Journal of Pathology and Translational Medicine最新文献_第9页

Clinicopathologic significance of the delta-like ligand 4, vascular endothelial growth factor, and hypoxia-inducible factor-2α in gallbladder cancer. 胆囊癌中 delta 样配体 4、血管内皮生长因子和缺氧诱导因子-2α的临床病理学意义。

IF 1.7

Journal of Pathology and Translational Medicine Pub Date : 2023-03-01 Epub Date: 2023-03-14 DOI: 10.4132/jptm.2023.02.01

Sujin Park, Junsik Kim, Woncheol Jang, Kyoung-Mee Kim, Kee-Taek Jang

{"title":"Clinicopathologic significance of the delta-like ligand 4, vascular endothelial growth factor, and hypoxia-inducible factor-2α in gallbladder cancer.","authors":"Sujin Park, Junsik Kim, Woncheol Jang, Kyoung-Mee Kim, Kee-Taek Jang","doi":"10.4132/jptm.2023.02.01","DOIUrl":"10.4132/jptm.2023.02.01","url":null,"abstract":"Background: Gallbladder cancer (GBC) is usually detected in advanced stages with a low 5-year survival rate. Delta-like ligand 4 (DLL4), vascular endothelial growth factor (VEGF), and hypoxia-inducible factor-2alpha (HIF2α) have been studied for their role in tumorigenesis and potential for therapeutic target, and multiple clinical trials of the agents targeting them are ongoing. We investigated the expression of these markers in surgically resected GBC and tried to reveal their association with the clinicopathologic features, mutual correlation of their expression, and prognosis of the GBC patients by their expression.Methods: We constructed the tissue microarray blocks of 99 surgically resected GBC specimens and performed immunohistochemistry of DLL4, VEGF, and HIF2α. We used the quantitative digital image analysis to evaluate DLL4 and VEGF expression, while the expression of HIF2α was scored manually.Results: The expression of VEGF and HIF2α showed a significant trend with tumor differentiation (p= .028 and p= .006, respectively). We found that the high DLL4 and VEGF expression were significantly correlated with lymph node metastasis (p= .047, both). The expression of VEGF and HIF2α were significantly correlated (p < .001). The GBC patients with low HIF2α expression showed shorter recurrence-free survival than those with high HIF2α expression.Conclusions: This study suggested the possibility of the usage of DLL4 and VEGF to predict the lymph node metastasis and the possibility of VEGF and HIF2α to predict the expression level mutually. Further studies may be needed to validate our study results and eventually accelerate the introduction of the targeted therapy in GBC.","PeriodicalId":46933,"journal":{"name":"Journal of Pathology and Translational Medicine","volume":"57 2","pages":"113-122"},"PeriodicalIF":1.7,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5e/4c/jptm-2023-02-01.PMC10028008.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9538601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postmortem lung and heart examination of COVID-19 patients in a case series from Jordan. 约旦病例系列中COVID-19患者的死后肺和心脏检查

IF 2.4

Journal of Pathology and Translational Medicine Pub Date : 2023-03-01 DOI: 10.4132/jptm.2023.01.30

Maram Abdaljaleel, Isra Tawalbeh, Malik Sallam, Amjad Bani Hani, Imad M Al-Abdallat, Baheth Al Omari, Sahar Al-Mustafa, Hasan Abder-Rahman, Adnan Said Abbas, Mahmoud Zureigat, Mousa A Al-Abbadi

{"title":"Postmortem lung and heart examination of COVID-19 patients in a case series from Jordan.","authors":"Maram Abdaljaleel, Isra Tawalbeh, Malik Sallam, Amjad Bani Hani, Imad M Al-Abdallat, Baheth Al Omari, Sahar Al-Mustafa, Hasan Abder-Rahman, Adnan Said Abbas, Mahmoud Zureigat, Mousa A Al-Abbadi","doi":"10.4132/jptm.2023.01.30","DOIUrl":"https://doi.org/10.4132/jptm.2023.01.30","url":null,"abstract":"Background: Coronavirus disease 2019 (COVID-19) has emerged as a pandemic for more than 2 years. Autopsy examination is an invaluable tool to understand the pathogenesis of emerging infections and their consequent mortalities. The aim of the current study was to present the lung and heart pathological findings of COVID-19-positive autopsies performed in Jordan.Methods: The study involved medicolegal cases, where the cause of death was unclear and autopsy examination was mandated by law. We included the clinical and pathologic findings of routine gross and microscopic examination of cases that were positive for COVID-19 at time of death. Testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was confirmed through molecular detection by real-time polymerase chain reaction, serologic testing for IgM and electron microscope examination of lung samples.Results: Seventeen autopsies were included, with male predominance (76.5%), Jordanians (70.6%), and 50 years as the mean age at time of death. Nine out of 16 cases (56.3%) had co-morbidities, with one case lacking such data. Histologic examination of lung tissue revealed diffuse alveolar damage in 13/17 cases (76.5%), and pulmonary microthrombi in 8/17 cases (47.1%). Microscopic cardiac findings were scarcely detected. Two patients died as a direct result of acute cardiac disease with limited pulmonary findings.Conclusions: The detection of SARS-CoV-2 in postmortem examination can be an incidental or contributory finding which highlights the value of autopsy examination to determine the exact cause of death in controversial cases.","PeriodicalId":46933,"journal":{"name":"Journal of Pathology and Translational Medicine","volume":"57 2","pages":"102-112"},"PeriodicalIF":2.4,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a6/11/jptm-2023-01-30.PMC10028009.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9169595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unusual biclonal IgA plasma cell myeloma with aberrant expression of high-risk immunophenotypes: first report of a new diagnostic and clinical challenge. 异常双克隆IgA浆细胞骨髓瘤伴高危免疫表型异常表达:新诊断和临床挑战的首次报道。

IF 2.4

Journal of Pathology and Translational Medicine Pub Date : 2023-03-01 DOI: 10.4132/jptm.2023.02.07

Carlos A Monroig-Rivera, Clara N Finch Cruz

{"title":"Unusual biclonal IgA plasma cell myeloma with aberrant expression of high-risk immunophenotypes: first report of a new diagnostic and clinical challenge.","authors":"Carlos A Monroig-Rivera, Clara N Finch Cruz","doi":"10.4132/jptm.2023.02.07","DOIUrl":"https://doi.org/10.4132/jptm.2023.02.07","url":null,"abstract":"IgA plasma cell myeloma (PCM) has been linked to molecular abnormalities that confer a higher risk for adverse patient outcomes. However, since IgA PCM only accounts for approximately 20% of all PCM, there are very few reports on high-risk IgA PCM. Moreover, no such reports are found on the more infrequent biclonal IgA PCM. Hence, we present a 65-year-old Puerto Rican female with acute abdominal pain, concomitant hypercalcemia, and acute renal failure. Protein electrophoresis with immunofixation found high IgA levels and detected a biclonal IgA gammopathy with kappa specificity. Histomorphologically, bone marrow showed numerous abnormal plasma cells (32%) replacing over 50% of the marrow stroma. Immunophenotyping analysis detected CD45-negative plasma cells aberrantly expressing CD33, CD43, OCT-2, and c-MYC. Chromosomal analysis revealed multiple abnormalities including the gain of chromosome 1q. Thus, we report on an unusual biclonal IgA PCM and the importance of timely diagnosing aggressive plasma cell neoplasms.","PeriodicalId":46933,"journal":{"name":"Journal of Pathology and Translational Medicine","volume":"57 2","pages":"132-137"},"PeriodicalIF":2.4,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/88/c6/jptm-2023-02-07.PMC10028011.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9538602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A standardized pathology report for gastric cancer: 2nd edition. 胃癌标准化病理报告：第 2 版。

IF 1.7

Journal of Pathology and Translational Medicine Pub Date : 2023-01-01 Epub Date: 2023-01-15 DOI: 10.4132/jptm.2022.12.23

Young Soo Park, Myeong-Cherl Kook, Baek-Hui Kim, Hye Seung Lee, Dong-Wook Kang, Mi-Jin Gu, Ok Ran Shin, Younghee Choi, Wonae Lee, Hyunki Kim, In Hye Song, Kyoung-Mee Kim, Hee Sung Kim, Guhyun Kang, Do Youn Park, So-Young Jin, Joon Mee Kim, Yoon Jung Choi, Hee Kyung Chang, Soomin Ahn, Mee Soo Chang, Song-Hee Han, Yoonjin Kwak, An Na Seo, Mee-Yon Cho

{"title":"A standardized pathology report for gastric cancer: 2nd edition.","authors":"Young Soo Park, Myeong-Cherl Kook, Baek-Hui Kim, Hye Seung Lee, Dong-Wook Kang, Mi-Jin Gu, Ok Ran Shin, Younghee Choi, Wonae Lee, Hyunki Kim, In Hye Song, Kyoung-Mee Kim, Hee Sung Kim, Guhyun Kang, Do Youn Park, So-Young Jin, Joon Mee Kim, Yoon Jung Choi, Hee Kyung Chang, Soomin Ahn, Mee Soo Chang, Song-Hee Han, Yoonjin Kwak, An Na Seo, Mee-Yon Cho","doi":"10.4132/jptm.2022.12.23","DOIUrl":"10.4132/jptm.2022.12.23","url":null,"abstract":"The first edition of 'A Standardized Pathology Report for Gastric Cancer' was initiated by the Gastrointestinal Pathology Study Group of the Korean Society of Pathologists and published 17 years ago. Since then, significant advances have been made in the pathologic diagnosis, molecular genetics, and management of gastric cancer (GC). To reflect those changes, a committee for publishing a second edition of the report was formed within the Gastrointestinal Pathology Study Group of the Korean Society of Pathologists. This second edition consists of two parts: standard data elements and conditional data elements. The standard data elements contain the basic pathologic findings and items necessary to predict the prognosis of GC patients, and they are adequate for routine surgical pathology service. Other diagnostic and prognostic factors relevant to adjuvant therapy, including molecular biomarkers, are classified as conditional data elements to allow each pathologist to selectively choose items appropriate to the environment in their institution. We trust that the standardized pathology report will be helpful for GC diagnosis and facilitate large-scale multidisciplinary collaborative studies.","PeriodicalId":46933,"journal":{"name":"Journal of Pathology and Translational Medicine","volume":"57 1","pages":"1-27"},"PeriodicalIF":1.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7c/55/jptm-2022-12-23.PMC9846007.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10596597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammatory bowel disease-associated intestinal fibrosis. 炎症性肠病相关的肠纤维化。

IF 1.7

Journal of Pathology and Translational Medicine Pub Date : 2023-01-01 Epub Date: 2023-01-10 DOI: 10.4132/jptm.2022.11.02

Ji Min Park, Jeongseok Kim, Yoo Jin Lee, Sung Uk Bae, Hye Won Lee

引用次数: 0

Perspectives on single-nucleus RNA sequencing in different cell types and tissues. 不同细胞类型和组织中单核RNA测序的研究进展。

IF 2.4

Journal of Pathology and Translational Medicine Pub Date : 2023-01-01 DOI: 10.4132/jptm.2022.12.19

Nayoung Kim, Huiram Kang, Areum Jo, Seung-Ah Yoo, Hae-Ock Lee

引用次数: 8

The proteomic landscape shows oncologic relevance in cystitis glandularis. 蛋白质组学图显示腺性膀胱炎的肿瘤学相关性。

IF 2.4

Journal of Pathology and Translational Medicine Pub Date : 2023-01-01 DOI: 10.4132/jptm.2022.10.24

Jun Yong Kim, Dohyun Han, Hyeyoon Kim, Minsun Jung, Han Suk Ryu

{"title":"The proteomic landscape shows oncologic relevance in cystitis glandularis.","authors":"Jun Yong Kim, Dohyun Han, Hyeyoon Kim, Minsun Jung, Han Suk Ryu","doi":"10.4132/jptm.2022.10.24","DOIUrl":"https://doi.org/10.4132/jptm.2022.10.24","url":null,"abstract":"Background: The relationship between cystitis glandularis (CG) and bladder malignancy remains unclear.Methods: We identified the oncologic significance of CG at the molecular level using liquid chromatography-tandem mass spectrometry-based proteomic analysis of 10 CG, 12 urothelial carcinoma (UC), and nine normal urothelium (NU) specimens. Differentially expressed proteins (DEPs) were identified based on an analysis of variance false discovery rate < 0.05, and their functional enrichment was analyzed using a network model, Gene Set Enrichment Analysis, and Gene Ontology annotation.Results: We identified 9,890 proteins across all samples and 1,139 DEPs among the three entities. A substantial number of DEPs overlapped in CG/NU, distinct from UC. Interestingly, we found that a subset of DEP clusters (n = 53, 5%) was differentially expressed in NU but similarly between CG and UC. This \"UC-like signature\" was enriched for reactive oxygen species (ROS) and energy metabolism, growth and DNA repair, transport, motility, epithelial-mesenchymal transition, and cell survival. Using the top 10 shortlisted DEPs, including SOD2, PRKCD, CYCS, and HCLS1, we identified functional elements related to ROS metabolism, development, and transport using network analysis. The abundance of these four molecules in UC/CG than in NU was consistent with the oncologic functions in CG.Conclusions: Using a proteomic approach, we identified a predominantly non-neoplastic landscape of CG, which was closer to NU than to UC. We also confirmed a small subset of common DEPs in UC and CG, suggesting that altered ROS metabolism might imply potential cancerous risks in CG.","PeriodicalId":46933,"journal":{"name":"Journal of Pathology and Translational Medicine","volume":"57 1","pages":"67-74"},"PeriodicalIF":2.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2f/3a/jptm-2022-10-24.PMC9846008.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10590532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metallic implant-associated lymphoma: ALK-negative anaplastic large cell lymphoma associated with total knee replacement arthroplasty. 金属假体相关淋巴瘤:与全膝关节置换术相关的alk阴性间变性大细胞淋巴瘤。

IF 2.4

Journal of Pathology and Translational Medicine Pub Date : 2023-01-01 DOI: 10.4132/jptm.2022.10.30

Jai-Hyang Go

{"title":"Metallic implant-associated lymphoma: ALK-negative anaplastic large cell lymphoma associated with total knee replacement arthroplasty.","authors":"Jai-Hyang Go","doi":"10.4132/jptm.2022.10.30","DOIUrl":"https://doi.org/10.4132/jptm.2022.10.30","url":null,"abstract":"Metallic implant-associated lymphomas are extremely rare. Only seven cases have been reported in association with knee joint arthroplasty, and all tumors were large B-cell lymphomas. This report is the first case of anaplastic large cell lymphoma occurring after total knee replacement arthroplasty. An 80‑year‑old female patient was admitted because of right knee pain for 2 years. She had undergone total knee replacement arthroplasty 10 years prior. Computed tomography showed an irregular osteolytic lesion in the right lateral femoral condyle, adjacent to the metallic prosthesis. Histologic findings reveal sheets of anaplastic tumor cells that were positive for CD2, CD4, CD5, CD43, and CD30 but negative for CD3, CD20, CD15, and anaplastic lymphoma kinase. Epstein-Barr encoding region in situ hybridization was negative. Analysis of T-cell receptor γ gene rearrangement studies using BIOMED-2-based multiplex polymerase chain reaction confirmed monoclonal T cell proliferation. The woman was finally diagnosed with ALK-negative anaplastic large cell lymphoma.","PeriodicalId":46933,"journal":{"name":"Journal of Pathology and Translational Medicine","volume":"57 1","pages":"75-78"},"PeriodicalIF":2.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2d/f9/jptm-2022-10-30.PMC9846009.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10596567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Infections and immunity: associations with obesity and related metabolic disorders. 感染和免疫:与肥胖和相关代谢紊乱的关系。

IF 2.4

Journal of Pathology and Translational Medicine Pub Date : 2023-01-01 DOI: 10.4132/jptm.2022.11.14

Amitabha Ray, Melissa J L Bonorden, Rajashree Pandit, Katai J Nkhata, Anupam Bishayee

{"title":"Infections and immunity: associations with obesity and related metabolic disorders.","authors":"Amitabha Ray, Melissa J L Bonorden, Rajashree Pandit, Katai J Nkhata, Anupam Bishayee","doi":"10.4132/jptm.2022.11.14","DOIUrl":"https://doi.org/10.4132/jptm.2022.11.14","url":null,"abstract":"About one-fourth of the global population is either overweight or obese, both of which increase the risk of insulin resistance, cardiovascular diseases, and infections. In obesity, both immune cells and adipocytes produce an excess of pro-inflammatory cytokines that may play a significant role in disease progression. In the recent coronavirus disease 2019 (COVID-19) pandemic, important pathological characteristics such as involvement of the renin-angiotensin-aldosterone system, endothelial injury, and pro-inflammatory cytokine release have been shown to be connected with obesity and associated sequelae such as insulin resistance/type 2 diabetes and hypertension. This pathological connection may explain the severity of COVID-19 in patients with metabolic disorders. Many studies have also reported an association between type 2 diabetes and persistent viral infections. Similarly, diabetes favors the growth of various microorganisms including protozoal pathogens as well as opportunistic bacteria and fungi. Furthermore, diabetes is a risk factor for a number of prion-like diseases. There is also an interesting relationship between helminths and type 2 diabetes; helminthiasis may reduce the pro-inflammatory state, but is also associated with type 2 diabetes or even neoplastic processes. Several studies have also documented altered circulating levels of neutrophils, lymphocytes, and monocytes in obesity, which likely modifies vaccine effectiveness. Timely monitoring of inflammatory markers (e.g., C-reactive protein) and energy homeostasis markers (e.g., leptin) could be helpful in preventing many obesity-related diseases.","PeriodicalId":46933,"journal":{"name":"Journal of Pathology and Translational Medicine","volume":"57 1","pages":"28-42"},"PeriodicalIF":2.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ed/7c/jptm-2022-11-14.PMC9846011.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10596596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

What's new in neuromuscular pathology 2022: myopathy updates and gene therapies. 2022年神经肌肉病理学最新进展:肌病更新和基因治疗。

IF 2.4

Journal of Pathology and Translational Medicine Pub Date : 2023-01-01 DOI: 10.4132/jptm.2022.10.14

Chunyu Cai

引用次数: 0