{"title":"Exuberant granulomatous reaction masking primary mediastinal seminoma.","authors":"Sally Ziatabar, Brittany Bass, Liying Han, Oleg Epelbaum","doi":"10.1177/14782715251394930","DOIUrl":"10.1177/14782715251394930","url":null,"abstract":"<p><p>Primary mediastinal seminoma is an important diagnostic consideration for an anterior mediastinal mass in a young man. Occasionally, seminomas can elicit a florid granulomatous reaction that can obscure the underlying tumour on a small biopsy like the one obtained with a core needle from an anterior mediastinal mass. Herein, we illustrate such a scenario, which can lead to diagnostic confusion if this association is not recognised.</p>","PeriodicalId":46606,"journal":{"name":"Journal of the Royal College of Physicians of Edinburgh","volume":" ","pages":"292-294"},"PeriodicalIF":0.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145453542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A solitary rectal ulcer in an elderly patient.","authors":"Dennis Poon","doi":"10.1177/14782715251394938","DOIUrl":"10.1177/14782715251394938","url":null,"abstract":"<p><p>A 92 year old female with multiple co-morbidities was admitted following a fall at home. She was found to be suffering from ongoing loose stool with intermittent rectal bleeding during hospitalisation. An inpatient flexible sigmoidoscopy identified a large well-demarcated, superficial, non-bleeding ulcer in the rectum. Histology of biopsies of the rectal ulcer showed inflammation and ulceration with crypt distortions in the ulcer base. Immunohistochemistry for cytomegalovirus (CMV) confirmed presence of inclusion bodies which was suggestive of CMV proctitis. Her CMV IgG serology was positive with a high DNA level of 15,861 IU/mL. Oral valganciclovir was started and patient responded well to the anti-viral treatment with resolving bowel symptoms.</p>","PeriodicalId":46606,"journal":{"name":"Journal of the Royal College of Physicians of Edinburgh","volume":" ","pages":"283-285"},"PeriodicalIF":0.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145472041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Features in this issue.","authors":"Graeme P Currie","doi":"10.1177/14782715251401743","DOIUrl":"10.1177/14782715251401743","url":null,"abstract":"","PeriodicalId":46606,"journal":{"name":"Journal of the Royal College of Physicians of Edinburgh","volume":" ","pages":"247"},"PeriodicalIF":0.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145641222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zi Heng Tee, Zac Forbes, Louise Galloway, Sajiyabanu Suleman Kazi, Lindsay McLeman, Ashis Mukhopadhya
{"title":"Leptospiral infection overlapping with autoimmune hepatitis: A diagnostic conundrum.","authors":"Zi Heng Tee, Zac Forbes, Louise Galloway, Sajiyabanu Suleman Kazi, Lindsay McLeman, Ashis Mukhopadhya","doi":"10.1177/14782715251394936","DOIUrl":"10.1177/14782715251394936","url":null,"abstract":"<p><p>Autoimmune hepatitis (AIH) is characterised by the presence of circulating auto-antibodies, elevated serum globulin, lymphocytic and plasma cell infiltration on liver biopsy, in the absence of markers of viral hepatitis. Management typically involves use of oral or intravenous corticosteroids in combination with immunosuppressants. We report a rare case of a young patient with a background of AIH that failed to respond to such interventions and was diagnosed to have superadded leptospirosis. In this case report, we describe our challenges in localising the aetiology and management for his acute hepatitis. This report highlights the need to recognise alternative diagnosis in acute hepatitis, especially in AIH patients that fail to respond to conventional management.</p>","PeriodicalId":46606,"journal":{"name":"Journal of the Royal College of Physicians of Edinburgh","volume":" ","pages":"295-298"},"PeriodicalIF":0.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145507082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Realigning history: The Toronto Four insulin discovery team.","authors":"Kenneth McHardy","doi":"10.1177/14782715251369614","DOIUrl":"10.1177/14782715251369614","url":null,"abstract":"<p><p>This article describes the discovery and deployment of the world's first clinically useful insulin in Toronto more than 100 years ago. It addresses the propagation of a false account of how this breakthrough was achieved and the controversy that ensued leading to a diminution of the contribution of the Scottish academic leader of the discovery team. It describes how, despite the advent - some 60 years later - of a meticulously compiled and definitive history of what really happened in Toronto, the traditional account has proved resistant to correction. It concludes with a description of a spectacular memorial project in Aberdeen restoring the reputation of Professor JJR Macleod, and going on to respectfully reunite 'the Toronto Four'.</p>","PeriodicalId":46606,"journal":{"name":"Journal of the Royal College of Physicians of Edinburgh","volume":" ","pages":"317-323"},"PeriodicalIF":0.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christopher J Graham, Margaret Farquhar, Natasha J Armstrong, Charlotte Holmes
{"title":"Developing critical appraisal skills.","authors":"Christopher J Graham, Margaret Farquhar, Natasha J Armstrong, Charlotte Holmes","doi":"10.1177/14782715251388225","DOIUrl":"10.1177/14782715251388225","url":null,"abstract":"","PeriodicalId":46606,"journal":{"name":"Journal of the Royal College of Physicians of Edinburgh","volume":" ","pages":"360"},"PeriodicalIF":0.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145369041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dear doctor: A reply from Santa.","authors":"Clare Bostock","doi":"10.1177/14782715251387520","DOIUrl":"10.1177/14782715251387520","url":null,"abstract":"","PeriodicalId":46606,"journal":{"name":"Journal of the Royal College of Physicians of Edinburgh","volume":" ","pages":"248-249"},"PeriodicalIF":0.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145490720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Isolated intramuscular cysticercosis of the abdominal wall.","authors":"Atanu Chandra, Shyamash Mandal, Tanmoy Chowdhury, Prabir Kumar Kundu, Mehebub Alam Khandakar, Suvendu Mondal","doi":"10.1177/14782715251394931","DOIUrl":"10.1177/14782715251394931","url":null,"abstract":"","PeriodicalId":46606,"journal":{"name":"Journal of the Royal College of Physicians of Edinburgh","volume":" ","pages":"326-328"},"PeriodicalIF":0.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145472126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dr Archibald Hewan (1832-1883) and the University of Glasgow's medical libraries.","authors":"Matthew Daniel Eddy, Robert MacLean, Emma Yan","doi":"10.1177/14782715251397295","DOIUrl":"10.1177/14782715251397295","url":null,"abstract":"<p><strong>Background: </strong>We provide historical context for the recently discovered University of Glasgow Library records of Archibald Hewan (1832- 1883), the first Black medical doctor known to have served as a missionary in Africa.</p><p><strong>Methods: </strong>An audit of several different manuscript records of the University of Glasgow's Archives and Special Collections and an analysis of their meaning within the broader historical context of medical libraries during the mid nineteenth century.</p><p><strong>Results: </strong>The records offer insight into what kinds of books were borrowed, how they connected to the curricula of Glasgow's universities, where they were consulted and what kinds of topics caught the attention of students.</p><p><strong>Conclusion: </strong>The records of medical libraries offer unique insight into the information sources and learning strategies employed by Hewan and other contemporary university students who later worked in colonial locations.</p>","PeriodicalId":46606,"journal":{"name":"Journal of the Royal College of Physicians of Edinburgh","volume":" ","pages":"329-338"},"PeriodicalIF":0.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145641230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dealing with manuscript rejections in academic medicine: It takes two hands to clap.","authors":"Isaac Ks Ng, Wilson Gw Goh","doi":"10.1177/14782715251372412","DOIUrl":"10.1177/14782715251372412","url":null,"abstract":"<p><p>Academic publishing is increasingly prevalent in clinical training and practice, as part of the burgeoning field of academic medicine, where physicians are expected not only to perform their conventional clinical duties and responsibilities, but also increasingly have to engage in various forms of scholarly activities to contribute to evidence-based practice, as part of their key performance indicators. However, for physicians who are not trained as academics or scientists, the learning curve for scholarly endeavours can be steep and fraught with setbacks and rejections. Therefore, in this editorial article, we offer our perspectives as residents-in-training on the roles of both clinician-authors and journal editorial/peer review teams in facilitating healthy cognitive-emotional processing of unfavourable manuscript decisions in academic medicine.</p>","PeriodicalId":46606,"journal":{"name":"Journal of the Royal College of Physicians of Edinburgh","volume":" ","pages":"314-316"},"PeriodicalIF":0.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}