Therapeutic Advances in Infectious Disease最新文献

{"title":"Pre-exposure prophylaxis access, uptake and usage by young people: a systematic review of barriers and facilitators.","authors":"Sarah Warzywoda, James A Fowler, Amalie Dyda, Lisa Fitzgerald, Amy B Mullens, Judith A Dean","doi":"10.1177/20499361241303415","DOIUrl":"10.1177/20499361241303415","url":null,"abstract":"<p><strong>Background: </strong>Young people's sexual health decision-making, including decisions to access and adhere to HIV prevention strategies such as Pre-Exposure Prophylaxis (PrEP), are influenced by a range of internal and external factors. Synthesizing these factors is essential to guide the development of youth-focused PrEP health promotion strategies to contribute to international goals of ending HIV transmission.</p><p><strong>Objective: </strong>To understand the individual, interpersonal, sociocultural and systemic barriers and facilitators to PrEP access, uptake and use experienced by young people 24 years and younger.</p><p><strong>Design: </strong>A systematic review that adhered to the Preferred Reporting Items of Systematic Review and Meta-Analysis Protocols.</p><p><strong>Data sources and methods: </strong>Eight databases (PubMed, Scopus, Cochrane, Medline, CINAHL, JBI, EMBASE, Web of Science) were systematically searched using terms related to young people, HIV and PrEP use. A narrative synthesis approach was used to delineate key barriers and facilitators to PrEP access, uptake and use.</p><p><strong>Results: </strong>Of 11,273 returned articles, 32 met the eligibility criteria for inclusion: 18 from the United States, 10 from African nations and two from Brazil. Barriers and facilitators to PrEP access, uptake and use experienced by young people were identified across intrapersonal, interpersonal, community and systems levels. These factors are described under four overarching themes that relate to knowledge, side effects and perceptions of risk; attitudes and perceptions of family and partners; community attitudes and stigma; and negative healthcare provider experiences and difficulties navigating complex costly healthcare systems.</p><p><strong>Conclusion: </strong>Findings suggest individual-level factors need consideration alongside the impacts of healthcare systems and broader systemic sociocultural structures within young people's relationships when developing PrEP health promotion strategies and services. Without considering these wider external implications to access, uptake and use of PrEP, global targets towards the elimination of HIV transmission will likely remain out of reach.</p><p><strong>Registration: </strong>This review was registered with Prospero (CRD42022296550).</p>","PeriodicalId":46154,"journal":{"name":"Therapeutic Advances in Infectious Disease","volume":"11 ","pages":"20499361241303415"},"PeriodicalIF":3.8,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11624559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cholera's global resurgence: urgent appeal for enhanced vaccine availability in Nigeria, and beyond.","authors":"Roland I Stephen, Jamiu S Olumoh, Jimmy A Reyes, Malachy I Okeke, Jennifer A Tyndall, Nura Umaru, Oyelola A Adegboye","doi":"10.1177/20499361241303431","DOIUrl":"10.1177/20499361241303431","url":null,"abstract":"","PeriodicalId":46154,"journal":{"name":"Therapeutic Advances in Infectious Disease","volume":"11 ","pages":"20499361241303431"},"PeriodicalIF":3.8,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11613216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social disparities on PrEP use and awareness among sexual and gender minorities using smartphones in India.","authors":"Harsh Agarwal, Karin Yeatts, Stephanie R Chung, Jack Harrison-Quintana, Thiago S Torres","doi":"10.1177/20499361241299992","DOIUrl":"10.1177/20499361241299992","url":null,"abstract":"<p><strong>Background: </strong>Pre-exposure prophylaxis (PrEP) is a safe and effective HIV prevention strategy. However, in countries such as India where PrEP is driven by the private healthcare system and there is no centralized reporting, it is unknown which populations benefit from PrEP and which populations are being left behind.</p><p><strong>Objectives: </strong>We examined and characterized PrEP use and awareness among the sexual and gender minorities using smartphones in India and found measures of association of PrEP use.</p><p><strong>Design: </strong>This is a cross-sectional study design.</p><p><strong>Methods: </strong>We used Grindr-a widely used geosocial mobile application-to conduct a national cross-sectional survey in India, including respondents who were 18 years or older and reported sex with men (those who identified as cis-gender females were excluded). We examined overall PrEP awareness and PrEP use, then calculated adjusted prevalence odds ratio and 95% confidence intervals to understand PrEP use correlation with socio-behavioral factors.</p><p><strong>Results: </strong>Out of the total of 3116 eligible participants, 30.3% (<i>N</i> = 947) were aware of PrEP and 3.1% (<i>N</i> = 97) reported current PrEP use. Our multivariate regression model found that there was a statistically significant association of PrEP use with higher income, being employed, preferred language as English for survey, relationship status as single, and use of party drugs. At the same time, there was a statistically significant association of PrEP awareness with age group, having higher education as a graduate or above, higher income, use of party drugs, and multiple sexual partners.</p><p><strong>Conclusion: </strong>We found overall low awareness and low PrEP use in our cross-sectional sample. PrEP use and awareness were higher among those who belonged to higher-income groups. Including PrEP in existing programmatic interventions by government and NGOs may contribute to PrEP scale-up, which is urgent to stop the HIV epidemic in India.</p>","PeriodicalId":46154,"journal":{"name":"Therapeutic Advances in Infectious Disease","volume":"11 ","pages":"20499361241299992"},"PeriodicalIF":3.8,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11580082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges in the treatment of cutaneous leishmaniasis caused by <i>L. braziliensis</i> in four travelers: a case series.","authors":"Carolina Moreira Sarmiento, Guy Crowder, Bonnie Meatherall, Jacob Bezemer, Yenjean Hwang, Ariel Gordon, Aisha Mumtaz, Brittany Jackson, Juan David Ramírez, Alberto Paniz-Mondolfi, Carlos Franco-Paredes, Valida Bajrovic","doi":"10.1177/20499361241274254","DOIUrl":"10.1177/20499361241274254","url":null,"abstract":"<p><p>We describe a group of four travelers returning to the United States and Canada who acquired <i>Leishmania braziliensis</i> infection in the Peruvian Amazon. Pentavalent antimonials are the preferred treatment option for cutaneous leishmaniasis (CL) in most endemic countries in Central and South America. However, we initially treated our patients with liposomal amphotericin B (LAB) and miltefosine since these are the only two available Food and Drug Administration approved drugs in the United States. Refractory disease was common as three of the four travelers required repeated courses of miltefosine and two also received LAB. One patient required intravenous therapy with meglumine antimoniate (NMG), and one received intralesional NMG. Given the increasing number of cases of CL identified in the United States, there is an urgent need for expanded access to pentavalent antimonials for treating leishmaniasis acquired in Central and South America.</p>","PeriodicalId":46154,"journal":{"name":"Therapeutic Advances in Infectious Disease","volume":"11 ","pages":"20499361241274254"},"PeriodicalIF":3.8,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fungal Infections, Treatment and Antifungal Resistance: The Sub-Saharan African Context.","authors":"Emily Boakye-Yiadom, Alex Odoom, Abdul-Halim Osman, Onyansaniba K Ntim, Fleischer C N Kotey, Bright K Ocansey, Eric S Donkor","doi":"10.1177/20499361241297525","DOIUrl":"10.1177/20499361241297525","url":null,"abstract":"<p><p>Fungal pathogens cause a wide range of infections in humans, from superficial to disfiguring, allergic syndromes, and life-threatening invasive infections, affecting over a billion individuals globally. With an estimated 1.5 million deaths annually attributable to them, fungal pathogens are a major cause of mortality in humans, especially people with underlying immunosuppression. The continuous increase in the population of individuals at risk of fungal infections in sub-Saharan Africa, such as HIV patients, tuberculosis patients, intensive care patients, patients with haematological malignancies, transplant (haematopoietic stem cell and organ) recipients and the growing global threat of multidrug-resistant fungal strains, raise the need for an appreciation of the region's perspective on antifungal usage and resistance. In addition, the unavailability of recently introduced novel antifungal drugs in sub-Saharan Africa further calls for regular evaluation of resistance to antifungal agents in these settings. This is critical for ensuring appropriate and optimal use of the limited available arsenal to minimise antifungal resistance. This review, therefore, elaborates on the multifaceted nature of fungal resistance to the available antifungal drugs on the market and further provides insights into the prevalence of fungal infections and the use of antifungal agents in sub-Saharan Africa.</p>","PeriodicalId":46154,"journal":{"name":"Therapeutic Advances in Infectious Disease","volume":"11 ","pages":"20499361241297525"},"PeriodicalIF":3.8,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11562003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142630107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polio: Background and perspective on how international travel can be made safe against polio.","authors":"Dhanya Dharmapalan, Thekkekara Jacob John, Robert Steinglass, Norbert Hirschhorn","doi":"10.1177/20499361241298857","DOIUrl":"10.1177/20499361241298857","url":null,"abstract":"<p><p>International spread of polio continues to be a Public Health Emergency of International Concern since its declaration by the World Health Organization in 2014 and its reiteration in 2024. In 2023 and 2024, two countries remained endemic for wild poliovirus (WPV) but 20 countries reported polio outbreaks due to vaccine-derived polioviruses (VDPVs) in 2023 and 10 countries in 2024 (up to mid-June). Guidelines from various agencies recommend polio vaccination before travelling to or from polio-affected countries, or attending mass gatherings anywhere in the world, particularly if the crowd is international. Immunity protects against polio paralysis but not against poliovirus re-infection, irrespective of which vaccine was involved - live attenuated oral polio vaccine (OPV) or inactivated poliovirus vaccine (IPV). Infection with WPV or circulating VDPV in the vast majority of non-immune individuals (first infection) is asymptomatic, while they are efficient virus transmitters. Re-infections in immune individuals are always asymptomatic, but they are also infectious and may act as source for further transmission, although less efficiently than the former. Thus, travellers can become transmission vectors, illustrated by many episodes of importations of WPV or VDPVs into polio-free countries in recent years. The route of poliovirus transmission remains controversial, with many believing it to be faecal-oral, but epidemiological analysis is consistent with respiratory route and not faecal-oral. Transmission occurs person-to-person during social contact. Travellers must ensure they are adequately immunised to avoid polio, and becoming vectors of virus importation. The vaccine efficacy (VE) of OPV is highly variable - high in temperate climate countries, particularly rich countries, but low or very low in tropical low-income countries. On the other hand, VE of IPV is excellent everywhere irrespective of geography.</p>","PeriodicalId":46154,"journal":{"name":"Therapeutic Advances in Infectious Disease","volume":"11 ","pages":"20499361241298857"},"PeriodicalIF":3.8,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11561982/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142630112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging trends in fungal endocarditis: clinical complexity, diagnostic challenges, and therapeutic implications - a case series and literature review.","authors":"Santhanam Naguthevar, Akshatha Ravindra, Deepak Kumar, Durga Shankar Meena, Gopal Krishana Bohra, Vidhi Jain, M K Garg, Surender Deora, Rahul Choudhary","doi":"10.1177/20499361241293655","DOIUrl":"https://doi.org/10.1177/20499361241293655","url":null,"abstract":"<p><strong>Background: </strong>Fungal infective endocarditis (IE) is a rare, yet increasingly recognised condition associated with substantial mortality rates. <i>Candida</i> and <i>Histoplasma</i> are among the notable causative agents, presenting diverse clinical manifestations and complexities in diagnosis and management.</p><p><strong>Objectives: </strong>This study was undertaken to examine the clinical profiles, diagnostic challenges, treatment modalities, and outcomes of four compelling cases involving <i>Candida</i> and <i>Histoplasma</i> endocarditis.</p><p><strong>Methods & design: </strong>This was a descriptive case series study conducted from July 2021 to July 2023. All patients with definite/possible endocarditis diagnosed based on modified Duke's criteria were reviewed in this study. Data on demographics, risk factors, clinical signs and symptoms, echocardiography findings, microbiological aetiology, complications, treatment, and outcomes were collected.</p><p><strong>Results: </strong>Among 212 suspected IE cases reviewed, 54 met the modified Duke's criteria for possible or definite IE, with four instances identified as fungal endocarditis. <i>Candida</i> species accounted for three cases, while an uncommon instance of <i>Histoplasma</i> Endocarditis (HE) was also observed. Clinical presentations varied, with fever and dyspnoea being prominent symptoms. Risk factors included chronic kidney disease, prior surgeries, prosthetic valves, and immunocompromised states. Diagnosis posed challenges due to the resemblance to bacterial IE, low blood culture yields, and delayed suspicion. Various diagnostic approaches, including blood cultures, serological markers, and imaging, were employed. Therapeutic strategies involved antifungal agents and surgical intervention, where feasible. However, despite prompt treatment initiation, many patients faced rapid clinical deterioration, emphasising the severity and aggressive nature of fungal endocarditis. Mortality rates remained notably high across the cohort.</p><p><strong>Conclusion: </strong>This study highlights the criticality of early suspicion, prompt diagnosis, and a multidisciplinary approach to managing fungal endocarditis. While recognising the limitations in current diagnostic tools and therapeutic options, the study underscores the urgent need for enhanced diagnostic modalities and novel treatment strategies to improve outcomes in these challenging cases.</p>","PeriodicalId":46154,"journal":{"name":"Therapeutic Advances in Infectious Disease","volume":"11 ","pages":"20499361241293655"},"PeriodicalIF":3.8,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11550493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142630104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying CNS infections in transplantation and immunomodulatory therapy.","authors":"Luisa F Alviz, Benjamin A Jones, Shruti P Agnihotri, Kiran T Thakur","doi":"10.1177/20499361241298456","DOIUrl":"https://doi.org/10.1177/20499361241298456","url":null,"abstract":"<p><p>Opportunistic central nervous system (CNS) infections are a significant cause of morbidity and mortality in immunocompromized patients, including those undergoing transplantation and receiving immunomodulatory therapy. Particularly in these individuals, the clinical presentation of these infections may have atypical patterns, emphasizing the need to consider various diagnostic possibilities, including noninfectious conditions. Quick and accurate identification, along with prompt treatment, is crucial for improving patient outcomes. Therefore, understanding which pathogens are likely to cause infection based on factors such as timing post-transplantation, specific organ transplant, and the mechanism of action of immunomodulatory medications is essential. This review will provide a detailed description of the types of infections that may arise in the context of transplantation and immunomodulatory therapy.</p>","PeriodicalId":46154,"journal":{"name":"Therapeutic Advances in Infectious Disease","volume":"11 ","pages":"20499361241298456"},"PeriodicalIF":3.8,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11550508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142630111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of generalized cat scratch disease in a patient with ulcerative colitis on immunosuppressive therapy.","authors":"Bruna Rošić Despalatović, Andre Bratanić, Dora Božić, Katarina Vilović, Nenad Kunac, Žarko Ardalić","doi":"10.1177/20499361241271832","DOIUrl":"https://doi.org/10.1177/20499361241271832","url":null,"abstract":"<p><p>Cat scratch disease (CSD) is a zoonotic disease transmitted to humans, usually via scratches or bites. <i>Bartonella henselae</i> is the primary causative agent. It causes a mild, self-limiting disease. In immunocompromised patients, the course of the infection can be more serious because of the suppressed antibacterial response, causing a life-threatening disease. A 54-year-old male patient presented with ulcerative colitis. Five days after receiving the first dose of infliximab 400 mg intravenously and 0.5 mg/kg methylprednisolone, he presented with enlarged axillary lymph nodes and colliquation of the intraabdominal lymph node with intrahepatic colliquating areas caused by <i>B. henselae</i> after cat bites. Long-term treatment with multiple antibiotics and prednisolone resulted in clinical improvement and regression of the liver and intra-abdominal lymph nodes. After further treatment for ulcerative colitis, we assessed the possibility of reintroducing immunosuppressive therapy. Adalimumab was introduced after consulting an infectious disease specialist. At the follow-up visit, the patient was in remission of ulcerative colitis and without signs of reactivation of bartonellosis. Diseases such as CSD with a benign clinical appearance and prognosis can develop a severe and life-threatening course in immunocompromised patients. This requires a complex understanding of the immune processes in such patients, and the reintroduction of immunosuppressive therapy after successful treatment of CSD probably does not increase the risk of reactivation.</p>","PeriodicalId":46154,"journal":{"name":"Therapeutic Advances in Infectious Disease","volume":"11 ","pages":"20499361241271832"},"PeriodicalIF":3.8,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11549701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142630100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subclinical malaria among pregnant women living in refugee settlements in Northern Uganda.","authors":"Winnie Kibone, Felix Bongomin, Sarah Lebu, Stephen Ochaya, Ritah Nantale, Jerom Okot, Byron Awekonimungu, Rachel Beardsley, Chimdi Muoghalu, Musa Manga","doi":"10.1177/20499361241296002","DOIUrl":"https://doi.org/10.1177/20499361241296002","url":null,"abstract":"<p><strong>Background: </strong>Malaria during pregnancy contributes to significant perinatal morbidity and mortality, accounting for almost 25% of global maternal mortality. However, the epidemiology and risk factors for subclinical malaria among pregnant women living in refugee settlements is poorly understood.</p><p><strong>Objective: </strong>To determine the prevalence and predictors of subclinical malaria among pregnant women in refugee settlements in Northern Uganda.</p><p><strong>Design: </strong>We conducted a multi-center, cross-sectional study.</p><p><strong>Methods: </strong>The study was conducted between April and June 2023 and involved pregnant women aged 18-45 years attending routine antenatal care (ANC) at three health facilities serving refugee communities in Adjumani district, Uganda. We collected sociodemographic, environmental, maternal, and obstetric factors using a structured questionnaire. Both CareStart Malaria HRP-2/pLDH (Pf/Pan) combo rapid diagnostic test (RDT) and blood smear microscopy with 3% Giemsa staining were simultaneously performed on samples from each patient. Logistic regression analysis identified factors independently associated with subclinical malaria, reported as adjusted odds ratios (aORs) and 95% confidence intervals (CIs).</p><p><strong>Results: </strong>We enrolled 304 pregnant women, with a mean age of 25 years. In total, 68.8% (<i>n</i> = 209) had lived in the settlement for over 12 months, 25.7% (<i>n</i> = 78) were primigravida, and 1.0% (<i>n</i> = 3) were living with HIV. Malaria prevalence was 5.3% (<i>n</i> = 16) by RDT and 3.2% (<i>n</i> = 10; seven <i>Plasmodium falciparum</i> and three <i>P. malariae</i>) by microscopy. Only 4 (25.0%) of the RDT-positive cases were also positive by microscopy (Cohen's kappa: 0.278-Fair agreement). All participants were asymptomatic. Factors associated with higher odds of subclinical malaria included primiparity (aOR: 2.79, 95% CI: 1.25-6.25, <i>p</i> = 0.013), ⩾4 ANC visits (aOR: 2.41, 95% CI: 1.34-4.34, <i>p</i> = 0.003), and residence in the settlement for less than 12 months (aOR: 2.54, 95% CI: 2.0-3.22, <i>p</i> < 0.001). Living in the settlement for over 3 years, being primigravida, and being married were associated with 68%, 50%, and 68% lower odds of subclinical malaria, respectively (aOR: 0.32, 95% CI: 0.13-0.79, <i>p</i> = 0.014; aOR: 0.50, 95% CI: 1.22-5.52, <i>p</i> = 0.016; aOR: 0.32, 95% CI: 0.13-0.78, <i>p</i> = 0.012).</p><p><strong>Conclusion: </strong>Our study reveals the high prevalence of subclinical malaria among pregnant women in refugee settlements, particularly among primiparous women and recent arrivals. The poor agreement between RDT and microscopy suggests the need for dual screening in asymptomatic pregnant women.</p>","PeriodicalId":46154,"journal":{"name":"Therapeutic Advances in Infectious Disease","volume":"11 ","pages":"20499361241296002"},"PeriodicalIF":3.8,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11542121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}