HLA-B*51:01 in Iranian patients with Behcet uveitis syndrome

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-11-01 DOI:10.1016/j.reuma.2024.07.001

Zahra Hoseini , Fatemeh Rezaei Rad , Mohammad Zarei , Nazanin Ebrahimiadib , Zahra Salimian , Mahdi Zamani

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引用次数: 0

Abstract

Background

Behcet's disease (BD) is a multisystem disorder prevalent along the historic Silk Road, with Behcet's uveitis (BU) representing a significant complication contributing to disability. Various studies have linked different HLA alleles with BD across diverse populations.

Methods

In this study, we investigated the association between HLA-B51:01/x and HLA-B27/x genotypes with Behcet's uveitis in 50 unrelated Iranian patients diagnosed with Behcet's uveitis, comparing them to a control group of 70 healthy individuals. Our analysis aimed to determine the susceptibility conferred by these alleles and assess their clinical relevance.

Results

Our findings indicate a notable susceptibility conferred by the HLA-B51:01/x genotype for Behcet's uveitis (P = 0.0001). Conversely, the B27/x genotype did not demonstrate significant associations with Behcet's uveitis. Furthermore, we employed prevalence-corrected positive predictive value (PcPPV) calculations to gauge the clinical utility of testing for these alleles within the Iranian Behcet's uveitis patient population. The PcPPV for B27/x genotype testing was determined to be 0.05%, while the PcPPV for B51:01/x genotype testing in the same population was 0.065%. These results suggest that carriers of the B*51:01 allele, when presenting with clinical symptoms, exhibit a heightened risk for Behcet's uveitis compared to the general population.

Conclusion

Individuals carrying the B51:01 allele, when symptomatic, face an elevated Behcet's uveitis risk. This insight aids in targeted clinical assessments for at-risk populations.

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伊朗白塞氏葡萄膜炎综合征患者的 HLA-B*51:01

背景白塞氏病（BD）是历史上丝绸之路沿线流行的一种多系统疾病，白塞氏葡萄膜炎（BU）是导致残疾的重要并发症。在这项研究中，我们调查了 50 名被诊断为白塞氏葡萄膜炎的无亲属关系的伊朗患者的 HLA-B51:01/x 和 HLA-B27/x 基因型与白塞氏葡萄膜炎之间的关系，并将他们与 70 名健康人组成的对照组进行了比较。我们的分析旨在确定这些等位基因的易感性并评估其临床相关性。结果我们的研究结果表明，HLA-B51:01/x 基因型对白塞氏葡萄膜炎具有显著的易感性（P = 0.0001）。相反，B27/x 基因型与白塞氏葡萄膜炎的关系并不明显。此外，我们还采用了患病率校正阳性预测值（PcPPV）计算方法，以衡量在伊朗白塞氏葡萄膜炎患者群体中检测这些等位基因的临床实用性。经测定，B27/x 基因型检测的阳性预测值为 0.05%，而同一人群中 B51:01/x 基因型检测的阳性预测值为 0.065%。这些结果表明，与普通人群相比，B*51:01 等位基因携带者在出现临床症状时，罹患白塞氏葡萄膜炎的风险更高。这一观点有助于对高危人群进行有针对性的临床评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.