Mesenchymal stem cell secretome: A promising therapeutic strategy for erectile dysfunction?

IF 2.4 3区医学 Q2 UROLOGY & NEPHROLOGY

Asian Journal of Urology Pub Date : 2024-07-01 DOI:10.1016/j.ajur.2024.02.003

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引用次数: 0

Abstract

Objective

The secretome, comprising bioactive chemicals released by mesenchymal stem cells (MSCs), holds therapeutic promise in regenerative medicine. This review aimed to explore the therapeutic potential of the MSC secretome in regenerative urology, particularly for treating erectile dysfunction (ED), and to provide an overview of preclinical and clinical research on MSCs in ED treatment and subsequently to highlight the rationales, mechanisms, preclinical investigations, and therapeutic potential of the MSC secretome in this context.

Methods

The review incorporated an analysis of preclinical and clinical research involving MSCs in the treatment of ED. Subsequently, it delved into the existing knowledge regarding the MSC secretome, exploring its therapeutic potential. The methods included a comprehensive examination of relevant literature to discern the processes underlying the therapeutic efficacy of the MSC secretome.

Results

Preclinical research indicated the effectiveness of the MSC secretome in treating various models of ED. However, the precise mechanisms of its therapeutic efficacy remain unknown. The review provided insights into the anti-inflammatory, pro-angiogenic, and trophic properties of the MSC secretome. It also discussed potential advantages, such as avoiding issues related to cellular therapy, including immunogenicity, neoplastic transformation, and cost.

Conclusion

This review underscores the significant therapeutic potential of the MSC secretome in regenerative urology, particularly for ED treatment. While preclinical studies demonstrate promising outcomes, further research is essential to elucidate the specific mechanisms underlying the therapeutic efficacy before clinical application. The review concludes by discussing future perspectives and highlighting the challenges associated with the clinical translation of the MSC secretome in regenerative urology.

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间充质干细胞分泌组：治疗勃起功能障碍的有效策略？

目的由间充质干细胞释放的生物活性化学物质组成的分泌组在再生医学中具有治疗前景。这篇综述旨在探讨间充质干细胞分泌组在再生泌尿学中的治疗潜力，尤其是治疗勃起功能障碍（ED）的潜力，并概述间充质干细胞治疗ED的临床前和临床研究，随后强调间充质干细胞分泌组在这方面的原理、机制、临床前研究和治疗潜力。随后，它深入研究了有关间充质干细胞分泌组的现有知识，并探讨了其治疗潜力。研究方法包括对相关文献进行全面检查，以了解间充质干细胞分泌组治疗功效的基本过程。然而，其疗效的确切机制仍然未知。综述深入探讨了间充质干细胞分泌组的抗炎、促血管生成和营养特性。本综述强调了间充质干细胞分泌组在再生泌尿外科，尤其是 ED 治疗方面的巨大治疗潜力。虽然临床前研究显示了良好的结果，但在临床应用之前，进一步的研究对于阐明治疗效果的具体机制至关重要。综述最后讨论了未来的前景，并强调了间充质干细胞分泌组在再生泌尿外科临床转化过程中面临的挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asian Journal of Urology UROLOGY & NEPHROLOGY-

CiteScore

4.00

自引率

3.80%

发文量

100

审稿时长

4 weeks

期刊介绍： Asian Journal of Urology (AJUR), launched in October 2014, is an international peer-reviewed Open Access journal jointly founded by Shanghai Association for Science and Technology (SAST) and Second Military Medical University (SMMU). AJUR aims to build a communication platform for international researchers to effectively share scholarly achievements. It focuses on all specialties of urology both scientifically and clinically, with article types widely covering editorials, opinions, perspectives, reviews and mini-reviews, original articles, cases reports, rapid communications, and letters, etc. Fields of particular interest to the journal including, but not limited to: • Surgical oncology • Endourology • Calculi • Female urology • Erectile dysfunction • Infertility • Pediatric urology • Renal transplantation • Reconstructive surgery • Radiology • Pathology • Neurourology.