Egyptian Rheumatologist最新文献

{"title":"Disease- and mental health-related predictors of quality of life among radiographic axial spondyloarthritis patients","authors":"Suzan S. Al-Adle ,&nbsp;Radwa S. ELbahnasy ,&nbsp;Shirin M. El-Makawi ,&nbsp;Hania S. Zayed","doi":"10.1016/j.ejr.2025.09.003","DOIUrl":"10.1016/j.ejr.2025.09.003","url":null,"abstract":"<div><h3>Background</h3><div>Radiographic axial spondyloarthritis (r-axSpA) significantly impacts health-related quality of life (HRQoL).</div></div><div><h3>Aim of the work</h3><div>To evaluate the disease-and mental health-related predictors of HRQoL in r-axSpA patients.</div></div><div><h3>Patients and methods</h3><div>Fifty-five r-axSpA patients and 55 age-, sex- and education-matched healthy controls were studied. Patients were evaluated by the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), Bath Ankylosing Spondylitis Metrology Index (BASMI) and patient global (PG) assessment of disease activity. Patients and controls were evaluated by the Short Form-36 (SF-36), its physical and mental component summaries (PCS and MCS, respectively), the Depression, Anxiety and Stress scale (DASS) and the Montreal Cognitive Assessment (MoCA)-Basic test.</div></div><div><h3>Results</h3><div>Patients’ mean age was 36.4 ± 7.48 years, median disease duration 10 years with interquartile range (IQR) (6–14) and 47 (85.5 %) were males. DASS scores were significantly higher while MoCA, PCS and MCS scores were lower in patients than controls, p &lt; 0.001. BASDAI (r = −0.701), BASFI (r = −0.73), BASMI (r = −0.52), PG (r = −0.51), depression (r = −0.73), anxiety (r = −0.627) and stress (r = −0.691) scores showed significant negative correlations with PCS, p &lt; 0.001. BASDAI (r = −0.602), BASFI (r = −0.668), BASMI (r = −0.37), PG (r = −0.45), depression (r = −0.74), anxiety (r = −0.63) and stress (r = −0.68) showed significant negative correlations with MCS; p &lt; 0.001. MoCA significantly correlated with PCS (r = 0.36, p = 0.007) and MCS (r = 0.36, p = 0.008). On multivariable logistic regression analyses, PG and stress were independent predictors for PCS (β = −0.22, p = 0.041 and β = −0.35, p = 0.038, respectively), and stress was an independent predictor for MCS (β = −0.39, p = 0.035).</div></div><div><h3>Conclusion</h3><div>The PG assessment and stress scale are predictors of HRQoL in r-axSpA patients.</div></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"47 4","pages":"Pages 232-237"},"PeriodicalIF":1.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145117678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subclinical cognitive dysfunction in systemic lupus erythematosus patients: Insights from clinical and electrophysiological measures","authors":"Esraa M. Seif El-Din ,&nbsp;Ahmed K. Mohamed ,&nbsp;Dina F. Osman","doi":"10.1016/j.ejr.2025.09.001","DOIUrl":"10.1016/j.ejr.2025.09.001","url":null,"abstract":"<div><h3>Background</h3><div>Cognitive dysfunction is common in systemic lupus erythematosus (SLE) with considerable impact on patients’ quality of life.</div></div><div><h3>Aim of the work</h3><div>To evaluate cognitive function in SLE patients with (NPSLE) and without (non-NPSLE) neuropsychiatric involvement and their association with disease parameters.</div></div><div><h3>Patients and methods</h3><div>The study included 30 SLE patients (15 NPSLE and 15 non-NPSLE) and 30 matched controls. Cognitive evaluation included the mini-mental state examination (MMSE), symbol digit modalities test (SDMT) and electrophysiological event-related potentials (P300). Audiological assessment was performed. The SLE disease activity index (SLEDAI) was assessed.</div></div><div><h3>Results</h3><div>Patients were 26 females and 4 males with a mean of age of 36.4 ± 6.3 years. All patients had a prolonged P300 latency, reduced P300 amplitude, lower MMSE and SDMT scores compared to the control (408.9 ± 40.08 <em>vs</em> 313.8 ± 10.72, 3.63 ± 0.8 <em>vs</em> 4.85 ± 0.9, 26.6 ± 1.1<em>vs</em> 29.17 ± 0.8 and 35.1 ± 3.06 <em>vs</em> 50.47 ± 2.54, all p &lt; 0.001). The SDMT was significantly lower in NPSLE (33.80 ± 3.61) compared to non-NPSLE (36.4 ± 1.68,p = 0.03) patients. There was a significant correlation between MMSE and P300 latency in NPSLE and non-NPSLE groups (r = -0.54, p = 0.03 and r = -0.84, p &lt; 0.001 respectively). Cognitive performance via MMSE negatively correlated with disease duration in both NPSLE and non-NPSLE (r = -0.553,p = 0.032 and r = -0.784,p = 0.001 respectively) as well as P300 latency negatively correlated significantly with disease duration in the non-NPSLE (r = 0.764,p = 0.001). The SDMT had significant predictive ability in differentiating NPSLE from non-NPSLE (sensitivity 73.3 % and specificity 60 %,p = 0.023).</div></div><div><h3>Conclusion</h3><div>Cognitive impairment is frequent in SLE patients, regardless of neuropsychiatric involvement. Early cognitive screening is warranted, and chronic disease progression rather than activity may underlie cognitive deficits.</div></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"47 4","pages":"Pages 227-231"},"PeriodicalIF":1.0,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145003958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lupus profundus in a three years old boy with a favorable response to hydroxychloroquine and steroids: Case report & a comprehensive case-based review","authors":"Hamad A. Alfahaad ,&nbsp;Anwar A. Farhan ,&nbsp;Ola A. Farhan ,&nbsp;Ammar A. Farhan ,&nbsp;Hussain H. Alhatailah ,&nbsp;Rashad A. Feddah ,&nbsp;Soliman A. Alsaiari","doi":"10.1016/j.ejr.2025.08.002","DOIUrl":"10.1016/j.ejr.2025.08.002","url":null,"abstract":"<div><h3>Background</h3><div>To ensure patients receive timely dermatologic care, dermatologists and rheumatologists must be fully aware of the full range of cutaneous diseases in systemic lupus erythematosus (SLE).</div></div><div><h3>Aim of the work</h3><div>This report aims to highlight a rare presentation of lupus profundus in a pre-school aged boy to highlight diagnostic challenges, management, and outcome. Similar juvenile cases worldwide are also presented for a comparison via a comprehensive review of existing literature.</div></div><div><h3>Case presentation</h3><div>A three-year-old Saudi boy of non-consanguineous parents and with six healthy siblings, presented at two years of age with multiple 1–2 cm firm, erythematous, indurated and mildly tender subcutaneous nodules and plaques on the right upper-arm and lower-extremities. Some lesions were ulcerative with suppurative discharge. There were no systemic symptoms of fever, arthritis, or photosensitivity, making the diagnosis of SLE unlikely. Anti-nuclear antibody (ANA) was negative and complements normal. Skin biopsy revealed perivascular lymphohistiocytic infiltrate mixed with plasma cells, follicular plugging, superficial telangiectasia, dermal fibrosis, lobular and septal panniculitis and hyaline fat necrosis. The patient received potent topical steroid twice daily, and hydroxychloroquine (HCQ) 5 mg/kg, and prednisolone 5 mg oral daily. At 8-weeks, there was complete clinical resolution, with residual mild lipoatrophy. A 1-year follow-up found no recurrence or progression to SLE.</div></div><div><h3>Conclusion</h3><div>The diagnosis of lupus profundus in children is confirmed by biopsy and early intervention using HCQ, local and systemic steroid therapy can noticeably lead to rapid complete remission and to minimize cosmetic and psychosocial sequelae. Long-term follow-up is recommended to monitor for recurrence or SLE progression in the pediatric population.</div></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"47 4","pages":"Pages 221-226"},"PeriodicalIF":1.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144988229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical expression of axial spondyloarthritis among a cohort of Egyptian patients","authors":"Basma R Sakr ,&nbsp;Kamal El-Garf ,&nbsp;Maha Mousa","doi":"10.1016/j.ejr.2025.08.003","DOIUrl":"10.1016/j.ejr.2025.08.003","url":null,"abstract":"<div><h3>Aim of the work</h3><div>To study characteristics of axial spondyloarthritis (axSpA) among Egyptian patients in relation to disease and gender related features.</div></div><div><h3>Patients and methods</h3><div>This study recruited 88 axSpA patients. Evaluation of demographics, clinical characteristics, laboratory tests, Bath ankylosing spondylitis disease activity index (BASDAI), Axial Spondyloarthritis Disease Activity Score (ASDAS), Bath Ankylosing Spondylitis Functional Index (BASFI), and health index (HI) was performed.</div></div><div><h3>Results</h3><div>Patients with axSpA showed male predominance (M: F 2.3:1), human leucocytic antigen-B27 (HLA-B27) positivity in 59.4 %, high ASDAS in 60.2 %, poor HI in 13.3 %, peripheral manifestations were mainly arthritis, and enthesitis, extra musculoskeletal manifestations were mainly anterior uveitis. Early axSpA was reported in 8 % of patients. Females displayed initial axial and peripheral symptoms (p = 0.019), more arthritis (p = 0.003), dactylitis (p &lt; 0.001), enthesitis (p = 0.042), and family history of SpA (p = 0.022) than males, with comparable BASDAI, ASDAS, BASFI and HI. Patients with radiographic axSpA (r-axSpA) exhibited initial axial symptoms (p &lt; 0.001), male predominance (p = 0.002), higher C-reactive protein (CRP) (p = 0.016), HI (p = 0.007) and HLA-B27 positivity (p = 0.04), while non-radiographic axSpA (nr-axSpA) patients displayed initial axial and peripheral symptoms (p &lt; 0.001), more arthritis (p &lt; 0.001), dactylitis (p &lt; 0.001), enthesitis (p = 0.001), early axSpA (p = 0.001), family history of SpA (p = 0.021), with comparable BASDAI, ASDAS and BASFI.</div></div><div><h3>Conclusion</h3><div>Patients with r-axSpA were predominantly males, with higher CRP, HLA-B27 positivity, initial axial presentation, worse HI, less frequent arthritis, dactylitis and enthesitis, early axSpA, and family history of SpA compared to nr-axSpA. Females displayed more arthritis, dactylitis and enthesitis, initial axial and peripheral symptoms, and family history of SpA compared to males.</div></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"47 4","pages":"Pages 216-220"},"PeriodicalIF":1.0,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144932023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency and clinical impact of fibromyalgia among patients with multiple sclerosis in Saudi Arabia: A cross-sectional study","authors":"Hind Abdullah Alnajashi","doi":"10.1016/j.ejr.2025.08.001","DOIUrl":"10.1016/j.ejr.2025.08.001","url":null,"abstract":"<div><h3>Background</h3><div>Pain is a prevalent and disabling symptom in multiple sclerosis (MS). Fibromyalgia (FM), a chronic widespread pain syndrome, may coexist with MS and exacerbate fatigue, anxiety, depression, and poor quality of life (QoL). While this association has been studied in Western populations, data from Saudi-Arabia and the Middle-East are limited.</div></div><div><h3>Aim of the work</h3><div>To determine the frequency of FM in Saudi MS patients and assess its impact on fatigue, disability, depression, anxiety, and quality of life as well as its association with disease characteristics and treatment.</div></div><div><h3>Patients and methods</h3><div>This retrospective study included 73 Saudi adults with MS. FM was screened using the Arabic Fibromyalgia Rapid Screening Tool (FiRST). Fatigue was assessed using the modified fatigue impact scale (MFIS), disability via expanded disability status scale (EDSS), depression with the patient health questionnaire (PHQ-9), anxiety with the generalized anxiety disorder (GAD-7) and QoL with the MS international QoL (MusiQoL) questionnaire.</div></div><div><h3>Results</h3><div>The mean patient age was 37.3 ± 10.2 years; 52 females and 21 males. FM was detected in 11 (15.1 %) patients. Disease-modifying therapies were significantly less frequently received by patients with FM (p = 0.015). FIRST score significantly correlated with MFIS (r = 0.45,p &lt; 0.0001), PHQ-9 (r = 0.3,p = 0.009) and GAD-7 (r = 0.29,p = 0.013) and inversely with MusiQoL (r = -0.3,p = 0.011). In regression analysis, fatigue remained the only significant predictor of FM.</div></div><div><h3>Conclusion</h3><div>FM is not uncommon in Saudi MS patients and is associated with fatigue, depression, anxiety, and reduced QoL. Fatigue emerged as a significant predictor of FM. Early identification and integrated management of FM may improve outcomes in MS.</div></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"47 4","pages":"Pages 212-215"},"PeriodicalIF":1.0,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144860287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular involvement in Behçet’s disease patients: Carotid atherosclerosis, neutrophil–lymphocyte ratio, platelet-lymphocyte ratio, and serum asymmetric dimethylarginine","authors":"Omima A. Sayed ,&nbsp;Rasha A. Abdel-Magied ,&nbsp;Hazem M.A. Farrag ,&nbsp;Mostafa A. Abu Elela ,&nbsp;Abdallah M.M. Safwat ,&nbsp;Ahmed M. Abdel-Nasser","doi":"10.1016/j.ejr.2025.07.004","DOIUrl":"10.1016/j.ejr.2025.07.004","url":null,"abstract":"<div><h3>Aim of the work</h3><div>To assess the frequency of subclinical atherosclerosis in Behçet’s disease (BD) and the influence of neutrophil–lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and serum asymmetric dimethylarginine (ADMA) compared to traditional cardiovascular risk factors and their relation to the disease characteristics.</div></div><div><h3>Patients and methods</h3><div>This study included 60 BD patients and 30 age and sex matched healthy controls. The BD current activity form (BDCAF) was scored. Traditional cardiovascular risk factors were evaluated. Complete blood count was assessed and both NLR and PLR were calculated. Serum ADMA level was measured. Radiological evaluation of carotid intima media thickness (CIMT) was performed.</div></div><div><h3>Results</h3><div>The mean age of patients was 36.5 ± 10 years and were 48 males and 12 females (M:F 4:1). BD patients had significantly higher CIMT and carotid atherosclerotic plaques compared to the control (0.53 ± 0.14 versus 0.41 ± 0.09, p &lt; 0.001 and 21.7 % versus 0 % respectively) despite similar rate of traditional cardiovascular risk factors. CIMT of BD patients correlated with age (r = 0.38,p = 0.003), disease duration (r = 0.3,p = 0.02), presence of ocular manifestation (r = 0.31,p = 0.02), waist/hip ratio (WHR)(r = 0.29,p = 0.03), NLR (r = 0.42, p = 0.001), PLR (r = 0.27, p = 0.04) and ADMA (r = 0.5,p &lt; 0.001). Only serum ADMA level was found to be a significant determinant of CIMT in BD (p &lt; 0.001), contributing in 37.9 % of the variance of CIMT. NLR, PLR and ADMA can differentiate BD with subclinical atherosclerosis at cut-off values 2.36, 125.51 and 1.27 umol/L respectively.</div></div><div><h3>Conclusion</h3><div>BD is associated with an increased rate of subclinical atherosclerosis, which is best determined by increased hematological indices and serum ADMA level rather than traditional cardiovascular risk factors.</div></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"47 4","pages":"Pages 201-206"},"PeriodicalIF":1.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144704362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Class V membranous nephropathy in patients with systemic lupus erythematosus: Clinical characteristics, outcome and prognosis","authors":"Nermeen Samy,&nbsp;Sherin H. Hamza,&nbsp;Fatma I. Mabrouk,&nbsp;Duaa F. Atyaallah,&nbsp;Mohammed M. Mohammed","doi":"10.1016/j.ejr.2025.07.003","DOIUrl":"10.1016/j.ejr.2025.07.003","url":null,"abstract":"<div><h3>Aim of the work</h3><div>To study the clinical presentation, course, outcome and prognostic factors of membranous lupus nephritis (MLN) in systemic lupus erythematosus (SLE) patients.</div></div><div><h3>Patients and methods</h3><div>Ninty-six SLE patients with MLN were studied. The SLE disease activity index (SLEDAI) and SLE International Collaborating Clinics damage index (SLICC-DI) were assessed. 48 patients had pure MLN (Class V) and another 48 mixed (membranous plus proliferative classes III/IV) were recruited. The median follow-up was 24 months after the initial renal biopsy.</div></div><div><h3>Results</h3><div>Out of 96 patients, 86 were females and 10 were males with a mean age of 34.9 ± 10.6 years and disease duration of 8.85 ± 1.7 years. 43 (44.8 %) had nephrotic and 25 (26 %) nephritic syndrome.The mean SLICC-DI was 2.46 ± 1.2 while SLEDAI was 12.6 ± 4.3.76 (79.2 %) achieved complete remission, and 20 (20.8 %) partial remission. 4.2 % developed renal or extra-renal flare, 13.5 % had chronic kidney disease. Patients with mixed-type had a significantly higher SLEDAI (p &lt; 0.0001), anti-double-stranded deoxyribonucleic acid (anti-dsDNA) titre (p = 0.028), serum creatinine (p = 0.016), chronicity index of renal biopsy (p = 0.001) and longer duration to achieve nephritis remission (p = 0.001) together with lower creatinine clearance (p = 0.009) in comparison with pure type. SLICC-DI &gt; 3 (p = 0.002), SLEDAI &gt; 14 (p &lt; 0.001), Albumin/ Creatinine &gt; 4.5 g/day (p = 0.013), serum creatinine &gt; 1.36 mg/dl (p &lt; 0.001), creatinine clearance &lt; 84.3 mL/min (p = 0.002), urinary casts (p &lt; 0.0001) and chronicity index &gt; 6 (p = 0.003) were the main predictors of poor outcome among patients with MLN.</div></div><div><h3>Conclusion</h3><div>Mixed MLN had more severe clinical and histological presentations and a longer time to achieve complete and partial remission than the pure MLN.</div></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"47 4","pages":"Pages 207-211"},"PeriodicalIF":1.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144704363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asymptomatic hyperuricemia and the risk of colistin-induced acute kidney injury in critically-ill patients with ventilator-associated pneumonia","authors":"Alia H. Abd El Fatah,&nbsp;Mohamed M.Y. Khaled,&nbsp;Mohammed S. Sayed,&nbsp;Mohamed A. Fakher,&nbsp;Sherif R.A. Mohamed","doi":"10.1016/j.ejr.2025.07.001","DOIUrl":"10.1016/j.ejr.2025.07.001","url":null,"abstract":"<div><h3>Background</h3><div>Hyperuricemia has been associated with many chronic metabolic diseases, such as cardiovascular disease, chronic kidney disease, and metabolic syndrome.</div></div><div><h3>Aim of the work</h3><div>To reveal the risk of hyperuricemia and its association with development of acute kidney injury (AKI) during treatment with colistin incritically-illpatients with multidrug and extensive drug resistant ventilator-associated pneumonia not known to be hyperuricemic.</div></div><div><h3>Patients and methods</h3><div>This study included 60 patients with ventilator-associated pneumonia admitted to the intensive care unit (ICU): 23 with hyperuricemia and 37with normal serum uric acid (SUA) levels. The APACHE II (Acute Physiology And Chronic Health Evaluation) and Sequential Organ Failure Assessment (SOFA) were scored. All patients were receiving intravenous colistin 2.5–5 mg/kg/d in 2–4 divided doses.</div></div><div><h3>Results</h3><div>The mean age of the patients was 61.3 ± 14.4 years, 17 females (F:M 1:2.19), the APACHE II and SOFA were lower in those with hyperuricemia (20.5 ± 6.3 and 16.0 ± 4.9) compared to those with normal SUA (24.8 ± 9.3 and 8.7 ± 5.6; p = 0.0.04 and p = 0.001). 12 (52.1 %) patients with hyperuricemia developed AKI and 11 (47.8 %) died while 5 (13.5 %) developed AKI and 17 (45.9 %) died in those with normal SUA (p = 0.001 and p = 0.89 respectively). The area under the curve (AUC) for SUA levels predicting AKI was 0.77 (95 %CI:0.62–0.9) at &gt; 7 mg/dL (sensitivity 71 %, specificity 77 %) (p = 0.001).</div></div><div><h3>Conclusion</h3><div>Asymptomatic hyperuricemia is a potential risk factor for AKI in critically-ill patients with multidrug resistant ventilator-associated pneumonia. It may play a role in the development of sepsis-related AKI, and managing hyperuricemia could potentially serve as an effective strategy to prevent its development.</div></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"47 4","pages":"Pages 197-200"},"PeriodicalIF":1.0,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144679822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolving role of long non-coding (lnc) RNA RP11-273G15.2, mRNA-RSAD2 and mRNA-IFI44 in systemic lupus erythematosus patients","authors":"Basma R. Sakr ,&nbsp;Neama M Abdelazim ,&nbsp;Olfat G. Shaker ,&nbsp;Mona G. Nada ,&nbsp;Marwa Mamdouh","doi":"10.1016/j.ejr.2025.07.002","DOIUrl":"10.1016/j.ejr.2025.07.002","url":null,"abstract":"<div><div><strong><em>Aim of the work:</em></strong> To assess expression level of long non-coding (lnc) RNA RP11-273G15.2, microRNA (mRNA) RSAD2, and mRNAIFI44 in systemic lupus erythematosus (SLE) patients and to study their relationship with clinical manifestations, hematological indices, and disease activity. <strong><em>Patients and methods</em>:</strong> This study recruited 40 SLE patients and 40 controls. SLE disease activity index (SLEDAI) was assessed. Quantitative analysis by real-time polymerized-chain reaction was accomplished for lncRNA RP11-273G15.2, mRNA-RSAD2 and mRNA-IFI44. <strong><em>Results:</em></strong> The mean age of the patients was 33.4 ± 8.1 years, 36 females (F:M 9:1) and disease duration 7.4 ± 6.2 years. The mRNA IFI44 was significantly upregulated in patients (p = 0.004), while lnc RNA RP11-273G15.2 and mRNA-RSAD2 were comparable between patients and controls. The lnc RNA RP11-273G15.2, mRNA IFI44 and mRNA RSAD2 were similar between patients with and without musculoskeletal, cardiac, pulmonary, mucocutaneous, central nervous system, or renal manifestations. The mRNA RSAD2 exhibited significantly lower expression level in patients with history of thrombosis (p = 0.03). The lnc RNA RP11-273G15.2, mRNA-IFI44 and mRNA-RSAD2 were comparable in relation to the other blood indices anti-dsDNA positivity and complement consumption. There was no association of any of the studied parameters with SLEDAI. <strong><em>Conclusion:</em></strong> The mRNA IFI44 was significantly upregulated in SLE patients signifying its role in the molecular pathophysiology of SLE, while lncRNA RP11-273G15.2, and mRNA-RSAD2 were comparable between patients and controls. The lncRNA RP11-273G15.2, mRNA-IFI44 and mRNA-RSAD2 were not related to clinical manifestations, hematological indices, immune profile, or disease activity of SLE patients, apart from significant down regulation of mRNA-RSAD2 in patients with history of thrombosis.</div></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"47 4","pages":"Pages 192-196"},"PeriodicalIF":1.0,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of clinical characteristics of patients with Behҫet’s disease in two different geographical areas in the United States","authors":"Hamdy Ahmed ,&nbsp;Sebastian E. Sattui ,&nbsp;Dongmei Sun ,&nbsp;Ammar Alkassm ,&nbsp;Angelo Gaffo","doi":"10.1016/j.ejr.2025.06.002","DOIUrl":"10.1016/j.ejr.2025.06.002","url":null,"abstract":"<div><h3>Aim of the work</h3><div>The current data regarding regional differences in the characteristics of Behҫet disease (BD) within the United States are scarce. The aim of the study is to explore these differences in two distinct regions of the United States: Northeast and Southeast.</div></div><div><h3>Patients and Methods</h3><div>This chart review study was conducted at three medical centers. Medical records from patients with ICD-9/10 (136.1/M25.2) codes for BD between 2012 and 2019 were reviewed. Cases included fulfilled the international criteria for BD (ICBD) and International Study Group (ISG) criteria. Data on demographics, clinical and laboratory features was collected. Characteristics were compared by geographic region, sex, and race/ethnicity.</div></div><div><h3>Results</h3><div>A total of 153 patients met ICBD criteria; 77 Northeast and 76 Southeast. The majority of the patients were female (73 %), and white race (73 %), with and median age at diagnosis of 31 years. There was a greater proportion of White non-Hispanic patients in southeast US (85.3 % vs 61 %) and more Hispanic in Northeast (11 % vs 0 %). Females had a higher incidence of genital ulcers (92.5 % vs 69 %, p = 0.01) and arthralgia (34.2 % vs 14.3 %, p = 0.03). Similar trends of race/ethnicity were found using ISG criteria, but no differences in clinical characteristics. Males were more frequent in patients with positive HLA-B51 (50 %) vs negative (22.6 %) (p = 0.048), associated with fewer genital ulcers (55.6 % vs 87 %, p = 0.013), and more gastrointestinal involvement (50 % vs 16.1 %, p = 0.01).</div></div><div><h3>Conclusion</h3><div>In the US, few differences in demographic and clinical features were observed among patients with BD in two different geographical regions.</div></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"47 4","pages":"Pages 187-191"},"PeriodicalIF":1.0,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144535573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}