Decoding complexity: tackling the challenge of how many transcription factors regulate a plant gene.

IF 3.6 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
John Gray, Erich Grotewold
{"title":"Decoding complexity: tackling the challenge of how many transcription factors regulate a plant gene.","authors":"John Gray, Erich Grotewold","doi":"10.1080/21541264.2025.2521767","DOIUrl":null,"url":null,"abstract":"<p><p>The regulation of transcription is a major control point in the flow of information from the genome to the phenome. Central to this regulation are transcription factors (TFs), which bind specific DNA motifs in gene regulatory regions. In both metazoans and plants, 5-7% of all genes encode TFs. Although individual TFs can recognize and regulate thousands of target genes, an important question remains: how many TFs are required to precisely control the expression of a single gene? In this review, we compare the regulation of gene expression in plants and metazoans, outline key methodologies for identifying genes recognized or regulated by TFs, and explore what is currently known about the number of TFs needed to define the expression of any given plant gene. As the volume of high-throughput sequencing data continues to grow exponentially, it becomes increasingly clear that transcriptional regulatory networks exhibit remarkable complexity, characterized by many targets influenced by each TF; and that many TFs, often several dozens, contribute to the regulation of individual genes.</p>","PeriodicalId":47009,"journal":{"name":"Transcription-Austin","volume":" ","pages":"1-23"},"PeriodicalIF":3.6000,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Transcription-Austin","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/21541264.2025.2521767","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

The regulation of transcription is a major control point in the flow of information from the genome to the phenome. Central to this regulation are transcription factors (TFs), which bind specific DNA motifs in gene regulatory regions. In both metazoans and plants, 5-7% of all genes encode TFs. Although individual TFs can recognize and regulate thousands of target genes, an important question remains: how many TFs are required to precisely control the expression of a single gene? In this review, we compare the regulation of gene expression in plants and metazoans, outline key methodologies for identifying genes recognized or regulated by TFs, and explore what is currently known about the number of TFs needed to define the expression of any given plant gene. As the volume of high-throughput sequencing data continues to grow exponentially, it becomes increasingly clear that transcriptional regulatory networks exhibit remarkable complexity, characterized by many targets influenced by each TF; and that many TFs, often several dozens, contribute to the regulation of individual genes.

解码复杂性:解决多少转录因子调控植物基因的挑战。
转录调控是信息流从基因组到表型的一个主要控制点。这种调控的核心是转录因子(TFs),它结合基因调控区域的特定DNA基序。在后生动物和植物中,5-7%的基因编码tf。虽然单个tf可以识别和调节数千个靶基因,但一个重要的问题仍然存在:精确控制单个基因的表达需要多少个tf ?在这篇综述中,我们比较了植物和后生动物中基因表达的调控,概述了鉴定由tf识别或调控的基因的关键方法,并探讨了目前已知的定义任何给定植物基因表达所需的tf数量。随着高通量测序数据量持续呈指数级增长,越来越清楚的是,转录调控网络表现出显着的复杂性,其特征是每个TF影响许多靶点;许多tf,通常是几十个,对个体基因的调节有贡献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Transcription-Austin
Transcription-Austin BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
6.50
自引率
5.60%
发文量
9
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信