Topics in Spinal Cord Injury Rehabilitation最新文献

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Student Competition (Technology Innovation) ID 1972228 学生竞赛(科技创新) ID 1972228
IF 2.9
Topics in Spinal Cord Injury Rehabilitation Pub Date : 2023-09-01 DOI: 10.46292/sci23-1972228s
Nicholas Zhao, J. Zariffa
{"title":"Student Competition (Technology Innovation) ID 1972228","authors":"Nicholas Zhao, J. Zariffa","doi":"10.46292/sci23-1972228s","DOIUrl":"https://doi.org/10.46292/sci23-1972228s","url":null,"abstract":"Upper limb rehabilitation after cervical spinal cord injury is vital for regaining independence. Hand function assessments are critical for upper limb rehabilitation, but are unable to accurately reflect performance in the individual’s home environment. Video from wearable cameras (egocentric video), paired with deep learning, can assess hand function during activities of daily living (ADLs) at home. Previous studies have focused on analyzing quantitative aspects of hand usage, but there has yet to be a study that uses deep neural networks to assess the quality of hand usage from egocentric video. To train a deep neural network to predict hand function assessment scores from egocentric video. The dataset used contained egocentric videos of ADLs performed by 17 participants with AIS grades from A-D in a home simulation laboratory. Tasks were annotated with scores adapted from the Graded Redefined Assessment of Strength Sensibility and Prehension (GRASSP). The annotated video was then used to train and validate a SlowFast neural network to predict GRASSP scores, using leave-one-subject-out cross validation. Model performance was evaluated by mean absolute error, accuracy, and F1 score. The model was optimized with a hyperparameter sweep. The top performing model demonstrated a mean absolute error of 0.52±0.19, an accuracy of 0.55±0.14, and F1 score of 0.55±0.16, on an ordinal scale from 1 to 5. These results demonstrate that automated assessment of hand function is possible by applying deep learning to egocentric video. Future work should expand the model to larger datasets with more variability.","PeriodicalId":46769,"journal":{"name":"Topics in Spinal Cord Injury Rehabilitation","volume":"15 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139344244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Poster (Clinical/Best Practice Implementation) ID 1981325 海报(临床/最佳实践实施) ID 1981325
IF 2.9
Topics in Spinal Cord Injury Rehabilitation Pub Date : 2023-09-01 DOI: 10.46292/sci23-1981325s
Laura M. Oldford, Lauren E. Casey, Samuel Campbell, S. McCullum, Erica J. de Passillé, Colleen M. O’Connell
{"title":"Poster (Clinical/Best Practice Implementation) ID 1981325","authors":"Laura M. Oldford, Lauren E. Casey, Samuel Campbell, S. McCullum, Erica J. de Passillé, Colleen M. O’Connell","doi":"10.46292/sci23-1981325s","DOIUrl":"https://doi.org/10.46292/sci23-1981325s","url":null,"abstract":"Many barriers prevent those with spinal cord injury or disease (SCI/D) from adhering to recommended exercise guidelines, thus increasing risks of secondary health conditions. Mainstream technology options, such as virtual reality (VR), have the potential to facilitate needed exercise participation. However, further research on VR exercise modalities is needed to determine feasibility, effectiveness and to ultimately guide practice recommendations. The goal of this pilot feasibility study was to determine whether VR exergaming is non-inferior to the current standard of care (SoC) upper extremity aerobic exercise for individuals with SCI/D. 25 participants with SCI/D completed 10-minute exercise sessions with either VR or the SoC, and after a rest break, then completed 10 minutes of exercise with the other modality. Primary outcomes of heart rate (HR) and rate of perceived exertion (RPE) were collected at baseline, 5 minutes into exercise, and at 10 min (end of the exercise session) for each modality. Secondary exploratory measures included a Numeric Pain Rating Scale measured pre- and post- each exercise session, and a post-study likeability survey. There were no significant differences in HR or RPE between virtual reality exergaming and the standard of care, and 100% of participants preferred the VR over SoC for the exercise. VR exergaming was non-inferior to the SoC for short duration upper extremity exercise in those with SCI/D. Implementing VR for patients with SCI/D should be studied further to observe the longer term effect on cardiovascular health and to determine feasibility and compliance for home use.","PeriodicalId":46769,"journal":{"name":"Topics in Spinal Cord Injury Rehabilitation","volume":"98 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139346193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Student Competition (Knowledge Generation) ID 1986472 学生竞赛(知识生成) ID 1986472
IF 2.9
Topics in Spinal Cord Injury Rehabilitation Pub Date : 2023-09-01 DOI: 10.46292/sci23-1986472s
S. Gautam, Vivian K. Mushahwar, Mandira Baniya, K. P. Manhas, Raju Dhakal, C. Groves, Chester Ho
{"title":"Student Competition (Knowledge Generation) ID 1986472","authors":"S. Gautam, Vivian K. Mushahwar, Mandira Baniya, K. P. Manhas, Raju Dhakal, C. Groves, Chester Ho","doi":"10.46292/sci23-1986472s","DOIUrl":"https://doi.org/10.46292/sci23-1986472s","url":null,"abstract":"Spinal cord injury (SCI) results in physical impairments and psychosocial issues that generate challenges to individuals, families, and society. Understanding the acute care hospital experience after SCI is important as it may have an impact on persons with spinal cord injuries’ (PWSCI) subsequent journey to the rehabilitation center and community. This experience has not been studied in Nepal, especially from the perspective of PWSCI. To understand how PWSCI (1) are involved in decision-making for their care; (2) are educated about secondary complications and, (3) perceive overall positive and negative experiences regarding their care during their acute care hospital stay in Nepal. Qualitative study based on Van Manen’s phenomenology using purposive sampling at the Spinal Injury Rehabilitation Center, the only dedicated SCI center in Nepal. We interviewed participants (n=24) who were referred from nine different acute hospitals using a semi-structured interview guide co-developed with SCI experts and PWSCI. Using thematic analysis, we extracted the findings with Manen’s approach. We identified three preliminary themes: (1) Families, but not PWSCI, are often included in the decision-making process; (2) For education on secondary complications, only pressure injury prevention was recalled; (3) Timeliness of spinal surgery was a concern. There are opportunities to improve the acute care experience for PWSCI in Nepal. PWSCI desired to be more engaged in the decision-making process and more involved in their own care. Concerns regarding the timeliness of surgery correlated with the findings of previous Nepali studies.","PeriodicalId":46769,"journal":{"name":"Topics in Spinal Cord Injury Rehabilitation","volume":"2014 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139346588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Poster (Health Services, Economics and Policy Change) ID 1977284 海报(医疗服务、经济学和政策变化)ID 1977284
IF 2.9
Topics in Spinal Cord Injury Rehabilitation Pub Date : 2023-09-01 DOI: 10.46292/sci23-1977284s
Brian Chan, Natascha Lam, Verena Rafael, Maureen Pakosh, Kristin E. Musselman
{"title":"Poster (Health Services, Economics and Policy Change) ID 1977284","authors":"Brian Chan, Natascha Lam, Verena Rafael, Maureen Pakosh, Kristin E. Musselman","doi":"10.46292/sci23-1977284s","DOIUrl":"https://doi.org/10.46292/sci23-1977284s","url":null,"abstract":"Activity-based therapies (ABT) are task specific, repetitive and intensive active movement interventions that may improve function and independence for individuals with spinal cord injury. The cost of implementing ABT is an important consideration for rehabilitation facilities interested in providing this intervention. Thus, a scoping review was conducted to evaluate the economic evidence for ABT for the rehabilitation of upper or lower limb impairment. A search of various scientific literature databases (including EMBASE, MEDLINE and CINAHL) was conducted using search terms developed in collaboration with a Medical Librarian. Studies were included if they were economic analyses of an ABT conducted for individuals with upper or lower limb mobility impairment. Titles and abstracts were initially screened by two of the authors followed by a full-text review of remaining articles. Articles included in the review were evaluated for methodological quality and presented descriptively because of the heterogeneity in study design, populations and outcomes. Of the 6,031 unique citations originally identified, 14 articles were included after full-text screening. Two-third of the studies were for stroke and half of the studies originated from the US. Robot-assisted therapies represented half of the studies and about a quarter were locomotor training programs. In the stroke and spinal cord injured population, robot-assisted therapies and body supported treadmill therapy appear to be cost-effective respectively. There is some evidence to support the cost-effectiveness of robot-assisted therapies and body supported treadmill therapy. However, the evidence is very limited and additional research is needed.","PeriodicalId":46769,"journal":{"name":"Topics in Spinal Cord Injury Rehabilitation","volume":"95 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139346798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Poster (Clinical/Best Practice Implementation) ID 1984967 海报(临床/最佳实践实施) ID 1984967
IF 2.9
Topics in Spinal Cord Injury Rehabilitation Pub Date : 2023-09-01 DOI: 10.46292/sci23-1984967s
Suban Kangatharan, Mohammadreza Amiri, Louise Brisbois, Farnoosh Farahani, B. C. Craven
{"title":"Poster (Clinical/Best Practice Implementation) ID 1984967","authors":"Suban Kangatharan, Mohammadreza Amiri, Louise Brisbois, Farnoosh Farahani, B. C. Craven","doi":"10.46292/sci23-1984967s","DOIUrl":"https://doi.org/10.46292/sci23-1984967s","url":null,"abstract":"Assessment of physical activity (PA) prescription recall and serum screening for dyslipidemia are critical to describe and mitigate Cardiometabolic Disease (CMD) risk among adults with spinal cord injury or disease (SCI/D). To report: 1) the frequency of PA prescription recall; and, 2) the frequency of lipid profile assessment and interpretation recall among inpatients with SCI/D during rehabilitation. Adults with SCI/D completed the SCI-HIGH CMD intermediary outcome indicators. A Kinesiologist collected data via interview and chart abstraction among UHN inpatients. Survey responses were scored using Reachlite’s optical character recognition software. Descriptive statistics were used to characterize the participant’s age, sex, impairment characteristics, and report recall rates and the frequency of lipid screening/interpretation. Based on the participant’s needs, either educational materials to increase future adherence to PA guidelines and/or a Mediterranean diet were provided. Adult inpatients (n=124), mean age 59 years, 64% paraplegic, and 36% female participated. In total, 14% of participants (16/117) reported being taught the benefits of PA for their heart health; of whom 69% (11/16) recalled exercise instruction. Similarly, 15% of inpatients (17/114) recalled lipid screening during rehabilitation, although chart abstraction revealed that 30% (37/124) had completed lipid screening. Clinical interpretation of their lipid values was recalled by 30% of inpatients. There is a significant opportunity to advance PA instruction and lipid profile education and management among inpatients with SCI/D to reduce CMD risk. Inclusion of PA and lipid management instructions in patient-oriented discharge summaries may enhance patient recall/adherence.","PeriodicalId":46769,"journal":{"name":"Topics in Spinal Cord Injury Rehabilitation","volume":"2 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139346848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Post Doc Competition (Knowledge Generation) ID 1986617 博士后竞赛(知识生成) ID 1986617
IF 2.9
Topics in Spinal Cord Injury Rehabilitation Pub Date : 2023-09-01 DOI: 10.46292/sci23-1986617s
Jeonghoon Oh, Michelle S. Scheffler, Catherine A. Martin, Jenny Dinh, Alexander G. Steele, D. Sayenko
{"title":"Post Doc Competition (Knowledge Generation) ID 1986617","authors":"Jeonghoon Oh, Michelle S. Scheffler, Catherine A. Martin, Jenny Dinh, Alexander G. Steele, D. Sayenko","doi":"10.46292/sci23-1986617s","DOIUrl":"https://doi.org/10.46292/sci23-1986617s","url":null,"abstract":"Transcutaneous spinal stimulation (TSS) is emerging as a valuable tool for electrophysiological and clinical assessments. The objectives of this study were to investigate: (1) TSS above and below a spinal cord injury (SCI) lesion results in different recruitment pattern of upper limb (UL) motor pools compared to neurologically intact subjects (NIS), and (2) the relationship between recruitment pattern of UL motor pools and neurological and functional status in individuals with SCI. Methods: Eleven NIS and six participants with cervical SCI were recruited in this study. We compared spinally evoked motor potentials in UL muscles during TSS delivered to the cervical spinal cord between the spinous process of C3-C4 and C7-T1 vertebrae. As expected, TSS delivered over the cervical spinal cord in NIS can preferentially activate proximal and distal muscles along the rostrocaudal axis, as well as ipsilateral UL muscles along the mediolateral axis. However, in participants with SCI, the responses registered in UL muscles innervated by motor pools above and below the lesion demonstrated different recruitment compared to NIS, and were dependent on the level, extent, and side of SCI. The spatial map obtained from assessing evoked potentials above and below the lesion contributes to the comprehensive understanding of the viability and function of specific UL motor pools, and can be utilized to monitor changes in recruitment patterns of the UL motor pools during neurorehabilitation interventions after SCI.","PeriodicalId":46769,"journal":{"name":"Topics in Spinal Cord Injury Rehabilitation","volume":"53 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139347084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Student Competition (Health Services, Economics and Policy Change) ID 1977283 学生竞赛(卫生服务、经济学和政策变化)ID 1977283
IF 2.9
Topics in Spinal Cord Injury Rehabilitation Pub Date : 2023-09-01 DOI: 10.46292/sci23-1977283s
Chaitali Desai, Rosalie Wang, Maureen Pakosh, Brian Chan
{"title":"Student Competition (Health Services, Economics and Policy Change) ID 1977283","authors":"Chaitali Desai, Rosalie Wang, Maureen Pakosh, Brian Chan","doi":"10.46292/sci23-1977283s","DOIUrl":"https://doi.org/10.46292/sci23-1977283s","url":null,"abstract":"Assistive technologies (AT) span a large range of products from mobility aides such as canes to electronic systems that provide reminders. These technologies are important in facilitating independence, recovery and improved quality of life for individuals with spinal cord injury (SCI). However, clinical and economic outcomes for AT evaluated in the scientific literature is unclear. Thus, the aim of this study is to review the clinical and economic evidence for AT in the SCI population. Scientific literature databases including EMBASE, MEDLINE and CINAHL will be searched using terms identified in collaboration with a Medical Librarian. In the first stage, the titles and abstracts of clinical studies and economic analyses of AT focused in SCI will be screened by two reviewers. This will be followed by a second stage full-text screening for inclusion in the review by the same reviewers. The types of ATs evaluated will be identified along with the outcomes measured. Where applicable, study results will be presented using summary statistics. Work is currently underway to identify the citations. Two reviewers will then screen the titles and abstracts. It is anticipated that a large majority of the citations will be screened out with a small number of studies remaining. Most studies are also expected to be for the clinical evaluation of AT with variable outcomes. The results of this scoping review will provide valuable insight on the types of AT where clinical and economic evidence is available and identify where the current research gaps are.","PeriodicalId":46769,"journal":{"name":"Topics in Spinal Cord Injury Rehabilitation","volume":"18 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139343638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Poster (Clinical/Best Practice Implementation) ID 1978673 海报(临床/最佳实践实施)ID 1978673
IF 2.9
Topics in Spinal Cord Injury Rehabilitation Pub Date : 2023-09-01 DOI: 10.46292/sci23-1978673s
Jo Anne L. Savoie, Serene Qiu, Chelsea M. Crockford, Laura Kabbash
{"title":"Poster (Clinical/Best Practice Implementation) ID 1978673","authors":"Jo Anne L. Savoie, Serene Qiu, Chelsea M. Crockford, Laura Kabbash","doi":"10.46292/sci23-1978673s","DOIUrl":"https://doi.org/10.46292/sci23-1978673s","url":null,"abstract":"To address gaps in peer-supported services for those with a mobility disability, a virtual group was designed to have trained mentors with lived experience working alongside rehabilitation professionals to share resources and strategies that promote healthy living. Sessions offered knowledge and support in goal setting, healthy eating, physical activity, adapted recreation, emotional well-being, and social connectedness. Three rounds of the group were offered with 12 participants completing the group in its entirety. Pre- and post-measures included the Self-Efficacy to Manage Scale (Lorig, et al, 2001), the Life Satisfaction Questionnaire-11 (Fugl-Meyer, et al., 1991), and the Readiness Ruler adapted to each wellness topic (Moyers, et al., 2009). Analyses before and after group showed a slight increase (Cohen’s d = 0.3) in their subjective well-being on the life satisfaction scale and a moderately higher sense of self-efficacy (Cohen’s d = 0.6) in managing symptoms. Although perceived importance for change was similar, participants reported higher confidence in their ability to change (Cohen’s d = 0.4) and greater readiness to make changes (Cohen’s d = 0.4) after the group. The program resulted in several successes including slight increase in life satisfaction and moderately higher sense of self-efficacy in managing symptoms. Confidence in ability and readiness to make change also increased. The project had a small sample size, but the outcomes support the value of embedding a peer-support element into traditional healthcare delivery.","PeriodicalId":46769,"journal":{"name":"Topics in Spinal Cord Injury Rehabilitation","volume":"28 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139344076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Poster (Knowledge Generation) ID 1969461 海报(知识生成)ID 1969461
IF 2.9
Topics in Spinal Cord Injury Rehabilitation Pub Date : 2023-09-01 DOI: 10.46292/sci23-1969461s
S. Mohammadi, Victoria Bogle, Heather F. Cathcart, Sarah Park, William C. Miller
{"title":"Poster (Knowledge Generation) ID 1969461","authors":"S. Mohammadi, Victoria Bogle, Heather F. Cathcart, Sarah Park, William C. Miller","doi":"10.46292/sci23-1969461s","DOIUrl":"https://doi.org/10.46292/sci23-1969461s","url":null,"abstract":"Individuals with SCI often receive care from their family members. Caregiving responsibilities lead to caregiver burden. Receiving social support may mitigate the negative impacts of caregiving. Caregivers can obtain support from people they meet in-person, such as family members and people with whom they interact through social platforms. Our objective was to investigate the moderating effect of in-person and online social supports on the association between relationship quality, caregiver competence, caregiver distress and caregiver burden. 115 caregivers who resided in Canada or the United States, understood and spoke English, and self-identified as primary family caregivers of an individual with SCI were sampled. Participants completed measures assessing relationship quality, competence, distress, burden, and in-person and online social support. Three separate moderation analyses for each outcome variable (i.e. relationship quality, competence, and distress), were conducted. In analyses, burden was the predictor, and online and in-person support were moderators. Moderation analyses showed that online support moderates the link between caregiver burden and distress. Slope analyses revealed that the positive relationship between burden and distress was weaker when caregivers reported lower levels of online support (p=0.005); this relationship was more robust when caregivers reported higher levels of online support (p <.001). Other moderation analyses were not statistically significant. Online support increases distress in family caregivers. It is likely that comparing their life with other caregivers or being exposed to other caregivers’ grief negatively affects caregivers. More research is needed to understand how online support impacts caregivers negatively.","PeriodicalId":46769,"journal":{"name":"Topics in Spinal Cord Injury Rehabilitation","volume":"38 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139344097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Student Competition (Knowledge Generation) ID 1985735 学生竞赛(知识生成) ID 1985735
IF 2.9
Topics in Spinal Cord Injury Rehabilitation Pub Date : 2023-09-01 DOI: 10.46292/sci23-1985735s
Saina Aliabadi, Kristin E. Musselman, S. L. Hitzig, Susn Jaglal, B. C. Craven
{"title":"Student Competition (Knowledge Generation) ID 1985735","authors":"Saina Aliabadi, Kristin E. Musselman, S. L. Hitzig, Susn Jaglal, B. C. Craven","doi":"10.46292/sci23-1985735s","DOIUrl":"https://doi.org/10.46292/sci23-1985735s","url":null,"abstract":"Individuals with chronic spinal cord injury or disease (SCI/D) are at an increased risk of lower extremity fractures. Novel interventions, including nutraceuticals and pharmacotherapy, are being explored to reduce fracture-related morbidity and mortality. This retrospective cohort study aims to evaluate the effectiveness of Denosumab injections with dietary calcium and vitamin D supplements on proximaltibia bone mineral density (BMD) in adults with low bone mass and chronic SCI/D. Adult patients with SCI/D over age 18 years, with a baseline distal femur or proximal tibia Z-score <-2.0 or T-score <-2.5 exposed to at least three doses of Denosumab 60mcg/1ml vial injections will consent to chart abstraction. The cumulative Denosumab dose will be the exposure variable. Calcium intake and vitamin D serum levels will be recorded as effect modifiers. Age, sex, and BMI will be recorded as potential confounders. The primary outcome will be the change in proximal tibia BMD from baseline and secondarily the incidence of lower extremity fracture(s). Demographic and impairment characteristics of the study population will be reported using appropriate descriptive statistics. The associations between mean BMD change and Denosumab exposure will be calculated and adjusted for confounders using an appropriate univariate/multivariate model based on sample size and data distribution. This retrospective cohort study will determine the effectiveness of Denosumab injections (with calcium and vitamin D) for maintaining or increasing proximal tibia BMD among patients with chronic SCI/D. The study findings will have a significant impact on Denosumab prescribing practices.","PeriodicalId":46769,"journal":{"name":"Topics in Spinal Cord Injury Rehabilitation","volume":"8 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139344853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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