Archives of Bone and Joint Surgery-ABJS最新文献

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A Novel Mini External Fixation Technique versus Percutaneous Pinning in the Treatment of Phalanx Fracture in Hand. 一种新型微型外固定技术与经皮钉钉治疗手部指骨骨折。
IF 1.6
Archives of Bone and Joint Surgery-ABJS Pub Date : 2026-01-01 DOI: 10.22038/ABJS.2025.91151.4128
Kang Qin, Yichen Xu, Weiqiang Liang
{"title":"A Novel Mini External Fixation Technique versus Percutaneous Pinning in the Treatment of Phalanx Fracture in Hand.","authors":"Kang Qin, Yichen Xu, Weiqiang Liang","doi":"10.22038/ABJS.2025.91151.4128","DOIUrl":"10.22038/ABJS.2025.91151.4128","url":null,"abstract":"","PeriodicalId":46704,"journal":{"name":"Archives of Bone and Joint Surgery-ABJS","volume":"14 2","pages":"165-166"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147869994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Platelet-Rich Plasma: Are We Ahead of the Evidence? 富血小板血浆:我们是否领先于证据?
IF 1.6
Archives of Bone and Joint Surgery-ABJS Pub Date : 2026-01-01 DOI: 10.22038/abjs.2026.95992.4305
Mostafa Shahrezaee, Ali Noroozi-Aghideh
{"title":"Platelet-Rich Plasma: Are We Ahead of the Evidence?","authors":"Mostafa Shahrezaee, Ali Noroozi-Aghideh","doi":"10.22038/abjs.2026.95992.4305","DOIUrl":"10.22038/abjs.2026.95992.4305","url":null,"abstract":"","PeriodicalId":46704,"journal":{"name":"Archives of Bone and Joint Surgery-ABJS","volume":"14 7","pages":"423-425"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13429142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148664136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Conventional Titanium Acetabular Cups vs. Trabecular Titanium Acetabular Cups in Primary Total Hip Arthroplasty: Ten-year Follow-up Clinical and Radiological Results. 常规钛髋臼杯与小梁钛髋臼杯在初次全髋关节置换术中的对比:十年随访临床和放射学结果。
IF 1.6
Archives of Bone and Joint Surgery-ABJS Pub Date : 2026-01-01 DOI: 10.22038/ABJS.2025.89443.4056
Sarah Mills-Gañán, Ricardo Fernández-Fernández, Luis-Rodrigo Merino-Rueda, Pablo Díaz-Freire, Ana Cruz-Pardos, E Carlos Rodriguez-Merchan
{"title":"Conventional Titanium Acetabular Cups vs. Trabecular Titanium Acetabular Cups in Primary Total Hip Arthroplasty: Ten-year Follow-up Clinical and Radiological Results.","authors":"Sarah Mills-Gañán, Ricardo Fernández-Fernández, Luis-Rodrigo Merino-Rueda, Pablo Díaz-Freire, Ana Cruz-Pardos, E Carlos Rodriguez-Merchan","doi":"10.22038/ABJS.2025.89443.4056","DOIUrl":"10.22038/ABJS.2025.89443.4056","url":null,"abstract":"<p><strong>Objectives: </strong>Evidence supporting the use of trabecular titanium acetabular cups in primary total hip arthroplasty (THA) is generally favorable, especially in the short and mid-term. However, certain considerations remain, and long-term data are still unavailable.</p><p><strong>Methods: </strong>A total of 53 THAs in 47 patients performed at our institution between 2011 and 2015 were included and divided into two groups to compare clinical and radiological outcomes. Group A included 15 patients with conventional titanium cups, while Group B comprised 38 patients who received trabecular titanium cups.</p><p><strong>Results: </strong>There were no significant differences between groups regarding demographics, surgical variables, or complication rates. However, patients in Group B were significantly younger and more frequently underwent surgery via a posterolateral approach. Both groups demonstrated significant improvement in Harris Hip Score (HHS) postoperatively (p < 0.05), with Group B showing significantly higher final scores (p < 0.02). Radiographic cup positioning was similar in both groups. Group B exhibited a higher incidence of initial bone-implant gaps in zone 2, which correlated with higher Body Mass Index (p = 0.005) and greater abduction angles (p = 0.03). No osteolysis or component migration was observed. One asymptomatic loosening was noted in Group A. No cup revisions were required in either group during the minimum 10-year follow-up.</p><p><strong>Conclusion: </strong>Both acetabular cup designs achieved excellent long-term clinical and radiological results. In this cohort, tantalum cups were associated with slightly superior functional outcomes, supporting the hypothesis that higher porosity may promote improved biological integration while maintaining implant stability.</p>","PeriodicalId":46704,"journal":{"name":"Archives of Bone and Joint Surgery-ABJS","volume":"14 1","pages":"41-48"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13084178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impact of Vitamin D Supplementation on Postoperative Outcomes Following Total Joint Arthroplasty: A Systematic Review. 维生素D补充对全关节置换术后预后的影响:一项系统综述。
IF 1.6
Archives of Bone and Joint Surgery-ABJS Pub Date : 2026-01-01 DOI: 10.22038/ABJS.2026.89311.4049
Ali Salmani, Yashar Khani, Negarsadat Namazi, Sadra Mohebbi, Negin Ashoori, Amir Mehrvar
{"title":"The Impact of Vitamin D Supplementation on Postoperative Outcomes Following Total Joint Arthroplasty: A Systematic Review.","authors":"Ali Salmani, Yashar Khani, Negarsadat Namazi, Sadra Mohebbi, Negin Ashoori, Amir Mehrvar","doi":"10.22038/ABJS.2026.89311.4049","DOIUrl":"10.22038/ABJS.2026.89311.4049","url":null,"abstract":"<p><strong>Objectives: </strong>This systematic review examines the effects of vitamin D supplementation on postoperative outcomes following total knee and hip arthroplasty, taking into account its role in musculoskeletal health and the high prevalence of vitamin D deficiency among arthroplasty patients.</p><p><strong>Methods: </strong>A comprehensive search of PubMed, Scopus, Embase, and Web of Science was conducted through April 2026. Eligible studies included randomized clinical trials assessing vitamin D supplementation in patients undergoing total knee or hip arthroplasty. Two reviewers independently screened studies, extracted data, and evaluated methodological quality using the Cochrane RoB-2 tool. Due to substantial methodological heterogeneity, a qualitative synthesis was performed.</p><p><strong>Results: </strong>Five randomized controlled trials comprising 519 patients were included. Higher-dose and oral regimens resulted in greater increases in serum 25(OH)D levels, including higher postoperative concentrations with 2000 IU versus 800 IU at 24 months (45.5 vs. 37.1 ng/mL) and with oral versus intramuscular administration of 600,000 IU on postoperative day 14. However, most studies reported no significant between-group differences in functional outcomes, pain scores, complications, or other clinical endpoints. One study demonstrated significantly greater muscle strength in the supplementation group, including hip abductor strength (P = 0.03) and knee extensor strength (P = 0.01).</p><p><strong>Conclusion: </strong>Vitamin D supplementation appears to improve perioperative vitamin D status, particularly with higher-dose and oral regimens. However, current evidence for consistent benefits on broader postoperative functional and clinical outcomes after joint arthroplasty remains limited and inconclusive.</p><p><strong>Level of evidence: </strong>II.</p>","PeriodicalId":46704,"journal":{"name":"Archives of Bone and Joint Surgery-ABJS","volume":"14 9","pages":"571-580"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13596986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149026234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intraarticular Tranexamic Acid in Arthroscopic Knee Procedures: Has There Been Any Progress in the Last 5 Years (2021-2025)? 关节镜下膝关节手术中的关节内氨甲环酸:过去5年(2021-2025)有任何进展吗?
IF 1.6
Archives of Bone and Joint Surgery-ABJS Pub Date : 2026-01-01 DOI: 10.22038/ABJS.2026.93762.4230
E Carlos Rodriguez-Merchan
{"title":"Intraarticular Tranexamic Acid in Arthroscopic Knee Procedures: Has There Been Any Progress in the Last 5 Years (2021-2025)?","authors":"E Carlos Rodriguez-Merchan","doi":"10.22038/ABJS.2026.93762.4230","DOIUrl":"10.22038/ABJS.2026.93762.4230","url":null,"abstract":"","PeriodicalId":46704,"journal":{"name":"Archives of Bone and Joint Surgery-ABJS","volume":"14 8","pages":"488-490"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13544420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148898112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation between Opioid Prescribing Habits and Patient Satisfaction. 阿片类药物处方习惯与患者满意度的关系。
IF 1.6
Archives of Bone and Joint Surgery-ABJS Pub Date : 2026-01-01 DOI: 10.22038/ABJS.2025.83211.3792
Abdo Bachoura, Jacob Tulipan, Daren Aita, Daniel Fletcher, Pedro Beredjiklian
{"title":"Correlation between Opioid Prescribing Habits and Patient Satisfaction.","authors":"Abdo Bachoura, Jacob Tulipan, Daren Aita, Daniel Fletcher, Pedro Beredjiklian","doi":"10.22038/ABJS.2025.83211.3792","DOIUrl":"10.22038/ABJS.2025.83211.3792","url":null,"abstract":"<p><strong>Objectives: </strong>The purpose is to evaluate the correlation between patient-reported satisfaction measures and opioid prescribing practices of hand surgeons.</p><p><strong>Methods: </strong>This retrospective study evaluated the opioid prescription practices of 19 fellowship-trained hand surgeons at a single practice, over a 12-month period. The total number of opioid prescriptions sent, opioid prescriptions per surgery, average total morphine milligram equivalents (MME) prescribed per patient and the average MME per prescription were determined. The correlation coefficients were calculated for the total opioid prescriptions and the likelihood to recommend a physician, the overall service impression and the impression of physician empathy.</p><p><strong>Results: </strong>5,089 patient satisfaction surveys were completed. Pearson's correlation demonstrated the \"likelihood to recommend a surgeon\" exhibited a moderate negative correlation with the total number of opioid prescriptions and the average MME per prescription (R=-0.38, R2=0.142, and R=-0.30, R2=0.089) respectively. Overall service impression exhibited a moderate negative correlation with total opioid prescriptions and average MME per prescription (R=-0.39, R2=0.142, and R=-0.30, R2=0.088), respectively. Perception of physician empathy exhibited a very weak negative correlation with total opioid prescriptions and weak correlation with average MME per prescription (R=-0.06, R2=0.004 and R=-0.29, R2=0.087), respectively. There were no statistically significant differences.</p><p><strong>Conclusion: </strong>This study demonstrated that measures of patient satisfaction did not correlate with opioid prescriptions.</p>","PeriodicalId":46704,"journal":{"name":"Archives of Bone and Joint Surgery-ABJS","volume":"14 1","pages":"49-53"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13084179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Are Standing Spinopelvic Parameters Different in Patients with Hip Osteoarthritis Compared to Healthy Individuals? A Comparative Study. 与健康人相比,髋关节骨关节炎患者的站立性脊柱骨盆参数不同吗?比较研究。
IF 1.6
Archives of Bone and Joint Surgery-ABJS Pub Date : 2026-01-01 DOI: 10.22038/ABJS.2025.82977.3803
Mohammadreza Razzaghof, Hooshmand Zarei, Seyed Mohammadmisagh Moteshakereh, Furqan Mohammed Yaseen Khan, Mohammad Reza Barzegar, Mohammad Ghorbanzadeh, Sm Javad Mortazavi
{"title":"Are Standing Spinopelvic Parameters Different in Patients with Hip Osteoarthritis Compared to Healthy Individuals? A Comparative Study.","authors":"Mohammadreza Razzaghof, Hooshmand Zarei, Seyed Mohammadmisagh Moteshakereh, Furqan Mohammed Yaseen Khan, Mohammad Reza Barzegar, Mohammad Ghorbanzadeh, Sm Javad Mortazavi","doi":"10.22038/ABJS.2025.82977.3803","DOIUrl":"10.22038/ABJS.2025.82977.3803","url":null,"abstract":"<p><strong>Objectives: </strong>This case-control study aimed to investigate standing sagittal spinopelvic alignment in patients with advanced hip osteoarthritis (HOA) and to determine whether their alignment differs from that of healthy individuals.</p><p><strong>Methods: </strong>This study included 240 participants, comprising 120 healthy individuals in the control group and 120 candidates for total hip arthroplasty due to primary HOA in the case group. Pelvic incidence (PI), sacral slope (SS), and pelvic tilt (PT) were measured in both groups using standing lateral X-rays.</p><p><strong>Results: </strong>The demographic characteristics of the two groups were not significantly different. In patients with primary HOA, the mean PI, PT, and SS angles were 52.3 ± 10.1, 9.2 ± 4.2, and 44.4 ± 9.3 degrees, respectively. In the control group, the mean PI, PT, and SS values in were 50.2 ± 8.1, 11.2 ± 5.5, and 39.1 ± 8.5 degrees, respectively. The P-value indicated no significant difference in spinopelvic parameters between the control and case groups.</p><p><strong>Conclusion: </strong>Our study demonstrated that standing spinopelvic parameters do not significantly differ between patients with primary HOA and healthy individuals.</p>","PeriodicalId":46704,"journal":{"name":"Archives of Bone and Joint Surgery-ABJS","volume":"14 1","pages":"54-59"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13084174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Distribution of Caput-Collum-Diaphyseal (CCD) Angles in the Iranian Elderly Population: Implications for Proximal Femoral Nail Design. 伊朗老年人头柱骨干(CCD)角的分布:股骨近端钉设计的意义。
IF 1.6
Archives of Bone and Joint Surgery-ABJS Pub Date : 2026-01-01 DOI: 10.22038/ABJS.2025.89209.4052
Mohammadreza Razzaghof, Seyed Hadi Kalantar, Pooya Hosseini-Monfared, Alireza Mirahmadi, Alireza Talebi, Behzad Nezhad Tabrizi, Erfan Khosravi, Mohammad Poursalehian, Sm Javad Mortazavi
{"title":"The Distribution of Caput-Collum-Diaphyseal (CCD) Angles in the Iranian Elderly Population: Implications for Proximal Femoral Nail Design.","authors":"Mohammadreza Razzaghof, Seyed Hadi Kalantar, Pooya Hosseini-Monfared, Alireza Mirahmadi, Alireza Talebi, Behzad Nezhad Tabrizi, Erfan Khosravi, Mohammad Poursalehian, Sm Javad Mortazavi","doi":"10.22038/ABJS.2025.89209.4052","DOIUrl":"10.22038/ABJS.2025.89209.4052","url":null,"abstract":"<p><strong>Objectives: </strong>Proximal femoral nails (PFNs) are widely used in managing unstable proximal femur fractures. These implants are designed with fixed femoral neck-shaft angles in different sizes, based on anthropometric studies of the Western population. In this study, we aimed to evaluate the Caput-collum-diaphyseal (CCD) angle in the Iranian population and determine whether any design modification for PFNs is needed for this population.</p><p><strong>Methods: </strong>In this retrospective study, we evaluated patients who underwent hip and pelvic radiography at our hospital between 2015 and 2023. The CCD angles were measured on AP pelvic and hip radiographs. The mean CCD angle of the Iranian population was calculated. Correlation analysis was also conducted to evaluate the CCD angle in different age and sex groups.</p><p><strong>Results: </strong>The CCD angle was evaluated in 1040 patients with a median age of 72 (range 60-99) in this study. The mean CCD angle in the Iranian population was 130.6 ± 5.9 (range: 115.4-149). 117 (11.3%) of the patients had Coxa Vara or Coxa Valga. The CCD angles did not differ significantly between men and women. We observed a significant correlation between the patient's age and the CCD angle. It was found that 20.35% of our population's CCD is not covered by the most commonly available Western PFN designs.</p><p><strong>Conclusion: </strong>This study's findings demonstrated that the Iranian population's mean CCD angle is higher than in Western countries. Therefore, future PFN designs should consider the CCD angles of the specific populations.</p>","PeriodicalId":46704,"journal":{"name":"Archives of Bone and Joint Surgery-ABJS","volume":"14 7","pages":"457-463"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13429149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148664478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-Term Outcomes of Pyrocarbon Hemiarthroplasty in a Young Patient with Severe Chondrolysis. 热炭半关节置换术治疗严重软骨溶解的年轻患者的长期疗效。
IF 1.6
Archives of Bone and Joint Surgery-ABJS Pub Date : 2026-01-01 DOI: 10.22038/ABJS.2024.82753.3766
Mohamad Y Fares, Peter Boufadel, Joseph A Abboud
{"title":"Long-Term Outcomes of Pyrocarbon Hemiarthroplasty in a Young Patient with Severe Chondrolysis.","authors":"Mohamad Y Fares, Peter Boufadel, Joseph A Abboud","doi":"10.22038/ABJS.2024.82753.3766","DOIUrl":"10.22038/ABJS.2024.82753.3766","url":null,"abstract":"<p><p>Pyrocarbon hemiarthroplasty is a novel procedure that has shown promise for the complex cases of young patients with severe shoulder arthritis. This prosthesis aims to overcome challenges faced by conventional hemiarthroplasty designs, particularly the issue of significant glenoid arthrosis over time. Results of the pyrocarbon hemiarthroplasty have generally shown good promise, but there has been a scarcity in studies and reports that explore the long-term outcomes of this procedure. In this report, we describe the case of a young male patient who underwent a pyrocarbon hemiarthroplasty for significant glenohumeral chondrolysis. The patient underwent the procedure and was able to demonstrate seven-year postoperative outcomes, reporting an American Shoulder and Elbow Surgeon's score of 97, a single assessment numeric evaluation score of 95 and a visual analogue scale pain score of 0 at final follow-up. Radiological imaging revealed some progressive glenoid arthrosis and superior glenoid erosion over the course of seven years.</p>","PeriodicalId":46704,"journal":{"name":"Archives of Bone and Joint Surgery-ABJS","volume":"14 5","pages":"363-370"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13240993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148200463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Vitamin C Supplementation in Total Knee Arthroplasty Outcomes: A Systematic Review of Randomized Controlled Trials. 补充维生素C在全膝关节置换术结果中的作用:随机对照试验的系统回顾。
IF 1.6
Archives of Bone and Joint Surgery-ABJS Pub Date : 2026-01-01 DOI: 10.22038/ABJS.2025.92058.4177
Fardis Vosoughi, Golnaz Nikeghbalii, Mohammadhasan Sharafi, Ehsan Najafi, Iman Menbari Oskouie
{"title":"The Role of Vitamin C Supplementation in Total Knee Arthroplasty Outcomes: A Systematic Review of Randomized Controlled Trials.","authors":"Fardis Vosoughi, Golnaz Nikeghbalii, Mohammadhasan Sharafi, Ehsan Najafi, Iman Menbari Oskouie","doi":"10.22038/ABJS.2025.92058.4177","DOIUrl":"10.22038/ABJS.2025.92058.4177","url":null,"abstract":"<p><strong>Objectives: </strong>Oxidative stress, inflammation, and endothelial dysfunction contribute to perioperative morbidity following total knee arthroplasty (TKA). Vitamin C (ascorbic acid), an essential antioxidant cofactor, has been proposed to mitigate these pathways. This systematic review evaluates current evidence on perioperative vitamin C supplementation in TKA and its effects on pain, inflammation, blood loss, and postoperative recovery.</p><p><strong>Methods: </strong>A systematic search of PubMed, Embase, Scopus, and Web of Science was conducted from database inception through July 2025, following PRISMA 2020 guidelines. Randomized controlled trials (RCTs) assessing perioperative vitamin C use in primary TKA were included. Methodologic quality was appraised using the Cochrane Risk-of-Bias tool (RoB 2). Owing to heterogeneity in dosing, timing, and outcomes, results were synthesized narratively.</p><p><strong>Results: </strong>Ten RCTs involving 1,364 patients met the inclusion criteria. Vitamin C administration varied substantially in dose, route, and timing. Across studies, findings for postoperative pain, inflammatory markers, blood loss, and functional recovery were inconsistent. Several reported numerical trends favors vitamin C, but most outcomes lacked statistical significance or were supported by a single study. Evidence for reduced complex regional pain syndrome (CRPS) was more consistent but still limited by small sample sizes. No major safety concerns were identified.</p><p><strong>Conclusion: </strong>Current evidence does not support a definitive benefit of perioperative vitamin C supplementation in TKA. While isolated studies suggest potential reductions in inflammation, blood loss, or pain, these findings are not consistent across trials and often lack statistical significance. Larger, methodologically sound RCTs with standardized dosing protocols are needed before recommending vitamin C as a routine perioperative supplement.</p>","PeriodicalId":46704,"journal":{"name":"Archives of Bone and Joint Surgery-ABJS","volume":"14 3","pages":"170-178"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13168806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147943260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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