Transcription-Austin最新文献

Decoding complexity: tackling the challenge of how many transcription factors regulate a plant gene. 解码复杂性：解决多少转录因子调控植物基因的挑战。

IF 3.6

Transcription-Austin Pub Date : 2025-06-25 DOI: 10.1080/21541264.2025.2521767

John Gray, Erich Grotewold

引用次数: 0

GATA3 and E2F6 negatively regulate WDR77 expression to inhibit prostate cancer cell growth. GATA3和E2F6负向调控WDR77的表达，抑制前列腺癌细胞的生长。

IF 3.6

Transcription-Austin Pub Date : 2025-03-12 DOI: 10.1080/21541264.2025.2476848

Robin Brice, Zhengxin Wang

引用次数: 0

Rho-dependent termination: a bacterial evolutionary capacitor for stress resistance. rho依赖终止：细菌抗应力进化电容器。

IF 3.6

Transcription-Austin Pub Date : 2025-03-05 DOI: 10.1080/21541264.2025.2474367

Sarah B Worthan, Megan I Grant, Megan G Behringer

{"title":"Rho-dependent termination: a bacterial evolutionary capacitor for stress resistance.","authors":"Sarah B Worthan, Megan I Grant, Megan G Behringer","doi":"10.1080/21541264.2025.2474367","DOIUrl":"10.1080/21541264.2025.2474367","url":null,"abstract":"Since the Modern Synthesis, interest has grown in resolving the \"black box\" between genotype and phenotype. Contained within this black box are highly plastic RNA and proteins with global effects on chromosome integrity and gene expression that serve as evolutionary capacitors - elements that enable the accumulation and buffering of genetic variation in normal conditions and reveal hidden genetic variation when induced by environmental stress. Discussion of evolutionary capacitors has primarily focused on eukaryotic translation factors and chaperones, such as Hsp90 and PSI+ prion. However, due to the coupling of transcription and translation in prokaryotes, transcription factors can be equally impactful in the modulation of gene expression and phenotypes. In this review, we discuss the prokaryotic transcription terminator Rho and how mutagenesis and plasticity of Rho influence epistasis, evolvability, and adaptation to stress in bacteria. We discuss the effects of variation in Rho generated by nature, laboratory mutagenesis, and experimental evolution; and how this variation is constrained or encouraged by Rho's extensive network of protein interactors. Exploring Rho's role as an evolutionary capacitor, along with identifying additional elements that can serve this function, can significantly advance our understanding of how organisms adapt to thrive in diverse environments.","PeriodicalId":47009,"journal":{"name":"Transcription-Austin","volume":" ","pages":"1-14"},"PeriodicalIF":3.6,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of lncRNA in plant growth and domestication. lncRNA在植物生长和驯化中的作用。

IF 3.6

Transcription-Austin Pub Date : 2025-03-04 DOI: 10.1080/21541264.2025.2473224

Vijay Gahlaut, Vandana Jaiswal

引用次数: 0

Harnessing transcription factors for therapeutic purposes. 利用转录因子进行治疗。

IF 3.6

Transcription-Austin Pub Date : 2025-02-01 Epub Date: 2025-02-14 DOI: 10.1080/21541264.2025.2460249

Joaquin M Espinosa

引用次数: 0

Hypoxia-inducible transcription factors: architects of tumorigenesis and targets for anticancer drug discovery. 缺氧诱导转录因子：肿瘤发生的设计师和抗癌药物发现的目标。

IF 3.6

Transcription-Austin Pub Date : 2025-02-01 Epub Date: 2024-10-29 DOI: 10.1080/21541264.2024.2417475

Alexander McDermott, Ali Tavassoli

{"title":"Hypoxia-inducible transcription factors: architects of tumorigenesis and targets for anticancer drug discovery.","authors":"Alexander McDermott, Ali Tavassoli","doi":"10.1080/21541264.2024.2417475","DOIUrl":"10.1080/21541264.2024.2417475","url":null,"abstract":"Hypoxia-inducible factors (HIFs) play a pivotal role as master regulators of tumor survival and growth, controlling a wide array of cellular processes in response to hypoxic stress. Clinical data correlates upregulated HIF-1 and HIF-2 levels with an aggressive tumor phenotype and poor patient outcome. Despite extensive validation as a target in cancer, pharmaceutical targeting of HIFs, particularly the interaction between α and βsubunits that forms the active transcription factor, has proved challenging. Nonetheless, many indirect inhibitors of HIFs have been identified, targeting diverse parts of this pathway. Significant strides have also been made in the development of direct inhibitors of HIF-2, exemplified by the FDA approval of Belzutifan for the treatment of metastatic clear cell renal carcinoma. While efforts to target HIF-1 using various therapeutic modalities have shown promise, no clinical candidates have yet emerged. This review aims to provide insights into the intricate and extensive role played by HIFs in cancer, and the ongoing efforts to develop therapeutic agents against this target.","PeriodicalId":47009,"journal":{"name":"Transcription-Austin","volume":" ","pages":"86-117"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142523307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting bacterial transcription factors for infection control: opportunities and challenges. 针对细菌转录因子进行感染控制：机遇与挑战。

IF 3.6

Transcription-Austin Pub Date : 2025-02-01 Epub Date: 2023-12-21 DOI: 10.1080/21541264.2023.2293523

Ahmed Al-Tohamy, Anne Grove

{"title":"Targeting bacterial transcription factors for infection control: opportunities and challenges.","authors":"Ahmed Al-Tohamy, Anne Grove","doi":"10.1080/21541264.2023.2293523","DOIUrl":"10.1080/21541264.2023.2293523","url":null,"abstract":"The rising threat of antibiotic resistance in pathogenic bacteria emphasizes the need for new therapeutic strategies. This review focuses on bacterial transcription factors (TFs), which play crucial roles in bacterial pathogenesis. We discuss the regulatory roles of these factors through examples, and we outline potential therapeutic strategies targeting bacterial TFs. Specifically, we discuss the use of small molecules to interfere with TF function and the development of transcription factor decoys, oligonucleotides that compete with promoters for TF binding. We also cover peptides that target the interaction between the bacterial TF and other factors, such as RNA polymerase, and the targeting of sigma factors. These strategies, while promising, come with challenges, from identifying targets to designing interventions, managing side effects, and accounting for changing bacterial resistance patterns. We also delve into how Artificial Intelligence contributes to these efforts and how it may be exploited in the future, and we touch on the roles of multidisciplinary collaboration and policy to advance this research domain.Abbreviations: AI, artificial intelligence; CNN, convolutional neural networks; DTI: drug-target interaction; HTH, helix-turn-helix; IHF, integration host factor; LTTRs, LysR-type transcriptional regulators; MarR, multiple antibiotic resistance regulator; MRSA, methicillin resistant Staphylococcus aureus; MSA: multiple sequence alignment; NAP, nucleoid-associated protein; PROTACs, proteolysis targeting chimeras; RNAP, RNA polymerase; TF, transcription factor; TFD, transcription factor decoying; TFTRs, TetR-family transcriptional regulators; wHTH, winged helix-turn-helix.","PeriodicalId":47009,"journal":{"name":"Transcription-Austin","volume":" ","pages":"141-168"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138832205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing p53 for targeted cancer therapy: new advances and future directions. 利用p53靶向癌症治疗：新进展和未来方向。

IF 3.6

Transcription-Austin Pub Date : 2025-02-01 Epub Date: 2025-03-03 DOI: 10.1080/21541264.2025.2452711

Zdenek Andrysik, Joaquin M Espinosa

{"title":"Harnessing p53 for targeted cancer therapy: new advances and future directions.","authors":"Zdenek Andrysik, Joaquin M Espinosa","doi":"10.1080/21541264.2025.2452711","DOIUrl":"10.1080/21541264.2025.2452711","url":null,"abstract":"The transcription factor p53 is the most frequently impaired tumor suppressor in human cancers. In response to various stress stimuli, p53 activates transcription of genes that mediate its tumor-suppressive functions. Distinctive characteristics of p53 outlined here enable a well-defined program of genes involved in cell cycle arrest, apoptosis, senescence, differentiation, metabolism, autophagy, DNA repair, anti-viral response, and anti-metastatic functions, as well as facilitating autoregulation within the p53 network. This versatile, anti-cancer network governed chiefly by a single protein represents an immense opportunity for targeted cancer treatment, since about half of human tumors retain unmutated p53. During the last two decades, numerous compounds have been developed to block the interaction of p53 with the main negative regulator MDM2. However, small molecule inhibitors of MDM2 only induce a therapeutically desirable apoptotic response in a limited number of cancer types. Moreover, clinical trials of the MDM2 inhibitors as monotherapies have not met expectations and have revealed hematological toxicity as a characteristic adverse effect across this drug class. Currently, combination treatments are the leading strategy for enhancing efficacy and reducing adverse effects of MDM2 inhibitors. This review summarizes efforts to identify and test therapeutics that work synergistically with MDM2 inhibitors. Two main types of drugs have emerged among compounds used in the following combination treatments: first, modulators of the p53-regulated transcriptome (including chromatin modifiers), translatome, and proteome, and second, drugs targeting the downstream pathways such as apoptosis, cell cycle arrest, DNA repair, metabolic stress response, immune response, ferroptosis, and growth factor signaling. Here, we review the current literature in this field, while also highlighting overarching principles that could guide target selection in future combination treatments.","PeriodicalId":47009,"journal":{"name":"Transcription-Austin","volume":" ","pages":"3-46"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcription factors in the development and treatment of immune disorders. 转录因子在免疫疾病的发展和治疗中的作用。

IF 3.6

Transcription-Austin Pub Date : 2025-02-01 Epub Date: 2023-12-15 DOI: 10.1080/21541264.2023.2294623

Samantha D Patalano, Paula Fuxman Bass, Juan I Fuxman Bass

{"title":"Transcription factors in the development and treatment of immune disorders.","authors":"Samantha D Patalano, Paula Fuxman Bass, Juan I Fuxman Bass","doi":"10.1080/21541264.2023.2294623","DOIUrl":"10.1080/21541264.2023.2294623","url":null,"abstract":"Immune function is highly controlled at the transcriptional level by the binding of transcription factors (TFs) to promoter and enhancer elements. Several TF families play major roles in immune gene expression, including NF-κB, STAT, IRF, AP-1, NRs, and NFAT, which trigger anti-pathogen responses, promote cell differentiation, and maintain immune system homeostasis. Aberrant expression, activation, or sequence of isoforms and variants of these TFs can result in autoimmune and inflammatory diseases as well as hematological and solid tumor cancers. For this reason, TFs have become attractive drug targets, even though most were previously deemed \"undruggable\" due to their lack of small molecule binding pockets and the presence of intrinsically disordered regions. However, several aspects of TF structure and function can be targeted for therapeutic intervention, such as ligand-binding domains, protein-protein interactions between TFs and with cofactors, TF-DNA binding, TF stability, upstream signaling pathways, and TF expression. In this review, we provide an overview of each of the important TF families, how they function in immunity, and some related diseases they are involved in. Additionally, we discuss the ways of targeting TFs with drugs along with recent research developments in these areas and their clinical applications, followed by the advantages and disadvantages of targeting TFs for the treatment of immune disorders.","PeriodicalId":47009,"journal":{"name":"Transcription-Austin","volume":" ","pages":"118-140"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138802192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond small molecules: advancing MYC-targeted cancer therapies through protein engineering. 超越小分子：通过蛋白质工程推进myc靶向癌症治疗。

IF 3.6

Transcription-Austin Pub Date : 2025-02-01 Epub Date: 2025-01-29 DOI: 10.1080/21541264.2025.2453315

Rama Edaibis, Raneem Akel, Jumi A Shin

{"title":"Beyond small molecules: advancing MYC-targeted cancer therapies through protein engineering.","authors":"Rama Edaibis, Raneem Akel, Jumi A Shin","doi":"10.1080/21541264.2025.2453315","DOIUrl":"10.1080/21541264.2025.2453315","url":null,"abstract":"Protein engineering has emerged as a powerful approach toward the development of novel therapeutics targeting the MYC/MAX/E-box network, an active driver of >70% of cancers. The MYC/MAX heterodimer regulates numerous genes in our cells by binding the Enhancer box (E-box) DNA site and activating the transcription of downstream genes. Traditional small molecules that inhibit MYC face significant limitations that include toxic effects, drug delivery challenges, and resistance. Recent advances in protein engineering offer promising alternatives by creating protein-based drugs that directly disrupt the MYC/MAX dimerization interface and/or MYC/MAX's binding to specific DNA targets. Designed DNA binding proteins like Omomyc, DuoMyc, ME47, MEF, and Mad inhibit MYC activity through specific dimerization, sequestration, and DNA-binding mechanisms. Compared to small molecules, these engineered proteins can offer superior specificity and efficacy and provide a potential pathway for overcoming the limitations of traditional cancer therapies. The success of these protein therapeutics highlights the importance of protein engineering in developing cancer treatments.","PeriodicalId":47009,"journal":{"name":"Transcription-Austin","volume":" ","pages":"67-85"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0