Clinical Neuropsychiatry最新文献

{"title":"Intellectual Profiles in Children with Unilateral and Bilateral Cerebral Palsy: A Multilevel Analysis of the Wisc-Iv Scale.","authors":"Maria Chiara Di Lieto, Costanza Rufini, Elisa Matteucci, Benedetta Del Lucchese, Elena Beani, Veronica Barzacchi, Antea Scrocco, Chiara Pecini, Giuseppina Sgandurra","doi":"10.36131/cnfioritieditore20260204","DOIUrl":"10.36131/cnfioritieditore20260204","url":null,"abstract":"<p><strong>Objective: </strong>Cerebral palsy (CP) is a neurodevelopmental disorder primarily affecting motor functioning and often accompanied by cognitive impairments. Although intellectual profiles in children with CP are known to be heterogeneous, standard intelligence assessments often rely on a single global IQ score, which may obscure important intra-individual differences and limit clinical usefulness. This study aimed to explore intellectual functioning in children with unilateral and bilateral spastic cerebral palsy using a detailed multi-level analysis to examine how motor impairments may influence performance on WISC-IV indices and subtests.</p><p><strong>Method: </strong>A cross-sectional study was conducted on 48 children aged 6-15 years with spastic cerebral palsy (24 unilateral, 24 bilateral). Inclusion required at least one WISC-IV index score above 80. Intellectual functioning was assessed through Full Scale IQ, four cognitive indices (verbal comprehension, perceptual reasoning, working memory, processing speed), and individual subtests. Participants were classified by cerebral palsy type and gross motor function level. Descriptive and comparative statistics identified significant group differences.</p><p><strong>Results: </strong>Intellectual profiles showed marked heterogeneity. Over half of the children showed marked discrepancies among WISC-IV index scores, making the Full Scale IQ difficult to interpret as a representation of their overall cognitive functioning. Working Memory and Processing Speed were the most frequently impaired indices. Processing Speed deficits were consistent across CP types and motor levels, while Working Memory impairments were more pronounced in children with bilateral CP. Perceptual and verbal reasoning differences were more evident in bilateral cases. Greater motor impairment correlated with lower Perceptual Reasoning and Processing Speed scores, highlighting the influence of motor functioning on performance.</p><p><strong>Conclusions: </strong>Detailed, multi-level assessments of WISC-IV performance provides a clearer understanding of cognitive functioning in children with CP. Considering indices and subtests in relation to motor constraints helps distinguish true cognitive abilities from motor-related limitations, supporting accurate diagnosis and targeted interventions.</p>","PeriodicalId":46700,"journal":{"name":"Clinical Neuropsychiatry","volume":"23 2","pages":"154-164"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13116283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Pleiotropic Role of KIF21B in Schizophrenia and Multiple Sclerosis: A Bioinformatics Analysis.","authors":"Ela Doruk Korkmaz, Elif Everest","doi":"10.36131/cnfioritieditore20260202","DOIUrl":"10.36131/cnfioritieditore20260202","url":null,"abstract":"<p><strong>Objective: </strong>Genome-wide association studies have identified shared genetic risk loci between schizophrenia (SCZ) and multiple sclerosis (MS), suggesting overlapping biological mechanisms despite distinct clinical presentations. Here, we aimed to characterize the biological plausibility of <i>KIF21B</i> as a shared genetic risk gene for SCZ and MS, two disorders with overlapping genetic risk loci despite distinct clinical presentations.</p><p><strong>Method: </strong>We performed bioinformatics analyses of <i>KIF21B</i> using publicly available data from GTEx, STRING, and the GWAS Catalog, including tissue-specific expression profiling, protein interaction network analysis, transcriptome-wide co-expression analysis, and phenome-wide association analysis.</p><p><strong>Results: </strong><i>KIF21B</i> expression was significantly enriched in both brain and immune tissues compared to other tissue types. Protein interaction network analysis demonstrated that <i>KIF21B</i> functions within microtubule-based transport machinery essential for axonal function. Co-expression analysis identified significant correlation with immune-related genes, including the established MS susceptibility gene <i>ANKRD55</i>, with pathway enrichment for T cell activation and lymphocyte diferentiation. Phenome-wide association analysis confirmed <i>KIF21B</i> pleiotropy across multiple autoimmune and psychiatric conditions.</p><p><strong>Conclusions: </strong>These findings support <i>KIF21B</i> as a biologically plausible shared risk gene whose dual neural and immune functions may contribute to susceptibility for both neuropsychiatric and autoimmune diseases of the central nervous system.</p>","PeriodicalId":46700,"journal":{"name":"Clinical Neuropsychiatry","volume":"23 2","pages":"136-143"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13116282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Multi-Method Meta-Analysis of Neuro-Behavioral Motor Inhibition Outcomes Across Substance-Use Problems and Related Developmental Psychopathological Conditions: A Self-Regulation Approach.","authors":"Marco Cavicchioli, Sara Masoumi, Cesare Maffei, Simona Scaini, Federica Galli, Andrea Scalabrini","doi":"10.36131/cnfioritieditore20260206","DOIUrl":"10.36131/cnfioritieditore20260206","url":null,"abstract":"<p><strong>Objectives: </strong>Alterations in motor inhibition (MI) may be involved in the homotypic and heterotypic developmental pathways of substance use disorders (SUDs) and related conditions (e.g., binge drinking). However, no studies have clarified the neuro-behavioral correlates of MI across the various conditions (e.g., ADHD and major depressive disorder in childhood/adolescence) constituting developmental trajectories of SUDs and related problems, especially within a self-regulation conceptual framework.</p><p><strong>Method: </strong>A multi-method meta-analysis (i.e., voxel-based, network, and multilevel) of MI tasks (i.e., Go/No-Go; Stop Signal) was conducted. Neuroimaging (fMRI) and event-related potential (ERP) data were analyzed. The study included children and adolescents with ADHD, adolescents with major depressive disorder, and subjects with SUDs and related conditions.</p><p><strong>Results: </strong>Sixty-eight studies (fMRI: 42; ERPs: 26) were included. The analysis showed a shared increased responsiveness of the rostral anterior cingulate cortex among conditions of interest during \"No-Go\" trials compared to healthy controls (HCs). Reduced N200/P300 waves, together with increased reaction times in response to MI task experimental conditions, were found among conditions of interest compared to HCs. Network meta-analysis results showed that distinct patterns of neural activity linked to different self-regulation domains differentiated these clinical conditions from one another.</p><p><strong>Conclusions: </strong>Common and distinct patterns of neuro-behavioral responses associated with self-regulation mechanisms, especially regarding MI, should be considered key latent dimensions involved in the homotypic and heterotypic developmental pathways of SUDs and related problems.</p>","PeriodicalId":46700,"journal":{"name":"Clinical Neuropsychiatry","volume":"23 2","pages":"182-192"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13116279/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smartphone And Internet Addiction, Social Support, And Mental Health Among Health Science Students: A Structural Equation Modeling Approach.","authors":"Huynh Ngoc Linh, Ngo Thi Tam, Tran Quoc Thang, Nguyen Thi Lan Huong, Nguyen Bich Nguyet, Hoang Duc Hanh","doi":"10.36131/cnfioritieditore20260107","DOIUrl":"10.36131/cnfioritieditore20260107","url":null,"abstract":"<p><strong>Objective: </strong>This study assessed smartphone addiction, internet addiction, eHealth literacy, social support, loneliness, depression, and sleep quality among health sciences students, and examined their structural relationships using structural equation modeling (SEM).</p><p><strong>Method: </strong>A cross-sectional survey was conducted among 447 Medicine, Nursing, and Pharmacy students at a university in Hanoi. Data were collected using a self-administered paper questionnaire incorporating validated instruments: SAS-SV, IAT-6, eHEALS, DUFSSQ-8, UCLA-3, PHQ-9, and B-PSQI. Descriptive statistics, correlation analyses, and SEM were performed using Stata 17 and SmartPLS 3.0.</p><p><strong>Results: </strong>Participants reported moderate levels of smartphone addiction (35.7 ± 8.9) and internet addiction (13.1 ± 4.8). Internet addiction demonstrated direct effects on higher depression (β = 0.36, p < 0.001), poorer sleep quality (β = 0.27, p < 0.001), and lower social support (β = -0.25, p < 0.001). Smartphone addiction was positively associated with eHealth literacy (β = 0.21, p < 0.001) and loneliness (β = 0.16, p = 0.003). Social support showed strong inverse associations with depression, loneliness, and poor sleep, and mediated the effects of internet addiction on all three outcomes. eHealth literacy did not attenuate adverse effects.</p><p><strong>Conclusions: </strong>Among Vietnamese health science students, problematic smartphone and internet use is associated with greater loneliness, depressive symptoms, and sleep disturbances. Enhancing social support ‒ rather than relying solely on eHealth literacy ‒ appears critical to reducing these harms. Universities should implement strategies that foster digital well-being, limit problematic technology use, and strengthen peer connectedness and supportive campus environments.</p>","PeriodicalId":46700,"journal":{"name":"Clinical Neuropsychiatry","volume":"23 1","pages":"69-76"},"PeriodicalIF":3.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12937498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147327641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why The Polyvagal Theory Is Untenable: An international expert evaluation of the polyvagal theory and commentary upon Porges, S.W. (2025). Polyvagal theory: current status, clinical applications, and future directions. Clin. Neuropsychiatry, 22(3), 169-184.","authors":"Paul Grossman, Gareth L Ackland, Andrew M Allen, Gary G Berntson Berntson, Lindsea C Booth, Gordon M Burghardt, Julie Buron, Vladimir Dinets, J Sean Doody, Mathias Dutschmann, David G S Farmer, James P Fisher, Alexander V Gourine, Michael J Joyner, John M Karemaker, Sahib S Khalsa, Edward G Lakatta, Cleo A C Leite, Vaughan G Macefield, Benedito H Machado, Robin M Machado, Clément Menuet, David Mendelowitz, Davi J A Moraes, Winfried Neuhuber, Matteo M Ottaviani, David J Paterson, Julian F Paton Paton, Peter R Pellegrino, Rohit Ramchandra, Julia Shanks, James S Schwaber, Kalyanam Shivkumar, K Michael Spyer, Edwin W Taylor, J Andrew Taylor, Tobias Wang, Song T Yao, Irving H Zucker","doi":"10.36131/cnfioritieditore20260110","DOIUrl":"10.36131/cnfioritieditore20260110","url":null,"abstract":"<p><p>Thirty-nine highly acknowledged experts in the areas of the physiology and the evolution of the vagus nerve and of vertebrate social behavior (many whose works have been cited in the polyvagal theory [PVT] literature as supporting the theory) were invited by the first author to participate as co-authors of this article. They were asked to evaluate the PVT and comment upon an overview of the theory written by its author (Porges, 2025a). All those invited, save one, accepted and co-authored the paper. The dissenting scholar was \"unfamiliar with the PVT.\" This article specifically appraises--based upon the current state of knowledge of autonomic function and vertebrate evolution--several major elements of the PVT, as described in Porges (2025a) and elsewhere. These include: 1) the validity of PVT assumptions that respiratory sinus arrhythmia is a direct measure of the extent of central vagal drive to the heart; 2) PVT characterizations regarding the neuroanatomy and functions of two major brainstem vagal nuclei, the ventrally situated Nucleus Ambiguus and the Dorsal Motor Nucleus of the vagus nerve; 3) PVT assertions regarding the evolution of the vagus nerve; 4) PVT claims about the specificity of mammalian social behavior in relation to nonmammalian vertebrates, and 5) PVT interpretations of earlier seminal physiological literature. All co-authors agree that major tenets of the PVT are not supported by past or current knowledge and, in several instances, are inconsistent with the broader evidence base. Since the topics addressed constitute fundamental premises of the PVT, we conclude that the PVT is untenable, because it is not defensible based on existing neurophysiological and evolutionary evidence. The psychological elements composing the superstructure of the PVT are primarily derived from earlier psychological literature and are neither clarified nor strengthened by PVT constructs that lack evidence. This article does not intend to address alternative explanations about relations between vagal function and psychological processes, although such explanations do exist.</p>","PeriodicalId":46700,"journal":{"name":"Clinical Neuropsychiatry","volume":"23 1","pages":"100-112"},"PeriodicalIF":3.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12937499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147327624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep Quality And Its Associated Factors In Patients With Systemic Lupus Erythematosus.","authors":"Lai Thuy Duong, Nguyen Thi Phuong Thuy, Duong Minh Tam, Tran Thi Thu Ha, Pham Thi Minh Nham, Cao Thi Trinh, Nguyen Hoang Thanh","doi":"10.36131/cnfioritieditore20260105","DOIUrl":"10.36131/cnfioritieditore20260105","url":null,"abstract":"<p><strong>Objective: </strong>To assess the prevalence of poor sleep quality and identify associated factors among patients with systemic lupus erythematosus (SLE).</p><p><strong>Method: </strong>A cross-sectional study was conducted at Bach Mai Hospital, Vietnam, from January 2024 to December 2024. Adult SLE patients meeting the ACR/EULAR 2019 classification criteria were consecutively enrolled. Data were collected on sociodemographic, clinical, behavioral, and psychological characteristics. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI), with a global score >5 indicating poor sleep. Depression and anxiety were measured using the Beck Depression Inventory-II (BDI-II) and Hamilton Anxiety Rating Scale (HAM-A), respectively. Multivariate logistic and Tobit regression analyses were performed to identify factors associated with poor sleep quality and PSQI score.</p><p><strong>Results: </strong>A total of 453 SLE patients participated, of whom 66.7% exhibited poor sleep quality. In multivariate regression, poor sleep quality was independently associated with older age (OR: 1.05, 95% CI: 1.02-1.07), higher disease activity (SLEDAI; OR: 1.04, 95% CI: 1.01-1.06), greater organ damage (SLICC/ACR index; OR: 1.17, 95% CI: 1.02-1.34), and higher anxiety severity (mild: OR 2.51, moderate: OR 3.53). Alcohol use (OR: 0.24, 95% CI: 0.07-0.90) and opioid use (OR: 0.08, 95% CI: 0.01-0.99) were associated with lower odds of poor sleep quality. For PSQI score, worse sleep quality was significantly associated with older age (Coef.: 0.09, 95% CI: 0.06-0.11), more frequent lupus flares (2 episodes: Coef. 1.14; ≥3 episodes: Coef. 1.76), and higher anxiety severity (mild: 1.82; moderate: 2.34; severe: 3.99).</p><p><strong>Conclusions: </strong>Multidisciplinary approaches targeting psychological well-being, disease control, and healthy lifestyle behaviors are essential to improve sleep and quality of life in this population.</p>","PeriodicalId":46700,"journal":{"name":"Clinical Neuropsychiatry","volume":"23 1","pages":"56-62"},"PeriodicalIF":3.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12937497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147327560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Narrative Identity Development In Adolescents And Young Adults: A Scoping Review.","authors":"Cecilia Maria Esposito, Giovanni Stanghellini","doi":"10.36131/cnfioritieditore20260102","DOIUrl":"10.36131/cnfioritieditore20260102","url":null,"abstract":"<p><strong>Objective: </strong>Adolescence is a vulnerable phase of life, especially in relation to the development of personal identity. Researchers and clinicians must pay close attention to how the perception of time, the organization of events and information into a coherent narrative, and the development of self-representations unfold during this period of life. Aim of the present review is to summarize the research evidence about narrative identity development in healthy adolescents and discuss this in the framework of contemporary socio-cultural changes.</p><p><strong>Method: </strong>Conducted as a scoping review following the PRISMA-ScR guidelines, a literature search was performed in PubMed without predefined restrictions. Eligibility criteria included original human studies in English, involving non-clinical participants aged 11-22 years. Twenty-six studies met inclusion criteria and were analyzed regarding narrative coherence, narrative self-awareness, and developmental trajectories.</p><p><strong>Results: </strong>Among the included studies we identified two main areas of investigation, that are narrative coherence and narrative self-awareness. Studies about narrative coherence generally show an age-related increase. Narrative self-awareness development was found to be related to the influence of the environment and to psychological well-being from adolescents to adulthood.</p><p><strong>Conclusions: </strong>Anomalies of narrative identity have been studied in psychopathological contexts but are understudied in healthy adolescents. Given that narrative identity development is influenced by the environment, and in light of rapid socio-cultural changes (e.g., digitalization and episodic temporal modes), more research is needed to explore how contemporary conditions affect identity construction in adolescents. The findings highlight developmental patterns in narrative identity that reflect both maturational processes and socio-cultural influences. Refining our understanding of these dynamics can guide future longitudinal studies and inform identity-focused interventions in adolescent mental health.</p>","PeriodicalId":46700,"journal":{"name":"Clinical Neuropsychiatry","volume":"23 1","pages":"14-29"},"PeriodicalIF":3.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12937495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147327360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Roles Of Adverse Childhood Experiences And Early Maladaptive Schemas In Antisocial Personality Disorder: A Systematic Review.","authors":"Marianna Aceto, Nicole Loren Angelo, Andrea Gragnani","doi":"10.36131/cnfioritieditore20260103","DOIUrl":"10.36131/cnfioritieditore20260103","url":null,"abstract":"<p><strong>Objective: </strong>Antisocial personality disorder (ASPD) is characterized by a pattern of negligence towards social norms, illicit and aggressive conduct, and lack of remorse. Adverse Childhood Experiences (ACEs) and subsequent development of Early Maladaptive Schemas (EMS) play a significant role in psychopathology vulnerability, including personality disorders. However, the evidence on the link between cognitive and environmental vulnerability in ASPD specifically is still limited. The aim of the present review is to analyze and discuss the available literature exploring the role of specific ACEs and EMSs in the development of ASPD and investigate the possible mediating role of cognitive variables between environmental factors and ASPD.</p><p><strong>Method: </strong>A systematic analysis was conducted of records published from January 1st, 2002 to March 18th, 2025 on APAJournals, MEDLINE, Google Scholar, PubMed, using keywords pertaining to three concepts: \"antisocial personality disorder\", \"early maladaptive schema/schema mode\", \"adverse childhood experiences\".</p><p><strong>Results: </strong>A total of 7719 records were screened, while 229 records were analyzed against our eligibility criteria, resulting in the inclusion of 26 records. The studies emphasize the contribution of physical abuse, and Disconnection/Rejection and Impaired limits domains in the etiology of ASPD. Regarding the mediation between ACEs and ASPD, various studies focused on dysfunctional schema-modes, finding that Child, Over-compensatory, and Healthy Adult modes play a role in ASPD, highlighting the relevance of maladaptive coping and rapid emotional fluctuation in the disorder.</p><p><strong>Conclusions: </strong>The results enhance our understanding of the contribution of ACEs and EMS in the development of ASPD; however, evidence of a link between cognitive and environmental variables in the development of the disorder is scarce and heterogeneous. Going forward, studies should particularly investigate environmental and cognitive vulnerability to promote a greater understanding of ASPD functioning and tailor clinical interventions based on specific hyper-invested goals and the learned maladaptive coping strategies to pursue them.</p>","PeriodicalId":46700,"journal":{"name":"Clinical Neuropsychiatry","volume":"23 1","pages":"30-48"},"PeriodicalIF":3.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12937500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147327465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Internal States In Children With Neuromuscular Disorders Through An Oral Narrative Task.","authors":"Paola Cristofani, Costanza Ruffini, Bianca Buchignani, Guja Astrea, Bianca Noli, Benedetta Magozzi, Chiara Pecini, Roberta Battini","doi":"10.36131/cnfioritieditore20260101","DOIUrl":"10.36131/cnfioritieditore20260101","url":null,"abstract":"<p><strong>Objective: </strong>Neuromuscular disorders (NMD) are rare, chronic diseases affecting muscle and nerve function, leading to motor, cognitive, and socio-emotional challenges. While physical and cognitive aspects have been widely studied, socio-emotional functioning remains underexplored. This study assessed the feasibility of using invented oral stories to examine internal state language in children with NMD compared to typically developing peers.</p><p><strong>Method: </strong>Forty 5-12 years old children (20 with NMD, 20 typically developing) spontaneously narrated fictional stories, analyzed for structure, cohesion, and psychological lexicon that refers to words expressing internal mental and emotional states.</p><p><strong>Results: </strong>Results showed no significant differences in narrative structure or cohesion, supporting the feasibility of oral storytelling. However, children with NMD used more physiological and socio-relational terms, emphasizing their attention to bodily experiences and social interactions as coping strategies.</p><p><strong>Conclusions: </strong>These findings highlight oral narratives as a valuable tool to access socio-emotional development in children with NMD through narrative-based interventions.</p>","PeriodicalId":46700,"journal":{"name":"Clinical Neuropsychiatry","volume":"23 1","pages":"3-13"},"PeriodicalIF":3.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12937491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147327737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants Of Cognitive Impairment Among Older Adults In Hanoi, Vietnam: Insights From The Montreal Cognitive Assessment.","authors":"Doan Thi Hue, Le Thi Thu Ha, Nguyen Van Tuan, Nguyen Van Phi, Le Cong Thien, Nguyen Hoang Yen, Nguyen Thi Hoa, Nguyen Thu Ha, Tran Thi Thu Ha, Tran Thi Thu Huong, Nguyen Hoang Thanh","doi":"10.36131/cnfioritieditore20260106","DOIUrl":"10.36131/cnfioritieditore20260106","url":null,"abstract":"<p><strong>Objective: </strong>Cognitive impairment is a growing public health concern among aging populations, yet evidence from Vietnam remains limited. This study aimed to assess the prevalence of cognitive impairment among older adults in Hanoi and identify demographic, socioeconomic, lifestyle, and health-related determinants.</p><p><strong>Method: </strong>A cross-sectional study was conducted among 763 adults aged ≥60 years from one urban ward and one rural commune in Hanoi (June-December 2023). Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA), with impairment classified into mild, moderate, and severe levels. Mental health, anxiety, and sleep quality were measured using the PHQ-9, GAD-7, and PSQI. Multivariate logistic regression with stepwise forward selection identified independent predictors of cognitive impairment.</p><p><strong>Results: </strong>Cognitive impairment was highly prevalent, affecting 70.4% of participants (46.1% mild, 19.3% moderate, 5.0% severe). Mean MoCA score was 21.3 (SD=6.3). Age was the strongest predictor (OR=1.11 per year, 95% CI: 1.08-1.15). Female gender (OR=1.63, 95% CI: 1.09-2.44), lower education (OR=0.58 for >high school vs <high school, 95% CI: 0.34-1.00), rural residence (OR=0.58, 95% CI: 0.34-0.99), and lack of pension income (OR=0.54, 95% CI: 0.32-0.93) were significant socioeconomic risk factors. Physical inactivity showed the largest effect size (OR=3.18, 95% CI: 1.34-7.55). Poor sleep quality (OR=1.62, 95% CI: 1.11-2.36) and mental health disorders (OR=1.91, 95% CI: 1.05-3.49) were also independently associated. No significant association was found with COVID-19 status.</p><p><strong>Conclusions: </strong>Cognitive impairment is widespread among older adults in Hanoi and is shaped by demographic, socioeconomic, and modifiable health factors. Interventions to promote physical activity, mental health, and economic security, alongside improved access to screening and elder care in rural areas, are essential for supporting healthy cognitive aging in Vietnam.</p>","PeriodicalId":46700,"journal":{"name":"Clinical Neuropsychiatry","volume":"23 1","pages":"63-68"},"PeriodicalIF":3.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12937493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147327709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}