Asian Journal of Urology最新文献

{"title":"Radiation exposure in flexible ureteroscopy with a flexible and navigable suction ureteral access sheath: A European Association of Urology–Endourology multicenter study","authors":"Vineet Gauhar ,&nbsp;Olivier Traxer ,&nbsp;Thomas R.W. Herrmann ,&nbsp;Daniele Castellani ,&nbsp;Hatem Kamkoum ,&nbsp;Wissam Kamal ,&nbsp;Tzevat Tefik ,&nbsp;Heng Chin Tiong ,&nbsp;Mehmet Ilker Gökce ,&nbsp;Michael Y.C. Wong ,&nbsp;Khi Yung Fong ,&nbsp;Ben Hall Chew ,&nbsp;Manoj Monga ,&nbsp;Vincent de Connick ,&nbsp;Bhaskar Kumar Somani ,&nbsp;Steffi Kar Kei Yuen","doi":"10.1016/j.ajur.2025.01.002","DOIUrl":"10.1016/j.ajur.2025.01.002","url":null,"abstract":"<div><h3>Objective</h3><div>We aimed to study the effect of flexible ureteroscopy (FURS) for renal stones using a flexible and navigable suction ureteral access sheath (FANS) on intraoperative radiation dose and time.</div></div><div><h3>Methods</h3><div>This was a multicenter study of adults who underwent FURS with FANS. The correlation analysis was done to identify factors affecting radiation dose and time measured by the C-arm fluoroscopy intraoperatively.</div></div><div><h3>Results</h3><div>We analyzed 110 patients, with a median age of 50 years. Of them, 72% were pre-stented prior to the procedure. The median stone volume was 1503 mm³ and the median operative time was 39 min. The median radiation dose was 7.4 mSv and median radiation time was 0.6 min. Totally, 91% of patients achieved stone-free status (Grade A or B) on the non-contrast CT scan within 30 days postoperatively. There were no cases of postoperative sepsis. Body mass index, stone volume, and total operation time were associated with a higher radiation dose. Procedures performed under general anesthesia had a lower radiation dose and time than those performed under spinal anesthesia. Disposable scopes were associated with higher radiation time than reusable scopes but not dose. A low-power holmium laser had longer radiation time than other laser sources, but only the thulium fiber laser was associated with a significantly lower radiation dose.</div></div><div><h3>Conclusion</h3><div>Our study is the first to highlight the multitude of factors affecting radiation exposure in FURS with FANS. Although not a direct measure of surgeons' actual exposure, it has important implications for the As Low As Reasonably Achievable principle which is commonly used to minimize radiation exposure to patients and operating room staff.</div></div>","PeriodicalId":46599,"journal":{"name":"Asian Journal of Urology","volume":"12 3","pages":"Pages 385-392"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145050646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erectile function after laparoscopic versus robotic-assisted radical prostatectomy: A systematic review and meta-analysis","authors":"Ana J. Pina ,&nbsp;Vitor C. Melo ,&nbsp;Vinícius W. Carlos ,&nbsp;Luca S. Tristão ,&nbsp;Clara L. Santos ,&nbsp;Wanderley M. Bernardo ,&nbsp;Aguinaldo C. Nardi","doi":"10.1016/j.ajur.2024.10.002","DOIUrl":"10.1016/j.ajur.2024.10.002","url":null,"abstract":"<div><h3>Objective</h3><div>Prostate cancer is a common malignancy in men over 50 years old, and radical prostatectomy, particularly via laparoscopic and robotic-assisted techniques, significantly impacts quality of life, especially in terms of erectile dysfunction. This systematic review and meta-analysis aimed to evaluate the preservation of erectile function following robotic-assisted and laparoscopic radical prostatectomy, with a separate analysis of randomized clinical trials and non-randomized studies.</div></div><div><h3>Methods</h3><div>This review was carried out using randomized and non-randomized studies involving adult patients diagnosed with localized prostate cancer undergoing radical prostatectomy, according to Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines and registered in PROSPERO. Applicable literature from PubMed, Cochrane, Embase, and the Latin American and Caribbean Health Sciences Literature database was analysed. The bias in randomized clinical trials was assessed using the Cochrane Risk of Bias 2.0 tool, and observational studies were evaluated via the Newcastle-Ottawa Scale. The statistical analysis was performed using Review Manager version 5.4.</div></div><div><h3>Results</h3><div>Our analysis included 13 studies involving 6281 patients. Comparative meta-analysis of non-randomized studies demonstrated that robotic techniques were significantly more effective in preserving erectile function at 3 months (risk difference [RD] 0.05, 95% confidence interval [CI] 0.00–0.11; <em>p</em>=0.040), 6 months (RD 0.10, 95% CI 0.03–0.17; <em>p</em>=0.006), and 12 months postoperatively (RD 0.06, 95% CI 0.02–0.10; <em>p</em>=0.002).</div></div><div><h3>Conclusion</h3><div>Robotic-assisted surgery showed greater preservation of erectile function 3 months, 6 months, and 12 months after radical prostatectomy. However, additional studies with meticulous methodological criteria are necessary for future analysis.</div></div>","PeriodicalId":46599,"journal":{"name":"Asian Journal of Urology","volume":"12 3","pages":"Pages 281-289"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145050229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does the brain weep? Post-hysterectomy vaginal leak may not always be urine!","authors":"Sajal Gupta,&nbsp;Abheesh Varma Hegde,&nbsp;Geover Joslen Lobo","doi":"10.1016/j.ajur.2025.03.007","DOIUrl":"10.1016/j.ajur.2025.03.007","url":null,"abstract":"","PeriodicalId":46599,"journal":{"name":"Asian Journal of Urology","volume":"12 3","pages":"Pages 412-413"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145050654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of postoperative infectious complications after partial nephrectomy: Analysis at a referral institution","authors":"Riccardo Bertolo ,&nbsp;Francesco Ditonno ,&nbsp;Alessandro Veccia ,&nbsp;Francesca Montanaro ,&nbsp;Francesco Artoni ,&nbsp;Alberto Baielli ,&nbsp;Michele Boldini ,&nbsp;Davide Brusa ,&nbsp;Sonia Costantino ,&nbsp;Marcella Sibani ,&nbsp;Vincenzo De Marco ,&nbsp;Filippo Migliorini ,&nbsp;Antonio Benito Porcaro ,&nbsp;Riccardo Rizzetto ,&nbsp;Maria Angela Cerruto ,&nbsp;Riccardo Autorino ,&nbsp;Alessandro Antonelli","doi":"10.1016/j.ajur.2024.06.002","DOIUrl":"10.1016/j.ajur.2024.06.002","url":null,"abstract":"<div><h3>Objective</h3><div>Infectious complications after partial nephrectomy (PN) remain a significant concern. We aimed to analyze predictive factors of postoperative infectious complications (PICs) occurring after PN.</div></div><div><h3>Methods</h3><div>Data on patients undergoing PN for renal masses between January 2018 and May 2023 were retrieved from prospectively maintained institutional database and retrospectively analyzed. Patients were stratified into two groups based on the occurrence of PICs during admission for PN. A PIC was defined by clinical and/or imaging findings of an infectious process plus microbial isolation upon culture examination. Multivariable logistic regression analysis after adjusting for potential confounders evaluated predictors of a PIC.</div></div><div><h3>Results</h3><div>Six-hundred and twenty-seven patients underwent PN; rough incidence of PICs was 11%, with median time to PIC onset of 1 (interquartile range 0–3) day. Compared to patients without PIC events, the PIC group showed a significantly higher proportion of open surgeries (54% <em>vs.</em> 20%, <em>p</em>&lt;0.001), bleeding events (23% <em>vs.</em> 10%, <em>p</em>&lt;0.01), postoperative transfusion (19% <em>vs.</em> 5.0%, <em>p</em>&lt;0.001), and urinary leakage (4.2% <em>vs.</em> 0.18%, <em>p</em>=0.01), and a statistically significantly higher median hemoglobin drop from baseline (−2.6 g/dL <em>vs</em>. −1.7 g/dL, <em>p</em>=0.001). At multivariable logistic regression, the odds of experiencing a PIC were statistically significantly lower after minimally-invasive surgery compared to open surgery (odds ratio 0.32, 95% confidence interval 0.17–0.59), and higher for patients who received transfusion (odds ratio 1.68, 95% confidence interval 1.10–2.54).</div></div><div><h3>Conclusion</h3><div>We underlined factors that impact the occurrence of PICs and, consequently, duration of hospitalization following PN. By addressing these predictors, clinicians can promote enhanced patient recovery.</div></div>","PeriodicalId":46599,"journal":{"name":"Asian Journal of Urology","volume":"12 2","pages":"Pages 236-243"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141713663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robotic uro-oncology applications of the SSI Mantra™ surgical robotic system","authors":"Sudhir K. Rawal ,&nbsp;Ashish Khanna ,&nbsp;Amitabh Singh ,&nbsp;Sarbartha K. Pratihar ,&nbsp;Ishan Malla ,&nbsp;Mujahid Ali ,&nbsp;Vivek Vasudeo ,&nbsp;Kaushik Jaganthan ,&nbsp;Bhuvan Kumar ,&nbsp;Nikhil Saurabh","doi":"10.1016/j.ajur.2024.04.009","DOIUrl":"10.1016/j.ajur.2024.04.009","url":null,"abstract":"<div><h3>Objective</h3><div>To report our preliminary clinical experience and outcomes of uro-oncology procedures conducted utilizing the SSI Mantra™ surgical robotic system.</div></div><div><h3>Methods</h3><div>Data of consecutive patients who underwent various robot-assisted uro-oncology procedures using the SSI Mantra™ surgical robotic system at our institution between July 2022 and September 2023 were recorded. The specific surgical configurations employed with the SSI Mantra™ for these procedures were duly noted. We assessed the feasibility of these procedures with this novel surgical robotic system and report the outcomes.</div></div><div><h3>Results</h3><div>A total of 156 patients were operated with the SSI Mantra™ surgical robotic system. The spectrum of procedures performed comprised robot-assisted laparoscopic radical prostatectomy with bilateral extended pelvic lymph node dissection (<em>n</em>=77), robot-assisted radical cystectomy with bilateral extended pelvic lymph node dissection with extracorporeal urinary diversion (<em>n</em>=39), robot-assisted radical nephrectomy (<em>n</em>=32), robot-assisted partial nephrectomy (<em>n</em>=6), robot-assisted radical nephroureterectomy with bladder cuff excision (<em>n</em>=1), and bilateral robot-assisted video endoscopic inguinal lymph node dissection (<em>n</em>=1). One robot-assisted laparoscopic radical prostatectomy had to be converted to open in view of system malfunction. However, no system-related intraoperative complications or injuries were encountered.</div></div><div><h3>Conclusion</h3><div>The SSI Mantra™ surgical robotic system demonstrates significant promise as an innovative robotic platform. In this single-center experience, we have demonstrated the feasibility of a diverse array of surgical procedures using this platform. Further research, involving a larger cohort of patients, is imperative to refine the operative techniques and comprehensively understand the perioperative outcomes of the SSI Mantra™ surgical robotic system, particularly in comparison to other robotic surgical platforms.</div></div>","PeriodicalId":46599,"journal":{"name":"Asian Journal of Urology","volume":"12 2","pages":"Pages 143-151"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143904402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robotic urologic applications of the hinotori™ Surgical Robot System","authors":"Shunsuke Miyamoto,&nbsp;Tomoya Hatayama,&nbsp;Hiroyuki Shikuma,&nbsp;Kazuma Yukihiro,&nbsp;Kyohsuke Iwane,&nbsp;Ryo Tasaka,&nbsp;Yuki Kohada,&nbsp;Takafumi Fukushima,&nbsp;Kenshiro Takemoto,&nbsp;Miki Naito,&nbsp;Kohei Kobatake,&nbsp;Yohei Sekino,&nbsp;Hiroyuki Kitano,&nbsp;Kenichiro Ikeda,&nbsp;Keisuke Goto,&nbsp;Akihiro Goriki,&nbsp;Keisuke Hieda,&nbsp;Nobuyuki Hinata","doi":"10.1016/j.ajur.2024.05.002","DOIUrl":"10.1016/j.ajur.2024.05.002","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the safety and effectiveness of urological tumor surgeries using the hinotori™ Surgical Robot System (hinotori) in a real-world clinical setting.</div></div><div><h3>Methods</h3><div>All surgeries including robot-assisted radical prostatectomy (RARP), robot-assisted partial nephrectomy (RAPN), robot-assisted radical nephrectomy (RARN), robot-assisted nephroureterectomy (RANU), robot-assisted adrenalectomy (RAA), and robot-assisted radical cystectomy with intracorporeal urinary diversion (RARC+ICUD) for urological tumors with the hinotori and da Vinci surgical system (da Vinci) from January 2022 to September 2023 were enrolled. We evaluated the safety and effectiveness of surgeries using the hinotori compared with those using the da Vinci.</div></div><div><h3>Results</h3><div>Robotic surgeries using the hinotori were performed in a total of 91 cases, comprising 42 cases of RARP, 18 cases of RAPN, six cases of RARN, 10 cases of RANU, 13 cases of RAA, and two cases of RARC+ICUD; no major intraoperative complications were observed in any of the cases using the hinotori; no major postoperative complications occurred in any of the cases; no case experienced an unrecoverable equipment error during surgery. Meanwhile, robotic surgeries using the da Vinci were performed in a total of 277 cases, comprising 126 cases of RARP, 94 cases of RAPN, 12 cases of RARN, 10 cases of RANU, 20 cases of RAA, and 15 cases of RARC+ICUD; major intraoperative complications occurred in two cases; major postoperative complications occurred in seven cases; seven cases required transfusion; one case underwent conversion to open surgery; during the study period, no case experienced an unrecoverable equipment error. Surgical outcomes for cases with the hinotori were comparable to those with the da Vinci.</div></div><div><h3>Conclusion</h3><div>This study demonstrated that the hinotori is a safe and feasible tool for robotic surgeries in the field of urology.</div></div>","PeriodicalId":46599,"journal":{"name":"Asian Journal of Urology","volume":"12 2","pages":"Pages 162-168"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143904403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of deferred cytoreductive nephrectomy on survival in advanced renal cell carcinoma: A systematic review and meta-analysis","authors":"Mohammad Taufiq Alamsyah ,&nbsp;Fauriski Febrian Prapiska ,&nbsp;Syah Mirsya Warli","doi":"10.1016/j.ajur.2024.06.003","DOIUrl":"10.1016/j.ajur.2024.06.003","url":null,"abstract":"<div><h3>Objective</h3><div>Stage IV renal cell carcinoma (RCC) is associated with a significant decrease in survival rates. Cytoreductive nephrectomy (CN) is one of the treatments for stage IV RCC. However, there are studies showing that delayed CN might have benefits for the survival of the patients. We aimed to examine the impact of deferred CN on the survival of patients with advanced RCC in relation to sequential management with targeted therapy (TT).</div></div><div><h3>Methods</h3><div>A literature search was conducted in PubMed, EMBASE, EBSCOhost, MedRxiv, and Scopus. We included the randomized clinical trial and non-randomized study of intervention comparing the overall survival (OS) of upfront CN with deferred CN in patients with advanced RCC undergoing TT. Meta-analysis was carried out using Review Manager v5.4 software. The fixed-effect and random-effects models were used to obtain pooled estimates using the hazard ratio and standard error, presented using the forest plot with 95% confidence interval.</div></div><div><h3>Results</h3><div>Four studies were analyzed quantitatively. Our analysis revealed that patients with upfront TT followed by deferred CN had significantly improved OS compared to those who underwent upfront CN followed by TT (hazard ratio 0.50, 95% confidence interval 0.40–0.64, <em>p</em>&lt;0.001).</div></div><div><h3>Conclusion</h3><div>The findings of the study suggest that considering upfront TT followed by deferred CN may lead to improved OS in patients with advanced RCC. However, more research is needed to fully understand the role, optimal timing, and sequencing of TT and CN in the treatment of advanced RCC.</div></div>","PeriodicalId":46599,"journal":{"name":"Asian Journal of Urology","volume":"12 2","pages":"Pages 204-209"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143904405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering riddles in molecular subtyping of bladder cancer","authors":"Yuxiao Li ,&nbsp;Suyuelin Huang ,&nbsp;Wenlong Ju ,&nbsp;Dingheng Lu ,&nbsp;Jiazhu Sun ,&nbsp;Weitao Zhan ,&nbsp;Xinyang Niu ,&nbsp;Yuchen Shi ,&nbsp;Kai Yu ,&nbsp;Ben Liu","doi":"10.1016/j.ajur.2024.09.006","DOIUrl":"10.1016/j.ajur.2024.09.006","url":null,"abstract":"<div><h3>Objective</h3><div>Bladder cancer (BCa) is a prevalent malignant tumor in the urinary system. Molecular subtyping, utilizing molecular characteristics, represents a novel classification system that has demonstrated its efficacy in tumor diagnosis and treatment. Given the critical role of molecular subtyping in the BCa treatment, acquiring a comprehensive understanding is imperative for guiding treatment decisions, optimizing risk assessment systems, and ultimately improving patient prognosis.</div></div><div><h3>Methods</h3><div>In this review, we provide a comprehensive overview of the research progress in molecular subtyping of BCa, with a primary focus on discussing its utility in guiding various treatment modalities including neoadjuvant chemotherapy, neoadjuvant immunotherapy, and targeted therapy. In addition, this review also covers the trimodality treatment, antibody-drug conjugates, and the treatment of small cell BCa.</div></div><div><h3>Results</h3><div>We present a comprehensive overview of the responsiveness or resistance of different molecular subtypes of BCa to various therapeutic modalities. The basal subtype demonstrates favorable sensitivity to neoadjuvant chemotherapy across multiple classification systems, whereas the luminal infiltrated subtype exhibits potential susceptibility to immunotherapy. In terms of targeted therapy, the basal-like and the basal/squamous subtypes in some classifications have shown notable responsiveness to epidermal growth factor receptor-targeted therapy. Moreover, the luminal subtype in the University of Texas M.D. Anderson Cancer Center classification, the luminal papillary subtypes according to the Cancer Genome Atlas Research Network classification in 2017, and the luminal unstable type in the 2019 Molecular Subtyping classification show potential for the fibroblast growth factor receptor 3-targeted treatment.</div></div><div><h3>Conclusion</h3><div>The significance and impact of BCa molecular subtyping in guiding treatment, evaluating progression, and predicting prognosis are increasingly acknowledged. Accurate subtyping and broad application can bring good benefits to clinical decision-making, risk assessment, and prognostic evaluation.</div></div>","PeriodicalId":46599,"journal":{"name":"Asian Journal of Urology","volume":"12 2","pages":"Pages 217-231"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143904274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of varicocelectomy in infertile patients with clinical varicocele and isolated sperm defects","authors":"Mohamed M. Arafa ,&nbsp;Ahmad A. Majzoub ,&nbsp;Walid A. El Ansari ,&nbsp;Ahmad H. AlMalki ,&nbsp;Mohammed Y. Mahdi ,&nbsp;Kareim M. Khalafalla ,&nbsp;Khalid J. AlKubaisi ,&nbsp;Sami S. AlSaid ,&nbsp;Haitham T. ElBardisi","doi":"10.1016/j.ajur.2024.08.001","DOIUrl":"10.1016/j.ajur.2024.08.001","url":null,"abstract":"<div><h3>Objective</h3><div>This study investigated the outcomes of microsurgical subinguinal varicocelectomy (MSV) on semen and hormonal parameters in cases with isolated sperm defects (oligozoospermia, asthenozoospermia, or teratozoospermia).</div></div><div><h3>Methods</h3><div>A retrospective review of charts of patients who underwent MSV for clinically palpable varicocele between January 1, 2011 and January 1, 2019 at Hamad Medical Corporation was undertaken. All patients diagnosed with isolated oligozoospermia, asthenozoospermia, or teratozoospermia in the preoperative semen analysis were included. Men with multiple sperm defects, genetic abnormalities, azoospermia, history of genitourinary infection, exposure to chemotherapy or radiotherapy, or prior use of peri-operative fertility treatment were excluded. Data extracted from the electronic medical records included (collected before MSV and up to 6 months postoperatively): demographics (age), clinical data (fertility-related medical history and surgical interventions), family history (consanguinity and infertility), physical examination findings from general and local genital exam (varicocele side and grade), laboratory data such as semen analysis, sperm DNA fragmentation tests, and hormone levels (follicle-stimulating hormone, luteinizing hormone, total testosterone, estradiol, and prolactin), and imaging (scrotal color Doppler ultrasound).</div></div><div><h3>Results</h3><div>A total of 331 patients with isolated sperm defects were included. Postoperatively, 83.3% of patients showed an improvement in sperm concentration with a median increase of 7 millions/mL. Postoperatively, 76.7% of isolated asthenozoospermic patients showed an improvement in total motility and 66.0% had an improvement in progressive motility with median increases of 15.0% and 7.5%, respectively. Postoperatively, 70.0% of the teratozoospermic patients showed an improvement in normal sperm morphology with a median increase of 6%. No changes were observed in other semen or hormone parameters that were examined.</div></div><div><h3>Conclusion</h3><div>MSV is a valid and effective treatment modality for patients with isolated sperm defects that significantly corrects their respective semen abnormality and improves their chances of natural conception.</div></div>","PeriodicalId":46599,"journal":{"name":"Asian Journal of Urology","volume":"12 2","pages":"Pages 267-274"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143904278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review of pharmacological, complementary, and alternative therapies for the prevention of calcium oxalate stones","authors":"Christopher Y.Z. Lo ,&nbsp;Qian Hui Khor ,&nbsp;Victor A. Abdullatif ,&nbsp;Cesar Delgado ,&nbsp;Yadong Lu ,&nbsp;Jonathan Katz ,&nbsp;Roger L. Sur","doi":"10.1016/j.ajur.2024.04.006","DOIUrl":"10.1016/j.ajur.2024.04.006","url":null,"abstract":"<div><h3>Objective</h3><div>Several therapeutic modalities for the prevention of calcium oxalate (CaOx) stones have been studied, but only a select few of these modalities have been incorporated into the American Urological Association guidelines. Our study aimed to organize and interrogate existing research that may be promising for CaOx prevention.</div></div><div><h3>Methods</h3><div>A literature search was conducted using MEDLINE and Embase from inception to November 16, 2022. Our study population included adults with or without a history of CaOx kidney stones. Studies in which patients were treated with pharmacotherapies, herbal supplements, or uncategorized research chemicals that are not included in the current American Urological Association guidelines for preventing CaOx stones were included. Nonoriginal research was excluded.</div></div><div><h3>Results</h3><div>Out of the 6155 identified articles, 38 were included in the final analysis. The five distinct categories of interventions for stone prevention were “medications”, “herbal supplements”, “food and macronutrients”, “micronutrients”, and “enzymes and probiotics”. Modalities that were found to reduce known urinary risk factors were tolvaptan, cranberry juice, magnesium citrate, oxalate-degrading enzyme ALLN-177, and malic acid. Prophylaxis that reduced stone formation were sodium-glucose cotransporter-2 inhibitors, eicosapentaenoic acid, ethane-1-hydroxy-1,1-disphosphonate. Therapies that reduced urinary risk factors and stone formation were <em>Phyllanthus niruri</em>, rice bran, and magnesium hydroxide.</div></div><div><h3>Conclusion</h3><div>Several of the identified therapies may provide prophylactic benefits for CaOx stone formation and may be useful for inclusion in guidelines for kidney stone prevention.</div></div>","PeriodicalId":46599,"journal":{"name":"Asian Journal of Urology","volume":"12 2","pages":"Pages 169-188"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141690706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}