Transcription-Austin最新文献_第3页

From silence to symphony: transcriptional repression and recovery in response to DNA damage. 从沉默到交响乐：DNA损伤时的转录抑制和恢复。

IF 3.6

Transcription-Austin Pub Date : 2024-06-01 Epub Date: 2024-10-01 DOI: 10.1080/21541264.2024.2406717

Kamal Ajit, Monika Gullerova

引用次数: 0

RNA polymerase collisions and their role in transcription. RNA 聚合酶碰撞及其在转录中的作用

IF 3.6

Transcription-Austin Pub Date : 2024-02-01 Epub Date: 2024-02-15 DOI: 10.1080/21541264.2024.2316972

Ling Wang

引用次数: 0

Bacterial phenotypic heterogeneity through the lens of single-cell RNA sequencing. 通过单细胞 RNA 测序透视细菌表型异质性。

IF 3.6

Transcription-Austin Pub Date : 2024-02-01 Epub Date: 2024-03-26 DOI: 10.1080/21541264.2024.2334110

Alex W Walls, Adam Z Rosenthal

{"title":"Bacterial phenotypic heterogeneity through the lens of single-cell RNA sequencing.","authors":"Alex W Walls, Adam Z Rosenthal","doi":"10.1080/21541264.2024.2334110","DOIUrl":"10.1080/21541264.2024.2334110","url":null,"abstract":"Bacterial transcription is not monolithic. Microbes exist in a wide variety of cell states that help them adapt to their environment, acquire and produce essential nutrients, and engage in both competition and cooperation with their neighbors. While we typically think of bacterial adaptation as a group behavior, where all cells respond in unison, there is often a mixture of phenotypic responses within a bacterial population, where distinct cell types arise. A primary phenomenon driving these distinct cell states is transcriptional heterogeneity. Given that bacterial mRNA transcripts are extremely short-lived compared to eukaryotes, their transcriptional state is closely associated with their physiology, and thus the transcriptome of a bacterial cell acts as a snapshot of the behavior of that bacterium. Therefore, the application of single-cell transcriptomics to microbial populations will provide novel insight into cellular differentiation and bacterial ecology. In this review, we provide an overview of transcriptional heterogeneity in microbial systems, discuss the findings already provided by single-cell approaches, and plot new avenues of inquiry in transcriptional regulation, cellular biology, and mechanisms of heterogeneity that are made possible when microbial communities are analyzed at single-cell resolution.","PeriodicalId":47009,"journal":{"name":"Transcription-Austin","volume":" ","pages":"48-62"},"PeriodicalIF":3.6,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11093040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140294946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maintaining transcriptional homeostasis during cell cycle. 在细胞周期中维持转录平衡

IF 3.6

Transcription-Austin Pub Date : 2024-02-01 Epub Date: 2023-09-01 DOI: 10.1080/21541264.2023.2246868

Lucía Ramos-Alonso, Pierre Chymkowitch

引用次数: 0

An emerging paradigm in epigenetic marking: coordination of transcription and replication. 表观遗传标记的新范式：转录与复制的协调。

IF 3.6

Transcription-Austin Pub Date : 2024-02-01 Epub Date: 2024-02-20 DOI: 10.1080/21541264.2024.2316965

Tyler K Fenstermaker, Svetlana Petruk, Alexander Mazo

{"title":"An emerging paradigm in epigenetic marking: coordination of transcription and replication.","authors":"Tyler K Fenstermaker, Svetlana Petruk, Alexander Mazo","doi":"10.1080/21541264.2024.2316965","DOIUrl":"10.1080/21541264.2024.2316965","url":null,"abstract":"DNA replication and RNA transcription both utilize DNA as a template and therefore need to coordinate their activities. The predominant theory in the field is that in order for the replication fork to proceed, transcription machinery has to be evicted from DNA until replication is complete. If that does not occur, these machineries collide, and these collisions elicit various repair mechanisms which require displacement of one of the enzymes, often RNA polymerase, in order for replication to proceed. This model is also at the heart of the epigenetic bookmarking theory, which implies that displacement of RNA polymerase during replication requires gradual re-building of chromatin structure, which guides recruitment of transcriptional proteins and resumption of transcription. We discuss these theories but also bring to light newer data that suggest that these two processes may not be as detrimental to one another as previously thought. This includes findings suggesting that these processes can occur without fork collapse and that RNA polymerase may only be transiently displaced during DNA replication. We discuss potential mechanisms by which RNA polymerase may be retained at the replication fork and quickly rebind to DNA post-replication. These discoveries are important, not only as new evidence as to how these two processes are able to occur harmoniously but also because they have implications on how transcriptional programs are maintained through DNA replication. To this end, we also discuss the coordination of replication and transcription in light of revising the current epigenetic bookmarking theory of how the active gene status can be transmitted through S phase.","PeriodicalId":47009,"journal":{"name":"Transcription-Austin","volume":" ","pages":"22-37"},"PeriodicalIF":3.6,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11093037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139913687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 更正。

IF 3.6

Transcription-Austin Pub Date : 2024-02-01 Epub Date: 2024-03-21 DOI: 10.1080/21541264.2024.2333606

引用次数: 0

Transcriptional and spatiotemporal regulation of the dauer program. 脑电程序的转录和时空调控。

IF 3.6

Transcription-Austin Pub Date : 2023-11-01 Epub Date: 2023-03-23 DOI: 10.1080/21541264.2023.2190295

Luciana F Godoy, Daniel Hochbaum

{"title":"Transcriptional and spatiotemporal regulation of the dauer program.","authors":"Luciana F Godoy, Daniel Hochbaum","doi":"10.1080/21541264.2023.2190295","DOIUrl":"10.1080/21541264.2023.2190295","url":null,"abstract":"Caenorhabditis elegans can enter a diapause stage called \"dauer\" when it senses that the environment is not suitable for development. This implies a detour from the typical developmental trajectory and requires a tight control of the developmental clock and a massive tissue remodeling. In the last decades, core components of the signaling pathways that govern the dauer development decision have been identified, but the tissues where they function for the acquisition of dauer-specific traits are still under intense study. Growing evidence demonstrates that these pathways engage in complex cross-talk and feedback loops. In this review, we summarize the current knowledge regarding the transcriptional regulation of the dauer program and the relevant tissues for its achievement. A better understanding of this process will provide insight on how developmental plasticity is achieved and how development decisions are under a robust regulation to ensure an all-or-nothing response. Furthermore, this developmental decision can also serve as a simplified model for relevant developmental disorders.Abbreviations: AID Auxin Induced Degron DA dafachronic acid Daf-c dauer formation constitutive Daf-d dauer formation defective DTC Distal Tip Cells ECM modified extracellular matrix GPCRs G protein-coupled receptors IIS insulin/IGF-1 signaling ILPs insulin-like peptides LBD Ligand Binding Domain PDL4 Post Dauer L4 TGF-β transforming growth factor beta WT wild-type.","PeriodicalId":47009,"journal":{"name":"Transcription-Austin","volume":"14 1-2","pages":"27-48"},"PeriodicalIF":3.6,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10353326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9833792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The circular logic of mRNA homeostasis. mRNA稳态的循环逻辑。

IF 3.6

Transcription-Austin Pub Date : 2023-11-01 Epub Date: 2023-02-26 DOI: 10.1080/21541264.2023.2183684

Alysia R Bryll, Craig L Peterson

引用次数: 0

Never a dull enzyme, RNA polymerase II. 决不是一种迟钝的酶，RNA聚合酶II。

IF 3.6

Transcription-Austin Pub Date : 2023-11-01 Epub Date: 2023-05-02 DOI: 10.1080/21541264.2023.2208023

Jie Huang, Xiong Ji

引用次数: 0

Transcription machinery of the minimalist: comparative genomic analysis provides insights into the (de)regulated transcription mechanism of microsporidia - fungal-relative parasites. 极简转录机制:比较基因组分析提供了对微孢子虫-真菌相关寄生虫(非)调节转录机制的见解。

IF 3.6

Transcription-Austin Pub Date : 2023-11-01 Epub Date: 2023-02-09 DOI: 10.1080/21541264.2023.2174765

Sittinan Chanarat

{"title":"Transcription machinery of the minimalist: comparative genomic analysis provides insights into the (de)regulated transcription mechanism of microsporidia - fungal-relative parasites.","authors":"Sittinan Chanarat","doi":"10.1080/21541264.2023.2174765","DOIUrl":"10.1080/21541264.2023.2174765","url":null,"abstract":"Microsporidia are eukaryotic obligate intracellular parasites closely related to fungi. Co-evolving with infected hosts, microsporidia have highly reduced their genomes and lacked several biological components. As it is beneficial for intracellular parasites like microsporidia to reduce their genome size, it is therefore reasonable to assume that genes encoding multifactorial complex machinery of transcription could be a potential target to be excluded from microsporidian genomes during the reductive evolution. In such a case, an evolutionary dilemma occurs because microsporidia cannot remove all transcription-machinery-encoding genes, products of which are essential for initialthe initial steps of gene expression. Here, I propose that while genes encoding core machinery are conserved, several genes known to function in fine-tune regulation of transcription are absent. This genome compaction strategy may come at the cost of loosely regulated or less controllable transcription. Alternatively, analogous to microsporidian polar tube, the parasites may have specialized factors to regulate their RNA synthesis.","PeriodicalId":47009,"journal":{"name":"Transcription-Austin","volume":"14 1-2","pages":"1-17"},"PeriodicalIF":3.6,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10353337/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10210024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0