Topics in Spinal Cord Injury Rehabilitation最新文献

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Differential Expression of Vascular-Related MicroRNA in Circulating Endothelial Microvesicles in Adults With Spinal Cord Injury: A Pilot Study. 脊髓损伤成人循环内皮微囊中血管相关微RNA的差异表达:一项试点研究
IF 2.9
Topics in Spinal Cord Injury Rehabilitation Pub Date : 2023-01-01 Epub Date: 2023-04-03 DOI: 10.46292/sci22-00032
Andrew J Park, Hannah K Fandl, Vinicius P Garcia, Geoff B Coombs, Noah M DeSouza, Jared J Greiner, Otto F Barak, Tanja Mijacika, Zeljko Dujic, Philip N Ainslie, Christopher A DeSouza
{"title":"Differential Expression of Vascular-Related MicroRNA in Circulating Endothelial Microvesicles in Adults With Spinal Cord Injury: A Pilot Study.","authors":"Andrew J Park, Hannah K Fandl, Vinicius P Garcia, Geoff B Coombs, Noah M DeSouza, Jared J Greiner, Otto F Barak, Tanja Mijacika, Zeljko Dujic, Philip N Ainslie, Christopher A DeSouza","doi":"10.46292/sci22-00032","DOIUrl":"10.46292/sci22-00032","url":null,"abstract":"<p><strong>Background: </strong>Spinal cord injury (SCI) is associated with an increased risk and prevalence of cardiopulmonary and cerebrovascular disease-related morbidity and mortality. The factors that initiate, promote, and accelerate vascular diseases and events in SCI are poorly understood. Clinical interest in circulating endothelial cell-derived microvesicles (EMVs) and their microRNA (miRNA) cargo has intensified due to their involvement in endothelial dysfunction, atherosclerosis, and cerebrovascular events.</p><p><strong>Objectives: </strong>The aim of this study was to determine whether a subset of vascular-related miRNAs is differentially expressed in EMVs isolated from adults with SCI.</p><p><strong>Methods: </strong>We assessed eight adults with tetraplegia (7 male/1 female; age: 46±4 years; time since injury: 26±5 years) and eight uninjured (6 male/2 female; age: 39±3 years). Circulating EMVs were isolated, enumerated, and collected from plasma by flow cytometry. The expression of vascular-related miRNAs in EMVs was assessed by RT-PCR.</p><p><strong>Results: </strong>Circulating EMV levels were significantly higher (~130%) in adults with SCI compared with uninjured adults. The expression profile of miRNAs in EMVs from adults with SCI were significantly different than uninjured adults and were pathologic in nature. Expression of miR-126, miR-132, and miR-Let-7a were lower (~100-150%; <i>p</i> < .05), whereas miR-30a, miR-145, miR-155, and miR-216 were higher (~125-450%; <i>p</i> < .05) in EMVs from adults with SCI.</p><p><strong>Conclusion: </strong>This study is the first examination of EMV miRNA cargo in adults with SCI. The cargo signature of vascular-related miRNAs studied reflects a pathogenic EMV phenotype prone to induce inflammation, atherosclerosis, and vascular dysfunction. EMVs and their miRNA cargo represent a novel biomarker of vascular risk and a potential target for intervention to alleviate vascular-related disease after SCI.</p>","PeriodicalId":46769,"journal":{"name":"Topics in Spinal Cord Injury Rehabilitation","volume":"29 2","pages":"34-42"},"PeriodicalIF":2.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9536360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Commentary: Spinal Cord Stimulation to Improve Autonomic Regulation After Spinal Cord Injury: Can Reflex Control Be Restored. 评论:脊髓刺激改善脊髓损伤后的自主神经调节:反射控制能否恢复。
IF 2.9
Topics in Spinal Cord Injury Rehabilitation Pub Date : 2023-01-01 Epub Date: 2023-05-22 DOI: 10.46292/sci22-00048
Ryan Solinsky, J Andrew Taylor
{"title":"Commentary: Spinal Cord Stimulation to Improve Autonomic Regulation After Spinal Cord Injury: Can Reflex Control Be Restored.","authors":"Ryan Solinsky, J Andrew Taylor","doi":"10.46292/sci22-00048","DOIUrl":"10.46292/sci22-00048","url":null,"abstract":"","PeriodicalId":46769,"journal":{"name":"Topics in Spinal Cord Injury Rehabilitation","volume":"29 2","pages":"31-33"},"PeriodicalIF":2.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9928443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exercises With Optimal Scapulothoracic Muscle Activation for Individuals With Paraplegia. 针对截瘫患者的肩胛胸肌最佳激活运动。
IF 2.9
Topics in Spinal Cord Injury Rehabilitation Pub Date : 2023-01-01 Epub Date: 2023-12-30 DOI: 10.46292/sci21-00059
Linda M Riek, Amy Aronson, Kacie Giust, Samantha Putnam, Hannah Froese, Sean Rutherford, Mary Kathryn White
{"title":"Exercises With Optimal Scapulothoracic Muscle Activation for Individuals With Paraplegia.","authors":"Linda M Riek, Amy Aronson, Kacie Giust, Samantha Putnam, Hannah Froese, Sean Rutherford, Mary Kathryn White","doi":"10.46292/sci21-00059","DOIUrl":"10.46292/sci21-00059","url":null,"abstract":"<p><strong>Background: </strong>Individuals with paraplegia and coexisting trunk and postural control deficits rely on their upper extremities for function, which increases the risk of shoulder pain. A multifactorial etiology of shoulder pain includes \"impingement\" of the supraspinatus, infraspinatus, long head of the biceps tendons, and/or subacromial bursa resulting from anatomic abnormalities, intratendinous degeneration, and altered scapulothoracic kinematics and muscle activation. Targeting serratus anterior (SA) and lower trapezius (LT) activation during exercise, as part of a comprehensive plan, minimizes impingement risk by maintaining optimal shoulder alignment and kinematics during functional activities. To prevent excessive scapular upward translation, minimizing upper trapezius (UT) to SA and LT activation is also important.</p><p><strong>Objectives: </strong>To determine which exercises (1) maximally activate SA and minimize UT:SA ratio and (2) maximally activate LT and minimize UT:LT ratio.</p><p><strong>Methods: </strong>Kinematic and muscle activation data were captured from 10 individuals with paraplegia during four exercises: \"T,\" scaption (sitting), dynamic hug, and SA punch (supine). Means and ratios were normalized by percent maximum voluntary isometric contraction (MVIC) for each muscle. One-way repeated measures analysis of variance determined significant differences in muscle activation between exercises.</p><p><strong>Results: </strong>Exercises were rank ordered: (1) maximum SA activation: SA punch, scaption, dynamic hug, \"T\"; (2) maximum LT activation: \"T,\" scaption, dynamic hug, SA punch; 3) minimum UT:SA ratio: SA punch, dynamic hug, scaption, \"T\"; and (4) minimum UT:LT ratio: SA punch, dynamic hug, \"T,\" scaption. Exercise elicited statistically significant changes in percent MVIC and ratios. Post hoc analyses revealed multiple significant differences between exercises (<i>p</i> < .05).</p><p><strong>Conclusion: </strong>SA punch produced the greatest SA activation and lowest ratios. Dynamic hug also produced optimal ratios, suggesting supine exercises minimize UT activation more effectively. To isolate SA activation, individuals with impaired trunk control may want to initiate strengthening exercises in supine. Participants maximally activated the LT, but they were not able to minimize UT while upright.</p>","PeriodicalId":46769,"journal":{"name":"Topics in Spinal Cord Injury Rehabilitation","volume":"29 2","pages":"43-55"},"PeriodicalIF":2.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9584411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Look at Spinal Cord Injury in Canada: Rick Hansen Spinal Cord Injury Registry (RHSCIR) - 2021 SCI Data Summary. 加拿大脊髓损伤概况:里克-汉森脊髓损伤登记处(Rick Hansen Spinal Cord Injury Registry,RHSCIR)--2021 年 SCI 数据摘要。
IF 2.4
Topics in Spinal Cord Injury Rehabilitation Pub Date : 2023-01-01 Epub Date: 2023-11-17 DOI: 10.46292/sci23-00031S
Vanessa K Noonan
{"title":"A Look at Spinal Cord Injury in Canada: Rick Hansen Spinal Cord Injury Registry (RHSCIR) - 2021 SCI Data Summary.","authors":"Vanessa K Noonan","doi":"10.46292/sci23-00031S","DOIUrl":"10.46292/sci23-00031S","url":null,"abstract":"<p><p>The Rick Hansen Spinal Cord Injury Registry (RHSCIR) is a prospective registry of individuals who sustain a spinal cord injury (SCI) from 18 acute and 14 rehabilitation (rehab) Canadian hospitals specializing in SCI care. The data summary provides demographic and clinical details on 1148 people with either a traumatic spinal cord injury (tSCI) or a nontraumatic spinal cord injury (ntSCI) who were treated at a RHSCIR hospital in 2021. Information about the patient demographics, cause and severity of injury, care pathway, length of hospital stay, secondary complications, and social impacts after SCI were included. Data from the summary can provide researchers, healthcare providers, and decision makers with knowledge and evidence that may support strategies to improve SCI care services within their institutions.</p>","PeriodicalId":46769,"journal":{"name":"Topics in Spinal Cord Injury Rehabilitation","volume":"29 Suppl","pages":"165-170"},"PeriodicalIF":2.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10759878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139089023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identifying Patterns of Primary Care Antibiotic Prescribing for a Spinal Cord Injury (SCI) Cohort Using an Electronic Medical Records (EMR) Database. 利用电子病历 (EMR) 数据库识别脊髓损伤 (SCI) 群体的初级保健抗生素处方模式。
IF 2.4
Topics in Spinal Cord Injury Rehabilitation Pub Date : 2023-01-01 Epub Date: 2023-11-17 DOI: 10.46292/sci23-00047S
Arrani Senthinathan, Melanie Penner, Karen Tu, Andrew M Morris, B Catharine Craven, Zhiyin Li, Jun Guan, Susan B Jaglal
{"title":"Identifying Patterns of Primary Care Antibiotic Prescribing for a Spinal Cord Injury (SCI) Cohort Using an Electronic Medical Records (EMR) Database.","authors":"Arrani Senthinathan, Melanie Penner, Karen Tu, Andrew M Morris, B Catharine Craven, Zhiyin Li, Jun Guan, Susan B Jaglal","doi":"10.46292/sci23-00047S","DOIUrl":"10.46292/sci23-00047S","url":null,"abstract":"<p><strong>Background: </strong>Individuals with a spinal cord injury (SCI) are considered higher users of antibiotics. However, to date there have been no detailed studies investigating outpatient antibiotic use in this population.</p><p><strong>Objectives: </strong>(1) To describe primary care antibiotic prescribing patterns in adults with SCI rostered to a primary care physician (PCP), and (2) to identify patient or PCP factors associated with number of antibiotics prescribed and antibiotic prescription duration.</p><p><strong>Methods: </strong>A retrospective cohort study using linked health administrative and electronic medical records (EMR) databases from January 1, 2013 to December 31, 2015 among 432 adults with SCI in Ontario, Canada. Negative binomial regression analyses were conducted to identify patient or physician factors associated with number of antibiotics prescribed and prescription duration.</p><p><strong>Results: </strong>During the study period, 61.1% of the SCI cohort received an antibiotic prescription from their PCP. There were 59.8% of prescriptions for urinary tract infections (UTI) and 24.6% of prescriptions for fluoroquinolones. Regression analysis found catheter use was associated with increased number of antibiotics prescribed (relative risk [RR] = 3.1; 95% CI, 2.3-4.1; <i>p</i> < .001) and late career PCPs, compared to early-career PCPs, prescribed a significantly longer duration (RR = 1.8; 95% CI, 1.1-3.1; <i>p</i> = .02).</p><p><strong>Conclusion: </strong>UTIs were the number one prescription indication, and fluoroquinolones were the most prescribed antibiotic. Catheter use was associated with number of antibiotics, and PCP's years of practice was associated with duration. The study provided important information about primary care antibiotic prescribing in the SCI population and found that not all individuals received frequent antibiotics prescriptions.</p>","PeriodicalId":46769,"journal":{"name":"Topics in Spinal Cord Injury Rehabilitation","volume":"29 Suppl","pages":"153-164"},"PeriodicalIF":2.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10759849/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139089034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Using Risk Scores to Estimate Lower Extremity Fragility Fracture Risk among Individuals with Chronic Spinal Cord Injury: A Preliminary Model. 使用风险评分估算慢性脊髓损伤患者的下肢脆性骨折风险:初步模型
IF 2.4
Topics in Spinal Cord Injury Rehabilitation Pub Date : 2023-01-01 Epub Date: 2023-11-17 DOI: 10.46292/sci23-00063S
B Catharine Craven, Lora M Giangregorio, Isabelle Côté, Lindsie Blencowe, Masae Miyatani, Mohammad Alavinia
{"title":"Using Risk Scores to Estimate Lower Extremity Fragility Fracture Risk among Individuals with Chronic Spinal Cord Injury: A Preliminary Model.","authors":"B Catharine Craven, Lora M Giangregorio, Isabelle Côté, Lindsie Blencowe, Masae Miyatani, Mohammad Alavinia","doi":"10.46292/sci23-00063S","DOIUrl":"10.46292/sci23-00063S","url":null,"abstract":"<p><strong>Objectives: </strong>To develop SCI-FX, a risk score to estimate 5-year lower extremity fragility fracture risk among patients living with chronic spinal cord injury (cSCI).</p><p><strong>Methods: </strong>Adults with traumatic cSCI (<i>n</i> = 90) participated in a 2-year prospective longitudinal cohort study describing bone mineral density (BMD) change and fracture incidence conducted at the Lyndhurst Centre (University Health Network), University of Waterloo, and Physical Disability Rehabilitation Institute of Québec City. Prior publication and clinical intuition were used to identify fragility fracture risk factors including prior fragility fracture, years post-injury, motor complete injury (AIS A/B), benzodiazepine use, opioid use, and parental osteoporosis. We conducted bivariate analyses to identify variables associated with fracture. Multiple logistic regressions were performed using fragility fracture incidence as the dependent variable and all variables from the univariate analyses with a highly liberal <i>p</i> value at 0.2. Using the odds ratios (ORs) from the multiple logistic regression model, a point system for fragility fracture risk score was developed, and the odds of fracture for each point was estimated.</p><p><strong>Results: </strong>All initial variables, with the exception of benzodiazepine exposure, were included in the final model.</p><p><strong>Conclusion: </strong>We identified a simple preliminary model for clinicians to estimate 5-year fracture risk among patients with cSCI based on their total score.</p>","PeriodicalId":46769,"journal":{"name":"Topics in Spinal Cord Injury Rehabilitation","volume":"29 Suppl","pages":"112-113"},"PeriodicalIF":2.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10759896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139089041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is It Really the Foley? A Systematic Review of Bladder Management and Infection Risk. 真的是 Foley 吗?膀胱管理与感染风险的系统回顾。
IF 2.4
Topics in Spinal Cord Injury Rehabilitation Pub Date : 2023-01-01 Epub Date: 2023-02-15 DOI: 10.46292/sci22-00009
Matthew Davis, Lavina Jethani, Emily Robbins, Mahmut Kaner
{"title":"Is It Really the Foley? A Systematic Review of Bladder Management and Infection Risk.","authors":"Matthew Davis, Lavina Jethani, Emily Robbins, Mahmut Kaner","doi":"10.46292/sci22-00009","DOIUrl":"10.46292/sci22-00009","url":null,"abstract":"<p><strong>Background: </strong>The belief that intermittent catheterization results in fewer infections than indwelling catheters is commonly expressed in the spinal cord injury literature. Some practice guidelines strongly recommend intermittent over indwelling catheterization due to concerns about infections and other complications. However, studies on this topic are of low quality. Guidelines from the Consortium for Spinal Cord Medicine suggest the data regarding infection risk are mixed, and they do not recommend one bladder management method over the other.</p><p><strong>Objectives: </strong>To compare risk of bias in studies reporting higher rates of urinary tract infection (UTI) with indwelling catheters to studies that found equal rates of UTI between indwelling and intermittent catheterization, and to describe implications in clinical decision-making.</p><p><strong>Methods: </strong>A systematic search of PubMed, CINAHL, Embase, and SCOPUS databases from January 1, 1980, to September 15, 2020, was conducted. Eligible studies compared symptomatic UTI rates between indwelling and intermittent catheterization. We used a risk of bias assessment tool to evaluate each study.</p><p><strong>Results: </strong>Twenty-four studies were identified. Only three of these reported significantly higher UTI risk with indwelling catheters, and all three demonstrated a critical risk of bias. More than half of the studies reported differences in UTI risk of less than 20% between the two methods. Studies with larger (nonsignificant) differences favoring intermittent catheterization were more susceptible to bias from confounding.</p><p><strong>Conclusion: </strong>The hypothesis that indwelling catheters cause more UTIs than intermittent catheterization is not supported by the scientific literature. Most studies failed to demonstrate a significant difference in UTI risk, and studies with nonsignificant trends favoring intermittent catheterization were more susceptible to bias from confounding. Perceived risk of infection should not influence a patient's choice of catheter type.</p>","PeriodicalId":46769,"journal":{"name":"Topics in Spinal Cord Injury Rehabilitation","volume":"29 1","pages":"94-107"},"PeriodicalIF":2.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9936901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10777873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Opioid Dependence and Associated Health Care Utilization and Cost in Traumatic Spinal Cord Injury Population: Analysis Using Marketscan Database. 创伤性脊髓损伤人群中的阿片类药物依赖及相关医疗使用和成本:使用 Marketscan 数据库进行分析。
IF 2.9
Topics in Spinal Cord Injury Rehabilitation Pub Date : 2023-01-01 Epub Date: 2023-02-15 DOI: 10.46292/sci22-00026
Riley L Wilkinson, Camilo Castillo, April Herrity, Dengzhi Wang, Mayur Sharma, Nick Dietz, Shawn Adams, Nicholas Khattar, Miriam Nuno, Doniel Drazin, Maxwell Boakye, Beatrice Ugiliweneza
{"title":"Opioid Dependence and Associated Health Care Utilization and Cost in Traumatic Spinal Cord Injury Population: Analysis Using Marketscan Database.","authors":"Riley L Wilkinson, Camilo Castillo, April Herrity, Dengzhi Wang, Mayur Sharma, Nick Dietz, Shawn Adams, Nicholas Khattar, Miriam Nuno, Doniel Drazin, Maxwell Boakye, Beatrice Ugiliweneza","doi":"10.46292/sci22-00026","DOIUrl":"10.46292/sci22-00026","url":null,"abstract":"<p><strong>Background: </strong>Postinjury pain is a well-known debilitating complication of spinal cord injury (SCI), often resulting in long-term, high-dose opioid use with the potential for dependence. There is a gap in knowledge about the risk of opioid dependence and the associated health care utilization and cost in SCI.</p><p><strong>Objectives: </strong>To evaluate the association of SCI with postinjury opioid use and dependence and evaluate the effect of this opioid dependence on postinjury health care utilization.</p><p><strong>Methods: </strong>Using the MarketScan Database, health care utilization claims data were queried to extract 7187 adults with traumatic SCI from 2000 to 2019. Factors associated with post-SCI opioid use and dependence, postinjury health care utilization, and payments were analyzed with generalized linear regression models.</p><p><strong>Results: </strong>After SCI, individuals were more likely to become opioid users or transition from nondependent to dependent users (negative change: 31%) than become nonusers or transition from dependent to nondependent users (positive change: 14%, <i>p</i> < .0001). Individuals who were opioid-dependent users pre-SCI had more than 30 times greater odds of becoming dependent after versus not (OR 34; 95% CI, 26-43). Dependent users after injury (regardless of prior use status) had 2 times higher utilization payments and 1.2 to 6 times more health care utilization than nonusers.</p><p><strong>Conclusion: </strong>Opioid use and dependence were associated with high health care utilization and cost after SCI. Pre-SCI opioid users were more likely to remain users post-SCI and were heavier consumers of health care. Pre- and postopioid use history should be considered for treatment decision-making in all individuals with SCI.</p>","PeriodicalId":46769,"journal":{"name":"Topics in Spinal Cord Injury Rehabilitation","volume":"29 1","pages":"118-130"},"PeriodicalIF":2.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9936895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10777876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Scoping Review of Epidural Spinal Cord Stimulation for Improving Motor and Voiding Function Following Spinal Cord Injury. 硬膜外脊髓刺激改善脊髓损伤后运动和排尿功能的范围综述。
IF 2.9
Topics in Spinal Cord Injury Rehabilitation Pub Date : 2023-01-01 Epub Date: 2023-05-15 DOI: 10.46292/sci22-00061
Nina D'hondt, Karmi Margaret Marcial, Nimish Mittal, Matteo Costanzi, Yasmine Hoydonckx, Pranab Kumar, Marina F Englesakis, Anthony Burns, Anuj Bhatia
{"title":"A Scoping Review of Epidural Spinal Cord Stimulation for Improving Motor and Voiding Function Following Spinal Cord Injury.","authors":"Nina D'hondt, Karmi Margaret Marcial, Nimish Mittal, Matteo Costanzi, Yasmine Hoydonckx, Pranab Kumar, Marina F Englesakis, Anthony Burns, Anuj Bhatia","doi":"10.46292/sci22-00061","DOIUrl":"10.46292/sci22-00061","url":null,"abstract":"<p><strong>Objectives: </strong>To identify and synthesize the existing evidence on the effectiveness and safety of epidural spinal cord stimulation (SCS) for improving motor and voiding function and reducing spasticity following spinal cord injury (SCI).</p><p><strong>Methods: </strong>This scoping review was performed according to the framework of Arksey and O'Malley. Comprehensive serial searches in multiple databases (MEDLINE, Embase, Cochrane Central, Cochrane Database of Systematic Reviews, LILACS, PubMed, Web of Science, and Scopus) were performed to identify relevant publications that focused on epidural SCS for improving motor function, including spasticity, and voiding deficits in individuals with SCI.</p><p><strong>Results: </strong>Data from 13 case series including 88 individuals with complete or incomplete SCI (American Spinal Injury Association Impairment Scale [AIS] grade A to D) were included. In 12 studies of individuals with SCI, the majority (83 out of 88) demonstrated a variable degree of improvement in volitional motor function with epidural SCS. Two studies, incorporating 27 participants, demonstrated a significant reduction in spasticity with SCS. Two small studies consisting of five and two participants, respectively, demonstrated improved supraspinal control of volitional micturition with SCS.</p><p><strong>Conclusion: </strong>Epidural SCS can enhance central pattern generator activity and lower motor neuron excitability in individuals with SCI. The observed effects of epidural SCS following SCI suggest that the preservation of supraspinal transmission is sufficient for the recovery of volitional motor and voiding function, even in patients with complete SCI. Further research is warranted to evaluate and optimize the parameters for epidural SCS and their impact on individuals with differing degrees of severity of SCI.</p>","PeriodicalId":46769,"journal":{"name":"Topics in Spinal Cord Injury Rehabilitation","volume":"29 2","pages":"12-30"},"PeriodicalIF":2.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9584405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Communicating Standing and Walking Data after Spinal Cord Injury: A Patient-Engaged, Qualitative Study. 脊髓损伤后站立和行走数据的交流:患者参与的定性研究。
IF 2.4
Topics in Spinal Cord Injury Rehabilitation Pub Date : 2023-01-01 Epub Date: 2023-11-17 DOI: 10.46292/sci23-00019S
Katherine Chan, Lovisa Cheung, Chris Taylor, Chelsea Wong, Grace Inglis, Kristen Walden, Kristin E Musselman
{"title":"Communicating Standing and Walking Data after Spinal Cord Injury: A Patient-Engaged, Qualitative Study.","authors":"Katherine Chan, Lovisa Cheung, Chris Taylor, Chelsea Wong, Grace Inglis, Kristen Walden, Kristin E Musselman","doi":"10.46292/sci23-00019S","DOIUrl":"10.46292/sci23-00019S","url":null,"abstract":"<p><strong>Background: </strong>The Standing and Walking Assessment Tool has been implemented by physical therapists across Canada, but there is no standardized communication tool to inform inpatients living with spinal cord injury (SCI) about their standing and walking ability.</p><p><strong>Objectives: </strong>To identify how inpatients with SCI are currently receiving feedback on their standing and walking ability, and to determine if and how they would like to receive information on their standing and walking.</p><p><strong>Methods: </strong>Ontario's Patient Engagement Framework informed study protocol development. Inpatients with SCI were recruited from a rehabilitation centre in Canada. Purposeful sampling considering severity of SCI and sex was adopted. Three to four months following discharge from inpatient rehabilitation, a semi-structured interview was conducted to explore participants'experiences and preferences regarding feedback on standing and walking ability during inpatient SCI rehabilitation. Interviews were audio-recorded and transcribed verbatim. A conventional content analysis was completed.</p><p><strong>Results: </strong>Fifteen individuals with SCI (5 female, 10 male) participated. Four themes emerged from the transcripts: (1) motivation for standing and walking, (2) current standing and walking practice, (3) participant preferences for feedback on standing and walking ability, and (4) perceptions of preexisting tools.</p><p><strong>Conclusion: </strong>Information on standing and walking ability was shared with inpatients with SCI in a variety of ways. Participants identified various preferences for the nature, format, and frequency of feedback concerning standing and walking ability during inpatient rehabilitation, which suggests the need for an individualized approach to communicating this information.</p>","PeriodicalId":46769,"journal":{"name":"Topics in Spinal Cord Injury Rehabilitation","volume":"29 Suppl","pages":"1-14"},"PeriodicalIF":2.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10759847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139089027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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