Nora A Alexander, Kwasi Enin, Jenny Ji, Emily Spataro
{"title":"Functional and Aesthetic Outcomes of Post-Mohs Nasal Reconstruction.","authors":"Nora A Alexander, Kwasi Enin, Jenny Ji, Emily Spataro","doi":"10.3390/cmtr18010017","DOIUrl":"https://doi.org/10.3390/cmtr18010017","url":null,"abstract":"<p><strong>Background: </strong>Similar to patients undergoing rhinoplasty, patients undergoing post-Mohs micrographic surgery (MMS) nasal reconstruction are concerned with both nasal form and function.</p><p><strong>Objectives: </strong>The objectives were to identify patient, defect, and surgical characteristics associated with post-MMS nasal reconstruction outcomes.</p><p><strong>Methods & materials: </strong>A retrospective single-institution cohort study was conducted of post-MMS nasal reconstruction surgeries occurring between 2015 and 2020. Patient, defect, and surgical details were collected along with nasal aesthetic and functional outcomes. Multivariable logistic regressions were used to analyze data.</p><p><strong>Results: </strong>A total of 167 nasal MMS defects among 160 patients met the inclusion criteria. The median age was 66 years, and 70% were female. A poor aesthetic outcome (<i>n</i> = 20, 12.0%) was associated with diabetes (aOR 6.277, 95% CI 2.193-17.965). Post-operative nasal obstruction (<i>n</i> = 17, 10.2%) was associated with obesity (aOR 20.976, 95% CI 2.406-182.845) and major revision surgery (aOR 12.192, 95% CI 2.838-52.382).</p><p><strong>Conclusion: </strong>Post-MMS nasal reconstruction aesthetic and functional outcomes are associated with obesity, diabetes, and revision surgery. Improved standardization of functional and cosmetic outcomes is important to better understand these results in the future.</p>","PeriodicalId":46447,"journal":{"name":"Craniomaxillofacial Trauma & Reconstruction","volume":"18 1","pages":"17"},"PeriodicalIF":0.8,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11995814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Morgan M Sandelski, Deema Martini, Todd M Kubon, Greg G Gion, Amy L Pittman
{"title":"General and Treatment-Specific Outcomes with Osseointegrated Implants in Auricular, Nasal, and Orbital Prosthetic Reconstruction.","authors":"Morgan M Sandelski, Deema Martini, Todd M Kubon, Greg G Gion, Amy L Pittman","doi":"10.3390/cmtr18010016","DOIUrl":"https://doi.org/10.3390/cmtr18010016","url":null,"abstract":"<p><strong>Background: </strong>Osseointegrated implants outside of dental restoration remain an integral area of facial reconstruction in which more outcomes data is needed. We aimed to describe our 13-year experience using osseointegrated implants for orbital, nasal, and auricular reconstruction, looking at general outcomes, including radiated and surgically manipulated bone.</p><p><strong>Methods: </strong>This retrospective chart review covered demographics and outcomes from January 2008 to August 2021 in patients who underwent an orbital exenteration, partial or total rhinectomy, and partial or total auriculectomy with subsequent osseointegrated implant placement. We hypothesized radiation would increase the failure rate of implants and prostheses.</p><p><strong>Results: </strong>There were 79 implants placed in 27 patients, with over half of the patients requiring implants for reconstruction because of malignancy. The success rate was 86%. Complications were uncommon. Only 2 (7.4%) patients were unable to use their prosthesis. Prior radiation and surgery to the bone were associated with an increased risk of loss of implant (<i>p</i> = 0.008 and <i>p</i> = 0.007, respectively) but not associated with other complications or prosthesis non-viability.</p><p><strong>Conclusions: </strong>Osseointegrated implants are a reliable, permanent option for a realistic prosthesis. Radiation and prior surgery are significantly associated with an increased risk of implant failure but not associated with the inability to use the prosthesis. Regardless of prior treatments, bone-retained implants should be considered in facial reconstruction, especially after failing autologous repair or with concerns for cosmetic outcomes.</p>","PeriodicalId":46447,"journal":{"name":"Craniomaxillofacial Trauma & Reconstruction","volume":"18 1","pages":"16"},"PeriodicalIF":0.8,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11995819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Majeed Rana, Daniel Buchbinder, Gregorio Sánchez Aniceto, Gerson Mast
{"title":"Patient-Specific Solutions for Cranial, Midface, and Mandible Reconstruction Following Ablative Surgery: Expert Opinion and a Consensus on the Guidelines and Workflow.","authors":"Majeed Rana, Daniel Buchbinder, Gregorio Sánchez Aniceto, Gerson Mast","doi":"10.3390/cmtr18010015","DOIUrl":"10.3390/cmtr18010015","url":null,"abstract":"<p><p>Reconstruction of cranio-maxillofacial defects following ablative surgeries requires a comprehensive approach that balances functional restoration with aesthetic outcomes. Advances in computer-aided design and manufacturing (CAD/CAM) technology have revolutionized this field, enabling precise preoperative planning, including 3D modeling, segmentation, and virtual resection planning. These methods allow for the production of patient-specific implants and surgical templates while facilitating the evaluation of treatment outcomes. CAD/CAM technology offers numerous benefits, such as enhanced surgical accuracy, improved aesthetic results, reduced operative times, and the possibility of single-stage resection and reconstruction. However, limitations exist, including high costs, the need for specialized expertise, and dependency on accurate imaging data. This paper provides a surgeon-centric evaluation of the advantages and limitations of CAD/CAM in cranio-maxillofacial reconstruction. The discussion encompasses the technological workflow, clinical applications, and recommendations for optimizing outcomes. Future perspectives highlight ongoing developments, such as integrating non-ionizing imaging techniques and expanding the applicability of virtual and augmented reality. By synthesizing technical advancements and clinical expertise, this review aims to establish practical guidelines for implementing CAD/CAM technology in routine surgical practice.</p>","PeriodicalId":46447,"journal":{"name":"Craniomaxillofacial Trauma & Reconstruction","volume":"18 1","pages":"15"},"PeriodicalIF":0.4,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11995815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Edgar Ochoa, James Cevallos, Ramon Bustos, Nina Patel, Chase M Heaton, Rahul Seth, P Daniel Knott, Andrea M Park
{"title":"Patient-Reported Donor Site Quality of Life Outcomes Following Fibula Free Flap Reconstruction.","authors":"Edgar Ochoa, James Cevallos, Ramon Bustos, Nina Patel, Chase M Heaton, Rahul Seth, P Daniel Knott, Andrea M Park","doi":"10.3390/cmtr18010014","DOIUrl":"https://doi.org/10.3390/cmtr18010014","url":null,"abstract":"<p><p><i>Study Design:</i> Retrospective cohort study. <i>Objective:</i> To (1) assess post-operative quality of life (QOL) and functional outcomes of fibula free flap (FFF) donor sites, (2) examine the incidence of post-operative claw toe deformities (CTDs) following FFF harvest, and (3) assess the effect of flexor hallicus longus (FHL) muscle preservation on the incidence of post-operative CTDs. <i>Methods:</i> Patients aged 18 years or older and at least 6 months from FFF reconstructive surgery completed the Manchester-Oxford Foot Questionnaire (MOXFQ)and the Short-form 36 (SF-36) Questionnaire. The incidence of post-operative CTDs reported by respondents was calculated. We assessed the associations between FHL preservation at time of surgery and QOL and functional outcomes, including the development of post-operative CTDs. <i>Results:</i> Sixty patients completed questionnaires at a mean of 38.3 months from surgery. The cohort consisted of 28 patients in whom the FHL muscle and nerve were preserved and 32 patients in whom they were not. Among respondents, 23.3% (14/60) reported post-operative CTDs. FHL status was not associated with post-operative CTDs or with worse scores in the domains of pain (<i>p</i> = 0.612), walking/standing (<i>p</i> = 0.431), or social functioning (<i>p</i> = 0.400). Overall, majority reported high post-operative QOL. <i>Conclusions:</i> While majority of patients who undergo FFF reconstruction can expect good long-term donor site QOL and functional outcomes, there are risks of functional impairment, including post-operative CTDs. Preservation of FHL muscle did not affect post-operative QOL outcomes or the incidence of CTDs. These data can inform patient QOL expectations following FFF harvest.</p>","PeriodicalId":46447,"journal":{"name":"Craniomaxillofacial Trauma & Reconstruction","volume":"18 1","pages":"14"},"PeriodicalIF":0.8,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11995820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sam Boroumand, Ismail Ajjawi, Tara Boroumand, Omar Allam, Lioba Huelsboemer, Viola A Stögner, Martin Kauke-Navarro, Siba Haykal, Michael Alperovich, Bohdan Pomahac
{"title":"Sobering Overview of Traumatic Craniofacial Injuries Involving Drugs and Alcohol: A Comprehensive Analysis of the NEISS Database.","authors":"Sam Boroumand, Ismail Ajjawi, Tara Boroumand, Omar Allam, Lioba Huelsboemer, Viola A Stögner, Martin Kauke-Navarro, Siba Haykal, Michael Alperovich, Bohdan Pomahac","doi":"10.3390/cmtr18010013","DOIUrl":"https://doi.org/10.3390/cmtr18010013","url":null,"abstract":"<p><p>The purpose of this study is to provide a comprehensive overview of the epidemiology of traumatic craniofacial injuries in the U.S. that occur in the context of drugs and/or alcohol. The National Electronic Injury and Surveillance System (NEISS) database was queried from 2019 to 2022 to identify all emergency department (ED) patients with reported traumatic injuries involving craniofacial anatomy. Clinical and demographic variables were assessed between cases that involved drugs/alcohol and those that did not, utilizing two-proportion z-tests. In total, 441,764 patients with traumatic craniofacial injuries were identified, with 20,285 cases involving drugs and/or alcohol. Cases involving drugs/alcohol had a significantly higher frequency of internal injuries (45.3% vs. 34.9%, <i>p</i> < 0.001), fractures (7.0% vs. 3.4%, <i>p</i> < 0.001), and hematomas (4.6% vs. 2.5%, <i>p</i> < 0.001) than those that did not. Craniofacial injuries involving drugs/alcohol also had a significantly higher frequency of falls to the floor (19.2% vs. 11.8%, <i>p</i> < 0.001) and down stairs/steps (18.3% vs. 6.6%, <i>p</i> < 0.001) and resulted in a significantly greater odds of hospital admission after ED presentation (OR 3.75, 95% CI: 3.63-3.88, <i>p</i> < 0.001). Ultimately, these epidemiological findings can be leveraged to provide clinicians invaluable qualitative context for the most frequent presentations of craniofacial injuries they can anticipate to treat among intoxicated patients.</p>","PeriodicalId":46447,"journal":{"name":"Craniomaxillofacial Trauma & Reconstruction","volume":"18 1","pages":"13"},"PeriodicalIF":0.8,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11995830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alf L Nastri, Isaac Liau, Jaewon Heo, Alexander Schramm
{"title":"Patient-Specific Orthognathic Solutions: Expert Opinion on Guidelines and Workflow.","authors":"Alf L Nastri, Isaac Liau, Jaewon Heo, Alexander Schramm","doi":"10.3390/cmtr18010012","DOIUrl":"10.3390/cmtr18010012","url":null,"abstract":"<p><p>This document outlines guidelines for the use of three-dimensional virtual surgical planning in orthognathic surgery, with relevance to data acquisition, clinical diagnosis, data workflow sequencing, and operative considerations. A detailed description regarding fundamental principles of orthognathic assessment and planning is beyond the scope of this paper.</p>","PeriodicalId":46447,"journal":{"name":"Craniomaxillofacial Trauma & Reconstruction","volume":"18 1","pages":"12"},"PeriodicalIF":0.4,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11995829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rodrigo Dos Santos Pereira, Rafael Vago Cypriano, Carlos Gaete Garcia, Juan José Larrañaga, Nicolas Homsi
{"title":"Overcoming Barriers: The AO Foundation's Role in Latin American Scientific Growth.","authors":"Rodrigo Dos Santos Pereira, Rafael Vago Cypriano, Carlos Gaete Garcia, Juan José Larrañaga, Nicolas Homsi","doi":"10.3390/cmtr18010011","DOIUrl":"https://doi.org/10.3390/cmtr18010011","url":null,"abstract":"<p><p>This manuscript presents an exploratory evaluation of the challenges and opportunities in scientific research among craniomaxillofacial surgeons in Latin America. It focuses on initiatives introduced by the AO Foundation's Research and Development (R&D) Committee to assess the current state of research involvement among AO Foundation members in the region and identify barriers to research. A survey conducted in 2023 among Latin American members of the AO Foundation gathered data on their interest in research, obstacles faced, and awareness of available opportunities, such as grants, fellowships, and mentorship programs. The outcomes revealed a strong interest in research, with 96.5% of respondents expressing a desire to engage. However, key barriers included limited time (46.5%), difficulties in project structuring and scientific writing (32.6%), and challenges in publishing (30.2%). Notably, 54.7% of respondents were unaware of the AO PEER program, and 65.6% were unfamiliar with the foundation's research grant opportunities. The AO Foundation aims to enhance scientific development in Latin America by promoting multicenter research studies, training opportunities, and developing research group leaders. These strategies seek to support and encourage surgeons in advancing their scientific activities.</p>","PeriodicalId":46447,"journal":{"name":"Craniomaxillofacial Trauma & Reconstruction","volume":"18 1","pages":"11"},"PeriodicalIF":0.8,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11995823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bert Rombaut, Matthias Ureel, Benjamin Van der Smissen, Nicolas Dhooghe, Renaat Coopman
{"title":"Training of Oral and Maxillofacial Surgery Residents in Virtual Surgical Planning: A Feasibility Study Comparing Open-Source Freeware and Commercially Available Software for Mandibular Reconstruction with Fibula Free Flap.","authors":"Bert Rombaut, Matthias Ureel, Benjamin Van der Smissen, Nicolas Dhooghe, Renaat Coopman","doi":"10.3390/cmtr18010010","DOIUrl":"10.3390/cmtr18010010","url":null,"abstract":"<p><p><i>Study Design:</i> This is an experimental feasibility study. <i>Objective:</i> The objective was to analyze the potential of open-source freeware (OSF) to train residents in virtual surgical planning (VSP) and compare this workflow with commercially available software (CAS). <i>Methods:</i> A workflow for mandibular reconstruction with a fibular free flap (FFF) was developed in 3D-Slicer<sup>®</sup> and Blender<sup>®</sup> and compared to our clinical workflow in Materialise Mimics Innovation Suite version 25 (Materialise InPrint<sup>®</sup>, ProPlan CMF<sup>®</sup> and 3-Matic<sup>®</sup>). Five CMF residents, inexperienced in VSP, were trained to use both the OSF and CAS workflows and then performed four planning sessions on OSF and CAS. The duration (minutes) and the amount of mouse clicks (MCs) of every step in the workflow were recorded. Afterwards, the experience with VSP was investigated with the System Usability Scale (SUS) and a self-developed questionnaire. <i>Results:</i> The total VSP time with CAS took 91 ± 15 min and needed 2325 ± 86 MCs compared to 111 ± 26 min and 1876 ± 632 MCs for OSF, respectively. The questionnaire had an 80% response rate. The SUS for CAS was 67.5 compared to 50 for OSF. The participants believe it is extremely valuable to learn VSP during their training and to be able to perform VSP as a surgeon. <i>Conclusion:</i> We believe OSF can be a cost-effective alternative compared to CAS for the training of surgical residents to gain insight in complex surgeries and to better understand CAD limitations and possibilities.</p>","PeriodicalId":46447,"journal":{"name":"Craniomaxillofacial Trauma & Reconstruction","volume":"18 1","pages":"10"},"PeriodicalIF":1.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11995818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparative Analysis of Open and Closed Nasal Fractures in Trauma Settings: Mechanisms, Intent, Surgical Interventions, and Outcomes.","authors":"Ahmad K Alnemare","doi":"10.3390/cmtr18010009","DOIUrl":"https://doi.org/10.3390/cmtr18010009","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to explore nasal fracture patterns, trauma mechanism and intent, treatment approaches, and mortality rates, offering insights for clinical practice and prevention in trauma settings.</p><p><strong>Design: </strong>This retrospective analysis was carried out using trauma data from the National Trauma Data Bank (NTDB) for the years 2013 to 2016.</p><p><strong>Main outcome measures: </strong>Trauma mechanism and mortality rates between closed and open fractures were conducted.</p><p><strong>Results: </strong>This study involved 122,574 closed and 9704 open nasal fractures to elucidate demographic, hospital, and clinical characteristics. Significant risk factors for open nasal fractures included a higher injury severity score, self-inflicted intent, unintentional causes, and firearm mechanism compared to assault injuries.</p><p><strong>Conclusions: </strong>Significant factors associated with open nasal fractures include injury severity, self-inflicted intent, trauma type, and firearm mechanisms, which notably increase the likelihood of open fractures. Findings highlight the need for targeted prevention, efficient resource allocation, and risk screening to enhance the management of complex facial traumas in the national trauma system.</p>","PeriodicalId":46447,"journal":{"name":"Craniomaxillofacial Trauma & Reconstruction","volume":"18 1","pages":"9"},"PeriodicalIF":0.8,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11995816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
John M Le, John Hofheins, Myra Rana, Jay Ponto, Anthony B Morlandt, Yedeh P Ying
{"title":"Oncological Outcomes Following Computer-Aided Reconstructive Jaw Surgery.","authors":"John M Le, John Hofheins, Myra Rana, Jay Ponto, Anthony B Morlandt, Yedeh P Ying","doi":"10.3390/cmtr18010008","DOIUrl":"10.3390/cmtr18010008","url":null,"abstract":"<p><p>The purpose of this study was to analyze computer-aided surgical planning (CAS) and margin status following oncological reconstructive surgery of the jaws. A retrospective study was conducted on patients who underwent microvascular reconstructive surgery from 2014 to 2021. The predictor variable was the use of CAS. The primary and secondary outcomes were histopathological bone margin status, local recurrence, and disease-free survival (DFS). Covariates included demographic, operative, pathological, and clinical outcomes. Thirty-five CAS and fifty-two non-CAS subjects were included for analysis. Demographic characteristics such as age, sex, and comorbidities were comparable between the study groups, with all <i>p</i>-values > 0.05. For operative variables, the osteocutaneous radial forearm flap was more commonly used in the non-CAS group (34.6%) compared to the CAS group (2.9%) (<i>p</i> < 0.01). The mean follow-up period was shorter in the CAS group (31.9 months) than in the non-CAS group (42.6 months) (<i>p</i> < 0.01). CAS was not associated with margin status (<i>p</i> = 0.65) or local recurrence (<i>p</i> = 0.08). DFS was comparable between the study groups (<i>p</i> = 0.74). Bone margin involvement was not associated with any covariates. The use of CAS in oncological reconstructive jaw surgery was not associated with increased bone margin involvement.</p>","PeriodicalId":46447,"journal":{"name":"Craniomaxillofacial Trauma & Reconstruction","volume":"18 1","pages":"8"},"PeriodicalIF":0.4,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11995824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}