surgery of the allograft kidney presents challenges regarding vascular anatomy, hilar, and parenchymal adhesions making the surgery difficult, but is feasible and oncologically safe for transplant recipients with tumors in the allograft kidney.</p>","PeriodicalId":47352,"journal":{"name":"Indian Journal of Urology","volume":"41 2","pages":"145-147"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12021362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large asymptomatic pseudoaneurysm post open partial nephrectomy - A rare case.","authors":"Kamalakanta Beheruk, Kumar Rajiv Ranjan, Soumya Mondal","doi":"10.4103/iju.iju_497_24","DOIUrl":"https://doi.org/10.4103/iju.iju_497_24","url":null,"abstract":"<p><p>A 52-year-old female presented with a history of left partial nephrectomy performed 1 year ago for a left renal mass. She was asymptomatic and was under post-operative follow-up. A contrast-enhanced computed tomography scan of the abdomen was obtained which revealed a large renal artery pseudoaneurysm (of size 79 mm ×67 mm ×78 mm). In view of large size, therapeutic angioembolization was performed safely without any post intervention complications.</p>","PeriodicalId":47352,"journal":{"name":"Indian Journal of Urology","volume":"41 2","pages":"151-152"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12021359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical epidemiology of young men with lower urinary tract symptoms: The SciCOM 3 project.","authors":"Sanjay Sinha, Sameer Trivedi, Ankur Mittal, Girdhar Bora, Rishi Nayyar, Pawan Vasudeva, Anita Patel, Harbans Bansal, Vijay Kumar Sarma Madduri, Niraj Kumar, Swarnendu Mandal, Vikas Kumar, Sujith Jose, Girish G Nelivigi, Anil Elhence, Harprit Singh","doi":"10.4103/iju.iju_429_24","DOIUrl":"https://doi.org/10.4103/iju.iju_429_24","url":null,"abstract":"<p><strong>Introduction: </strong>A study was performed to determine the most common and most bothersome symptoms and clinical associations in young men (18-40 years) presenting with lower urinary tract symptoms (LUTS).</p><p><strong>Methods: </strong>Cross-sectional study was conducted across 16 centers. Urinary symptoms, impact of bladder problems, bowel symptoms, erectile dysfunction, premature ejaculation, bladder pain, non-bladder myofascial pain, and general well-being were assessed by validated questionnaires.</p><p><strong>Results: </strong>A total of 448 men (median age 30 years) were included. Nocturia ≥1 (89.1%) and feeling of incomplete bladder evacuation (76.6%) were the most common symptoms while the most bothersome symptoms were daytime frequency and nocturia (median score 5; interquartile range 2-8, for both) on the International Consultation on Incontinence Questionnaire for Male LUTS questionnaire. Bladder symptoms were associated with severe or many severe problems (response 5 or 6, on the Patient Perception of Bladder Conditions Questionnaire) in 17.8% of the patients. Men between 18 and 20 years reported greater bother with their bladder condition. Normal erections and \"very good\" control over ejaculation were reported by 49.8% and 15.6%, respectively. Constipation and loose stools were reported by 22.8% and 12.9%, while bladder pain and non-bladder myofascial pain were reported by 72.5%, and 48.2%, respectively. 17.0% of the patients reported low scores on the WHO-5 Well-Being Scale. Two distinct patient clusters were identified. A larger cluster (63.9%) that presented with voiding symptoms and urgency but fewer sexual or pain symptoms, and a smaller cluster that showed pronounced sexual symptoms, pain, daytime frequency, and nocturia.</p><p><strong>Conclusions: </strong>The most common urinary symptoms in young men are nocturia and a sense of incomplete evacuation. Daytime frequency and nocturia are the most bothersome symptoms. It is important to assess associated symptoms in young men presenting with LUTS.</p>","PeriodicalId":47352,"journal":{"name":"Indian Journal of Urology","volume":"41 2","pages":"137-144"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12021365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expeditious management of an unexpected complication of left renal vein ligation during right retroperitoneoscopic simple nephrectomy: A lesson learned the hard way.","authors":"Priyank Bhargava, Kartik Sharma, Mahendra Singh","doi":"10.4103/iju.iju_119_24","DOIUrl":"10.4103/iju.iju_119_24","url":null,"abstract":"<p><p>We present a case of inadvertent left renal vein clipping during right retroperitoneoscopic nephrectomy (RPN) and describe its expeditious identification and management. A 13-year-old girl underwent RPN for nonfunctioning kidney due to urolithiasis. During the dissection of the right renal vein, the inferior vena cava (IVC) got lifted off the parietal wall and the left renal vein was mistakenly ligated. Based on a strong intra-operative suspicion, the patient underwent an urgent computed tomography angiography which confirmed the ligation of the left renal vein. The patient was reoperated immediately and an end-to-side anastomosis was performed between the left renal vein and the IVC.</p>","PeriodicalId":47352,"journal":{"name":"Indian Journal of Urology","volume":"41 1","pages":"66-68"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11778686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143068844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IJU Awards 2024.","authors":"","doi":"10.4103/iju.iju_494_24","DOIUrl":"https://doi.org/10.4103/iju.iju_494_24","url":null,"abstract":"","PeriodicalId":47352,"journal":{"name":"Indian Journal of Urology","volume":"41 1","pages":"80-81"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11778700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143068863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Andrology subspecialty: Training opportunities for Indian urologists.","authors":"Pramod Krishnappa, Rupin Shah","doi":"10.4103/iju.iju_353_24","DOIUrl":"10.4103/iju.iju_353_24","url":null,"abstract":"","PeriodicalId":47352,"journal":{"name":"Indian Journal of Urology","volume":"41 1","pages":"9-10"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11778691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143068781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of inferior alveolar plus buccal nerve block on donor site morbidity at buccal mucosal graft harvest site: A double-blinded, randomized placebo-controlled trial.","authors":"Vivek Tarigopula, Swarnendu Mandal, Gorrepati Rohith, Dheeraj Kumar Dheeroo, Manoj Kumar Das, Sambit Tripathy, Kalandi Barik, Prasant Nayak","doi":"10.4103/iju.iju_167_24","DOIUrl":"10.4103/iju.iju_167_24","url":null,"abstract":"<p><strong>Introduction: </strong>Pain at the buccal mucosal graft (BMG) harvest site in the immediate postoperative period is common and delays resumption of oral intake. This study compares the time for resumption of pain-free solid and liquid diets and postoperative pain scores at harvest site following the administration of inferior-alveolar nerve-block plus buccal-nerve block (IANB + BNB) versus placebo. We hypothesize that the intervention could decrease pain and aid in early food intake.</p><p><strong>Methods: </strong>A single-center, placebo-controlled, double-blinded randomized-control trial was conducted from September 2022 to August 2023 (CTRI). All individuals > 18 years undergoing BMG harvest were included. Patients with contraindications for BMG harvest and diabetes were excluded. Furthermore, patients requiring additional lingual/labial graft, bilateral BMG, or a history of prior BMG harvest were also excluded. IANB + BNB was performed with a 10 ml mixture comprising lignocaine, bupivacaine, and dexamethasone, while normal saline was administered in the control group. Both groups received submucosal local anesthetic infiltration.</p><p><strong>Results: </strong>After randomization (<i>n</i> = 28 in each group), patients who received IANB + BNB had an early return to pain-free liquid (median 1 vs. 2 days; <i>P</i> ≤ 0.001) and solid diet (median 2 vs. 3 days; <i>P</i> = 0.001) 1 day quicker than those who received placebo. In the intervention arm, Visual Analog Scale scores at harvest site were lower from 2 to 48 h postoperatively, had reduced paracetamol requirement (median 7 g vs. 9 g; <i>P</i> = 0.001), and fewer necessitated opioids for breakthrough pain (14.4% vs. 53.3%; <i>P</i> = 0.002).</p><p><strong>Conclusion: </strong>Patients who received IANB + BNB resumed a pain-free diet in the postoperative period quicker, reported lower pain scores, and there were lesser postoperative analgesic requirements.</p>","PeriodicalId":47352,"journal":{"name":"Indian Journal of Urology","volume":"41 1","pages":"45-50"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11778690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143068829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the duration of androgen deprivation therapy in prostate cancer-RADICALS-HD trial.","authors":"Prabhu E Rajendran","doi":"10.4103/iju.iju_347_24","DOIUrl":"10.4103/iju.iju_347_24","url":null,"abstract":"","PeriodicalId":47352,"journal":{"name":"Indian Journal of Urology","volume":"41 1","pages":"75-76"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11778699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143068818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}