Reumatologia Clinica最新文献

{"title":"Proyecto vitales: Consenso en la medición de resultados en salud para un mejor control integral de los pacientes con lupus eritematoso sistémico","authors":"José Luis Andreu ,&nbsp;Joaquín Borras ,&nbsp;José Luis Callejas ,&nbsp;Ricard Cervera ,&nbsp;Eva Chavarría ,&nbsp;Elvira Díez ,&nbsp;Fernando León ,&nbsp;Carlos Marras ,&nbsp;Enrique Morales ,&nbsp;Norberto Ortego ,&nbsp;Silvia Pérez Ortega ,&nbsp;Juan José Ríos Blanco","doi":"10.1016/j.reuma.2025.502022","DOIUrl":"10.1016/j.reuma.2025.502022","url":null,"abstract":"<div><h3>Introduction</h3><div>Systemic lupus erythematosus (SLE) is one of the most common systemic autoimmune diseases. It presents with a heterogeneous clinical picture and can cause irreversible damage. Its clinical manifestations vary over time, affecting different organs. This variability makes it complex but necessary to monitor, in a standardised and objective way, the manifestations of the disease through validated instruments that determine the degree of activity and the damage associated with the disease.</div></div><div><h3>Objective</h3><div>To define, through a national consensus, the standardisation of the measurement of health outcomes in SLE with the aim of improving the comprehensive control of patients with this disease.</div></div><div><h3>Conclusions</h3><div>The measurement of health outcomes in three major domains: disease activity, disease burden and quality of life, could help improve the control of the disease in patients with SLE from a comprehensive perspective, as well as obtaining information on the established therapeutic objectives and therefore allowing better clinical decisions to be made.</div></div>","PeriodicalId":47115,"journal":{"name":"Reumatologia Clinica","volume":"22 1","pages":"Article 502022"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145877073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guía de Práctica Clínica para el Manejo de Pacientes con Artritis Reumatoide. GUIPCAR 2025","authors":"Alejandro Balsa ,&nbsp;Petra Díaz del Campo Fontecha ,&nbsp;en nombre del Grupo Elaborador de la GUIPCAR","doi":"10.1016/j.reuma.2025.502039","DOIUrl":"10.1016/j.reuma.2025.502039","url":null,"abstract":"","PeriodicalId":47115,"journal":{"name":"Reumatologia Clinica","volume":"22 1","pages":"Article 502039"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145877074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Principal component and cluster analysis of functional parameters in rheumatic patients: Identifying the most efficient assessment tool","authors":"David Vega-Morales ,&nbsp;Jorge Medina-Castillo ,&nbsp;Pablo Herrera-Sandate ,&nbsp;Ana K. Vazquez-Bañuelos ,&nbsp;Rodrigo J. Castillo-de la Garza ,&nbsp;Luis A. Chavez-Alvarez ,&nbsp;Lourdes Gil-Flores ,&nbsp;Julio A. Lagarda-Ramos","doi":"10.1016/j.reuma.2025.502023","DOIUrl":"10.1016/j.reuma.2025.502023","url":null,"abstract":"<div><h3>Background</h3><div>Rheumatic diseases significantly impact hand function, leading to disability and reduced quality of life. Various tools assess upper limb function, including the DASH questionnaire, grip strength measurement, and range of motion (ROM) evaluation. However, the most efficient parameters for assessing functional impairment remain unclear.</div></div><div><h3>Objective</h3><div>To determine the most relevant anthropometric and functional measurements for evaluating hand function impairment in patients with rheumatic diseases, using principal component analysis (PCA) and cluster analysis.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional study in 36 patients with inflammatory arthritis, primarily rheumatoid arthritis (RA). Hand function was assessed using the DASH questionnaire, grip and pinch strength tests (Jamar dynamometer and Mathiowetz protocol), and ROM measurements. PCA was applied to identify the most relevant functional variables, and K-means clustering was used to classify patients into functional subgroups.</div></div><div><h3>Results</h3><div>Grip and pinch strength were the dominant factors, explaining 33.5% of total variance, while ROM contributed less to functional impairment assessment. Cluster analysis identified four functional subgroups, differentiating patients based on grip strength and disability levels (DASH score). Patients with higher grip strength exhibited lower disability, while those with severe disability had significantly weaker grip strength, reinforcing its importance as a functional marker.</div></div><div><h3>Conclusion</h3><div>Grip strength is a key indicator of upper limb function impairment in RA and other rheumatic diseases. Given its strong association with disability and its dominance in variance explanation, grip strength measurement alone may serve as a time-efficient and reliable assessment tool, especially in resource-limited settings. Further research should validate grip strength as a primary clinical indicator and optimize assessment protocols for rheumatic patients.</div></div>","PeriodicalId":47115,"journal":{"name":"Reumatologia Clinica","volume":"22 1","pages":"Article 502023"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145877075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of pulmonary hypertension in patients with Takayasu's arteritis: A transthoracic echocardiographic evaluation","authors":"Ata Koohi ,&nbsp;Farid Rashidi ,&nbsp;Davood Attaran ,&nbsp;Zahra Mirfeizi ,&nbsp;Mohammad Hasan Jokar ,&nbsp;Alireza Khabbazi ,&nbsp;Mehrzad Hajalilou ,&nbsp;Ehsan Ramezanian Nik ,&nbsp;Hoorac Poorzand ,&nbsp;Soroush Attaran ,&nbsp;Atiyeh Ghassemi","doi":"10.1016/j.reuma.2025.501994","DOIUrl":"10.1016/j.reuma.2025.501994","url":null,"abstract":"<div><h3>Aim</h3><div>In this study, we aim to evaluate the incidence of pulmonary hypertension (PH) using transthoracic echocardiography (TTE) in Takayasu arteritis (TA) patients.</div></div><div><h3>Methods</h3><div>Thirty-four outpatient Takayasu arteritis patients underwent transthoracic echocardiography (TTE) following the ESC-ERS guidelines. A tricuspid regurgitation velocity (TRV) greater than 3.4<!--> <!-->m/s indicated a high probability of pulmonary hypertension (PH). The patients were categorized based on their New York Heart Association (NYHA) functional class (FC) and symptomatic status. All patients underwent a six-minute walk test (6MWT) and pulmonary function tests (PFT).</div></div><div><h3>Results</h3><div>A total of 30 patients with a mean age of 40<!--> <!-->±<!--> <!-->9.3 years were enrolled in the study. Among these patients, four (13.3%) were met the criteria for high probability of PH (TRV: 4<!--> <!-->±<!--> <!-->0.92), with a mean systolic pulmonary artery pressure (SPAP) of 76.7<!--> <!-->±<!--> <!-->37. There were no significant differences in terms of age, disease duration, and erythrocyte sedimentation rate (ESR) between the PH and non-PH groups. However, there was a significant difference in tricuspid annular plane systolic excursion TAPSE/SPAP ratio between NYHA functional class (FC) Group 1 and Group 2 (1.2<!--> <!-->±<!--> <!-->0.16 vs 0.83<!--> <!-->±<!--> <!-->0.24, <em>p</em> <!-->=<!--> <!-->0.018). Additionally, TAPSE showed a correlation with forced expiratory volume in the first second/forced vital capacity (FEV₁/FVC) (<em>r</em> <!-->=<!--> <!-->0.446, <em>p</em> <!-->=<!--> <!-->0.043).</div></div><div><h3>Conclusions</h3><div>Pulmonary hypertension is a not uncommon complication in Takayasu arteritis (13.3% vs 11.3% in the literature). Considering the symptoms and functional capacity, lowering the threshold for initiating transthoracic echocardiography (TTE) evaluation may be beneficial for early risk stratification of pulmonary hypertension in patients with Takayasu arteritis.</div></div>","PeriodicalId":47115,"journal":{"name":"Reumatologia Clinica","volume":"21 10","pages":"Article 501994"},"PeriodicalIF":1.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145645934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RESER/NVAN: registro español de pacientes con vasculitis asociadas a ANCA: objetivos y metodología","authors":"Susana Romero-Yuste ,&nbsp;Manuel Macía ,&nbsp;Marta Domínguez-Álvaro ,&nbsp;Antonio Fernández-Nebro ,&nbsp;Miquel Blasco ,&nbsp;Javier Narváez ,&nbsp;Gema Fernández ,&nbsp;Íñigo Rúa-Figueroa ,&nbsp;Desirée Luis-Rodríguez ,&nbsp;Beatriz Ventosa ,&nbsp;en representación del Grupo colaborador del proyecto RESER/NVAN","doi":"10.1016/j.reuma.2025.501990","DOIUrl":"10.1016/j.reuma.2025.501990","url":null,"abstract":"<div><h3>Objective</h3><div>To describe the objectives, design and methods of the Spanish Multicentre Registry of Patients with ANCA-associated Vasculitis (RESER/NVAN), as well as its strengths and limitations. RESER/NVAN is a project promoted by the Spanish Society of Rheumatology, in collaboration with the Spanish Society of Nephrology, whose main objective is to estimate the incidence of ANCA-associated vasculitis in Spain.</div></div><div><h3>Methods</h3><div>Retrospective longitudinal observational study of ANCA-associated vasculitis patients ≥18 years of age diagnosed between 1 January 2015 and 31 March 2021. All patients in the reference area of each centre were included, with the reference area being the area that includes the population attended by the centre. Thirty-two centres distributed throughout the Spanish geography participated, and the administrative and/or clinical databases of each centre and those of the services that could be involved in the diagnosis and/or treatment of these patients were reviewed. Sociodemographic and anthropometric variables, lifestyle habits, comorbidities and variables characterising vasculitis were collected.</div></div><div><h3>Conclusions</h3><div>RESER/NVAN represents one of the largest cohorts of patients with ANCA-associated vasculitis in Spain. Despite its retrospective nature, the study provides comprehensive and reliable information on ANCA-associated vasculitis and is an excellent source of data for future analyses to increase knowledge of this disease.</div></div>","PeriodicalId":47115,"journal":{"name":"Reumatologia Clinica","volume":"21 10","pages":"Article 501990"},"PeriodicalIF":1.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145645939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diffuse idiopathic skeletal hyperostosis in patients with prediabetes","authors":"Ayfer Altıntas ,&nbsp;Emre Ali Acar ,&nbsp;Sadettin Uslu ,&nbsp;Ihsan Sebnem Orgüc ,&nbsp;Zeliha Hekimsoy ,&nbsp;Timur Pirildar","doi":"10.1016/j.reuma.2025.502017","DOIUrl":"10.1016/j.reuma.2025.502017","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the frequency of diffuse idiopathic skeletal hyperostosis (DISH) in patients with prediabetes.</div></div><div><h3>Material and methods</h3><div>A total of 166 prediabetic patients were prospectively evaluated, of whom 67 with symptoms suggestive of DISH underwent thoracic and lumbar radiography. DISH was diagnosed according to Resnick and Niwayama criteria. Demographic, clinical and laboratory data were analyzed.</div></div><div><h3>Results</h3><div>DISH was diagnosed in 9 patients (13.4% of symptomatic; 5.4% overall). Patients with DISH were older and more frequently hypertensive compared to those without DISH (<em>p</em> <!-->=<!--> <!-->0.004 and <em>p</em> <!-->=<!--> <!-->0.047, respectively). Other parameters such as body mass index, fasting glucose, and smoking showed higher trends in the DISH group but did not reach statistical significance.</div></div><div><h3>Conclusion</h3><div>This is the first study to examine DISH in a prediabetic population. Our findings suggest a possible association between DISH and prediabetic status, although further studies are needed to confirm this relationship.</div></div>","PeriodicalId":47115,"journal":{"name":"Reumatologia Clinica","volume":"21 10","pages":"Article 502017"},"PeriodicalIF":1.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145645937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and impact of chronic joint diseases on the sexual sphere compared to a healthy population: A multicenter cross-sectional study","authors":"Carlos Valera-Ribera ,&nbsp;Juan José Alegre-Sancho ,&nbsp;Àngels Martínez-Ferrer ,&nbsp;Montserrat Robustillo-Villarino","doi":"10.1016/j.reuma.2025.501993","DOIUrl":"10.1016/j.reuma.2025.501993","url":null,"abstract":"<div><h3>Objectives</h3><div>To describe the prevalence of sexual dysfunction (SD) in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA) and a control group, and identify associated factors.</div></div><div><h3>Methods</h3><div>Adults of any sexual orientation with PsA (CASPAR criteria) or RA (EULAR/ACR 2010 criteria) were consecutively included in this cross-sectional observational study. The Changes in Sexual Functioning Questionnaire (CSFQ-14) was self-administered to evaluate variations in sexual function due to disease or medication. We also evaluated the potential association of sociodemographic and clinical data with SD. Results were compared with a control group of healthy individuals.</div></div><div><h3>Results</h3><div>Overall 188 individuals were included, 72 with PsA and 27 with RA. In total, 30.43%, 48.15% and 5.88% of the PsA, RA and control groups, respectively, had scores within the SD range. The overall patient population had a mean CSFQ-14 score 8.2 points lower than the control group. All domains of the CSFQ-14 questionnaire were negatively affected by PsA or RA (<em>p</em> <!-->&lt;<!--> <!-->0.001). The risk of SD is associated with age, sex, perceived health, employment situation, and economic status. The estimated odds ratio of having SD was 8.7 times higher in patients diagnosed with PsA and 10 times higher in patients diagnosed with RA.</div></div><div><h3>Conclusions</h3><div>Patients with RA or PsA have a poorer sexual life in all sexual sphere domains, compared to a healthy population. Our study confirms the value of the CSFQ-14 questionnaire for assessing sexual health and as a tool for the integral management of patients with chronic joint diseases.</div></div>","PeriodicalId":47115,"journal":{"name":"Reumatologia Clinica","volume":"21 10","pages":"Article 501993"},"PeriodicalIF":1.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145645941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patients’ and rheumatologists’ perceptions about shared decision-making implementation: A Latin-American survey","authors":"Adriana Lucía Vanegas-García ,&nbsp;Mauricio Restrepo-Escobar ,&nbsp;Álvaro Arbeláez-Cortés ,&nbsp;Gina Sicilia Ochoa Galeano ,&nbsp;Luis Lira Weldt ,&nbsp;Guillermo Andrés Quiceno ,&nbsp;Virginia Pascual-Ramos","doi":"10.1016/j.reuma.2025.501974","DOIUrl":"10.1016/j.reuma.2025.501974","url":null,"abstract":"<div><h3>Background</h3><div>Shared decision-making (SDM) has been linked to improved patient- and physician-reported outcomes. To achieve these benefits, both parties need to agree on implementing SDM. The objective of the study was to compare the perception of SDM process implementation in daily practice between patients with rheumatic diseases (RMDs) and rheumatologists.</div></div><div><h3>Methods</h3><div>This cross-sectional study was conducted in April 2024 in Latin America (LATAM). Adult patients diagnosed with RMDs and rheumatologists were invited to participate in a web-based survey based on the Spanish patient version of the 9-item SDM questionnaire (SDM-Q-9) and the physician version (SDM-Q-Doc). Both versions were validated tools for evaluating patients’ and physicians’ perceived levels of SDM. Descriptive statistics and comparative tests (e.g., chi-square or Mann–Whitney <em>U</em> test) were used to analyze the data. Statistical significance was set at <em>p</em> <!-->&lt;<!--> <!-->0.05, and analyses were conducted using STATA 17 software.</div></div><div><h3>Results</h3><div>We received surveys from 369 patients, primarily systemic lupus erythematosus (51.8%) and rheumatoid arthritis (19.5%), across 17 countries. The largest number of responses was from Mexico (42%) and Colombia (11.9%). The survey was completed by 144 rheumatologists from 10 countries, primarily from Colombia (52.8%) and Chile (23.6%). Physicians most frequently strongly agree/agree that they engaged in the different steps of the SDM process, compared to patients, and this difference was less evident for the step “sharing with the patient the different options for treating the condition.” Also, a higher percentage of rheumatologists (96.5%) reported engaging in SDM during clinical practice compared to patients (62.3%), <em>p</em> <!-->=<!--> <!-->0.001.</div></div><div><h3>Conclusions</h3><div>In LATAM, rheumatologists more frequently referred to implementing the SDM process during clinical care than patients with RMDs. Further research is needed to improve patient-centered care.</div></div>","PeriodicalId":47115,"journal":{"name":"Reumatologia Clinica","volume":"21 10","pages":"Article 501974"},"PeriodicalIF":1.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145645938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic challenge: Bethlem myopathy mimicking inflammatory myopathy","authors":"Olga Rusinovich-Lovgach ,&nbsp;Luz Morán ,&nbsp;Oscar Toldos-Gonzalez ,&nbsp;Marta Vaquero Martínez ,&nbsp;Borja Cabal-Paz ,&nbsp;José Luis Andréu Sánchez","doi":"10.1016/j.reuma.2025.501997","DOIUrl":"10.1016/j.reuma.2025.501997","url":null,"abstract":"<div><div>We describe a young man with persistent hyperCKemia and MRI findings initially suggestive of inflammatory myopathy, in whom genetic testing confirmed Bethlem myopathy. This case illustrates how collagen VI-related myopathies can mimic idiopathic inflammatory myopathies (IIM), underlining the need for integrated clinical, imaging, biopsy, and genetic data to ensure diagnostic accuracy and avoid unnecessary immunosuppression.</div></div>","PeriodicalId":47115,"journal":{"name":"Reumatologia Clinica","volume":"21 10","pages":"Article 501997"},"PeriodicalIF":1.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145645521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tratamiento de la artritis reumatoide en pacientes con enfermedad renal crónica: una experiencia de vida real","authors":"Wilmer Gerardo Rojas-Zuleta,&nbsp;Yesith Guillermo Toloza-Pérez,&nbsp;Carolina Becerra Arias,&nbsp;Jorge Donado Gómez,&nbsp;Jeixa Jennifer Canizales Rodríguez,&nbsp;Oscar Jair Felipe Díaz","doi":"10.1016/j.reuma.2025.501995","DOIUrl":"10.1016/j.reuma.2025.501995","url":null,"abstract":"<div><h3>Introduction</h3><div>Rheumatoid arthritis is associated with an increased risk of chronic kidney disease, which complicates the safe use of disease-modifying antirheumatic drugs, particularly in patients with severe renal impairment. Our aim was to describe treatment patterns and clinical outcomes in this population.</div></div><div><h3>Methods</h3><div>Descriptive study of a cohort of rheumatoid arthritis patients with an estimated glomerular filtration rate<!--> <!-->&lt;<!--> <!-->30<!--> <!-->ml/min/1.73<!--> <!-->m², managed in a comprehensive care program between 2022 to 2024. Clinical, therapeutic, and safety data were collected.</div></div><div><h3>Results</h3><div>A total of 38 patients were identified, most of whom were elderly women with a high burden of comorbidities. Leflunomide was the most frequently used conventional synthetic disease-modifying antirheumatic drug. Biologic therapy was used in 42% of cases, with rituximab being the most commonly prescribed agent. Most patients achieved remission or low disease activity, with no serious adverse events reported.</div></div><div><h3>Conclusions</h3><div>These findings provide real-world evidence on the effectiveness and safety of disease-modifying antirheumatic drugs in a population often excluded from clinical trials, underscoring the need for prospective studies to inform long-term therapeutic decisions.</div></div>","PeriodicalId":47115,"journal":{"name":"Reumatologia Clinica","volume":"21 10","pages":"Article 501995"},"PeriodicalIF":1.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145645940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}