Scholars journal of applied medical sciences最新文献

{"title":"The Association between Serum Zinc Levels and Zinc Supplementation in Topical Retinoids Treated Acne Vulgaris Patients: A Randomized, Double-Blind, Placebo-Controlled Trial","authors":"Humayra Rumu, Rumana Ferdous, Sumayra Jhumu, Mohammad Rashedul Islam Akand, Farhana Nargis, Israt Zahan Zarin","doi":"10.36347/sjams.2023.v11i09.018","DOIUrl":"https://doi.org/10.36347/sjams.2023.v11i09.018","url":null,"abstract":"Background: The association between serum zinc levels and zinc supplementation, with topical retinoids treatment in acne vulgaris patients presents a multifaceted interplay involving both physiological and therapeutic aspects. Objective: To evaluate the association between serum zinc levels and zinc supplementation with topical retinoid-treated in acne vulgaris patients. Method: A clinical trial was carried out at the Department of Pharmacology and Department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University, spanning from March 2020 to January 2022, with participant enrollment commencing in April 2021. This study encompassed 122 recently diagnosed mild to moderate acne vulgaris (AV) patients who received 20 mg of zinc sulfate or 20mg of placebo tablet twice daily orally with topical retinoid treatment. Notably, nine participants withdrew from the study for various reasons, resulting in a cohort of 113 individuals for per-protocol (PP) analysis. The investigation featured both baseline and after 8-week follow-up assessments, scrutinizing GAGS acne severity scores and serum zinc levels. Results: After 8 weeks of intervention, serum zinc levels in the intervention arm significantly increased from the baseline (100.39 ± 22.26 vs. 59.03 ± 15.76, P = 0.00), and they were also significantly higher than in the control arm. Likewise, the GAGS score in the intervention arm significantly decreased after 8 weeks compared to the baseline (12.03 ± 5.39 vs. 16.74 ± 6.09, P = 0.00) and was significantly lower than in the control arm. Also shows a correlation between serum zinc level and GAGS score which was observed after 8 weeks of intervention. Conclusion: Our study suggests that combining zinc supplementation with topical retinoids for acne treatment depends on factors like patient traits, baseline zinc levels, formulations, and duration. While findings vary, there's an overall trend toward better outcomes with this combination. Zinc's .......","PeriodicalId":471520,"journal":{"name":"Scholars journal of applied medical sciences","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136100167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronary Heart Disease among the Patients of Age between 25-39 and 40-70 Years Attending Cardiology Outdoor of BSMMU, Dhaka, Bangladesh","authors":"Md. Hasibul Hasan","doi":"10.36347/sjams.2023.v11i09.017","DOIUrl":"https://doi.org/10.36347/sjams.2023.v11i09.017","url":null,"abstract":"Background: Ischemic heart disease (IHD), also known as Coronary Heart Disease (CHD) is a generic designation for a group of related syndromes resulting from myocardial ischemia. It comprises of stable angina, unstable angina, acute myocardial infarction and sudden death. Since the most common cause of IHD is coronary artery abnormality it is also termed as “Coronary artery disease”. Method: This cross sectional observational study was carried out in the department of Cardiology, UCC, BSMMU, Dhaka, during the period of September 2013 to December 2013. A total of 200 patients with primary diagnosis of CHD who were admitted for coronary angiogram were included in this study considering the inclusion and exclusion criteria. Results: Patients aged 25 to 40 years were grouped as group A and a 40 to 70 years were grouped as group B. Baseline clinical history, physical examination and investigations including reports of coronary angiogram were recorded accordingly. There were significant differences between two groups in respect to risk factors and angiographic findings. The prevalence of hypertension and diabetes were found to be more among group B CHD patients compare to group A patient (p<0.001) while, smoking and positive family history of IHD were more prevalent in younger age group (p<0.05). Normal or non-significant CAG findings were more common among group A compared to group B (p<0.05). Multiple vessel disease was observed to be more common amongst group B CHD patients (p<0.01). LAD and RCA involvement was more frequent in group B compared to group A patient (p<0.01). This indicated that risk factors and disease severity was different between two groups. In both the groups male predominance was observed but it was not different between two groups. Other risk factors like obesity and dyslipidemia were not found to be different. Conclusion: Even with best possible effort some limitations have been encountered in this study. Emerging risk factors we discussed .......","PeriodicalId":471520,"journal":{"name":"Scholars journal of applied medical sciences","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136100168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Foetal Assessment Based on Biophysical Profile Scoring","authors":"Shahanara Begum, Monowara Begum, Mahabuba Akter, Nafisa Jafreen","doi":"10.36347/sjams.2023.v11i09.016","DOIUrl":"https://doi.org/10.36347/sjams.2023.v11i09.016","url":null,"abstract":"Introduction: Accurate prenatal recognition of acquired and congenital disease states that affect foetal function and structure must be first critical step in reducing or preventing perinatal morbidity and mortality. Antepartum foetal heart rate tests based on acceleration of rate with foetal movement (non-stress test or NST) or the presence or absence of periodic decelerations with uterine contractions (contraction stress test or CST) have proved to be useful methods for antepartum assessment of foetal risk. Objective: To assess the foetal assessment based on biophysical profile scoring. Methods: A prospective design was considered suitable for the present study was conducted in the Department of Obstetrics &amp; Gynecology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka during the period from July 2006 to December 2006. Sample Based on enrolment criteria, a total of 60 patients were taken consecutively from study population to conduct the study. High risk pregnant women attending at BSMMU to have their babies checked/delivered were the study population. Results: Out of 53 subjects participated in the study, 5.7% were below 20 years of age, 18.9% between 20-25 years, 28.3% between 25-30 years, another 28.3% between 30-35 years and 18.9% 35 or above 35 years of age. The mean age of the subjects was 28.5 ± 5.5 years and the lowest and highest ages ranged from 19 to 39 years. shows that 35.8% of the subjects were primipara and 32.1% multipara. The rest one-third (32.1%) of the subjects did not have any experience of having live-birth. demonstrates that 70% of the subjects were primigravida and the rest multigravida. Distribution of the subjects by gestational age shows that 71.7% lie between 37 - 42 weeks of gestation at the time of BPP. The rest 28.3% had gestational age below 37 weeks. Clinical presentation of the subjects at the time of BPP shows that predominant sign was anaemia (75.5%) followed by oedema (62.3%). prteinuria (50.9%), diastolic blood ....","PeriodicalId":471520,"journal":{"name":"Scholars journal of applied medical sciences","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136238678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Contrast Enhanced MRI to Differentiate Between Neoplastic from Non-Neoplastic Ring Enhancing Brain Lesions","authors":"Pramod Sakhi, Shilpi Gupta, Kumud Julka, Bhavana Saraf","doi":"10.36347/sjams.2023.v11i09.015","DOIUrl":"https://doi.org/10.36347/sjams.2023.v11i09.015","url":null,"abstract":"Introduction: Ring enhancing lesions in MRI of the brain can be caused by different pathological conditions. The common lesions are being some primary brain tumours, abscess, granuloma, resolving haematoma and infarct. Gadolinium compounds, which are paramagnetic IV contrast media for brain imaging, are especially helpful for identification of extra-axial tumours and intra-axial lesions associated with disrupted blood-brain barrier. The enhancing ring of an abscess is usually thinner and more uniform than that found in the neoplasm. Granulomatous abscesses tend to have a thicker ring than pyogenic abscesses and have less surrounding edema. Demyelinating disorders revealed nodular pattern and incomplete ring-enhancing pattern. Infarcts often show gyral enhancement. Enhancement is uniform in immune competent patients while ring-like in immunocompromised patients. Tuberculomas on contrast administration appear as nodular or ring-like enhancing lesions. Aims: To evaluate the role of magnetic resonance imaging in distinguishing neoplastic from non-neoplastic ring enhancing brain lesions. Material and methods: Forty patients with various ring enhancing lesions in the brain were detected by MRI. The age range of the patients was 13 to 63 years. Routine sequences of T1, T2 and FLAIR spin echo sequences with IV contrast were carried out. Signal intensities on unenhanced T1- and T2- weighted images for enhanced and unenhanced solid portions, enhancement patterns, margins, cortical involvement, mass effect, and presence of vasogenic edema were studied. Result : MRI showed 20% of cases were non-neoplastic ring enhancing brain lesions in comparison with 25% revealed by histopathology.65% cases diagnosed by MRI as neoplastic ring enhancing brain lesions in comparison with =75% cases revealed by histopathology. Sensitivity of MRI in the detection of secondary neoplastic ring enhancing brain lesions was 80% and specificity was 81.8%. Percentage of primary brain tumor revealed .....","PeriodicalId":471520,"journal":{"name":"Scholars journal of applied medical sciences","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136378778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bowel Nosodes of Homoeopathy in Colorectal Cancer &amp; Autoimmune, Metabolic, Neuro-Psychiatric Disorders","authors":"Tridibesh Tripathy, Shankar Das, Dharmendra Pratap Singh, Umakant Prusty, Madan Mohan Mishra, Jeevan Krushna Pattanaik, Pramod Bihary Pradhan, Mr.Anil Dubey, Mr. Anjani Kumar, Ms. Sanskriti Tripathy, Rakesh Dwivedi, Mohini Gautam","doi":"10.36347/sjams.2023.v11i09.014","DOIUrl":"https://doi.org/10.36347/sjams.2023.v11i09.014","url":null,"abstract":"The age old problems of cholera, typhoid &amp; diarrheal diseases center around gut problems &amp; along with that typhoid continues to bother human race through its recurrence &amp; chronic nature as it affects the peyer’s patches of the gut or the enteron. This article brings out the relation between a healthy gut &amp; conditions like Atopy, Colorectal Cancer (CC) &amp; Auto-immune, Metabolic &amp; Neuro- Psychiatric Disorders. These disorders occur due to gut microbial dysbiosis in the humans. Here, Atopy manifests through skin &amp; respiratory issues, Metabolic manifests through Obesity &amp; Type 2 diabetes, Auto-immune manifests through Irritable Bowel Disease/Irritable Bowel Syndrome (IBD/IBS), Rheumatoid Arthritis (RA), Celiac Disease (CD) &amp; Neuro-Psychiatric manifests through Autism Spectrum Disorder (ASD) [6- 29]. Human gastrointestinal tract hosts a complex ecosystem of approximately 300-500 bacterial species. All these encompass nearly 2 million genes &amp; this is known as micro- biome. The number of bacteria within the human gut is roughly 10 times more than that of all the cells in the human body. The cumulative bacterial genomic content is immensely greater than the human genome [4- 30]. A generalized approach to Auto-immune Disorders (AD), Metabolic Disorders (MD), Neuro Psychiatric Disorders (NPD), Atopy &amp; Colorectal Cancer (CC) has failed &amp; modern medicine has already realized that new avenues to restore personalized interventions to restore microbial balance and improve overall health &amp; that too all the related disorders as well [4- 29]. It is here that the article delves into Homoeopathy as it is a personalized system of medicine. Further, it has a range of medicines called ‘Bowel Nosodes’ that are prepared from the bacteria of the gut. Here ‘Bowel’ means the gut and ‘Nosodes’ means medicines prepared from disease products or organisms. As the set of medicines are prepared from the bacteria of the gut, these are called ‘Bowel Nosodes’ [14, 15]. The article sees through the .....","PeriodicalId":471520,"journal":{"name":"Scholars journal of applied medical sciences","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135259491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Appendicular peritonitis at the Commune I Reference Health Center of Bamako","authors":"Diarra I, Tounkara C, Dembélé Ks, Sanogo M, Dramé Bm, Kanthé D, Koné O, Keita B, Touré S, Coulibaly B, Kassogué S, Karembé B, Kanté L","doi":"10.36347/sjams.2023.v11i09.013","DOIUrl":"https://doi.org/10.36347/sjams.2023.v11i09.013","url":null,"abstract":"Aim: To determine the frequency of appendicular peritonitis in the department. To determine the diagnostic and therapeutic aspects. To analyze the results of management. Methodology: This was a retrospective study conducted over a period of 05 years, from 01 January 2017 to 31 December 2021. Results: We collected 136 cases of acute generalised peritonitis, including 75 cases of appendicular peritonitis, i.e. 6.1% of surgical procedures. Males accounted for 73% of cases, with a sex ratio of 2.75 in favour of males. The mean age was 33.73 years, with a standard deviation of 12.22; the extremes ranged from 16 to 65 years. Abdominal pain was the most frequent reason for consultation, accounting for 97% of cases. In most cases, the diagnosis was made on clinical examination. Appendectomy, peritoneal cleansing and drainage were performed in all our patients. Post-operative management was straightforward in 87% of cases. Conclusion: Appendicular peritonitis is one of the most common aetiological entities. It is diagnosed clinically and managed medico-surgically.","PeriodicalId":471520,"journal":{"name":"Scholars journal of applied medical sciences","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135259488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-Year Study of Clinical Cardiotoxicity Follows Anthracyclin Treatment in Childhood Malignancy at Benghazi Children Hospital","authors":"Najat Elrugige, Muna Mustafa Ali, Mohamed Masoud Alferjani","doi":"10.36347/sjams.2023.v11i09.012","DOIUrl":"https://doi.org/10.36347/sjams.2023.v11i09.012","url":null,"abstract":"Background: Treatment of pediatric malignancy has greatly improved and survival according to SEER data, mortality rate declined by 40 percent between 1975 and 1995. This declined in mortality has accompanied by increase in the recognition of long term side effect from treatment of childhood cancer, one of major complication is cardiac, during or after administration of anthracyclin patient can develop acute cardiac toxicity. Aim: To determine the incidence of clinical cardiotoxicity from anthracycline chemotherapy in children with cancer and to identify risk factors. Material and Method: One-year study (2021) to children with cancer were received anthracycline as part of chemotherapy at Children Hospital Benghazi. Results: During the study period one year (Jan.2021- Dec. 2021) 51 cases received anthracyclin as part of chemotherapy were evaluated with echocardiography there is male predominance represented 62.7% &amp; females37.3%, M: F 1.6:1, Age range from 5 months to 14 years, the commonest age group 1-5 years around 25cases represented 49%, Most cases evaluated in our study diagnosed with Acute Lymphoblastic Leukemia (ALL) 24 cases represented 47.1%, 9 cases with Acute Myeloid Leukemia (AML) 17%, Lymphoma 7 cases represented 13,7%, wilm’s tumor 5 cases 9.8%, neuroblastoma 3 cases 5.8%, Each of Retinoblastoma, adrenocortical carcinoma and hepatoblastoma 1 case (2%), 34 cases were evaluated still on treatment 66.7%, 17 cases 33.3% were finished treatment on follow up 29 cases were received treatment for less than or equal to one year represented to 56.9%, while 22 cases 43.1% &gt;1year, We were divided the patient according to type of anthracyclin (Adriamycin or douanomycin) results show those received Adriamycin only 39.2%, cases were received douanomycin 7.8%, while cases received both of them 53%, 35.9 % of cases received total doses between 201-250 mg S.A of anthracyclin, 25 cases 32.1% were received less than 100 mgS. A, Echocardiography finding were normal .....","PeriodicalId":471520,"journal":{"name":"Scholars journal of applied medical sciences","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135485408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“ChatGPT and Digital Inequality: A Rising Concern”","authors":"Imran Ahmed Khan, Naresh Wamanrao Paliwal","doi":"10.36347/sjams.2023.v11i09.010","DOIUrl":"https://doi.org/10.36347/sjams.2023.v11i09.010","url":null,"abstract":"Since its launch of the latest version as GPT-4 (Generative Pre-trained Transformer) in March 2023, ChatGPT has drawn a lot of interest from a multitude of domains and the educational community as well. Unfortunately, the digital world is not accessible equally to all, and digital inequality continues to widen the gap between those who have and those who don't. ChatGPT, an advanced language model created by OpenAI, has the potential to completely change how people communicate and share information, but it also emphasizes how urgently the problem of digital inequality has to be addressed. The potential of such advanced technologies can only be optimally utilized if they are made accessible to all individuals, regardless of their socioeconomic background, geographical boundaries, and gender biasing. The actual revolutionary power of technology may be unlocked by bridging the digital gap through fair access, digital literacy, and inclusive practices, ensuring that no one is left behind in the digital age.","PeriodicalId":471520,"journal":{"name":"Scholars journal of applied medical sciences","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135785100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oropharyngeal Dysphagia &amp; Aspiration in a 63-Year-Old Man- A Case Report","authors":"Rana Mitwalli, Amro Abouzid, Asma Sayeed","doi":"10.36347/sjams.2023.v11i09.011","DOIUrl":"https://doi.org/10.36347/sjams.2023.v11i09.011","url":null,"abstract":"Introduction: Dysphagia due to nonmalignant causes is not an uncommon occurrence in patients over the age of 60. Males are more affected than the females. It can be associated with significant morbidity and mortality especially as it increases the risk for malnutrition, and pneumonias due to aspiration etc. Case Presentation: We present this rare case of worsening dysphagia and episodes of choking in a 63year old male due to large anterior cervical osteophytes. X-ray and flexible laryngoscopy revealed a large bulge over the posterior pharyngeal wall in the midline. Conclusion: Dysphagia in the elderly can lead to increased morbidity and life-threatening complications. Anterior osteophytes are found in nearly 20% to30% of the elderly population but rarely cause dysphagia. However, in some cases especially when associated with diffuse idiopathic skeletal hyperostosis (DISH/ Forestier’s disease) and ankylosing spondylitis these can cause severe dysphagia. In many cases of symptomatic anterior osteophytes surgery is considered an ultimate measure to relieve symptoms, decrease mortality, and improve the quality of life. We did a thorough literature search to know the prevalence and management of dysphagia due to anterior osteophytes.","PeriodicalId":471520,"journal":{"name":"Scholars journal of applied medical sciences","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135785098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender Differences in Perception of Dyspnea and Spirometric Abnormalities in Asthma","authors":"Prashanth Thaviti, K. Ramesh Kumar, Narra Sweta, A. Siva Prasad","doi":"10.36347/sjams.2023.v11i09.009","DOIUrl":"https://doi.org/10.36347/sjams.2023.v11i09.009","url":null,"abstract":"Asthma prevalence and severity have gender preference in various ages. In children, boys have an increased prevalence of asthma. In adults, women have an increased prevalence and severity of asthma. Sex hormones, genetic, and epige-netic variations, social, and envi-ronmental factors, and responses to asthma therapeutics are important factors that have an impact on the severity and response of symptoms.","PeriodicalId":471520,"journal":{"name":"Scholars journal of applied medical sciences","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136025336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}