{"title":"Evolution of Bruker EPR Spectrometers as well as Prospects for Present and Future EPR Applications","authors":"Ralph T. Weber","doi":"10.1007/s00723-024-01734-z","DOIUrl":"10.1007/s00723-024-01734-z","url":null,"abstract":"<div><p>EPR applications have evolved continuously with the development of the EPR technique. Since 1967, Bruker EPR is constantly developing its products to keep pace with these constantly changing demands. This article presents commercial EPR solutions in perspective of the past, present, and future.</p></div>","PeriodicalId":469,"journal":{"name":"Applied Magnetic Resonance","volume":"56 1-2","pages":"57 - 71"},"PeriodicalIF":1.1,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143109810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Donghoon Lee, Hwon Heo, Chul-Woong Woo, Yeon Ji Chae, Monica Young Choi, Joongkee Min, Dong-Cheol Woo, Do-Wan Lee
{"title":"In Vivo Assessment of Cerebral Functional Changes in a Rat Model of Sepsis-Associated Encephalopathy Using Multi-Parametric MR Imaging","authors":"Donghoon Lee, Hwon Heo, Chul-Woong Woo, Yeon Ji Chae, Monica Young Choi, Joongkee Min, Dong-Cheol Woo, Do-Wan Lee","doi":"10.1007/s00723-024-01735-y","DOIUrl":"10.1007/s00723-024-01735-y","url":null,"abstract":"<div><p>Sepsis-associated encephalopathy (SAE) results in widespread brain dysfunction due to systemic infection without direct central nervous system involvement. This study aimed to assess functional and metabolic alterations in a rat model of SAE using multi-parametric magnetic resonance imaging (mpMRI). Twenty-one rats were divided into control (CTRL, n = 7), SAE05 (5 mg/kg LPS, n = 7), and SAE10 (10 mg/kg LPS, n = 7) groups. MPI was performed 24 h post-LPS injection using a 7 T MR system to capture apparent diffusion coefficient (ADC), cerebral blood flow (CBF), T1, and T2 maps. In our study, the ADC and T1 values were significantly elevated in both the left and right hippocampi of the SAE05 and SAE10 groups compared to the CTRL group. However, the CBF and T2 values did not exhibit significant changes across the groups. This study utilized multi-parametric MRI to evaluate functional and metabolic changes in the brain associated with SAE. The results revealed significant increases in ADC and T1 values, indicating vasogenic edema and blood–brain barrier disruption in the hippocampus, which provide crucial insights for diagnosing and developing treatments for inflammatory brain diseases.</p></div>","PeriodicalId":469,"journal":{"name":"Applied Magnetic Resonance","volume":"56 4","pages":"429 - 439"},"PeriodicalIF":1.1,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00723-024-01735-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maruan Bracci, Ilenia Serra, Inés García-Rubio, Sabine Van Doorslaer
{"title":"Performance Comparison of Different Rapid Freeze–Quench Strategies for Electron Paramagnetic Resonance","authors":"Maruan Bracci, Ilenia Serra, Inés García-Rubio, Sabine Van Doorslaer","doi":"10.1007/s00723-024-01725-0","DOIUrl":"10.1007/s00723-024-01725-0","url":null,"abstract":"<div><p>This work addresses the development of a custom-made home-built rapid freeze–quench (RFQ) device and the comparison of its performance to the one of a commercial RFQ setup that was in-house custom adapted. Both systems consist of two syringes that push the reactants into a mixing chamber and the products to a subsequent freezing setup. Using the binding of azide to myoglobin as a calibration reaction, the quenching times of the different setups were compared, evaluating different instrumental parameters, such as software-controlled variation of the aging time, variations of the flow rate and variations of the distance travelled by the mixed sample before freezing. In addition to minimal sample consumption, the home-built RFQ device was found to lead to the shorter reaction times which could be controlled in a time range from 10 to 25 ms. The commercial RFQ system yielded optimal reaction control in a time range from 50 to 200 ms, although a larger volume of reactants needed to be used due to the significant dead volume of the system. Three different freezing methods were also evaluated, among which, in our hands, freezing the jet directly in a deep bath of cold isopentane yielded shorter and reproducible freezing times.</p></div>","PeriodicalId":469,"journal":{"name":"Applied Magnetic Resonance","volume":"56 1-2","pages":"229 - 252"},"PeriodicalIF":1.1,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143108733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Carlo Corvaja: On the Occasion of His 85th Birthday","authors":"Lorenzo Franco, Marco Ruzzi","doi":"10.1007/s00723-024-01728-x","DOIUrl":"10.1007/s00723-024-01728-x","url":null,"abstract":"","PeriodicalId":469,"journal":{"name":"Applied Magnetic Resonance","volume":"55 12","pages":"1467 - 1470"},"PeriodicalIF":1.1,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142679607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Comparable Study on the EPR g Factors and the Local Structures of the Substitutional and Interstitial Mo5+ Centers in Rutile","authors":"Fu Chen, Zifa Zhou","doi":"10.1007/s00723-024-01727-y","DOIUrl":"10.1007/s00723-024-01727-y","url":null,"abstract":"<div><p>The electron paramagnetic resonance (EPR) <i>g</i> factors and the local structures of Mo<sup>5+</sup> centers on the substitutional and interstitial sites in rutile are theoretically studied from the perturbation formulas of these parameters for a 3d<sup>1</sup> ion in rhombically compressed and elongated octahedra, respectively. In the calculation formulas, the crystal field parameters are determined from the superposition model, and the contributions from the spin–orbit coupling (SOC) of the ligands are taken into account. Based on the calculations, the ligand octahedron in the substitutional Mo<sup>5+</sup> center may suffer a larger axial compression with the parallel and perpendicular impurity—ligand length bonds <i>R</i>′<sub>||s</sub> ≈ 1.932 and <i>R</i>′<sub>⊥s</sub> ≈ 1.975 Å) than the bond lengths <i>R</i><sub>||s</sub> ≈ 1.99 and <i>R</i><sub>⊥s</sub> ≈ 1.94 Å in the host and the much smaller perpendicular distortion (<i>i.e.</i>, <i>θ</i><sub>s</sub>′ ≈ 87.32º) than that <i>θ</i><sub>s</sub> ≈ 81.21º) in the host related to the ideal angle <i>θ</i><sub>0</sub> ≈ 90º in a regular octahedron due to the Jahn–Teller (JT) effect. For the interstitial Mo<sup>5+</sup> center, the ligand octahedron exhibits the axial elongation (<i>i.e.</i>, <i>R</i>′<sub>||<i>i</i></sub> ≈ 2.155 and <i>R</i>′<sub>⊥<i>i</i></sub> ≈ 1.987 Å) rather than a compressed octahedra with <i>R</i><sub>||<i>i</i></sub> ≈ 1.67 and <i>R</i><sub>⊥<i>i</i></sub> ≈ 2.23 Å in the host and a smaller rhombic distortion (<i>θ</i><sub><i>i</i></sub>′ ≈ 95.2º) than that <i>θ</i><sub><i>i</i></sub> ≈ 97º in the host related to <i>θ</i><sub>0</sub> due to the JT effect. The reasonableness of these results are discussed.</p></div>","PeriodicalId":469,"journal":{"name":"Applied Magnetic Resonance","volume":"56 1-2","pages":"253 - 264"},"PeriodicalIF":1.1,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143108651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synthesis and Structure Identification of 1-[4-(4-pentylcyclohexyl)-phenyl]-3-(quinolin-8-ylamino)prop-2-en-1-one Molecules in Solvents of Different Polarities","authors":"M. Yu. Volkov, A. R. Sharipova, O. A. Turanova","doi":"10.1007/s00723-024-01726-z","DOIUrl":"10.1007/s00723-024-01726-z","url":null,"abstract":"<div><p>β-Enaminone 1-[4-(4-pentylcyclohexyl)-phenyl]-3-(quinolin-8-ylamino)prop-2-en-1-one was first synthesized and studied by NMR and UV spectroscopy. It was established that the molecules of this substance exist in the ketone form of the <i>cis-</i>isomer in both polar acetone and weakly polar chloroform. Exposing the solutions of this enaminone daylight at room temperature leads to the formation of small amounts of trans-isomer in them. 365 nm UV irradiation of the solution in chloroform leads to reversible <i>cis–trans</i> isomerization of the dissolved molecules of 1-[4-(4-pentylcyclohexyl)phenyl]-3-(quinolin-8-ylamino)prop-2-en-1-one.</p></div>","PeriodicalId":469,"journal":{"name":"Applied Magnetic Resonance","volume":"56 3","pages":"297 - 312"},"PeriodicalIF":1.1,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143471854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"New Approach to the Formation of a Bose–Einstein Condensate","authors":"K. M. Salikhov","doi":"10.1007/s00723-024-01723-2","DOIUrl":"10.1007/s00723-024-01723-2","url":null,"abstract":"<div><p>The observation of the exchange narrowing effect is a routine event in EPR spectroscopy. In this paper, I want to draw attention to the fact that every time we observe an exchange narrowing of the EPR spectrum, we have a gas of identical bosons, where the prerequisites of BEC formation are satisfied at room temperature. Imagine the possibility to create BEC without the need to cooling down to nano Kelvin temperatures to get a gas of identical bosons because the phenomenon of exchange narrowing of the EPR spectrum can be easily observed at room temperatures. This article provides a detailed explanation of how a gas of identical bosons can be formed at room temperature in dilute solutions of paramagnetic particles with a discrete EPR spectrum of individual particles. There are still many questions about the Bose–Einstein condensation of a spin polariton gas, which is created under conditions of exchange narrowing of EPR spectra. With the expectation of obtaining additional information about the condensation of bosons in the situation under consideration, this article proposes the protocol of one EPR experiment to prove that the effect of exchange narrowing of EPR spectra can be instrumental in creating BEC in dilute solutions at room temperature.</p></div>","PeriodicalId":469,"journal":{"name":"Applied Magnetic Resonance","volume":"56 1-2","pages":"213 - 228"},"PeriodicalIF":1.1,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143108369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Siyu Li, Hanming Yang, Heike Hofstetter, Marco Tonelli, Silvia Cavagnero
{"title":"Correction: Magnetic-Field Dependence of LC-Photo-CIDNP in the Presence of Target Molecules Carrying a Quasi-Isolated Spin Pair","authors":"Siyu Li, Hanming Yang, Heike Hofstetter, Marco Tonelli, Silvia Cavagnero","doi":"10.1007/s00723-024-01724-1","DOIUrl":"10.1007/s00723-024-01724-1","url":null,"abstract":"","PeriodicalId":469,"journal":{"name":"Applied Magnetic Resonance","volume":"56 3","pages":"427 - 427"},"PeriodicalIF":1.1,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143471859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fabio Seiji Otsuka, Maria Concepción García Otaduy, Otaciro Rangel Nascimento, Carlos Ernesto Garrido Salmon, Martina Huber
{"title":"Challenges of Continuous Wave EPR of Broad Signals—The Ferritin Case","authors":"Fabio Seiji Otsuka, Maria Concepción García Otaduy, Otaciro Rangel Nascimento, Carlos Ernesto Garrido Salmon, Martina Huber","doi":"10.1007/s00723-024-01719-y","DOIUrl":"10.1007/s00723-024-01719-y","url":null,"abstract":"<div><p>The study of continuous wave (cw) electron paramagnetic resonance (EPR) spectra still poses a challenge for very broad signals, especially when the spectrum extends over a large part of the accessible field range. The difficulties derive from instrumental challenges, because of insufficient modulation depth and the need to apply measurement conditions that enhance cavity background. The biggest problem, however, is how to define a baseline such that spectral distortions are minimized. Conventional methods rely on a suitable choice of points outside the range of the signal of interest to perform a polynomial interpolation. These methods are effective in most cases where the signal of interest comprises only a narrow range of magnetic field (narrow features). In this study, a novel method of baseline correction for broad signals is proposed and compared to conventional methods. It takes into account that there are only few anchor points for the baseline. The method is applied to the signal of the iron-storage protein ferritin. The ferritin signal is a broad band that extends from zero to 0.8 T. An approach is developed by which this broad signal is analyzed reliably. The method is also extended to the case where the broad signal is superimposed on narrow signals and enables to extract the parameters of both types of signals in a fitting pipeline.</p></div>","PeriodicalId":469,"journal":{"name":"Applied Magnetic Resonance","volume":"55 12","pages":"1605 - 1620"},"PeriodicalIF":1.1,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00723-024-01719-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142679583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}