Oral and Maxillofacial Surgery-Heidelberg最新文献

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Role of stereotactic radiotherapy for head neck cancer. 立体定向放疗在头颈癌中的作用。
IF 1.7
Oral and Maxillofacial Surgery-Heidelberg Pub Date : 2025-02-26 DOI: 10.1007/s10006-024-01314-2
Shrikant B Mali
{"title":"Role of stereotactic radiotherapy for head neck cancer.","authors":"Shrikant B Mali","doi":"10.1007/s10006-024-01314-2","DOIUrl":"https://doi.org/10.1007/s10006-024-01314-2","url":null,"abstract":"<p><strong>Aim: </strong>In recent years, stereotactic ablative radiotherapy (SABR) has been created. Using one or a small number of dosage fractions, SABR enables the hypofractionated treatment of extracranial tumours, delivering a high biologically effective dose with little damage. This review article explores role of stereotactic ablative radiotherapy in head neck cancers.</p><p><strong>Material methods: </strong>Using the search parameters SABR, stereotactic radiotherapy, and targeted radiation, the publications were found on PubMed and Scopus. For this review, the closest publications to SABR were consulted from the search results that were returned.</p><p><strong>Conclusion: </strong>In the treatment of patients with recurring and/or previously irradiated head and neck malignancies, SABR is technically possible, well-tolerated, and performs comparably to other salvage therapy options. It also offers the benefit of a quicker course of therapy. Timetable, increased adherence, and secure delivery in the outpatient context. This presents a chance to provide SABR as a therapy option for a limited number of patients. In order to properly administer a highly conformal ablative dosage to targets (or tumours) in the body, SBRT requires sophisticated technologies in radiation planning and imaging guiding. Because of its highly conformal dose distributions and stereotactic spatial precision in administration, SABR is being employed more and more to treat a range of head and neck tumours.</p>","PeriodicalId":47251,"journal":{"name":"Oral and Maxillofacial Surgery-Heidelberg","volume":"29 1","pages":"58"},"PeriodicalIF":1.7,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143504799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative analysis of lip morphology in Brazilian caucasian individuals between 20 and 50 years old using stereophotogrammetry. 用立体摄影测量法比较分析20 ~ 50岁巴西白种人的嘴唇形态。
IF 1.7
Oral and Maxillofacial Surgery-Heidelberg Pub Date : 2025-02-18 DOI: 10.1007/s10006-025-01349-z
Karolyn Sales Fioravanti, Maria Gabriela Robles Mengoa, Laura Vidoto Paludetto, Guilherme Yukio Arakaki Murayama, Thaís Marchini Oliveira, Chiarella Sforza, Karin Hermana Neppelenbroek, Simone Soares
{"title":"Comparative analysis of lip morphology in Brazilian caucasian individuals between 20 and 50 years old using stereophotogrammetry.","authors":"Karolyn Sales Fioravanti, Maria Gabriela Robles Mengoa, Laura Vidoto Paludetto, Guilherme Yukio Arakaki Murayama, Thaís Marchini Oliveira, Chiarella Sforza, Karin Hermana Neppelenbroek, Simone Soares","doi":"10.1007/s10006-025-01349-z","DOIUrl":"https://doi.org/10.1007/s10006-025-01349-z","url":null,"abstract":"<p><strong>Purpose: </strong>This observational, cross-sectional study evaluated healthy Caucasian Brazilian individuals' normal lip dimensions according to sex and age (20-50 years) using stereophotogrammetry.</p><p><strong>Methods: </strong>A total of 130 individuals divided into four groups according to sex and age were analyzed using stereophotogrammetry. Ten linear lip, five angular lip, and three lip surface measurements (upper, lower, and total lip vermilion) were obtained. Comparisons were performed using two-way ANOVA.</p><p><strong>Results: </strong>Mouth width, philtrum width, and lower lip cutaneous height were significantly greater in men than women. The upper lip height, upper lip cutaneous height, and average lower vermilion lip angle were significantly larger in men than women and increased with age (group), with medium or large effect sizes. A sex × group interaction was present for total vermilion height, upper vermilion height, total lip height, lower lip height, average upper vermilion lip angle, average Cupid's bow angle, mentolabial angle, and upper and total vermilion lip areas. When factors interact (sex/group), one affects the outcome of the other.</p><p><strong>Conclusions: </strong>Relevant linear lip measures were greater in men than women and increased with age in a mixed population from 20 to 50 years old. Thus, the lip and mouth are severly impacted by aging.</p>","PeriodicalId":47251,"journal":{"name":"Oral and Maxillofacial Surgery-Heidelberg","volume":"29 1","pages":"57"},"PeriodicalIF":1.7,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bizarre parosteal osteochondromatous proliferation in the jaws: a systematic review. 颌骨怪异的骨旁软骨瘤增生:系统回顾。
IF 1.7
Oral and Maxillofacial Surgery-Heidelberg Pub Date : 2025-02-14 DOI: 10.1007/s10006-025-01352-4
Silvia Helena Villela Castro de Paula, Paula de Sousa Lopes Cascaes, Mariela Peralta-Mamani, Andresa Borges Soares, José Luiz Junqueira, Mariana Quirino Silveira Soares
{"title":"Bizarre parosteal osteochondromatous proliferation in the jaws: a systematic review.","authors":"Silvia Helena Villela Castro de Paula, Paula de Sousa Lopes Cascaes, Mariela Peralta-Mamani, Andresa Borges Soares, José Luiz Junqueira, Mariana Quirino Silveira Soares","doi":"10.1007/s10006-025-01352-4","DOIUrl":"https://doi.org/10.1007/s10006-025-01352-4","url":null,"abstract":"<p><strong>Purpose: </strong>The bizarre parosteal osteochondromatous proliferation (bpop) is a rare lesion that affects long tubular bones of the feet and hands. Since these lesions are even rarer in the jaws, this systematic review aimed to summarize the up-to-date scientific evidence that can guide health professionals on the diagnosis and treatment of bpop in the jaws.</p><p><strong>Methods: </strong>This prisma-guided and prospero-registered (crd42024524576) review included case reports with confirmed anatomopathological diagnosis of bpop. The articles were searched in november 2024 in the pubmed, scopus, web of science, scielo, cochrane library, embase, and livivo databases and the academic repositories (proquest, open grey, ibict/bdt, and google scholar) without language or publication date restrictions.</p><p><strong>Results: </strong>Twelve cases of patients aged between 2 and 72 years (mean 26.5 ± 19.8 years) with equal gender distribution were included. Most lesions were clinically described as nodules or swellings (83.5%), asymptomatic (58.3%), with a mean diameter of 15.8 ± 16.2 mm, located in the mandible (58.3%) and anterior region of the jaws (75%). Radiographically, 66.7% of the lesions had well-defined borders and 91.7% were in continuity with the cortical bone. Histopathological findings revealed pleomorphic chondrocytes (83.3%), hypercellular cartilage (83.3%), and 'blue bone' (50%). All bpop lesions were surgically excised and recurrence was observed in 41.7% of cases with a mean follow-up of 8.8 months.</p><p><strong>Conclusion: </strong>Since bpop demonstrates a recurrent behavior, further investigations with long-term follow-up periods are needed to address its malignancy potential.</p>","PeriodicalId":47251,"journal":{"name":"Oral and Maxillofacial Surgery-Heidelberg","volume":"29 1","pages":"56"},"PeriodicalIF":1.7,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Postoperative anticoagulation in patients with microvascular reconstruction - a systematic review. 微血管重建患者术后抗凝治疗的系统综述。
IF 1.7
Oral and Maxillofacial Surgery-Heidelberg Pub Date : 2025-02-12 DOI: 10.1007/s10006-025-01351-5
Moritz Bleymehl, Julius Moratin, Maximilian Smielowski, Gregor Schnug, Thomas Rückschloß, Cornelius Busch, Michael Engel, Jürgen Hoffmann, Oliver Ristow
{"title":"Postoperative anticoagulation in patients with microvascular reconstruction - a systematic review.","authors":"Moritz Bleymehl, Julius Moratin, Maximilian Smielowski, Gregor Schnug, Thomas Rückschloß, Cornelius Busch, Michael Engel, Jürgen Hoffmann, Oliver Ristow","doi":"10.1007/s10006-025-01351-5","DOIUrl":"https://doi.org/10.1007/s10006-025-01351-5","url":null,"abstract":"<p><strong>Objective: </strong>To assess the currently applied regimens of antithrombotic therapy after microvascular reconstruction.</p><p><strong>Methods: </strong>A systematic literature review was performed using the MEDLINE/PubMed Database for work published until September 2022. Data synthesis and risk of bias were reported in accordance with NIH Study Quality Assessment Tools guidelines.</p><p><strong>Results: </strong>204 articles were found including the keywords either in the abstract or in the title. After screening their abstracts and titles, 41 articles were identified as suitable and the full texts were retrieved. 23 studies were included in this review. No gold standard could be shown; on the contrary, the applied antithrombotic regimens varied widely. A broad consensus could be obtained that Dextran should no longer be used after an increased complication rate was proven. The most commonly used agents are unfractionated (UFH) as well as low molecular weight (LMWH) heparin and acetylsalecylic acid (ASA), although the literature results are partly contradictory.</p><p><strong>Conclusions: </strong>A consensus could be found that it is useful to perform thromboprophylaxis when the patient is immobilized, but there is no evidence for a survival advantage of the flap by chemical prophylaxis. On the contrary, it has been shown that there is an increased rate of bleeding complications and flap loss combined with the simultaneous use of multiple chemical anticoagulants. In conclusion the generalized use of anticoagulation is explained less by microvascular grafting than by general medical risk factors. Thus, large prospective RCTs will be needed to establish a gold standard therapeutic regimen.</p>","PeriodicalId":47251,"journal":{"name":"Oral and Maxillofacial Surgery-Heidelberg","volume":"29 1","pages":"55"},"PeriodicalIF":1.7,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of ozone and low power laser as therapeutic alternatives on the alveolar repair process after tooth extraction in rats wistar exposed to nicotine. 臭氧和低功率激光对尼古丁暴露大鼠拔牙后牙槽修复的影响。
IF 1.7
Oral and Maxillofacial Surgery-Heidelberg Pub Date : 2025-02-07 DOI: 10.1007/s10006-025-01339-1
Thainy Oliveira Carvalho, Wilson Pereira de Almeida, Fabiano Rodrigues Palma, Paulo Vinícius Fontanella Pilati, Victoria Zanardo, Anna Júlia Leduc Chaves, Sarah Freygang Mendes Pilati
{"title":"Effect of ozone and low power laser as therapeutic alternatives on the alveolar repair process after tooth extraction in rats wistar exposed to nicotine.","authors":"Thainy Oliveira Carvalho, Wilson Pereira de Almeida, Fabiano Rodrigues Palma, Paulo Vinícius Fontanella Pilati, Victoria Zanardo, Anna Júlia Leduc Chaves, Sarah Freygang Mendes Pilati","doi":"10.1007/s10006-025-01339-1","DOIUrl":"10.1007/s10006-025-01339-1","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to evaluate the alveolar repair process in rats exposed to nicotine after tooth extraction, using ozonised water and low-power laser therapy (LPLT) as therapeutic adjuvants.</p><p><strong>Materials and methods: </strong>Thirty wistar rats (Rattus Norvegicus) were used and given the nicotine solution via subcutaneous tissue. After 7 days, the upper right central incisor was surgically extracted. Three days after the surgical procedure, the animals continued to receive nicotine until the day of euthanasia, totalling 21 days after extraction.</p><p><strong>Results: </strong>The result was that the groups that received coadjuvant therapy had neoformed mature bone, unlike the group that did not receive it.</p><p><strong>Conclusions: </strong>Based on the literature and the results obtained, we can conclude that nicotine negatively influenced the healing process and bone repair in the alveoli; however, the use of ozonised water and LPLT, even in the presence of nicotine, was effective, as it enhanced the repair process, making them good options for surgical procedures in patients who smoke.</p>","PeriodicalId":47251,"journal":{"name":"Oral and Maxillofacial Surgery-Heidelberg","volume":"29 1","pages":"54"},"PeriodicalIF":1.7,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic association of plasminogen activator inhibitor-1 gene polymorphisms (rs2227631 and rs6092) with susceptibility to oral premalignant disorders in a South Indian cohort. 南印度人群中纤溶酶原激活物抑制剂-1基因多态性(rs2227631和rs6092)与口腔恶性前病变易感性的遗传关系
IF 1.7
Oral and Maxillofacial Surgery-Heidelberg Pub Date : 2025-02-06 DOI: 10.1007/s10006-025-01350-6
Usha Subbiah, Kaniha Sivakumar
{"title":"Genetic association of plasminogen activator inhibitor-1 gene polymorphisms (rs2227631 and rs6092) with susceptibility to oral premalignant disorders in a South Indian cohort.","authors":"Usha Subbiah, Kaniha Sivakumar","doi":"10.1007/s10006-025-01350-6","DOIUrl":"https://doi.org/10.1007/s10006-025-01350-6","url":null,"abstract":"<p><strong>Introduction: </strong>Oral potentially malignant disorders impact the oral mucosa and elevate the risk of oral cancer. In India, the high prevalence of oral submucous fibrosis and leukoplakia is attributed to habits such as tobacco use and smoking. Plasminogen activator inhibitor-1 plays a crucial role in cancer progression. Single-nucleotide polymorphisms are the most widespread genetic variations associated with various diseases, including cancers.</p><p><strong>Aim: </strong>This study aimed to investigate the association between PAI-1 promoter rs2227631 (- 844G > A) and missense variant rs6092 (+ 43G > A) polymorphisms and the susceptibility to OSMF and leukoplakia in a South Indian cohort of chewers and smokers.</p><p><strong>Methods: </strong>The rs2227631 and rs6092 of PAI-1 were analysed using PCR- RFLP in 285 subjects including OSMF, leukoplakia and healthy controls, along with their habitual factors. The allele frequencies and genotypic associations were examined. The impact of these SNPs on mRNA secondary structure, gene-gene and protein-protein interactions was also analysed using in silico tools.</p><p><strong>Results: </strong>The habits of chewers and smokers were (79% and 72%) in OSMF and (62% and 75%) in leukoplakia and disease prevalent was (78% and 59%) males and (22% and 26%) females respectively. The G allele of rs2227631 and A allele of rs6092 were significantly associated with the diseases (P < 0.05).</p><p><strong>Conclusion: </strong>PAI-1 polymorphisms rs2227631 and rs6092 were associated with OSMF and leukoplakia of the south Indian cohort.</p>","PeriodicalId":47251,"journal":{"name":"Oral and Maxillofacial Surgery-Heidelberg","volume":"29 1","pages":"52"},"PeriodicalIF":1.7,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of vertical loading forces on three different sagittal split ramus osteotomy modifications. 三种不同矢状分叉支截骨方式的垂直载荷力分析。
IF 1.7
Oral and Maxillofacial Surgery-Heidelberg Pub Date : 2025-02-06 DOI: 10.1007/s10006-025-01346-2
Frederico Felipe Antonio Oliveira Nascimento, John Paul Stella, Leandro Eduardo Klüppel, Márcio de Moraes
{"title":"Analysis of vertical loading forces on three different sagittal split ramus osteotomy modifications.","authors":"Frederico Felipe Antonio Oliveira Nascimento, John Paul Stella, Leandro Eduardo Klüppel, Márcio de Moraes","doi":"10.1007/s10006-025-01346-2","DOIUrl":"https://doi.org/10.1007/s10006-025-01346-2","url":null,"abstract":"<p><strong>Objective: </strong>The study aimed to compare and analyze the in vitro mechanical behavior of vertical load on three different sagittal split osteotomy designs proposed by Epker, Wolford, and Wyatt, focusing on the implications of each design on mandibular stability.</p><p><strong>Study design: </strong>Synthetic polyurethane hemi-mandibular models were used to replicate the osteotomies according to the designs suggested by Epker, Wolford, and Wyatt. Each model group was subjected to linear vertical loading until system failure, with peak load and deformation recorded. The study utilized a controlled sample preparation and loading test to ensure standardization across all groups. Analysis of variance (ANOVA) and the Tukey test were applied to compare the mechanical responses among the different osteotomy designs.</p><p><strong>Results: </strong>The findings indicated no significant difference in displacement and vertical loading resistance between Groups 1 and 2; however, differences were found in Group 3 (Wyatt), where increased mandibular fragility was observed when screws were placed in thinner bone areas. Statistical analysis showed that the modifications in the osteotomy design led to significant differences in mechanical behavior, particularly in Group 3, highlighting the importance of bone thickness and osteotomy technique on postoperative early stability and mechanical stress distribution.</p><p><strong>Conclusions: </strong>The study concludes that the choice of sagittal split osteotomy design significantly impacts the mechanical behavior under vertical loading, with particular emphasis on the importance of bone thickness at fixation points and the technique used. The findings suggest a preference for the modification proposed in group 1 and 2 in cases where increased mandibular stability and minimized postoperative complications are desired.</p>","PeriodicalId":47251,"journal":{"name":"Oral and Maxillofacial Surgery-Heidelberg","volume":"29 1","pages":"53"},"PeriodicalIF":1.7,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Direct oral anticoagulant use in oral surgery: insights from a systematic review. 口腔手术中直接口服抗凝剂的使用:系统综述的启示。
IF 1.7
Oral and Maxillofacial Surgery-Heidelberg Pub Date : 2025-02-05 DOI: 10.1007/s10006-025-01348-0
Evyatar Yefet, Navot Givol, Michael Pesis
{"title":"Direct oral anticoagulant use in oral surgery: insights from a systematic review.","authors":"Evyatar Yefet, Navot Givol, Michael Pesis","doi":"10.1007/s10006-025-01348-0","DOIUrl":"https://doi.org/10.1007/s10006-025-01348-0","url":null,"abstract":"<p><strong>Purpose: </strong>The increasing use of direct oral anticoagulants (DOACs) in patients undergoing oral surgery highlights the need for well-defined, evidence-based recommendations on perioperative and postoperative bleeding management. This review aims to evaluate bleeding risks and strategies to optimize the management of patients treated with DOACs undergoing oral surgical procedures.</p><p><strong>Methods: </strong>A systematic review identified 628 articles, of which 17 met the inclusion criteria. These studies focused exclusively on patients treated with DOACs-Dabigatran, Rivaroxaban, Apixaban, and Edoxaban-undergoing oral surgical procedures, such as tooth extractions, dental implants, and soft tissue surgical procedures. Articles involving other anticoagulants or combined therapies were excluded to ensure precision in evaluating DOAC-specific outcomes.</p><p><strong>Results: </strong>The findings revealed that minor to moderate bleeding events were relatively common, while severe bleeding requiring hospitalization was rare. Bleeding events were effectively managed using standard local hemostatic measures in most cases. This review highlights the importance of scheduling procedures when DOAC levels are at their lowest, as this minimizes the risk of excessive bleeding. Furthermore, the continuation of DOAC therapy during oral surgery was deemed safe, with effective local management strategies mitigating bleeding risks.</p><p><strong>Conclusion: </strong>This review offers practical, evidence-based recommendations for the management of patients on DOAC therapy undergoing oral surgical procedures. The findings simplify clinical decision-making and improve patient safety by emphasizing the importance of timing and perioperative strategies. The exclusive focus on DOACs underscores the clinical significance of this work in guiding oral and maxillofacial surgeons.</p>","PeriodicalId":47251,"journal":{"name":"Oral and Maxillofacial Surgery-Heidelberg","volume":"29 1","pages":"51"},"PeriodicalIF":1.7,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the effects of smoking on the clinical and histological characteristics and levels of growth factors in autologous fibrin membranes. 评价吸烟对临床和组织学特征及自体纤维蛋白膜生长因子水平的影响。
IF 1.7
Oral and Maxillofacial Surgery-Heidelberg Pub Date : 2025-02-03 DOI: 10.1007/s10006-025-01345-3
Bruno Campos Amorim, Thiago Soares de Sá, Ignacio Triviño Solís, Ricardo Siufi, Elizabeth Ferreira Martinez
{"title":"Evaluation of the effects of smoking on the clinical and histological characteristics and levels of growth factors in autologous fibrin membranes.","authors":"Bruno Campos Amorim, Thiago Soares de Sá, Ignacio Triviño Solís, Ricardo Siufi, Elizabeth Ferreira Martinez","doi":"10.1007/s10006-025-01345-3","DOIUrl":"https://doi.org/10.1007/s10006-025-01345-3","url":null,"abstract":"<p><strong>Objectives: </strong>Considering the increase in regenerative dental treatments, autologous fibrin membranes (ARMs) have been widely used in tissue engineering, favoring the regeneration of hard and soft tissues, accelerating angiogenesis and promoting cell differentiation and migration. This study proposed evaluate the differences in clinical characteristics and levels of the growth factors BMP-2, IGF, PDGF and VEGF between smokers and nonsmokers were evaluated according to the guidelines of the US Preventive Service Task Force (USPSTF).</p><p><strong>Materials and methods: </strong>Fourteen smokers and 14 nonsmokers were selected. After processing, the samples were allowed to rest in tubes for 5 min for the organization of the matrix and completion of the fibrin clot. Only the yellow portion and the buffy coat were removed and stored. Four clots were obtained from each donor and used to quantify the release of the growth factors BMP2, PDGF, IGF and VEGF. In addition, histological analyses were performed, and clinical characteristics were evaluated.</p><p><strong>Results: </strong>The data were tabulated and subjected to statistical analysis with a significance level of 5%. In both groups, the membranes remained intact throughout the analysis period, indicating similar structural behavior. Histological evaluation of the membranes obtained from the participants revealed the presence of more homogeneous fibrin membranes in the nonsmoker group and many leukocytes bordering the entire fibrin clot. In the smoker group, heterogeneous fibrin clots, sometimes malformed, and fewer leukocytes in the region of the buffy coat and bordering the entire fibrin were observed.</p><p><strong>Conclusions: </strong>Smokers had significantly lower levels of VEGF, PDGF and BMP-2 (pg/ml in 1 µg total protein) than smokers did (p < 0.05), and there was no significant difference in IGF levels (p > 0.05) between the groups. There was also no statistically significant difference in membrane size between smokers and nonsmokers (mm, p > 0.05).</p><p><strong>Clinical relevance: </strong>Smoking may interfere with the formation of the fibrin mesh and consequently affects the quality and regenerative capacity in in smoking patients.</p>","PeriodicalId":47251,"journal":{"name":"Oral and Maxillofacial Surgery-Heidelberg","volume":"29 1","pages":"49"},"PeriodicalIF":1.7,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical implementation of the 3D 4K exoscope (Orbeye™) in reconstructive head and neck surgery. 三维 4K 外窥镜(Orbeye™)在头颈部整形手术中的临床应用。
IF 1.7
Oral and Maxillofacial Surgery-Heidelberg Pub Date : 2025-02-03 DOI: 10.1007/s10006-025-01342-6
Elena Hofmann, Christian Doll, Steffen Koerdt, Cynthia Kurth, Max Heiland, Kilian Kreutzer
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