{"title":"牙槽骨炎的治疗：2型糖尿病患者的新再生技术。","authors":"Hakob Khachatryan, Margarita Hovhannisyan, Gagik Hakobyan","doi":"10.1007/s10006-025-01375-x","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>Evaluation of the effectiveness Gengigel<sup>®</sup> Oral Gel (hyaluronic acid ) and photobiomodulation (magnetic laser) in the treatment of alveolar osteitis in patients with type 2 diabetes mellitus.</p><p><strong>Methods: </strong>This is a blind RCT study clinical prospective study in 69 patients with type 2 diabetes mellitus with alveolar osteitis. The subjects selected for study were examined under the inclusion and exclusion criteria and sign the written consent. The patients were blind randomly assigned into two groups: The Group I included 35 patients with alveolar osteitis, in which complex treatment including HA and magnetic laser therapy was carried out. The Group II is represented by 34 patients, with alveolar osteitis received treatment including antiseptic and inflammatory agents. Healing time and pain levels of the alveolar socket of the extracted tooth were appreciated. The pain levels in dynamics were assessed according to VAS.</p><p><strong>Results: </strong>After the 5th treatment session, 91% of patients in the 1st group had a VAS score of 0 (no pain), whereas in 9% of patients, the VAS score was 1-3. In group 2, a similar result of the VAS score was recorded but only on the 8th day of treatment.</p><p><strong>Conclusion: </strong>The results show that the use of Gengigel<sup>®</sup> Oral Gel (hyaluronic acid ) and photobiomodulation(magnetic laser) recommended for the treatment of dry socket in patients with type 2 diabetes mellitus, can be considered as a promising method, as it has not only anti-inflammatory but also pronounced analgesic and tissue regenerating properties.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":47251,"journal":{"name":"Oral and Maxillofacial Surgery-Heidelberg","volume":"29 1","pages":"77"},"PeriodicalIF":1.7000,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Management of alveolar osteitis: new regenerative techniques in patients with type 2 diabetes.\",\"authors\":\"Hakob Khachatryan, Margarita Hovhannisyan, Gagik Hakobyan\",\"doi\":\"10.1007/s10006-025-01375-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>Evaluation of the effectiveness Gengigel<sup>®</sup> Oral Gel (hyaluronic acid ) and photobiomodulation (magnetic laser) in the treatment of alveolar osteitis in patients with type 2 diabetes mellitus.</p><p><strong>Methods: </strong>This is a blind RCT study clinical prospective study in 69 patients with type 2 diabetes mellitus with alveolar osteitis. The subjects selected for study were examined under the inclusion and exclusion criteria and sign the written consent. The patients were blind randomly assigned into two groups: The Group I included 35 patients with alveolar osteitis, in which complex treatment including HA and magnetic laser therapy was carried out. The Group II is represented by 34 patients, with alveolar osteitis received treatment including antiseptic and inflammatory agents. Healing time and pain levels of the alveolar socket of the extracted tooth were appreciated. The pain levels in dynamics were assessed according to VAS.</p><p><strong>Results: </strong>After the 5th treatment session, 91% of patients in the 1st group had a VAS score of 0 (no pain), whereas in 9% of patients, the VAS score was 1-3. In group 2, a similar result of the VAS score was recorded but only on the 8th day of treatment.</p><p><strong>Conclusion: </strong>The results show that the use of Gengigel<sup>®</sup> Oral Gel (hyaluronic acid ) and photobiomodulation(magnetic laser) recommended for the treatment of dry socket in patients with type 2 diabetes mellitus, can be considered as a promising method, as it has not only anti-inflammatory but also pronounced analgesic and tissue regenerating properties.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>\",\"PeriodicalId\":47251,\"journal\":{\"name\":\"Oral and Maxillofacial Surgery-Heidelberg\",\"volume\":\"29 1\",\"pages\":\"77\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-04-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Oral and Maxillofacial Surgery-Heidelberg\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s10006-025-01375-x\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oral and Maxillofacial Surgery-Heidelberg","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s10006-025-01375-x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
Management of alveolar osteitis: new regenerative techniques in patients with type 2 diabetes.
Objectives: Evaluation of the effectiveness Gengigel® Oral Gel (hyaluronic acid ) and photobiomodulation (magnetic laser) in the treatment of alveolar osteitis in patients with type 2 diabetes mellitus.
Methods: This is a blind RCT study clinical prospective study in 69 patients with type 2 diabetes mellitus with alveolar osteitis. The subjects selected for study were examined under the inclusion and exclusion criteria and sign the written consent. The patients were blind randomly assigned into two groups: The Group I included 35 patients with alveolar osteitis, in which complex treatment including HA and magnetic laser therapy was carried out. The Group II is represented by 34 patients, with alveolar osteitis received treatment including antiseptic and inflammatory agents. Healing time and pain levels of the alveolar socket of the extracted tooth were appreciated. The pain levels in dynamics were assessed according to VAS.
Results: After the 5th treatment session, 91% of patients in the 1st group had a VAS score of 0 (no pain), whereas in 9% of patients, the VAS score was 1-3. In group 2, a similar result of the VAS score was recorded but only on the 8th day of treatment.
Conclusion: The results show that the use of Gengigel® Oral Gel (hyaluronic acid ) and photobiomodulation(magnetic laser) recommended for the treatment of dry socket in patients with type 2 diabetes mellitus, can be considered as a promising method, as it has not only anti-inflammatory but also pronounced analgesic and tissue regenerating properties.
期刊介绍：
Oral & Maxillofacial Surgery founded as Mund-, Kiefer- und Gesichtschirurgie is a peer-reviewed online journal. It is designed for clinicians as well as researchers.The quarterly journal offers comprehensive coverage of new techniques, important developments and innovative ideas in oral and maxillofacial surgery and interdisciplinary aspects of cranial, facial and oral diseases and their management. The journal publishes papers of the highest scientific merit and widest possible scope on work in oral and maxillofacial surgery as well as supporting specialties. Practice-oriented articles help improve the methods used in oral and maxillofacial surgery.Every aspect of oral and maxillofacial surgery is fully covered through a range of invited review articles, clinical and research articles, technical notes, abstracts, and case reports. Specific topics are: aesthetic facial surgery, clinical pathology, computer-assisted surgery, congenital and craniofacial deformities, dentoalveolar surgery, head and neck oncology, implant dentistry, oral medicine, orthognathic surgery, reconstructive surgery, skull base surgery, TMJ and trauma.Time-limited reviewing and electronic processing allow to publish articles as fast as possible. Accepted articles are rapidly accessible online.Clinical studies submitted for publication have to include a declaration that they have been approved by an ethical committee according to the World Medical Association Declaration of Helsinki 1964 (last amendment during the 52nd World Medical Association General Assembly, Edinburgh, Scotland, October 2000). Experimental animal studies have to be carried out according to the principles of laboratory animal care (NIH publication No 86-23, revised 1985).
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