JOURNAL OF MEDICAL INVESTIGATION最新文献_第8页

The role of thymic epithelium in thymus development and age-related thymic involution. 胸腺上皮在胸腺发育和与年龄相关的胸腺萎缩中的作用。

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JOURNAL OF MEDICAL INVESTIGATION Pub Date : 2024-01-01 DOI: 10.2152/jmi.71.29

Sayumi Fujimori, Izumi Ohigashi

引用次数: 0

Low prognostic nutrition index as a prognostic biomarker in elderly patients with early gastric cancer after gastrectomy. 低预后营养指数是老年早期胃癌患者胃切除术后的预后生物标志物。

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JOURNAL OF MEDICAL INVESTIGATION Pub Date : 2024-01-01 DOI: 10.2152/jmi.71.113

Takamasa Takahashi, Yuji Kaneoka, Atsuyuki Maeda, Yuichi Takayama, Hiroki Aoyama, Takahiro Hosoi, Kazuaki Seita

{"title":"Low prognostic nutrition index as a prognostic biomarker in elderly patients with early gastric cancer after gastrectomy.","authors":"Takamasa Takahashi, Yuji Kaneoka, Atsuyuki Maeda, Yuichi Takayama, Hiroki Aoyama, Takahiro Hosoi, Kazuaki Seita","doi":"10.2152/jmi.71.113","DOIUrl":"https://doi.org/10.2152/jmi.71.113","url":null,"abstract":"Purpose Non-invasive biomarkers including systemic inflammatory or nutrition-based index including neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) lymphocyte to monocyte ratio (LMR), and prognostic nutritional index (PNI) can be useful in determining treatment strategies for elderly patients with early gastric cancer (EGC). The aim of this study was to investigate the significance of these index for predicting the long-term survival of EGC patients aged 80 years over. Methods This study included 80 elderly EGC patients with pStageIA after gastrectomy. Optimal cutoff value for PNI, NLR, PLR and LMR were set by using receiver operating curve analysis. The long-term outcomes after gastrectomy were analyzed by univariate and multivariate Cox regression analyses. Results Cut-off value for PNI, NLR, PLR and LMR was set at 46.5, 2.8, 210 and 4.6, respectively. By univariate analyses, low PNI, high NLR, high PLR and low LMR were significantly associated with worse prognosis. By multivariate analysis, low PNI was confirmed as an independent prognostic factor after gastrectomy (HR 0.17 ; 95% CI 0.03-0.91 ; P = 0.04). 5-year overall survival rate of patients with low PNI (≤ 46.5) were 52.4%. Conclusion Low PNI might be useful biomarker to predict worse prognosis of elderly EGC patients after gastrectomy. J. Med. Invest. 71 : 113-120, February, 2024.","PeriodicalId":46910,"journal":{"name":"JOURNAL OF MEDICAL INVESTIGATION","volume":"71 1.2","pages":"113-120"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140913060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pancreatoduodenectomy combined with intestinal de-rotation as a complete artery-first approach for inexperienced surgeons. 胰十二指肠切除术联合肠道去转位术是一种适合经验不足的外科医生的完全动脉先入法。

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JOURNAL OF MEDICAL INVESTIGATION Pub Date : 2024-01-01 DOI: 10.2152/jmi.71.75

Yuji Morine, Yu Saito, Shinichiro Yamada, Teraoku Hiroki, Tetsuya Ikemoto, Mitsuo Shimada

{"title":"Pancreatoduodenectomy combined with intestinal de-rotation as a complete artery-first approach for inexperienced surgeons.","authors":"Yuji Morine, Yu Saito, Shinichiro Yamada, Teraoku Hiroki, Tetsuya Ikemoto, Mitsuo Shimada","doi":"10.2152/jmi.71.75","DOIUrl":"https://doi.org/10.2152/jmi.71.75","url":null,"abstract":"Background: Recent technical advances have reduced the incidence of intraoperative complications associated with pancreatoduodenectomy (PD). We aimed to determine whether inexperienced surgeons (ISs) would be as successful as experienced surgeons (ESs) when performing the complete artery-first approach using the intestinal de-rotation method of PD.Methods: Seventy patients who underwent PD using the intestinal de-rotation method in Tokushima University Hospital were enrolled in the present study. Intra- and post-operative parameters were compared between patients operated on by ESs (n=20) or ISs (n=50).Results: The surgical procedure lasted longer in the IS group (ES : 402 }68 min vs. IS : 483 }51 min, p<0.0001), but the volume of blood loss was similar (p=0.7304). There was no mortality in either group, and the incidences of postoperative complications with a Clavien-Dindo grade of>III did not differ between the groups. Grade B postoperative pancreatic fistulae developed in 20.0% of patients in the ES group and 22.0% in the IS group (p=0.9569). Finally, the postoperative hospital stay of the IS group (32 }33 days) was equivarent to that of the ES group (33 }16 days) (p=0.9256).Conclusion: ISs were able to perform similarly successful PDs using the intestinal de-rotation method to ESs. J. Med. Invest. 71 : 75-81, February, 2024.","PeriodicalId":46910,"journal":{"name":"JOURNAL OF MEDICAL INVESTIGATION","volume":"71 1.2","pages":"75-81"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140913063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clarification of Psychiatric Nurses' Intentions and Analysis Contents in Observing Schizophrenia Patient. 明确精神科护士观察精神分裂症患者的意图和分析内容。

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JOURNAL OF MEDICAL INVESTIGATION Pub Date : 2024-01-01 DOI: 10.2152/jmi.71.54

Shinichi Chiba, Masahito Tomotake, Rie Tsutsumi

{"title":"Clarification of Psychiatric Nurses' Intentions and Analysis Contents in Observing Schizophrenia Patient.","authors":"Shinichi Chiba, Masahito Tomotake, Rie Tsutsumi","doi":"10.2152/jmi.71.54","DOIUrl":"https://doi.org/10.2152/jmi.71.54","url":null,"abstract":"The purpose of this study was to clarify what psychiatric nurses intended to observe when observing schizophrenia patient and what they analyzed from their observations. Twenty-one experienced nurses were included in the study. Data were collected through semi-structured interviews, and content analysis was conducted. The results were as follows:Nurses' intentions in observing patient were [Observation of psychiatric symptoms], [Observation of normality or abnormality], [Possibility of self-harm or harming others], [Side effects of antipsychotics], [Degree of communication disorder], [Degree of self-care], [Observation of nutritional status], [Effects of external stimuli on patient], and [Less importance of observing doctor]. Nurses' analysis contents were [Analysis of psychiatric symptoms], [No risk of self-harm or harming others], [Effects of antipsychotics], [Presence of communication disorder], [Lack of trust in doctor], [Problems in daily life], [Consideration of future nursing intervention], [Assessment of normality or abnormality], [Unhealthy physical state], and [Unnecessary analysis]. The results of this study revealed the nurses' observational process. J. Med. Invest. 71 : 54-61, February, 2024.","PeriodicalId":46910,"journal":{"name":"JOURNAL OF MEDICAL INVESTIGATION","volume":"71 1.2","pages":"54-61"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140912999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of Outer Membrane Vesicles Produced by Vibrio vulnificus. 弧菌产生的外膜囊泡的特征。

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JOURNAL OF MEDICAL INVESTIGATION Pub Date : 2024-01-01 DOI: 10.2152/jmi.71.102

Ryo Higashiyama, Yuna Kanda, Takaaki Shimohata, Kai Ishida, Shiho Fukushima, Kohei Yamazaki, Takashi Uebanso, Kazuaki Mawatari, Takashige Kashimoto, Akira Takahashi

{"title":"Characterization of Outer Membrane Vesicles Produced by Vibrio vulnificus.","authors":"Ryo Higashiyama, Yuna Kanda, Takaaki Shimohata, Kai Ishida, Shiho Fukushima, Kohei Yamazaki, Takashi Uebanso, Kazuaki Mawatari, Takashige Kashimoto, Akira Takahashi","doi":"10.2152/jmi.71.102","DOIUrl":"https://doi.org/10.2152/jmi.71.102","url":null,"abstract":"Vibrio vulnificus (V. vulnificus) is a halophilic gram-negative bacterium that inhabits coastal warm water and induce severe diseases such as primary septicemia. To investigate the mechanisms of rapid bacterial translocation on intestinal infection, we focused on outer membrane vesicles (OMVs), which are extracellular vesicles produced by Gram-negative bacteria and deliver virulence factors. However, there are very few studies on the pathogenicity or contents of V. vulnificus OMVs (Vv-OMVs). In this study, we investigated the effects of Vv-OMVs on host cells. Epithelial cells INT407 were stimulated with purified OMVs and morphological alterations and levels of lactate dehydrogenase (LDH) release were observed. In cells treated with OMVs, cell detachment without LDH release was observed, which exhibited different characteristics from cytotoxic cell detachment observed in V. vulnificus infection. Interestingly, OMVs from a Vibrio Vulnificus Hemolysin (VVH) and Multifunctional-autoprocessing repeats-in -toxin (MARTX) double-deletion mutant strain also caused cell detachment without LDH release. Our results suggested that the proteolytic function of a serine protease contained in Vv-OMVs may contribute to pathogenicity of V. vulnificus by assisting bacterial translocation. This study reveals a new pathogenic mechanism during V. vulnificus infections. J. Med. Invest. 71 : 102-112, February, 2024.","PeriodicalId":46910,"journal":{"name":"JOURNAL OF MEDICAL INVESTIGATION","volume":"71 1.2","pages":"102-112"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140912998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Association between PDE5 Inhibitors and Aneurysm/Arterial Dissection:A Pharmacovigilance Study Using WHO Safety Database. PDE5 抑制剂与动脉瘤/动脉交叉的关系：利用世界卫生组织安全数据库进行的药物警戒研究。

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JOURNAL OF MEDICAL INVESTIGATION Pub Date : 2024-01-01 DOI: 10.2152/jmi.71.134

Koji Miyata, Yuki Izawa-Ishizawa, Takahiro Niimura, Hirofumi Hamano, Fuka Aizawa, Kenta Yagi, Kei Kawada, Yoshito Zamami, Mitsuhiro Goda, Keisuke Ishizawa

{"title":"The Association between PDE5 Inhibitors and Aneurysm/Arterial Dissection:A Pharmacovigilance Study Using WHO Safety Database.","authors":"Koji Miyata, Yuki Izawa-Ishizawa, Takahiro Niimura, Hirofumi Hamano, Fuka Aizawa, Kenta Yagi, Kei Kawada, Yoshito Zamami, Mitsuhiro Goda, Keisuke Ishizawa","doi":"10.2152/jmi.71.134","DOIUrl":"10.2152/jmi.71.134","url":null,"abstract":"Aneurysm and arterial dissection have been reported as adverse drug events, associated with angiogenesis inhibitors and fluoroquinolones. Specifically, several cases of severe arterial disease following cGMP-specific phosphodiesterase type 5 (PDE5) inhibitors usage have recently been reported. It is necessary to ascertain the risks of serious adverse events caused by PDE5 inhibitors. We aimed to evaluate the association of aneurysm and artery dissection with PDE5 inhibitors using VigiBase, which is a World Health Organization database of spontaneously reported adverse events, for explorative hypothesis-generating analysis. We performed disproportionality analysis using a dataset from inception in 1967 to December 2022 and calculated reporting odds ratios (ROR) between PDE5 inhibitors and arterial diseases. We extracted 195,839 reports on PDE5 inhibitors with 254 reports of arterial disease as adverse events from VigiBase. Disproportionality analysis showed disproportional signals for PDE5 inhibitors (ROR, 2.30;95% confidence intervals, 2.04-2.61);disproportional signals were detected in analyses restricting the lesion site to the aorta or cerebral arteries. From stratified analysis, disproportional signals were noted in females, as well as males, generally recognized as a risk factor for artery diseases. This real-world data analysis suggests that PDE5 inhibitors may play a role in the development of lethal arterial disease. J. Med. Invest. 71 : 134-140, February, 2024.","PeriodicalId":46910,"journal":{"name":"JOURNAL OF MEDICAL INVESTIGATION","volume":"71 1.2","pages":"134-140"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140913069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Survey on the incidence of multiple pregnancies and neonatal outcomes by fertility treatment in Tokushima Prefecture, Japan. 日本德岛县通过生育治疗多胎妊娠的发生率和新生儿结局调查。

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JOURNAL OF MEDICAL INVESTIGATION Pub Date : 2024-01-01 DOI: 10.2152/jmi.71.251

Takashi Kaji, Hiroki Noguchi, Kou Tamura, Hidenori Aoki, Atsuko Yoshida, Yuri Yamamoto, Kanako Yoshida, Takeshi Iwasa

{"title":"Survey on the incidence of multiple pregnancies and neonatal outcomes by fertility treatment in Tokushima Prefecture, Japan.","authors":"Takashi Kaji, Hiroki Noguchi, Kou Tamura, Hidenori Aoki, Atsuko Yoshida, Yuri Yamamoto, Kanako Yoshida, Takeshi Iwasa","doi":"10.2152/jmi.71.251","DOIUrl":"https://doi.org/10.2152/jmi.71.251","url":null,"abstract":"A survey on the incidence of multiple pregnancies and neonatal outcomes by assisted reproductive technology (ART) and non-ART fertility treatments was performed in 2011 and 2021. Questionnaires were sent to all institutions with obstetrics and gynecology departments in Tokushima Prefecture, Japan, to collect data on fertility treatments and neonatal outcomes in 2011 and 2021. Non-ART fertility treatments were classified into ovarian stimulation (treatments for cases without ovulation disorder) and ovulation induction (treatments for cases with ovulation disorder). Among all pregnancies, the multiple pregnancy rates in 2011 were 7.7% for ovarian stimulation, 5.5% for ovulation induction, and 8.4% for ART, whereas those in 2021 were 3.8%, 2.3%, and 1.9%, respectively. The rates of triplet pregnancies in 2011 were 0.85% for ovulation induction, 2.4% for ovulation induction, and 1.4% for ART, whereas those in 2021 were 0% for all treatments. The rates of low birth weight, admission to a neonatal intensive care unit, and neonatal death in 2011 were 53.8%, 9.61%, and 9.61%, respectively, whereas those in 2021 were 40.9%, 22.7%, and 0%, respectively. These findings indicate that rates of multiple pregnancies, including higher-order multiple pregnancies, by fertility treatment have decreased over the last 10 years in Tokushima Prefecture. However, some adverse neonatal outcomes have still occurred. J. Med. Invest. 71 : 251-253, August, 2024.","PeriodicalId":46910,"journal":{"name":"JOURNAL OF MEDICAL INVESTIGATION","volume":"71 3.4","pages":"251-253"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term effect of posterior nasal neurectomy for perennial allergic rhinitis. 鼻后神经切除术治疗常年性过敏性鼻炎的长期效果。

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JOURNAL OF MEDICAL INVESTIGATION Pub Date : 2024-01-01 DOI: 10.2152/jmi.71.62

Seiichiro Kamimura, Naoki Kimoto, Keisuke Ishitani, Takashi Takeda, Hitoshi Shono, Ryo Kanamura, Tatsuya Fujii, Eiji Kondo, Takahiro Azuma, Go Sato, Yoshiaki Kitamura

{"title":"Long-term effect of posterior nasal neurectomy for perennial allergic rhinitis.","authors":"Seiichiro Kamimura, Naoki Kimoto, Keisuke Ishitani, Takashi Takeda, Hitoshi Shono, Ryo Kanamura, Tatsuya Fujii, Eiji Kondo, Takahiro Azuma, Go Sato, Yoshiaki Kitamura","doi":"10.2152/jmi.71.62","DOIUrl":"https://doi.org/10.2152/jmi.71.62","url":null,"abstract":"Background: Surgical treatment is recommended for patients with severe allergic rhinitis (AR) refractory to medical treatment. Endoscopic posterior nasal neurectomy (PNN) is primarily performed to improve rhinorrhea in severe perennial AR, however studies on its long-term prognosis are lacking.Aims/objectives: This study aimed to investigate the long-term prognosis of PNN.Materials and methods: A questionnaire survey was administered to 17 patients (12 men and 5 women) at least 1 year after PNN. Nasal symptoms and medications, as well as patient satisfaction with surgery at the time of survey, were scored. Furthermore, scores were compared between patients with postoperative periods of >5 years and <5 years.Results: Nasal symptoms and medication scores significantly improved after surgery. There was no significant difference between patients with a postoperative period of >5 years and <5 years in both preoperative and postoperative nasal symptoms and medication scores. No correlation was found between patient satisfaction with surgery and postoperative period.Conclusions and significance: PNN improved nasal symptoms and medication scores in patients with severe perennial AR. Furthermore, the study results suggest that the long-term effect of PNN for perennial AR lasts for >5 years. J. Med. Invest. 71 : 62-65, February, 2024.","PeriodicalId":46910,"journal":{"name":"JOURNAL OF MEDICAL INVESTIGATION","volume":"71 1.2","pages":"62-65"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140913036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of completely resected cecum cancer with synchronous metastases to the small intestine found in acute appendicitis. 一例在急性阑尾炎中发现完全切除的盲肠癌与小肠同步转移的病例。

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JOURNAL OF MEDICAL INVESTIGATION Pub Date : 2024-01-01 DOI: 10.2152/jmi.71.293

Yutaro Shimizu, Takuya Shiraishi, Takuhisa Okada, Katsuya Osone, Yasuaki Enokida, Hiroomi Ogawa, Makoto Sohda, Ken Shirabe, Hiroshi Saeki

{"title":"A case of completely resected cecum cancer with synchronous metastases to the small intestine found in acute appendicitis.","authors":"Yutaro Shimizu, Takuya Shiraishi, Takuhisa Okada, Katsuya Osone, Yasuaki Enokida, Hiroomi Ogawa, Makoto Sohda, Ken Shirabe, Hiroshi Saeki","doi":"10.2152/jmi.71.293","DOIUrl":"10.2152/jmi.71.293","url":null,"abstract":"Purpose: Risk of malignant tumors increase with age;hence, careful examination of older patients should be consdiered when identifying the causes of acute appendicitis. Here, we report a case of a patient with cecum cancer with synchronous metastases to the small intestine that was found during acute appendicitis.Case report: A 74-year-old man presented with right lower abdominal pain. Physical examination revealed deep tenderness at McBurney's point. Enhanced computed tomography scan showed an abscess around the enlarged appendix and a thickened cecum wall. Colonoscopy revealed a type 2 tumor in the ileocecal region, and pathological examination of the biopsied specimen revealed adenocarcinoma. Microscopic findings revealed two type 2 tumors in the small intestine, pathologically diagnosed as cecum cancer metastases. The final diagnosis was acute appendicitis caused by cecum cancer with synchronous metastases to the small intestine, pStage ⅣB pT4bN1aM1b. The patient received adjuvant chemotherapy and has currently been disease-free for 24 months.Conclusions: In prolonged appendicitis among older adults, the possibility of malignancy should be considered during preoperative examination and prior to selecting a treatment plan. Delays in the diagnosis of colorectal cancer and metastases may lead to missed opportunities for complete resection and poor prognosis. J. Med. Invest. 71 : 293-297, August, 2024.","PeriodicalId":46910,"journal":{"name":"JOURNAL OF MEDICAL INVESTIGATION","volume":"71 3.4","pages":"293-297"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Achievements of perioperative assist team medical care in esophageal cancer surgery, Tokushima University Hospital. 德岛大学医院食道癌手术围手术期辅助团队医疗护理成果。

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JOURNAL OF MEDICAL INVESTIGATION Pub Date : 2024-01-01 DOI: 10.2152/jmi.71.279

Seiya Inoue, Masakazu Goto, Satoshi Fujiwara, Takahiro Yoshida, Fuyumi Izaki, Taihei Takeuchi, Hiroyuki Sumitomo, Mariko Misaki, Hiroaki Toba, Hiromitsu Takizawa, Yasuhiro Hamada, Tetsuya Matsuura, Keiko Aota, Hidenori Takano

{"title":"Achievements of perioperative assist team medical care in esophageal cancer surgery, Tokushima University Hospital.","authors":"Seiya Inoue, Masakazu Goto, Satoshi Fujiwara, Takahiro Yoshida, Fuyumi Izaki, Taihei Takeuchi, Hiroyuki Sumitomo, Mariko Misaki, Hiroaki Toba, Hiromitsu Takizawa, Yasuhiro Hamada, Tetsuya Matsuura, Keiko Aota, Hidenori Takano","doi":"10.2152/jmi.71.279","DOIUrl":"https://doi.org/10.2152/jmi.71.279","url":null,"abstract":"Background: Radical esophagectomy is highly invasive and associated with many postoperative complications. A decline in postoperative QOL is a serious issue for patients, and comprehensive perioperative management through multidisciplinary cooperation is necessary. Our institution has established a perioperative assist team (OPERA) to address this need since 2017.Methods: This study included 109 patients with esophageal cancer who underwent neoadjuvant chemotherapy and esophagectomy from 2009 to 2018. O group, means OPERA intervention group, included 57 patients, and N group, means Non-OPERA intervention group, included 52 patients. The effects of the OPERA intervention on reducing chemotherapy-related adverse events and improving postoperative outcomes were retrospectively investigated.Results: The OPERA intervention significantly reduced the incidence of chemotherapy-related adverse events (P=0.002). In particular, anorexia and diarrhea, febrile neutropenia were significantly reduced (P<0.001, P=0.002, P=0.025, respectively). Postoperatively, the start date of walking was significantly earlier (P<0.001), the incidence of pneumonia was lower (P=0.022). At the time of postoperative discharge, N group was significantly greater weight loss compared to O group (P=0.002). The 5-year survival rate was longer in O group (P=0.003).Conclusion: The OPERA intervention reduced the incidence of chemotherapy-related adverse events and postoperative complications and helped improved prognosis. J. Med. Invest. 71 : 279-285, August, 2024.","PeriodicalId":46910,"journal":{"name":"JOURNAL OF MEDICAL INVESTIGATION","volume":"71 3.4","pages":"279-285"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0