Clinical Neuropsychiatry最新文献

{"title":"Article Highlights.","authors":"Giulia Zanatta","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":46700,"journal":{"name":"Clinical Neuropsychiatry","volume":"20 1","pages":"5-6"},"PeriodicalIF":6.1,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10016096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9498905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symptoms of Prolonged Social Withdrawal, Problematic Internet Use, and Psychotic-Like Experiences in Emerging Adulthood: A Moderation Model.","authors":"Simone Amendola,&nbsp;Rita Cerutti,&nbsp;Fabio Presaghi","doi":"10.36131/cnfioritieditore20230104","DOIUrl":"https://doi.org/10.36131/cnfioritieditore20230104","url":null,"abstract":"<p><strong>Objective: </strong>Prolonged social withdrawal (PSW) or <i>hikikomori</i> and problematic internet use (PIU) have attracted the attention of mental health experts worldwide. The scientific literature suggests a complex relationship between these conditions and psychotic-like experiences (PLEs) or disorders. In the present cross-sectional study, we tested the role of PIU symptoms as a moderator of the relationship between symptoms of PSW and PLEs in a sample of 238 Italian emerging adults.</p><p><strong>Method: </strong>Data was collected using the 25-item Hikikomori Questionnaire, the Internet Disorder Scale, the Brief Prodromal Questionnaire, and the Brief Symptom Inventory. In addition, lifetime psychological disorders and drug and alcohol use during the last month were explored. No participant reported a lifetime episode of schizophrenia or other psychotic disorder.</p><p><strong>Results: </strong>Symptoms of PSW and PIU were significantly associated with PLEs total distress and PLEs total number of symptoms endorsed, after adjustment for age and symptoms of depression and anxiety. Further, PIU symptoms moderated the relationship between symptoms of PSW and PLEs total distress (b= 2.745, s.e.= 1.089, p= 0.012). However, PIU symptoms did not moderate the relationship between PSW and PLEs total symptoms (b= 0.615, s.e.= 0.349, p= 0.078). This study is limited because the participants were most likely university students and because of the cross-sectional design.</p><p><strong>Conclusions: </strong>Findings from this study partially support the role of high symptoms of PIU as a risk factor in the relationship between symptoms of PSW and PLEs. Future longitudinal research is needed to confirm our findings examining the temporal relationship between PSW, PIU, and PLEs using both dimensional and categorical approaches.</p>","PeriodicalId":46700,"journal":{"name":"Clinical Neuropsychiatry","volume":"20 1","pages":"29-38"},"PeriodicalIF":6.1,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10016104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9498911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric Properties of the Italian Version of the Emiq-Hp (Exercise in Mental Illness Questionnaire-Health Professionals Version) to Investigate the Views of Health Professionals Regarding Exercise for Treatment of Mental Illness.","authors":"Attilio Carraro,&nbsp;Erica Gobbi,&nbsp;Robert Stanton,&nbsp;Giampaolo Santi,&nbsp;Simon Rosenbaum","doi":"10.36131/cnfioritieditore20230107","DOIUrl":"https://doi.org/10.36131/cnfioritieditore20230107","url":null,"abstract":"<p><strong>Objective: </strong>People with mental illness experience a significantly increased mortality rate, partly attributable to high rates of premature metabolic disease. Exercise is increasingly recognized as an evidence-based component of treatment for improving both physical and mental illness. Ensuring health care staff have the necessary competence to support and promote exercise is critical to successful implementation. The Exercise in Mental Illness Questionnaire-Health Professionals Version (EMIQ-HP) was developed to determine the knowledge, attitudes, barriers, and behaviors of health practitioners regarding the role of exercise in the treatment for mental illness. This study aimed to translate and validate the questionnaire into Italian language (EMIQ-HP-IT) and to determine its test-retest reliability.</p><p><strong>Method: </strong>The questionnaire was translated from English to Italian then back translated using an established protocol. To determine the test-retest reliability of the EMIQ-HP-IT, mental health professionals from an Italian psychiatric hospital completed the questionnaire on two separate occasions, seven days apart. Intra-class correlation coefficients (ICC) were calculated for each item. Twenty-five mental health professionals (4 psychiatrists, 9 psychologists, 10 nurses and 2 exercise specialists) completed the EMIQ-HP-IT.</p><p><strong>Results: </strong>Except for two items, ICCs ranged from 0.48 to 0.92. The test-retest reliability of the EMIQ-HP-IT demonstrated comparable results to the English version.</p><p><strong>Conclusions: </strong>The EMIQ-HP-IT is a reliable measure of practitioners' knowledge, attitudes, beliefs, and behaviors regarding exercise interventions for people with mental illness.</p>","PeriodicalId":46700,"journal":{"name":"Clinical Neuropsychiatry","volume":"20 1","pages":"55-60"},"PeriodicalIF":6.1,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10016097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9514485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Internet Use Amongst Professional Tennis Players.","authors":"Donatella Marazziti,&nbsp;Elisabetta Parra,&nbsp;Alessandro Arone,&nbsp;Manuel Glauco Carbone,&nbsp;Luca Del Prete,&nbsp;Sara Fantasia,&nbsp;Stefania Palermo,&nbsp;Liliana Dell'Osso","doi":"10.36131/cnfioritieditore20230102","DOIUrl":"https://doi.org/10.36131/cnfioritieditore20230102","url":null,"abstract":"<p><strong>Objective: </strong>Next to its well-known benefits, Internet may trigger harmful consequences due to its abuse, thus delineating clinical pictures that are similar to abuse disorders, such as Problematic Internet Use (PIU). The matter becomes more elusive for sportsmen, as data regarding PIU in this specific group are scarce, particularly for tennis players. Therefore, our aim was to assess the prevalence and the features of PIU in a sample of either in current activity or retired professional tennis players, as compared with healthy controls.</p><p><strong>Method: </strong>Twenty-five professional tennis players were evaluated during two events held in two different European countries and were matched to an equal number of healthy subjects who were not performing any agonistic sport. The characteristics of Internet use were assessed by a specific instrument we developed (QUNT). Statistical analyses were carried out to evaluate both demographic and QUNT features and the possible intergroup differences.</p><p><strong>Results: </strong>Retired athletes presented statistically significant lower scores compared to both athletes in current activity and control subjects in the \"<i>Time spent online</i>\" and in the \"<i>Addiction to pornography</i>\" domains. Athletes in current activity presented statistically significant higher scores compared to retired athletes in the \"<i>Ludopathy</i>\" and Total score domains. Male athletes had a statistically significant lower score in the \"<i>Addiction to pornography</i>\" domain compared to both female and male healthy controls.</p><p><strong>Conclusions: </strong>Tennis players frequently indulge in the use of Internet facilities, particularly those in current activity, thus potentially being more vulnerable to PIU. Men and women seem to use Internet for different activities. The lifestyle that professional tennis players are obliged to follow might provide an explanation of our findings.</p>","PeriodicalId":46700,"journal":{"name":"Clinical Neuropsychiatry","volume":"20 1","pages":"9-16"},"PeriodicalIF":6.1,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10016101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9498907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is There an All-Embracing \"Intolerance to Uncertainty\" Construct? French Adaptation and Validation of the Intolerance to Uncertainty Scale-Revised.","authors":"Camille Mouguiama Daouda,&nbsp;M Annelise Blanchard,&nbsp;Alexandre Heeren","doi":"10.36131/cnfioritieditore20230106","DOIUrl":"https://doi.org/10.36131/cnfioritieditore20230106","url":null,"abstract":"<p><strong>Objective: </strong>Intolerance to uncertainty is a trait-like disposition largely studied in psychopathology and known to be involved in many psychological disorders. Yet, the very operationalization of this construct has prompted debate in the literature. Three different models have regularly been discussed: a correlated two-factor solution, a bifactorial solution, and a single-factor structure. A growing body of evidence suggests that the bifactorial model represents the adequate factorial solution; however, its validity has never been tested in a large French-speaking sample. Moreover, uncertainty remains regarding the associations between IUS-R and other psychological constructs, especially stress and depression. This project was designed to overcome these limitations.</p><p><strong>Method: </strong>To do so, we translated the scale into French and tested (n = 728) via confirmatory factor analyses (CFA) whether the French version would better fit with a bifactorial-, correlated, or single-factor structure, as implied by previous works. We also examined the internal reliability of the IUS-R, as well as its associations with concurrent measures of stress, depression, anxiety, and worry.</p><p><strong>Results: </strong>The results pointed to a bifactorial structure as the best-fitting model and provided evidence for a strong general intolerance of uncertainty factor that was more reliable and accounted for significantly more common variance than each subscale factor individually.</p><p><strong>Conclusions: </strong>We discuss how this bifactorial structure impacts the conceptualization of IU.</p>","PeriodicalId":46700,"journal":{"name":"Clinical Neuropsychiatry","volume":"20 1","pages":"48-54"},"PeriodicalIF":6.1,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10016102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9498903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological Psychiatry is Dead, Long Live Biological Psychiatry!","authors":"Alfonso Troisi","doi":"10.36131/cnfioritieditore20220601","DOIUrl":"https://doi.org/10.36131/cnfioritieditore20220601","url":null,"abstract":"<p><p>The failure of biological psychiatry to deliver on its promises of enlightening the origin of psychiatric disorders and optimizing their treatment is due to invalid theoretical postulates that derive from an outdated conceptualization of human biology. The crisis of biological psychiatry depends on its identification with functional biology. A major contribution of evolutionary biology (the other current of biological thought) is to integrate the study of environmental variables (developmental, interpersonal, and ecological) with those mechanisms that are the field of study of functional biology (genetics, anatomy, and physiology). A new theoretical framework based on the integration of functional and evolutionary explanations can revitalize the crippled field of biological psychiatry.</p>","PeriodicalId":46700,"journal":{"name":"Clinical Neuropsychiatry","volume":"19 6","pages":"351-354"},"PeriodicalIF":6.1,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10511159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Covid-19 Risk Perception and Vaccine Hesitancy in Cancer Patients: The Moderating Role of Externalizing Traits.","authors":"Simone Cheli,&nbsp;Maria Simona Pino,&nbsp;Gil Goldzweig,&nbsp;Silvia Scoccianti,&nbsp;Valentina Fabbroni,&nbsp;Clara Giordano,&nbsp;Veronica Cavalletti,&nbsp;Andrea Bassetti,&nbsp;Luisa Fioretto","doi":"10.36131/cnfioritieditore20220602","DOIUrl":"https://doi.org/10.36131/cnfioritieditore20220602","url":null,"abstract":"<p><strong>Objective: </strong>This mixed-methods study aimed to explore the role of externalizing traits in moderating the relationship between COVID-19 risk perception and vaccine hesitancy in patients diagnosed with cancer. A community-based participatory approach - comprising a preliminary qualitative inquiry and a subsequent cross-sectional research - was used to promote effective vaccination campaigns.</p><p><strong>Method: </strong>12 people diagnosed with cancer and 7 cancer professionals were recruited for the qualitative inquiry, 356 people either under cancer treatment or in follow-up care for the cross-sectional research.A phenomenological analysis explored the transcripts of two focus groups. The cross-sectional research tested the hypothesis emerged during the previous qualitative inquiry through self-reported questionnaires and moderated regression.</p><p><strong>Results: </strong>Phenomenological analysis suggested a pivotal role of externalizing traits in vaccine hesitancy. Moderated regression revealed how the association between risk perception and vaccine hesitancy is moderated by externalizing traits, even when controlled for treatment adherence.</p><p><strong>Conclusions: </strong>In the present study we found a stronger relationship between risk perception and vaccine hesitancy for patients with higher levels of externalizing traits. We suggest that vaccination campaigns should be personality-informed to offer individualized and effective solutions. Patients with externalizing traits may cope dysfunctionally with vaccination campaigns.</p>","PeriodicalId":46700,"journal":{"name":"Clinical Neuropsychiatry","volume":"19 6","pages":"355-364"},"PeriodicalIF":6.1,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10518550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Type 2 Diabetes Mellitus, Platelet Activation and Alzheimer's Disease: A Possible Connection.","authors":"Manuel Glauco Carbone,&nbsp;Nunzio Pomara,&nbsp;Camilla Callegari,&nbsp;Donatella Marazziti,&nbsp;Bruno Pietro Imbimbo","doi":"10.36131/cnfioritieditore20220604","DOIUrl":"https://doi.org/10.36131/cnfioritieditore20220604","url":null,"abstract":"<p><p>Type 2 diabetes mellitus DM (T2DM) is associated with a 70% increased risk for dementia, including Alzheimer's disease (AD). Insulin resistance has been proposed to play a pivotal role in both T2DM and AD and the concept of \"brain insulin resistance\" has been suggested as an interpretation to the growing literature regarding cognitive impairment and T2DM. Subjects with T2DM present an abnormal platelet reactivity that together with insulin resistance, hyperglycaemia and dyslipidaemia effect the vascular wall by a series of events including endothelial dysfunction, oxidative stress and low-grade inflammation. Activated platelets directly contribute to cerebral amyloid angiopathy (CAA) by promoting the formation of β-amyloid (Aβ) aggregates and that Aβ, in turn, activates platelets, creating a feed-forward loop suggesting the involvement of platelets in the AD pathogenesis. Moreover, islet amyloid polypeptide deposition, co-localized with Aβ deposits, is a common finding in the brain of patients with T2DM. These observations raise the intriguing prospect that traditional or novel antiplatelet therapeutic strategies may alleviate fibril formation and could be used in the prevention or treatment of AD subjects with diabetes.</p>","PeriodicalId":46700,"journal":{"name":"Clinical Neuropsychiatry","volume":"19 6","pages":"370-378"},"PeriodicalIF":6.1,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10511162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Article Highlights.","authors":"Federico Mucci","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":46700,"journal":{"name":"Clinical Neuropsychiatry","volume":"19 6","pages":"349-350"},"PeriodicalIF":6.1,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10513341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rehospitalization Rates Among Patients with Psychotic Disorders During Covid-19 Pandemic: Oral Versus Long-Acting Injectable Antipsychotics.","authors":"Tonći Mastelić,&nbsp;Tonka Borovina Marasović,&nbsp;Mihaela Rakušić,&nbsp;Dinko Martinović,&nbsp;Davor Lasić,&nbsp;Boran Uglešić,&nbsp;Trpimir Glavina","doi":"10.36131/cnfioritieditore20220603","DOIUrl":"https://doi.org/10.36131/cnfioritieditore20220603","url":null,"abstract":"<p><strong>Objective: </strong>The superiority of long-acting injectable antipsychotics (LAIs) versus oral antipsychotics is often emphasized, even in terms of adherence and rehospitaliza-tion rates. As such, LAIs are particularly recommended during the COVID-19 pandemic. The goal of our research was to determine whether there are differences in the number of rehospitalizations in patients treated for schizophrenia, schizophrenia-like disorders, and delusional states (psychotic disorders) with LAI antispychotics versus oral antispychotics.</p><p><strong>Method: </strong>Subjects with schizophrenia, schizophrenia-like disorders and delusional states participated in our retrospective study. 124 subjects were treated with oral anti-psychotics, while 72 received LAIs along with oral antipsychotics. We collected their sociodemographic data and psychiatric history data. Our main outcome measure was the number of rehospitalizations.</p><p><strong>Results: </strong>Statistical analysis showed that the studied groups did not differ according to sociodemographic parameters, except that in the group of patients with LAIs there was a significantly higher percentage of men (65 (52.4) vs 50 (69.4), p=0.029)). Also, the groups do not differ according to the psychiatric history data. There is no difference in the duration of the current hospitalization nor in the composition of the patients, considering the order of the current hospitalization. The difference in the number of rehospitalizations is not significant neither in the first year of follow-up (p=0.144), nor in the second (p=0.142), nor after two years of follow-up (p=0.083).</p><p><strong>Conclusions: </strong>Our research has shown that there is no difference in the number of rehospitalizations in patients with schizophrenia, schizophrenia-like disorders and delusional states, considering whether they take oral antipsychotics or they also take LAIs along with them. We can therefore conclude that it is particularly important to work on improving patient adherence. We must make psychiatrists aware that the pandemic, like other threats, can be our ally in improving adherence (\"perceived threat as a health belief\").</p>","PeriodicalId":46700,"journal":{"name":"Clinical Neuropsychiatry","volume":"19 6","pages":"365-369"},"PeriodicalIF":6.1,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10518548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}