Matenge Mutalange, Lukundo Siame, Chilala Cheelo, Sepiso K Masenga, Benson M Hamooya
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However, there is limited data on the burden and risk factors for kidney impairment in resource-limited settings.</p><p><strong>Objectives: </strong>This study aimed to determine the prevalence and factors associated with kidney impairment among PLWH receiving antiretroviral therapy (ART) at a tertiary hospital in Zambia.</p><p><strong>Design: </strong>This was a retrospective cross-sectional study.</p><p><strong>Methods: </strong>This study consisted of 374 PLWH aged ⩾18 years and on ART for ⩾ 6 months. We obtained clinical, laboratory, and demographic characteristics from a study that focused on metabolic syndrome among PLWH. Kidney impairment was defined as having an estimated glomerular filtration rate (eGFR) of <60 ml/min/1.73 m<sup>2</sup>. Data was analyzed using STATA version 15. Multivariable logistic regression was used to ascertain factors associated with kidney impairment.</p><p><strong>Results: </strong>The median age among the study participants was 44 years, and the majority were females, 63.4% (<i>n</i> = 237). The prevalence of kidney impairment was 10.7% (<i>n</i> = 40. After accounting for duration on ART, sex and blood pressure (systolic and diastolic), older age and being on a Dolutegravir (DTG) and tenofovir disoproxil fumarate/lamivudine (TDF/3TC) based regimen was positively associated with kidney impairment (adjusted odds ratio (aOR) 1.09; 95% CI: 1.05, 1.14, <i>p</i> < 0.001) and (aOR 2.44; 95% CI: 1.02, 5.79, <i>p</i> = 0.043), respectively.</p><p><strong>Conclusion: </strong>The prevalence of kidney impairment was common among adult PLWH and was significantly associated with older age and the use of a DTG and TDF/3TC-based regimen. There is a need to regularly monitor kidney function among people with HIV, especially older people who are on a DTG and TDF/3TC-based regimen.</p>","PeriodicalId":46154,"journal":{"name":"Therapeutic Advances in Infectious Disease","volume":"12 ","pages":"20499361251340795"},"PeriodicalIF":3.4000,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12141796/pdf/","citationCount":"0","resultStr":"{\"title\":\"Kidney impairment in HIV: an insight into the burden and associated factors among adults on antiretroviral therapy in Zambia. 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However, there is limited data on the burden and risk factors for kidney impairment in resource-limited settings.</p><p><strong>Objectives: </strong>This study aimed to determine the prevalence and factors associated with kidney impairment among PLWH receiving antiretroviral therapy (ART) at a tertiary hospital in Zambia.</p><p><strong>Design: </strong>This was a retrospective cross-sectional study.</p><p><strong>Methods: </strong>This study consisted of 374 PLWH aged ⩾18 years and on ART for ⩾ 6 months. We obtained clinical, laboratory, and demographic characteristics from a study that focused on metabolic syndrome among PLWH. Kidney impairment was defined as having an estimated glomerular filtration rate (eGFR) of <60 ml/min/1.73 m<sup>2</sup>. Data was analyzed using STATA version 15. Multivariable logistic regression was used to ascertain factors associated with kidney impairment.</p><p><strong>Results: </strong>The median age among the study participants was 44 years, and the majority were females, 63.4% (<i>n</i> = 237). The prevalence of kidney impairment was 10.7% (<i>n</i> = 40. After accounting for duration on ART, sex and blood pressure (systolic and diastolic), older age and being on a Dolutegravir (DTG) and tenofovir disoproxil fumarate/lamivudine (TDF/3TC) based regimen was positively associated with kidney impairment (adjusted odds ratio (aOR) 1.09; 95% CI: 1.05, 1.14, <i>p</i> < 0.001) and (aOR 2.44; 95% CI: 1.02, 5.79, <i>p</i> = 0.043), respectively.</p><p><strong>Conclusion: </strong>The prevalence of kidney impairment was common among adult PLWH and was significantly associated with older age and the use of a DTG and TDF/3TC-based regimen. 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引用次数: 0
摘要
背景：肾脏疾病，从无症状肾脏损害到终末期肾脏疾病，仍然是全球关注的公共卫生问题。肾脏疾病已被证明是艾滋病毒感染者（PLWH）死亡和发病的一个重要原因。然而，在资源有限的环境中，关于肾脏损害的负担和危险因素的数据有限。目的：本研究旨在确定在赞比亚一家三级医院接受抗逆转录病毒治疗（ART）的PLWH中肾脏损害的患病率和相关因素。设计：这是一项回顾性横断面研究。方法：该研究包括374名年龄大于或等于18岁的PLWH，并接受ART治疗大于或等于6个月。我们从一项关注PLWH代谢综合征的研究中获得了临床、实验室和人口学特征。肾损害定义为肾小球滤过率（eGFR）估计为2。使用STATA version 15分析数据。采用多变量logistic回归确定与肾损害相关的因素。结果：研究参与者的中位年龄为44岁，以女性居多，占63.4% （n = 237）。肾损害发生率为10.7% （n = 40）。在考虑了抗逆转录病毒治疗的持续时间、性别和血压（收缩压和舒张压）、年龄和使用多替替韦（DTG）和富马酸替诺福韦二氧吡酯/拉米夫定（TDF/3TC）为基础的方案与肾脏损害呈正相关(调整优势比（aOR） 1.09；95% CI: 1.05, 1.14, p = 0.043)。结论：肾损害的患病率在成人PLWH中很常见，并且与年龄和使用DTG和TDF/ 3tc为基础的方案显著相关。有必要定期监测艾滋病毒感染者的肾功能，特别是使用DTG和TDF/ 3tc方案的老年人。
Kidney impairment in HIV: an insight into the burden and associated factors among adults on antiretroviral therapy in Zambia. A retrospective cross-sectional study.
Background: Kidney disease, ranging from asymptomatic kidney impairment to end-stage renal disease, remains a public health concern globally. Kidney diseases have been shown to be a significant cause of mortality and morbidity among people living with HIV (PLWH). However, there is limited data on the burden and risk factors for kidney impairment in resource-limited settings.
Objectives: This study aimed to determine the prevalence and factors associated with kidney impairment among PLWH receiving antiretroviral therapy (ART) at a tertiary hospital in Zambia.
Design: This was a retrospective cross-sectional study.
Methods: This study consisted of 374 PLWH aged ⩾18 years and on ART for ⩾ 6 months. We obtained clinical, laboratory, and demographic characteristics from a study that focused on metabolic syndrome among PLWH. Kidney impairment was defined as having an estimated glomerular filtration rate (eGFR) of <60 ml/min/1.73 m2. Data was analyzed using STATA version 15. Multivariable logistic regression was used to ascertain factors associated with kidney impairment.
Results: The median age among the study participants was 44 years, and the majority were females, 63.4% (n = 237). The prevalence of kidney impairment was 10.7% (n = 40. After accounting for duration on ART, sex and blood pressure (systolic and diastolic), older age and being on a Dolutegravir (DTG) and tenofovir disoproxil fumarate/lamivudine (TDF/3TC) based regimen was positively associated with kidney impairment (adjusted odds ratio (aOR) 1.09; 95% CI: 1.05, 1.14, p < 0.001) and (aOR 2.44; 95% CI: 1.02, 5.79, p = 0.043), respectively.
Conclusion: The prevalence of kidney impairment was common among adult PLWH and was significantly associated with older age and the use of a DTG and TDF/3TC-based regimen. There is a need to regularly monitor kidney function among people with HIV, especially older people who are on a DTG and TDF/3TC-based regimen.
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