Uncovering the epidemiology of bladder cancer in the Arab world: A review of risk factors, molecular mechanisms, and clinical features

IF 2.4 3区 医学 Q2 UROLOGY & NEPHROLOGY
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引用次数: 0

Abstract

Objective

Bladder cancer (BC) is a significant public health concern in the Middle East and North Africa, but the epidemiology and clinicopathology of the disease and contributors to high mortality in this region remain poorly understood. The aim of this systematic review was to investigate the epidemiological features of BC in the Arab world and compare them to those in Western countries in order to improve the management of this disease.

Methods

An extensive electronic search of the PubMed/PMC and Cochrane Library databases was conducted to identify all articles published until May 2022, following the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. A total of 95 articles were included in the final analysis after title, abstract, and full-text screening, with additional data obtained from the GLOBOCAN and WHO 2020 databases.

Results

Most of the included articles were case-control studies examining the risk factors and molecular mechanisms of BC. These studies originated from 10 different countries, with Egypt being the most active contributor. While BC in the Arab world shares some common risk factors with Western countries, such as smoking and occupational exposure, it also exhibits unique features related to schistosomiasis. The high mortality rates in this region are alarming and can be attributed to various factors, including the prevalence of smoking, the impact of schistosomiasis, a combination of genetic and socioeconomic factors, treatment shortages, and limited access to care or inadequate assessment of the quality of care.

Conclusion

Despite the relatively low incidence of BC in Arab countries, the mortality rates are among the highest worldwide. BC tends to be more aggressive in the Arab world, making it essential to implement strategies to address this burden.

揭示阿拉伯世界的膀胱癌流行病学:风险因素、分子机制和临床特征综述
目的膀胱癌(BC)是中东和北非地区的一个重大公共卫生问题,但人们对该疾病的流行病学和临床病理学以及造成该地区高死亡率的原因仍然知之甚少。本系统综述旨在研究阿拉伯世界膀胱癌的流行病学特征,并将其与西方国家的流行病学特征进行比较,以改进对该疾病的管理。方法按照《系统综述和元分析首选报告项目》指南,对PubMed/PMC和Cochrane图书馆数据库进行了广泛的电子检索,以确定截至2022年5月发表的所有文章。经过标题、摘要和全文筛选,共有95篇文章被纳入最终分析,其他数据来自GLOBOCAN和WHO 2020数据库。这些研究来自 10 个不同的国家,其中埃及的研究最为活跃。虽然阿拉伯世界的BC与西方国家有一些共同的风险因素,如吸烟和职业暴露,但它也表现出与血吸虫病相关的独特特征。该地区的高死亡率令人震惊,可归因于多种因素,包括吸烟率、血吸虫病的影响、遗传和社会经济因素的综合作用、治疗短缺、获得护理的机会有限或对护理质量的评估不足。在阿拉伯世界,BC 的侵袭性更强,因此必须实施相关战略来解决这一问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Asian Journal of Urology
Asian Journal of Urology UROLOGY & NEPHROLOGY-
CiteScore
4.00
自引率
3.80%
发文量
100
审稿时长
4 weeks
期刊介绍: Asian Journal of Urology (AJUR), launched in October 2014, is an international peer-reviewed Open Access journal jointly founded by Shanghai Association for Science and Technology (SAST) and Second Military Medical University (SMMU). AJUR aims to build a communication platform for international researchers to effectively share scholarly achievements. It focuses on all specialties of urology both scientifically and clinically, with article types widely covering editorials, opinions, perspectives, reviews and mini-reviews, original articles, cases reports, rapid communications, and letters, etc. Fields of particular interest to the journal including, but not limited to: • Surgical oncology • Endourology • Calculi • Female urology • Erectile dysfunction • Infertility • Pediatric urology • Renal transplantation • Reconstructive surgery • Radiology • Pathology • Neurourology.
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