Biofuel Research Journal-BRJ最新文献_第2页

Machine-learning-aided thermochemical treatment of biomass: a review 机器学习辅助生物质热化学处理研究进展

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Biofuel Research Journal-BRJ Pub Date : 2023-03-01 DOI: 10.18331/brj2023.10.1.4

Hailong Li, Jiefeng Chen, Weijin Zhang, Hao-Yue Zhan, Chao He, Zequn Yang, Haoyi Peng, Lijian Leng

{"title":"Machine-learning-aided thermochemical treatment of biomass: a review","authors":"Hailong Li, Jiefeng Chen, Weijin Zhang, Hao-Yue Zhan, Chao He, Zequn Yang, Haoyi Peng, Lijian Leng","doi":"10.18331/brj2023.10.1.4","DOIUrl":"https://doi.org/10.18331/brj2023.10.1.4","url":null,"abstract":"Thermochemical treatment is a promising technique for biomass disposal and valorization. Recently, machine learning (ML) has been extensively used to predict yields, compositions, and properties of biochar, bio-oil, syngas, and aqueous phases produced by the thermochemical treatment of biomass. ML demonstrates great potential to aid the development of thermochemical processes. The present review aims to 1) introduce the ML schemes and strategies as well as descriptors of the input and output features in thermochemical processes; 2) summarize and compare the up-to-date research in both ML-aided wet (hydrothermal carbonization/liquefaction/gasification) and dry (torrefaction/pyrolysis/gasification) thermochemical treatment of biomass (i.e., predicting the yields, compositions, and properties of oil/char/gas/aqueous phases as well as thermal conversion behavior or kinetics); and 3) identify the gaps and provide guidance for future studies concerning how to improve predictive performance, increase generalizability, aid mechanistic and application studies, and effectively share data and models in the community. The development of biomass thermochemical treatment processes is envisaged to be greatly accelerated by ML in the near future.","PeriodicalId":46938,"journal":{"name":"Biofuel Research Journal-BRJ","volume":null,"pages":null},"PeriodicalIF":13.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41861712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 32

Exergy-based sustainability analysis of biogas upgrading using a hybrid solvent (imidazolium-based ionic liquid and aqueous monodiethanolamine) 混合溶剂(咪唑离子液体和单二乙醇胺)对沼气升级的可持续性分析

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Biofuel Research Journal-BRJ Pub Date : 2023-03-01 DOI: 10.18331/brj2023.10.1.3

Bilal Kazmi, Syed Imran Ali, Z. Awan

{"title":"Exergy-based sustainability analysis of biogas upgrading using a hybrid solvent (imidazolium-based ionic liquid and aqueous monodiethanolamine)","authors":"Bilal Kazmi, Syed Imran Ali, Z. Awan","doi":"10.18331/brj2023.10.1.3","DOIUrl":"https://doi.org/10.18331/brj2023.10.1.3","url":null,"abstract":"Energy may be generated in large quantities from fossil fuels, but this comes with environmental concerns. Thus, renewable resources like biogas, comprising carbon dioxide and methane, should be used alone or in combination with fossil fuels to mitigate the environmental footprints of energy generation systems. In this study, a new concept of hybrid solvent was presented, which combines 1-octyl-3-methylimidazolium tetrafluoroborate with aqueous mono diethanolamine for biogas upgrading process to provide high purity (≥ 99 wt%) and recovery (≥ 99 wt%) of biomethane. The process was simulated in ASPEN Plus® V.11. The thermodynamic framework was validated against experimental data, and rigorous regression was conducted to obtain binary parameters. To establish the efficacy of the suggested hybrid solvent, three scenarios were studied by altering the concentration of ionic liquid (5–20 wt%) linked with amine and compared to aqueous mono diethanolamine as the base case (50 wt%). The results showed that a hybrid solvent with 5 wt% 1-octyl-3-methylimidazolium tetrafluoroborate could increase CH4 purity to 99% (mol%). The hybrid solvent led to an energy saving of 64.94% compared to the amine-based system. Thermodynamic irreversibilities showed that 5 wt% 1-octyl-3-methylimidazolium tetrafluoroborate improved exergy efficiency by 54% over the amine-based procedure. Environmentally, the hybrid solvent system also achieved a higher capture rate (99%) and lower emissions (0.017 kW/kmol). Comparing the economic prospects, 5 wt% 1-octyl-3-methylimidazolium tetrafluoroborate saved 56% on total capital cost, making it competitive from an investment perspective.","PeriodicalId":46938,"journal":{"name":"Biofuel Research Journal-BRJ","volume":null,"pages":null},"PeriodicalIF":13.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46497783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Life cycle assessment for sustainability assessment of biofuels and bioproducts 生物燃料和生物产品可持续性评估的生命周期评估

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Biofuel Research Journal-BRJ Pub Date : 2023-03-01 DOI: 10.18331/brj2023.10.1.5

S. Gheewala

{"title":"Life cycle assessment for sustainability assessment of biofuels and bioproducts","authors":"S. Gheewala","doi":"10.18331/brj2023.10.1.5","DOIUrl":"https://doi.org/10.18331/brj2023.10.1.5","url":null,"abstract":"Bio-based materials have been used traditionally for millennia. Their use was overtaken in recent times by the discovery and utilization of fossil-based resources for materials and energy. However, concerns about the non-renewability of fossil resources and greenhouse gas and other emissions associated with their use have brought forth a renewed interest in using bio-based materials in recent years. The environmental advantages of bio-based materials cannot be taken for granted without a rigorous scientific assessment. Many tools based on energy, economics, and environmental impacts have been used. Life cycle assessment is one such tool developed and successfully utilized for the environmental assessment of biofuels and bioproducts. However, many methodological challenges, among other things related to system boundaries, functional units, allocation, and carbon accounting, still need further research and consideration. In this work, the related issues are summarized, and the directions for addressing them are discussed. Despite the methodological challenges in their assessment, biofuels and bioproducts show promise in terms of their environmental advantages compared to their fossil-oriented counterparts. These advantages can be further enhanced by utilizing all parts of the feedstock biomass, especially for value-added materials and chemicals via biorefineries.","PeriodicalId":46938,"journal":{"name":"Biofuel Research Journal-BRJ","volume":null,"pages":null},"PeriodicalIF":13.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46844400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Intensifying biofuel production using a novel bionic flow-induced peristaltic reactor: biodiesel production as a case study 利用新型仿生流动诱导蠕动反应器强化生物燃料生产——以生物柴油生产为例

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Biofuel Research Journal-BRJ Pub Date : 2022-12-01 DOI: 10.18331/brj2022.9.4.3

Jianyu Wang, A. Xia, Zhichao Deng, Yun Huang, Xianqing Zhu, Xun Zhu, Q. Liao

{"title":"Intensifying biofuel production using a novel bionic flow-induced peristaltic reactor: biodiesel production as a case study","authors":"Jianyu Wang, A. Xia, Zhichao Deng, Yun Huang, Xianqing Zhu, Xun Zhu, Q. Liao","doi":"10.18331/brj2022.9.4.3","DOIUrl":"https://doi.org/10.18331/brj2022.9.4.3","url":null,"abstract":"Intensification of biofuel production processes could play a critical role in boosting the economic and environmental features of the whole process. A novel bionic flow-induced peristaltic reactor with a high conversion rate is constructed to realize efficient biofuel production from high-concentration high-viscosity fluids. It is experimentally verified through biodiesel production from soybean oil. Experimental results show that the conversion efficiency is up to 89.9% at 10 s in the peristaltic reactor, which is 38.4% higher than that in the rigid tube reactor. Furthermore, a three-dimensional peristaltic model is conducted to understand the mechanism of heat and mass transfer enhancement. The simulation results show that an increase in peristaltic amplitude strengthens the mixing of the bionic peristaltic reactor by 92.5-100.8%. The temperature distribution in the bionic peristaltic reactor is more uniform than in the traditional rigid tube reactor. The results demonstrate that the conversion rate of soybean oil in the bionic flow-induced peristaltic reactor is 528.82% min-1, which is 17-60 times higher than other intensified reactors operating in either continuous or batch modes.","PeriodicalId":46938,"journal":{"name":"Biofuel Research Journal-BRJ","volume":null,"pages":null},"PeriodicalIF":13.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44621531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Enhancing the potential of sugarcane bagasse for the production of ENplus quality fuel pellets by torrefaction: an economic feasibility study 通过焙烧提高甘蔗渣生产ENplus优质燃料颗粒的潜力:经济可行性研究

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Biofuel Research Journal-BRJ Pub Date : 2022-12-01 DOI: 10.18331/brj2022.9.4.2

T. Jarunglumlert, A. Bampenrat, H. Sukkathanyawat, P. Pavasant, C. Prommuak

{"title":"Enhancing the potential of sugarcane bagasse for the production of ENplus quality fuel pellets by torrefaction: an economic feasibility study","authors":"T. Jarunglumlert, A. Bampenrat, H. Sukkathanyawat, P. Pavasant, C. Prommuak","doi":"10.18331/brj2022.9.4.2","DOIUrl":"https://doi.org/10.18331/brj2022.9.4.2","url":null,"abstract":"When fossil fuel substitution with biomass is viewed as a potential solution to global warming caused by greenhouse gas emissions, the demand for biomass fuel pellets has increased worldwide. Although agricultural waste is an attractive potential feedstock for fuel pellet production due to its relatively high calorific value and low cost, its excessive ash content is a major drawback. This research investigates the properties of sugarcane bagasse fuel pellets treated by dry and wet torrefaction and evaluates the economic value of selling the fuel pellets, which were priced based on their quality. It was found that the wet torrefaction could significantly reduce the ash content in the product (1% ash content at a torrefaction temperature of above 180°C), resulting in higher quality and more marketable fuel pellets. Consequently, the yield and the net present value of the production of wet torrefied fuel pellets were greater than those of dry torrefied pellets. Nevertheless, the production of fuel pellets from sugarcane bagasse treated by either process is shown to be economically viable.","PeriodicalId":46938,"journal":{"name":"Biofuel Research Journal-BRJ","volume":null,"pages":null},"PeriodicalIF":13.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42144580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Sustainability assessment of palm oil-based refinery systems for food, fuel, and chemicals 以棕榈油为基础的食品、燃料和化学品精炼系统的可持续性评估

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Biofuel Research Journal-BRJ Pub Date : 2022-12-01 DOI: 10.18331/brj2022.9.4.5

S. Gheewala, Ukrit Jaroenkietkajorn, P. Nilsalab, T. Silalertruksa, Thoranin Somkerd, N. Laosiripojana

{"title":"Sustainability assessment of palm oil-based refinery systems for food, fuel, and chemicals","authors":"S. Gheewala, Ukrit Jaroenkietkajorn, P. Nilsalab, T. Silalertruksa, Thoranin Somkerd, N. Laosiripojana","doi":"10.18331/brj2022.9.4.5","DOIUrl":"https://doi.org/10.18331/brj2022.9.4.5","url":null,"abstract":"Palm-based biorefinery system has gained attention worldwide because of potentially high economic returns. However, environmental impacts also increase with the additional production. Therefore, this study aims to assess the sustainability of (1) current palm-based biorefinery system in Thailand, including cooking oil and biodiesel, and (2) palm-based biorefinery system with value-added products, i.e., succinic acid, lactic acid, bio-hydrogenated diesel (BHD), and epichlorohydrin (ECH) that represent biomaterial, biofuel, and biochemical products, respectively. Accordingly, seven palm-based biorefinery scenarios were designed, and their sustainability was assessed through life cycle assessment (LCA), net energy balance (NEB) and net energy ratio (NER), employment generation, and eco-efficiency. The results revealed that value-added production increased global warming impacts by around 3 – 79% compared with the current system. Although environmental impacts increased due to the additional processes related to the production of the value-added products, total product values also increased, especially for succinic acid, generally leading to higher eco-efficiency values. The current palm-based biorefinery system with succinic acid production had the highest eco-efficiency among all the scenarios considered. The BHD production scenario had the highest NEB and NER because the products were used for energy. Employment generation increased for all the scenarios between 2 – 86% compared with the current system.","PeriodicalId":46938,"journal":{"name":"Biofuel Research Journal-BRJ","volume":null,"pages":null},"PeriodicalIF":13.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44615187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Pyrolysis of low-value waste sawdust over low-cost catalysts: physicochemical characterization of pyrolytic oil and value-added biochar 低价值废木屑在低成本催化剂上的热解:热解油和增值生物炭的物理化学表征

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Biofuel Research Journal-BRJ Pub Date : 2022-12-01 DOI: 10.18331/brj2022.9.4.4

R. Mishra, K. Mohanty

{"title":"Pyrolysis of low-value waste sawdust over low-cost catalysts: physicochemical characterization of pyrolytic oil and value-added biochar","authors":"R. Mishra, K. Mohanty","doi":"10.18331/brj2022.9.4.4","DOIUrl":"https://doi.org/10.18331/brj2022.9.4.4","url":null,"abstract":"The present work deals with an experimental investigation into the generation and characterization of pyrolytic oil and biochar from Sal wood sawdust (SW). The pyrolysis experiment was performed in a semi-batch reactor at 500 oC and 80 oC/min heating rate with CaO, CuO, and Al2O3 catalysts. Further, the pyrolytic oil and biochar were investigated using different analyses, including proximate analysis, elemental analysis, thermal stability, GC-MS, FTIR, field emission scanning electron microscopy, electrical conductivity analysis, higher heating value (HHV), zeta potential analysis, and ash content analysis. Pyrolysis results revealed that compared to thermal pyrolysis (46.02 wt%), the pyrolytic oil yield was improved by catalytic pyrolysis with CaO and CuO (50.02 and 48.23 wt%, respectively). Further, the characterization of pyrolytic oil revealed that the loading of catalysts considerably improved the oil's properties by lowering its viscosity (69.50 to 22 cSt), ash content (0.26 to 0.11 wt%), and oxygen content (28.32 to16.60 %) while raising its acidity (4.2 to 9.6), heating value (25.66 to 36.09 MJ/kg), and carbon content (61.79 to 74.28%). According to the FTIR analysis, the pyrolytic oil contained hydrocarbons, phenols, aromatics, alcohols, and oxygenated compounds. Additionally, the GC-MS analysis showed that catalysts significantly reduced oxygenated fractions, phenols (20.23 to 15.26%), acids (12.23 to 6.56%), and increased hydrocarbons (12 to 16 wt%). Additionally, the results of the biochar analysis demonstrated that SW biochar was appropriate for a range of industrial applications, including in catalysts, supercapacitors, fuel cells, and bio-composite materials.","PeriodicalId":46938,"journal":{"name":"Biofuel Research Journal-BRJ","volume":null,"pages":null},"PeriodicalIF":13.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42637578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Wood combustion nanoparticles emitted by conventional and advanced technology cordwood boilers, and their interactions in vitro with human lung epithelial monolayers 传统和先进技术的软木锅炉排放的木材燃烧纳米颗粒及其与人肺上皮单层的体外相互作用

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Biofuel Research Journal-BRJ Pub Date : 2022-09-01 DOI: 10.18331/brj2022.9.3.3

B. Panessa-Warren, T. Butcher, J. Warren, R. Trojanowski, K. Kisslinger, G. Wei, Y. Celebi

{"title":"Wood combustion nanoparticles emitted by conventional and advanced technology cordwood boilers, and their interactions in vitro with human lung epithelial monolayers","authors":"B. Panessa-Warren, T. Butcher, J. Warren, R. Trojanowski, K. Kisslinger, G. Wei, Y. Celebi","doi":"10.18331/brj2022.9.3.3","DOIUrl":"https://doi.org/10.18331/brj2022.9.3.3","url":null,"abstract":"Biomass-burning boilers and stoves are widely used in many parts of the world, producing combustion emissions linked with health risks. Combustion emission nanoparticles (NPs) were collected from four representative wood burning boilers using oak cordwood at specific times in the burn cycle. The morphology and composition of the NPs was characterized using transmission electron microscopy and energy dispersive X-ray analysis. To determine the degree of NP cytotoxicity with human lung tissue, the combustion NPs were introduced to incubated lung bronchial epithelial monolayers (NCI-H292) in vitro at doses of 0.1 × 10-6 and 3.0 × 10-6 kg/L for 2 and 4 h. Histochemical analysis showed that cell death increased by a factor of 3.5 for both doses after 4 h when compared to the control. Ultrapure NPs prepared by wet chemical methods were also introduced to the epithelial lung cells for similar doses and exposure times and the cultures exhibited significantly reduced mortality. Electron microscopy was used to study the mechanism of cell mortality for the synthesized and combustion-based NPs by examining how the NP byproducts interacted with individual cell organelles. It was found that cell survival was strongly correlated with the absence of contaminants (salts, heavy metals, poly aromatic hydrocarbons) associated with the NPs entering the cells. Synthesized NPs consisting of pure carbon were relatively well tolerated and could be excreted without damaging the cell ultrastructure. Thus, careful removal of extraneous contaminants by controlling the burn cycle with a catalyst is essential to minimize the health and environmental effects of wood biofuel combustion. In better words, optimized advanced technology wood-burning boilers and stoves can provide a CO2-neutral energy source and significantly contribute to a future where fossil fuels have a reduced role.","PeriodicalId":46938,"journal":{"name":"Biofuel Research Journal-BRJ","volume":null,"pages":null},"PeriodicalIF":13.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49335831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The role of sustainability assessment tools in realizing bioenergy and bioproduct systems 可持续性评估工具在实现生物能源和生物产品系统中的作用

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Biofuel Research Journal-BRJ Pub Date : 2022-09-01 DOI: 10.18331/brj2022.9.3.5

M. Aghbashlo, Homa Hosseinzadeh-Bandbafha, Hossein Shahbeik, M. Tabatabaei

{"title":"The role of sustainability assessment tools in realizing bioenergy and bioproduct systems","authors":"M. Aghbashlo, Homa Hosseinzadeh-Bandbafha, Hossein Shahbeik, M. Tabatabaei","doi":"10.18331/brj2022.9.3.5","DOIUrl":"https://doi.org/10.18331/brj2022.9.3.5","url":null,"abstract":"The pressing global challenges, including global warming and climate change, the Russia-Ukraine war, and the Covid-19 pandemic, all are indicative of the necessity of a transition from fossil-based systems toward bioenergy and bioproduct to ensure our plans for sustainable development. Such a transition, however, should be thoroughly engineered, considering the sustainability of the different elements of these systems. Advanced sustainability tools are instrumental in realizing this important objective. The present work critically reviews these tools, including techno-economic, life cycle assessment, emergy, energy, and exergy analyses, within the context of the bioenergy and bioproduct systems. The principles behind these methods are briefly explained, and then their pros and cons in designing, analyzing, and optimizing bioenergy and bioproduct systems are highlighted. Overall, it can be concluded that despite the promises held by these tools, they cannot be regarded as perfect solutions to address all the issues involved in realizing bioenergy and bioproduct systems, and integration of these tools can provide more reliable and accurate results than single approaches.","PeriodicalId":46938,"journal":{"name":"Biofuel Research Journal-BRJ","volume":null,"pages":null},"PeriodicalIF":13.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48380347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 131

Beyond conventional biomass valorisation: pyrolysis-derived products for biomedical applications 超越传统生物质增值:生物医学应用的热解衍生产品

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Biofuel Research Journal-BRJ Pub Date : 2022-09-01 DOI: 10.18331/brj2022.9.3.2

Mohd Amir Asyraf Mohd Hamzah, R. Hasham, Nik Ahmad Nizam Nik Malek, Z. Hashim, Maizatulakmal Yahayu, F. I. Abdul Razak, Z. Zakaria

{"title":"Beyond conventional biomass valorisation: pyrolysis-derived products for biomedical applications","authors":"Mohd Amir Asyraf Mohd Hamzah, R. Hasham, Nik Ahmad Nizam Nik Malek, Z. Hashim, Maizatulakmal Yahayu, F. I. Abdul Razak, Z. Zakaria","doi":"10.18331/brj2022.9.3.2","DOIUrl":"https://doi.org/10.18331/brj2022.9.3.2","url":null,"abstract":"Biomass valorisation is conventionally associated with the production of green biofuels. However, this could extend beyond the conventional perception of biomass application into other domains such as medical sciences. Acid condensate (AC) obtained from pyrolysis promises a good potential for biomedical applications, notably for its antimicrobial, antioxidant, and anti-inflammatory properties. In this study, concentrated AC extract (CACE) obtained from microwave-assisted pyrolysis of palm kernel shells was fractionated, and the resulting fractions were pooled according to similar thin layer chromatography profiles into combined fractions (CFACs). CFACs were evaluated for total phenolic content, antioxidant level, cytotoxicity, and wound healing activities toward human skin fibroblast cells (HSF 1184). CFAC-3 showed the highest total phenolic content (624.98 ± 8.70 µg GAE/mg of sample) and antioxidant activities (DPPH IC50 of 29.47 ± 0.74 µg/mL, ABTS of 1247.13 ± 27.89 μg TE/mg sample, FRAP of 24.26 ± 0.71 mmol Fe(II)/mg sample, HFRS of 257.74 ± 1.74 µg/mL) compared to CACE (DPPH IC50 of 81.76 ± 2.81 µg/mL, ABTS of 816.95 ± 30.49 μg TE/mg sample, FRAP of 9.22 ± 0.66 mmol Fe(II)/mg sample, HFRS of 689.30 ± 36.00 µg/mL), no cytotoxic properties at ≤50 µg/mL, and significantly faster wound closure (at 1.25 µg/mL) compared to the control 12 h after treatment. The phosphorylation of the phosphatidylinositol 3-kinase (PI3K) and protein kinase B (AKT) were upregulated, thus indicating that wound healing of CFAC-3 followed through this signalling pathway. To conclude, phenolic-rich CFAC-3 obtained from the pyrolysis of palm kernel shells demonstrated potential biomedical application as an alternative wound healing agent with high antioxidant and wound-healing activity. To the best of our knowledge, this was the first study to report on the wound healing activity of AC and its wound healing mechanism.","PeriodicalId":46938,"journal":{"name":"Biofuel Research Journal-BRJ","volume":null,"pages":null},"PeriodicalIF":13.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41560852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14