Journal of Pathology and Translational Medicine最新文献

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What's new in bone and soft tissue pathology 2023: guidelines for molecular testing. 骨骼和软组织病理学2023年的新进展:分子检测指南。
IF 2.4
Journal of Pathology and Translational Medicine Pub Date : 2023-05-01 DOI: 10.4132/jptm.2023.03.20
Farres Obeidin
{"title":"What's new in bone and soft tissue pathology 2023: guidelines for molecular testing.","authors":"Farres Obeidin","doi":"10.4132/jptm.2023.03.20","DOIUrl":"https://doi.org/10.4132/jptm.2023.03.20","url":null,"abstract":"<p><p>Our understanding of bone and soft tissue tumors has thoroughly evolved as a consequence of modern molecular techniques. DNA and RNA sequencing methods play an important diagnostic and therapeutic role in sarcoma pathology. Herein, we discuss current guidelines and best practices for molecular testing in bone and soft tissue tumors.</p>","PeriodicalId":46933,"journal":{"name":"Journal of Pathology and Translational Medicine","volume":"57 3","pages":"184-187"},"PeriodicalIF":2.4,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/34/d0/jptm-2023-03-20.PMC10209662.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9523470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Frequent apocrine changes in pleomorphic adenoma with malignant transformation: a possible pre-malignant step in ductal carcinoma ex pleomorphic adenoma. 多形性腺瘤伴恶性转化时频繁的大汗腺变化:导管癌非多形性腺瘤可能的癌前步骤。
IF 2.4
Journal of Pathology and Translational Medicine Pub Date : 2023-05-01 DOI: 10.4132/jptm.2023.03.13
Joon Seon Song, Yeseul Kim, Yoon-Se Lee, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim, Kyung-Ja Cho
{"title":"Frequent apocrine changes in pleomorphic adenoma with malignant transformation: a possible pre-malignant step in ductal carcinoma ex pleomorphic adenoma.","authors":"Joon Seon Song,&nbsp;Yeseul Kim,&nbsp;Yoon-Se Lee,&nbsp;Seung-Ho Choi,&nbsp;Soon Yuhl Nam,&nbsp;Sang Yoon Kim,&nbsp;Kyung-Ja Cho","doi":"10.4132/jptm.2023.03.13","DOIUrl":"https://doi.org/10.4132/jptm.2023.03.13","url":null,"abstract":"<p><strong>Background: </strong>The most common type of carcinoma ex pleomorphic adenoma (CPA) is histologically equivalent to salivary duct carcinoma, which has an apocrine phenotype. Invasive CPA is often accompanied by non-invasive or in situ carcinoma, an observation that suggests the presence of precursor lesions. The aim of this study was to identify candidate precursor lesions of CPA within pleomorphic adenoma (PA).</p><p><strong>Methods: </strong>Eleven resected cases of CPA with residual PA and 17 cases of PA with atypical changes were subjected to immunohistochemistry (IHC) for p53, human epidermal growth factor receptor 2 (HER2), androgen receptor (AR), pleomorphic adenoma gene 1, gross cystic disease fluid protein-15 (GCDFP-15), and anti-mitochondrial antibody.</p><p><strong>Results: </strong>Invasive or in situ carcinoma cells in all CPAs were positive for AR, GCDFP-15, and HER2. Atypical foci in PAs corresponded to either apocrine or oncocytic changes on the basis of their reactivity to AR, GCDFP-15, and anti-mitochondrial antibody. Atypical cells in PAs surrounding CPAs had an apocrine phenotype without HER2 expression.</p><p><strong>Conclusions: </strong>Our study identified frequent apocrine changes in residual PAs in CPA cases, suggesting a possible precursor role of apocrine changes. We recommend the use of HER2 IHC in atypical PAs, and that clinicians take HER2 positivity into serious consideration.</p>","PeriodicalId":46933,"journal":{"name":"Journal of Pathology and Translational Medicine","volume":"57 3","pages":"158-165"},"PeriodicalIF":2.4,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ab/81/jptm-2023-03-13.PMC10209664.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9577107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trouble-makers in cytologic interpretation of the uterine cervix. 宫颈细胞学解释的麻烦制造者。
IF 2.4
Journal of Pathology and Translational Medicine Pub Date : 2023-05-01 DOI: 10.4132/jptm.2023.04.25
Eunah Shin, Jaeeun Yu, Soon Won Hong
{"title":"Trouble-makers in cytologic interpretation of the uterine cervix.","authors":"Eunah Shin,&nbsp;Jaeeun Yu,&nbsp;Soon Won Hong","doi":"10.4132/jptm.2023.04.25","DOIUrl":"https://doi.org/10.4132/jptm.2023.04.25","url":null,"abstract":"<p><p>The development and standardization of cytologic screening of the uterine cervix has dramatically decreased the prevalence of squamous cell carcinoma of the uterine cervix. Advances in the understanding of biology of human papillomavirus have contributed to upgrading the histologic diagnosis of the uterine cervix; however, cytologic screening that should triage those that need further management still poses several difficulties in interpretation. Cytologic features of high grade intraepithelial squamous lesion (HSIL) mimics including atrophy, immature metaplasia, and transitional metaplasia, and glandular lesion masquerades including tubal metaplasia and HSIL with glandular involvement are described with accentuation mainly on the differential points. When the cytologic features lie in a gray zone between the differentials, the most important key to the more accurate interpretation is sticking to the very basics of cytology; screening the background and cellular architecture, and then scrutinizing the nuclear and cytoplasmic details.</p>","PeriodicalId":46933,"journal":{"name":"Journal of Pathology and Translational Medicine","volume":"57 3","pages":"139-146"},"PeriodicalIF":2.4,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0e/55/jptm-2023-04-25.PMC10209661.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9524928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression of specific microRNAs in tissue and plasma in colorectal cancer. 结直肠癌组织和血浆中特异性microrna的表达。
IF 2.4
Journal of Pathology and Translational Medicine Pub Date : 2023-05-01 DOI: 10.4132/jptm.2022.02.19
Allan Fellizar, Vivencio Refuerzo, John Donnie Ramos, Pia Marie Albano
{"title":"Expression of specific microRNAs in tissue and plasma in colorectal cancer.","authors":"Allan Fellizar,&nbsp;Vivencio Refuerzo,&nbsp;John Donnie Ramos,&nbsp;Pia Marie Albano","doi":"10.4132/jptm.2022.02.19","DOIUrl":"https://doi.org/10.4132/jptm.2022.02.19","url":null,"abstract":"<p><strong>Background: </strong>MicroRNAs (miRNA/miR) play significant roles in the regulation of cell differentiation, cell cycle progression, and apoptosis. They become dysregulated during carcinogenesis and are eventually released into the circulation, enabling their detection in body fluids. Thus, this study compared the miRNA expression in tissue and plasma samples of colorectal cancer (CRC) patients and clinically healthy controls and determined miRNA expression as a potential CRC biomarker.</p><p><strong>Methods: </strong>Using quantitative reverse transcription polymerase chain reaction (RT-qPCR), miR-21-5p, miR-29a-3p, miR-92a-3p, miR-135b-5p, miR-196b-5p, and miR-197-3p, expression was analyzed and compared between the malignant (n = 41) and the adjacent neoplasm free mucosal tissues (n = 41) of CRC patients. The findings were validated in plasma samples (n = 36) collected from the same CRC patients prior to surgery or any form of treatment and compared to plasma from their age and sex-matched controls (n = 36).</p><p><strong>Results: </strong>MiR-21-5p, miR-29a-3p, miR-92a-3p, and miR- 196b-5p were upregulated and miR-135b-5p was downregulated in CRC malignant tissues compared to their expression in adjacent neoplasm-free tissue. This was further observed in the plasma of the same CRC cases compared to controls. MiR-92a-3p showed itself the most sensitive (0.93; p < .001) and most specific (0.95; p < .001) in detecting CRC in tissue. In plasma, miR-196b-5p was the most sensitive (0.97; p < .001) and specific (0.94; p < .001) in detecting CRC. Plasma miR-92a-3p and miR-196b-5p were the most sensitive (0.95; p < .001) and specific (0.94; p < .001) in the early detection of CRC.</p><p><strong>Conclusions: </strong>Results show that specific miRNAs dysregulated in malignant tissues are released and can be detected in the circulation, supporting their potential as non-invasive biomarkers of CRC.</p>","PeriodicalId":46933,"journal":{"name":"Journal of Pathology and Translational Medicine","volume":"57 3","pages":"147-157"},"PeriodicalIF":2.4,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4c/58/jptm-2022-02-19.PMC10209663.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9515665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Thyroid pathology, a clue to PTEN hamartoma tumor syndrome. 甲状腺病理,PTEN错构瘤综合征的线索。
IF 2.4
Journal of Pathology and Translational Medicine Pub Date : 2023-05-01 DOI: 10.4132/jptm.2023.03.04
Yurimi Lee, Young Lyun Oh
{"title":"Thyroid pathology, a clue to PTEN hamartoma tumor syndrome.","authors":"Yurimi Lee,&nbsp;Young Lyun Oh","doi":"10.4132/jptm.2023.03.04","DOIUrl":"https://doi.org/10.4132/jptm.2023.03.04","url":null,"abstract":"<p><p>Phosphatase and tensin homolog (PTEN) hamartoma tumor syndrome (PHTS) is a hereditary disorder caused by germline inactivating mutations in the PTEN tumor suppressor gene. As a type of PHTS, Cowden syndrome is associated with abnormalities of the thyroid, breast, uterus, and gastrointestinal tract. A 52-year-old-woman visited the outpatient clinic of our endocrinology clinic with multiple thyroid nodules and Hashimoto's thyroiditis. Computed tomography imaging revealed a multinodular mass measuring up to 3.5 cm in the left thyroid lobe, causing laryngotracheal airway displacement. The total thyroidectomy specimen revealed multiple follicular adenomas and adenomatous nodules with lymphocytic thyroiditis and lipomatous metaplasia in the background. The patient was suspected of PTHS based on her thyroid pathology, family history, and numerous hamartomatous lesions of the breast, uterus, and skin. Her diagnosis was confirmed through molecular testing. This case demonstrates that pathologists must be well acquainted with thyroid pathology in PHTS.</p>","PeriodicalId":46933,"journal":{"name":"Journal of Pathology and Translational Medicine","volume":"57 3","pages":"178-183"},"PeriodicalIF":2.4,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/20/50/jptm-2023-03-04.PMC10209666.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9525709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unsuspected systemic Epstein-Barr virus-positive T-cell lymphoma of childhood diagnosed at autopsy in a potential homicide case. 未被怀疑的系统性eb病毒阳性儿童t细胞淋巴瘤在尸检中被诊断为潜在的杀人案件。
IF 2.4
Journal of Pathology and Translational Medicine Pub Date : 2023-03-01 DOI: 10.4132/jptm.2022.10.31
Daniel J Robbins, Erik A Ranheim, Jamie E Kallan
{"title":"Unsuspected systemic Epstein-Barr virus-positive T-cell lymphoma of childhood diagnosed at autopsy in a potential homicide case.","authors":"Daniel J Robbins,&nbsp;Erik A Ranheim,&nbsp;Jamie E Kallan","doi":"10.4132/jptm.2022.10.31","DOIUrl":"https://doi.org/10.4132/jptm.2022.10.31","url":null,"abstract":"<p><p>Systemic Epstein-Barr virus (EBV)-positive T-cell lymphoma of childhood (SETLC) is a rare, rapidly progressive, and often fatal disease of children and young adults characterized by monoclonal expansion of EBV-positive T cells in tissues or peripheral blood following infection with EBV. Its distinction from other EBV-positive T-cell lymphoproliferative disorders with overlapping features can be difficult, and particular diagnostic features may not be manifest until autopsy examination. We present the case of a 10-year-old boy with significant disability due to remote traumatic brain injury following non-accidental head trauma who died unexpectedly at home. Given the history of physical abuse and the potential for homicide charges, significant medicolegal implications arose with this case. Pathologic investigation ultimately revealed conclusive diagnostic features of SETLC including extensive proliferation of EBV-positive T cells in multiple organs. A natural manner of death was confirmed, thereby excluding delayed homicide related to complications of non-accidental head trauma.</p>","PeriodicalId":46933,"journal":{"name":"Journal of Pathology and Translational Medicine","volume":"57 2","pages":"123-127"},"PeriodicalIF":2.4,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/55/a5/jptm-2022-10-31.PMC10028015.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9158164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Solitary Peutz-Jeghers type harmartomatous polyp in duodenum with gastric foveolar epithelium: a case report. 十二指肠单发Peutz-Jeghers型错构瘤息肉伴胃小窝上皮1例。
IF 2.4
Journal of Pathology and Translational Medicine Pub Date : 2023-03-01 DOI: 10.4132/jptm.2022.11.07
Eugene Choi, Junghwan Lee, Youngsoo Park
{"title":"Solitary Peutz-Jeghers type harmartomatous polyp in duodenum with gastric foveolar epithelium: a case report.","authors":"Eugene Choi,&nbsp;Junghwan Lee,&nbsp;Youngsoo Park","doi":"10.4132/jptm.2022.11.07","DOIUrl":"https://doi.org/10.4132/jptm.2022.11.07","url":null,"abstract":"<p><p>Peutz-Jeghers type hamartomatous polyp is known to be associated with Peutz-Jeghers syndrome, which shows characteristic multiple hamartomatous polyp involvement in the gastrointestinal tract, combined with mucocutaneous symptom, familial history of Peutz- Jeghers syndrome or STK11/LTB1 mutation. However, some cases showing histologic appearance of the polyps discovered in Peutz- Jeghers syndrome while lacking other diagnostic criteria of the syndrome have been reported, and these are called solitary Peutz- Jeghers type polyps. Herein, we report a case of solitary Peutz-Jeghers type polyp covered with heterotopic epithelium. The patient was 47-year-old female without any mucocutaneous symptoms nor familial history of Peutz-Jeghers syndrome. Microscopic examination revealed Peutz-Jeghers type hamartomatous polyp in duodenum covered with gastric type foveolar epithelium. Considering the definition of hamartomatous polyp, which is, the abnormal overgrowth of the indigenous epithelial component, the histological feature of current case is noteworthy in a point that it shows proliferation of heterotopic component, rather than the indigenous component.</p>","PeriodicalId":46933,"journal":{"name":"Journal of Pathology and Translational Medicine","volume":"57 2","pages":"128-131"},"PeriodicalIF":2.4,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/be/98/jptm-2022-11-07.PMC10028010.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9159363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aneurysmal bone cyst: a review. 动脉瘤性骨囊肿:综述。
IF 2.4
Journal of Pathology and Translational Medicine Pub Date : 2023-03-01 DOI: 10.4132/jptm.2023.02.23
Elham Nasri, John David Reith
{"title":"Aneurysmal bone cyst: a review.","authors":"Elham Nasri,&nbsp;John David Reith","doi":"10.4132/jptm.2023.02.23","DOIUrl":"https://doi.org/10.4132/jptm.2023.02.23","url":null,"abstract":"<p><p>Aneurysmal bone cyst (ABC) is a benign locally destructive bone neoplasm composed of multi-loculated blood-filled cystic spaces. The most common sites of involvement are the meta-diaphysis of the long bones and posterior elements of the vertebrae. Secondary, ABC-like changes can complicate a variety of other benign and malignant primary bone neoplasms, including giant cell tumor, fibrous dysplasia, and osteosarcoma. About two-third of primary ABCs have a rearrangement of the USP6 gene, which is not present in the ABC-like changes that occur secondary to other primary bone tumors (i.e., secondary ABC). Primary ABC of bone carries a variable but generally high rate of local recurrence. This paper provides an overview of the pathophysiology, clinical presentation, radiographic and pathologic findings, treatment, and prognosis of ABC.</p>","PeriodicalId":46933,"journal":{"name":"Journal of Pathology and Translational Medicine","volume":"57 2","pages":"81-87"},"PeriodicalIF":2.4,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3f/37/jptm-2023-02-23.PMC10028014.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9169596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Current state of cytopathology residency training: a Korean national survey of pathologists. 细胞病理学住院医师培训现状:韩国病理学家全国调查。
IF 2.4
Journal of Pathology and Translational Medicine Pub Date : 2023-03-01 DOI: 10.4132/jptm.2023.01.06
Uiju Cho, Tae Jung Kim, Wan Seop Kim, Kyo Young Lee, Hye Kyoung Yoon, Hyun Joo Choi
{"title":"Current state of cytopathology residency training: a Korean national survey of pathologists.","authors":"Uiju Cho,&nbsp;Tae Jung Kim,&nbsp;Wan Seop Kim,&nbsp;Kyo Young Lee,&nbsp;Hye Kyoung Yoon,&nbsp;Hyun Joo Choi","doi":"10.4132/jptm.2023.01.06","DOIUrl":"https://doi.org/10.4132/jptm.2023.01.06","url":null,"abstract":"<p><strong>Background: </strong>Although the Korean Society for Cytopathology has developed educational goals as guidelines for cytopathology education in Korea, there is still no systematic approach to cytopathology education status for pathology residents. Furthermore, satisfaction with cytopathology education and with the outcome of the current training/educational program has not been investigated in Korea. This study aimed to obtain comprehensive data on the current state of cytopathology education for residents and evaluate education outcomes.</p><p><strong>Methods: </strong>An online survey was conducted in December 2020 for the board-certified pathologists and training residents registered as members of the Korean Society for Cytopathology. The questionnaire comprised questions that investigated the current status of cytopathology at each training institution, the degree of satisfaction with the work and education related to cytopathology, outcomes of cytopathology training, and educational accomplishments.</p><p><strong>Results: </strong>Of the participants surveyed, 12.3% (132/1,075) completed the questionnaire, and 36.8% (32/87) of cytopathology residents participated. The mean overall satisfaction with cytopathology education was 3.1 points (on a 1- to 5-point scale, 5: very satisfied). The most frequent suggestion among the free description format responses was to expand educational opportunities, such as online education opportunities, outside of the individual institutions.</p><p><strong>Conclusions: </strong>Our results showed that cytopathology training in Korea needs further improvement. We expect that this study will inform systematic training of competent medical personnel armed with broad cytopathology knowledge and strong problem-solving abilities.</p>","PeriodicalId":46933,"journal":{"name":"Journal of Pathology and Translational Medicine","volume":"57 2","pages":"95-101"},"PeriodicalIF":2.4,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ab/3d/jptm-2023-01-06.PMC10028013.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9169597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Significance of tumor-associated neutrophils, lymphocytes, and neutrophil-to-lymphocyte ratio in non-invasive and invasive bladder urothelial carcinoma. 非侵袭性和侵袭性膀胱尿路上皮癌中肿瘤相关中性粒细胞、淋巴细胞和中性粒细胞/淋巴细胞比值的意义。
IF 2.4
Journal of Pathology and Translational Medicine Pub Date : 2023-03-01 DOI: 10.4132/jptm.2022.11.06
Wael Abdo Hassan, Ahmed Kamal ElBanna, Noha Noufal, Mohamed El-Assmy, Hany Lotfy, Rehab Ibrahim Ali
{"title":"Significance of tumor-associated neutrophils, lymphocytes, and neutrophil-to-lymphocyte ratio in non-invasive and invasive bladder urothelial carcinoma.","authors":"Wael Abdo Hassan,&nbsp;Ahmed Kamal ElBanna,&nbsp;Noha Noufal,&nbsp;Mohamed El-Assmy,&nbsp;Hany Lotfy,&nbsp;Rehab Ibrahim Ali","doi":"10.4132/jptm.2022.11.06","DOIUrl":"https://doi.org/10.4132/jptm.2022.11.06","url":null,"abstract":"<p><strong>Background: </strong>Tumor-infiltrating neutrophils and lymphocytes play essential roles in promoting or combating various neoplasms. This study aimed to investigate the association between tumor-infiltrating neutrophils and lymphocytes and the neutrophil-to-lymphocyte ratio in the progression of urothelial carcinoma.</p><p><strong>Methods: </strong>A total of 106 patients diagnosed with urothelial carcinoma were was. Pathological examination for tumor grade and stage and for tumor-infiltrating neutrophils, both CD4 and CD8+ T lymphocytes, as well as the neutrophil- to-lymphocyte ratio were evaluated.</p><p><strong>Results: </strong>The presence of neutrophils and the neutrophil-to-lymphocyte ratio correlated with high-grade urothelial neoplasms. In both low- and high-grade tumors, the lymphocytes increased during progression from a non-invasive neoplasm to an early-invasive neoplasm. CD8+ T lymphocytes increased in low-grade non-muscle-invasive tumors compared to non-invasive tumors. Additionally, there was a significant decrease in CD8+ T lymphocytes during progression to muscle-invasive tumors.</p><p><strong>Conclusions: </strong>Our results suggest that tumor-infiltrating neutrophils and CD8+ T lymphocytes have a significant effect on tumor grade and progression.</p>","PeriodicalId":46933,"journal":{"name":"Journal of Pathology and Translational Medicine","volume":"57 2","pages":"88-94"},"PeriodicalIF":2.4,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8e/a1/jptm-2022-11-06.PMC10028012.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9159364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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