Egyptian Rheumatologist最新文献

{"title":"Knee ultrasonography in end stage kidney disease patients","authors":"Amany M. Diab ,&nbsp;Manal Eldeeb ,&nbsp;Samar S. Yousuf ,&nbsp;Amr M. Shaker","doi":"10.1016/j.ejr.2024.07.003","DOIUrl":"10.1016/j.ejr.2024.07.003","url":null,"abstract":"<div><h3>Aim of the work</h3><p>To detect ultrasonographic findings in the knees of end stage kidney disease (ESKD) patients on regular hemodialysis.</p></div><div><h3>Patients and methods</h3><p>Thirty adult ESKD patients on regular hemodialysis for more than one year were studied. Patients with gout, knee joint replacement or injection with steroids were excluded. Knee ultrasonography was done to evaluate the femoral cartilage as regards its thickness, sharpness or urate crystal deposition.</p></div><div><h3>Results</h3><p>This study included 13 male (43.3 %) and 17 females (56.7 %) with mean age 45 ± 12 years, body mass index (BMI) 26.4 ± 5.4 Kg/m2, duration of hemodialysis 1.5–27 years and serum uric acid 3.6 (1–10). Femoral cartilage double contour sign was present in 11 (36.7 %) patients, suprapatellar effusion in 20 (66.7 %), suprapatellar aggregates in 10 (33.3 %), medial patellar effusion in 8 (26.7 %), lateral patellar effusion in 12 (40 %) and lateral patellar aggregate was in 6 (20 %). Serum uric acid (SUA) level tended to correlate with body mass index (BMI), total cholesterol, LDL, fasting blood sugar (FBS), and platelet counts without significance and negatively correlated to age, hemoglobin (Hb) level, total leucocytic count (TLC), size of suprapatellar effusion and duration of hemodialysis.</p></div><div><h3>Conclusion</h3><p>Effusion, urate crystal deposition, double contour and aggregate were frequently observed in knee ultrasound in ESRD patients on hemodialysis. Both double contour and aggregates were the most common combined ultrasound finding. The ultrasonographic findings were not related to the duration of hemodialysis or uric acid level.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141950547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"C-reactive protein/albumin ratio and its improvement with disease activity among axial spondyloarthritis and psoriatic arthritis patients: A prospective study","authors":"Noha A. Abdelsalam,&nbsp;Enas I. Abdelhady,&nbsp;Mona Rabie,&nbsp;Reham Abd Elkhalek","doi":"10.1016/j.ejr.2024.07.002","DOIUrl":"10.1016/j.ejr.2024.07.002","url":null,"abstract":"<div><p><strong>Background</strong>: The C-reactive protein /albumin ratio (CAR) has emerged as a novel biomarker in inflammatory conditions. <strong>Aim of the work:</strong> To assess the association of CAR with disease activity and its possible role as a biomarker for improvement among Axial spondyloarthritis (axSpA) and Psoriatic Arthritis (PsA) patients. <strong>Patients and methods:</strong> The study was conducted on 85 axSpA and 51 PsA patients. C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), albumin, CAR, and the AS disease activity score (ASDAS) as well as the disease activity PsA (DAPSA) score measures were calculated at baseline and after three months during the follow-up visit. <strong>Results:</strong> The CAR significantly correlated with the ASDAS in axSpA patients (r = 0.58, p &lt; 0.001) and had a tendency to correlate with the DAPSA in the PsA group. (r = 0.1, p = 0.47). There was a fair agreement between CAR and ASDAS improvements. However, CAR was not suitable for the assessment of improvement in axSpA patients compared to both ASDAS and ASDAS clinically important improvement (ASDAS-CII) (sensitivity:86 %, specificity:46.9 %, accuracy:70.7 %, and sensitivity: 14 %, specificity: 75 %, accuracy: 37.8 %, respectively) or in PsA patients compared to both DAPSA improvement and response (sensitivity: 90 %, specificity: 30 %, accuracy: 78 % and sensitivity: 30 %, specificity: 70 %, accuracy: 38 %, respectively). <strong>Conclusion:</strong> The CAR is a simple rapid inexpensive objective test for evaluating the disease activity in axSpA rather than in PsA. On follow-up, the CAR improvement was unsuitable to assess improvement among axSpA and PsA patients.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141950548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hand and wrist musculoskeletal changes in systemic sclerosis patients","authors":"Caroline S. Morad ,&nbsp;Reem A. Habeeb ,&nbsp;Youssy S. Eshak Gergius ,&nbsp;Youssef S. Hendawy ,&nbsp;Sara M. Othman ,&nbsp;AlShymaa M. Farouk","doi":"10.1016/j.ejr.2024.06.004","DOIUrl":"https://doi.org/10.1016/j.ejr.2024.06.004","url":null,"abstract":"<div><h3>Aim of the work</h3><p>To study hand and wrist musculoskeletal changes among systemic sclerosis (SSc) patients.</p></div><div><h3>Patients and methods</h3><p>Thirty adult SSc patients were enrolled and subjected to detailed medical history, clinical examination, laboratory investigations, and imaging studies including X-ray and musculoskeletal ultrasound (MSUS) on both hands and wrists.</p></div><div><h3>Results</h3><p>The mean age of the studied patients was 40 ± 9.9 years, disease duration 5.4 ± 4.1 years and 28 (93.3 %) were females. Joint space narrowing (JSN) was the commonest finding in plain X-ray being detected in 9 (30 %) patients affecting mostly metacarpophalangeal joints (MCPs). Other X-ray findings included erosions (13.3 %), osteophytes (6.7 %), calcinosis (10 %), acro-osteolysis (13.3 %), and flexion contractures (3.3 %). Tenosynovitis was the most prevalent finding in MSUS detected in 43.3 % with the sclerosing pattern being the dominant type affecting mainly extensor tendons. 23.3 % of patients had active wrist synovitis, while 13.3 % of patients had wrist effusion, 13.3 % had MCP erosions, 13.3 % had MCP JSN, and 10 % had osteophytes. Patients who had no arthritis on presentation had a higher frequency of digital ulcers and tenosynovitis. Regression analysis showed that lack of hydroxychloroquine and methotrexate intake, absence of digital ulcers, presence of morning stiffness, erythrocyte sedimentation rate (ESR) &gt; 27 mm/h and C-reactive protein (CRP) &gt; 9 mg/dL, JSN by X-ray and absence of tenosynovitis by US were associated with arthritis.</p></div><div><h3>Conclusion</h3><p>Articular involvement in SSc is frequent and could be the main presenting symptom. Clinical examination, ESR and CRP testing, along with plain radiography, and musculoskeletal ultrasonography are important to detect arthritis early and treat accordingly.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141541129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A single-center experience: Enteropathic arthritis in inflammatory bowel diseases","authors":"Barış Çabuk ,&nbsp;Dilara Bulut Gökten ,&nbsp;Tevfik Solakoğlu ,&nbsp;Rafet Mete ,&nbsp;Nurten Türkel Küçükmetin ,&nbsp;Rıdvan Mercan","doi":"10.1016/j.ejr.2024.07.001","DOIUrl":"https://doi.org/10.1016/j.ejr.2024.07.001","url":null,"abstract":"<div><h3>Aim of the work</h3><p>To ascertain the frequency of enteropathic arthritis among patients diagnosed with inflammatory bowel disease (IBD) and to investigate the relation between spondyloarthritis (SpA) and patients treated for IBD.</p></div><div><h3>Patients and methods</h3><p>This study examined 124 adult patients with IBD. The evaluation encompassed both axial and peripheral SpA. Information pertaining to the patients’ age, gender, age at the time of IBD and SpA diagnosis, symptoms of inflammatory low back pain (iLBP), dactylitis, peripheral arthritis, history of uveitis, pelvic X-ray, sacroiliac joint magnetic resonance imaging (MRI), ankylosing spondylitis disease actviity score (ASDAS) and Bath ankylosing spondylitis disease actvity index (BASDAI) were compiled.</p></div><div><h3>Results</h3><p>The IBD patients were 82 having ulcerative colitis (UC) and 42 Crohns disease (CD). 58 (46.8 %) were female and 66 (53.2 %) males. 36 (29 %) were diagnosed with SpA, 18 males and 18 females. The age of the patients was 49 ± 11.2 years (18–74 years). The duration of IBD was 5.96 ± 5.54 years (1–29 years). Sacroiliitis was assessed in 60 (48.3 %) patients using MRI. None of the patients had psoriasis or uveitis. Dactylitis was present in 1.6 % and enthesitis in 8 % of patients with IBD. In UC group, 18 (21.9 %) were diagnosed with SpA and in CD group, 18 (42.8 %) had SpA. No significant relationship was found between the diagnosis of UC/CD and the general SpA group.</p></div><div><h3>Conclusion</h3><p>A considerable number of individuals with IBD also experience SpA. Any delay in diagnosing enteropathic arthritis could lead to functional limitations. Therefore, timely diagnosis is crucial to facilitate optimal treatment.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141541128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasoundhydrodistention in adhesivecapsulitis: Hospital versus home-based rehabilitation","authors":"Danilo Donati ,&nbsp;Roberto Tedeschi ,&nbsp;Paolo Spinnato ,&nbsp;Davide Pederiva ,&nbsp;Federico Pilla ,&nbsp;Cesare Faldini ,&nbsp;Maria Grazia Benedetti ,&nbsp;Enrico Guerra ,&nbsp;Marco Cavallo ,&nbsp;Marco Miceli ,&nbsp;Stefano Galletti ,&nbsp;Fabio Vita","doi":"10.1016/j.ejr.2024.06.003","DOIUrl":"https://doi.org/10.1016/j.ejr.2024.06.003","url":null,"abstract":"<div><h3>Background</h3><p>Adhesive capsulitis, or frozen shoulder, causes pain and reduces glenohumeral joint motion.</p></div><div><h3>Aim of the work</h3><p>This study aims to assesses ultrasound-guided hydrodistention with rehabilitation in hospital versus home settings.</p></div><div><h3>Patients and methods</h3><p>Forty patients with adhesive capsulitis were split into two groups: one received hydrodistention with hospital-assisted rehabilitation, and the other with home-based rehabilitation, following the same exercise protocol. Clinical assessments included range of motion (ROM), numeric pain rating scale (NPRS), shoulder pain and disability index (SPADI), disability of the arm, shoulder and hand (DASH), and assessment shoulder and elbow scale (ASES)</p></div><div><h3>Results</h3><p>The hospital-based group showed more rapid and substantial improvements in ROM and NPRS scores compared to the home-based group. The hospital-based group had a mean flexion ROM of 104.3 ± 31.6°, which increased to 149.5 ± 20.6° at the final follow-up. The home-based group started with a mean flexion ROM of 103.3 ± 29.2°, improving to 161.3 ± 23.2° by the end of the study. Both groups showed significant improvements, with the home-based group slightly outperforming in flexion ROM by the third follow-up. Initial NPRS scores were 4.7 ± 1.92 for the hospital-based group and 6.6 ± 1.63 for the home-based group. By the six-month mark, the hospital-based group’s SPADI score dropped to 17.4 ± 19.5, while the home-based group’s score was 10.5 ± 13.03. Both groups demonstrated significant improvements, with the hospital-based group showing slightly better outcomes at various follow-ups.</p></div><div><h3>Conclusion</h3><p>Hydrodistention combined with supervised rehabilitation is optimal for treating frozen shoulder, though home-based therapy is also effective. Both methods significantly benefit from hydrodistention, highlighting its importance in treatment strategies.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1110116424000759/pdfft?md5=045611f9515672ed3bf1755c574098eb&pid=1-s2.0-S1110116424000759-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141541127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between dry eye disease subtypes and rheumatoid arthritis","authors":"Hugo Pena-Verdeal ,&nbsp;Jacobo Garcia-Queiruga ,&nbsp;Belén Sabucedo-Villamarin ,&nbsp;Carlos Garcia-Resua ,&nbsp;Maria J. Giraldez ,&nbsp;Eva Yebra-Pimentel","doi":"10.1016/j.ejr.2024.06.002","DOIUrl":"https://doi.org/10.1016/j.ejr.2024.06.002","url":null,"abstract":"<div><h3>Aim of the work</h3><p>To evaluate the association of dry eye disease (DED) subtypes (aqueous deficient dry eye, ADDE and evaporative dry eye, EDE) and the presence of rheumatoid arthritis (RA) in patients.</p></div><div><h3>Patients and methods</h3><p>260 volunteer DED participants were recruited for an observational cross-sectional study based on the Tear Film Ocular Society Dry Eye Workshop II criteria, which included tear film osmolarity, fluorescence break-up time, and ocular surface damage assessment. Participants were recruited using QR linked to designated mobile forms to obtain symptomatology status, demographics, and RA diagnosis by their medical doctor. Tear meniscus and lipid layer were also evaluated to differentiate between ADDE, EDE, or mixed dry eye in addition to the DED diagnostic criteria. Participants with mixed dry eye were excluded from the analysis to avoid bias.</p></div><div><h3>Results</h3><p>After initial recruitment, 149 eligible participants with an ADDE or EDE diagnosis were included in the final analysis, where 12,1% have an RA diagnosis. The ADDE group had a higher likelihood of having RA (OR = 4.69, 95 %CI = 1.46–15.01) than the EDE group. Additionally, the number of participants with RA in the ADDE group was statistically higher than those in the EDE group (all p = 0.006). Furthermore, a correlation was obtained between RA and a diagnosis of ADDE (p = 0.005).</p></div><div><h3>Conclusion</h3><p>There was a significant association between ADDE and the presence of RA in patients and the association was more likely compared to those with EDE. This finding underscores the need for specific diagnostic and management strategies for RA patients presenting with DED.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141483615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Esophageal stenosis as an initial presentation of Behçet’s disease: A case report and literature review","authors":"Samaher Almousa ,&nbsp;Aya Alhalaki ,&nbsp;Ali Ahmad ,&nbsp;Adnan Abdulhaleem ,&nbsp;Ramy Khazem","doi":"10.1016/j.ejr.2024.06.001","DOIUrl":"https://doi.org/10.1016/j.ejr.2024.06.001","url":null,"abstract":"<div><h3>Introduction</h3><p>Behçet’s disease (BD) is a multiorgan inflammatory vascular disease of unknown etiology, affecting vessels of any size and type. While, gastrointestinal involvement in BD is uncommon, esophageal Behçet’s disease (EBD) is rarely reported, especially in the Mediterranean region.</p></div><div><h3>Aim of the work</h3><p>To report a case with esophageal stenosis as an initial presentation of BD and compare to reported cases worldwide.</p></div><div><h3>Case presentation</h3><p>A 30-year-old Syrian male presented with dysphagia, odynophagia with weight loss 20 kg. He had a history of recurrent oral ulcers and was otherwise healthy. On examination he appeared pale, dehydrated with normal systemic examination. Blood tests revealed anemia (hemoglobin 10.5 mg/dl), elevated erythrocyte sedimentation rate (ESR) (90 mm/1^sthr) and C-reactive protein (CRP)(98 mg/dl)levels. Upper gastrointestinal endoscopy showed mild ulceration with edema and mucosal thickness at the upper sphincter of the esophagus, leading to stenosis. Biopsy showed nonspecific inflammation, without granulomas or signs of malignancy. Percutaneous endoscopic gastrostomy (PEG) tube was placed and during hospitalization he developed genital ulcers and hemoptysis, with chest computed tomography revealing pulmonary vasculitis. The patient was diagnosed with BD, and treated with methylprednisolone and cyclophosphamide, leading to significant improvement. After two months he could swallow normally, and the PEG tube was removed with no recurrence after one year follow-up. He was maintained on azathioprine 100 g/day and prednisolone 7.5 mg/day.</p></div><div><h3>Conclusion</h3><p>BD is a diagnostic challenge due to its diverse manifestations and geographic variations. EBD is rare and can cause disability. Early diagnosis of EBD and appropriate treatment are crucial for improving outcomes.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141483614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic mutations and left ventricular dysfunction in children with familial Mediterranean fever","authors":"Doaa AbdelAziz ,&nbsp;Hanan Zekri ,&nbsp;Huda Marzouk ,&nbsp;Antoine AbdelMassih ,&nbsp;Rehab Elrifi ,&nbsp;Hala Talaat","doi":"10.1016/j.ejr.2024.05.001","DOIUrl":"https://doi.org/10.1016/j.ejr.2024.05.001","url":null,"abstract":"<div><h3>Aim of the work</h3><p>To evaluate subclinical cardiac involvement and ventricular function in children with familial Mediterranean fever (FMF) using speckle-tracking modalities and Doppler tissue imaging (DTI) and to study the association between ventricular dysfunction and genetic mutations.</p></div><div><h3>Patients and methods</h3><p>Fifty children with FMF with no cardiac symptoms were compared to 50 matched control. Echocardiographic data was recorded, including global longitudinal strain (GLS) and global circumferential strain (GCS) for assessment of the left ventricle systolic function using speckle tracking technique and the (E/E') ratio between early filling velocity (E) and peak early diastolic myocardial lengthening velocity (E'). Genetic mutation testing for M694I, M694V, M680I, E148Q was performed.</p></div><div><h3>Results</h3><p>Patients' mean age was 10.7 ± 2.6 years, 27 (54 %) were girls, and 52 % had homozygous mutations. M694I (20 %), M694V (18 %), and M680I (16 %) were the most common mutations. Diastolic dysfunction indicators (average E/É) were significant compared to control (p = 0.004). Patients had lower GLSs (p = 0.0001) and GCSs (p &lt; 0.0001). The M680I mutation was associated with increased left ventricular end-diastolic volume (p = 0.005) and average E/E' (p = 0.002). M694I mutation was associated with increased E/E' (p = 0.048), decreased GLS (p = 0.016), and GCS (p = 0.023). The M694V mutation was associated with increased disease severity (p = 0.008). The combination of M680I and V726A mutations was associated with a reduced ejection fraction (p = 0.001).</p></div><div><h3>Conclusion</h3><p>Children with FMF tend to have subclinical left ventricular diastolic dysfunction. Certain genetic mutations increase the likelihood of systolic ventricular dysfunction.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141073237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender-driven thyroid dysfunction in systemic lupus erythematosus patients: Clinical significance of an overlooked association and global stance","authors":"Ibtisam M.A. Jali","doi":"10.1016/j.ejr.2024.05.002","DOIUrl":"https://doi.org/10.1016/j.ejr.2024.05.002","url":null,"abstract":"<div><h3>Aim of the work</h3><p>This study aimed to determine the association of thyroid dysfunction in systemic lupus erythematosus (SLE) patients.</p></div><div><h3>Patients and methods</h3><p>Out of a cohort including 312 adult SLE patients those with thyroid dysfunction (n = 53) were further evaluated. The medical history, clinical examination, laboratory investigations and medications received were recorded. The SLICC damage index (SLICC-DI) was assessed.</p></div><div><h3>Results</h3><p>Thyroid dysfunction formed 17 % of the patients and their mean age was 39.5 ± 11.5 years and disease duration 5.6 ± 3.3 years were comparable to those without thyroid disorder, however female gender was predominantly higher (F:M 52:1 vs 6.2:1, p &lt; 0.0001). The frequency of thyroid dysfunction was alike in Saudi (16 %) and non-Saudi (17.9 %) patients (p = 0.66). The majority of cases (96.2 %) had hypothyroidism, one with autoimmune thyroiditis, while only 2 (3.8 %) had hyperthyroidism. There was a significantly increased frequency of associated neuropsychiatric manifestations (64.2 % vs 45.2 %;p = 0.012), and hematological involvement (32.1 % vs 14.3 %; p = 0.011) and less complement (C4) consumption (15.1 % vs 23.6 %; p = 0.048) in those with thyroid dysfunction compared to those without. The frequency of anti-double stranded deoxyribonucleic acid (anti-dsDNA) positivity tended to be higher (71.7 % vs 66.8 %) and its titre significantly lower (316.3 ± 319.8 IU/ml vs 461.3 ± 459.1; p = 0.013). The SLICC-DI and mortality rate were comparable between groups. Only the presence of proteinuria inversely significantly correlated with the level of T4 (r = -0.31, p = 0.007).</p></div><div><h3>Conclusion</h3><p>Thyroid dysfunction forms a notable percentage of SLE patients with a prominent female gender propensity. The significant relation of thyroid disorders to neuropsychiatric manifestations, hematological involvement, C4 consumption and anti-dsDNA deserves recognition.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141068821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trunk position sense, spine posture and static postural sway in axial spondyloarthritis patients: Relation to disease metrology, activity and functional status","authors":"Yasemin Mirza ,&nbsp;Bahar Anaforoğlu ,&nbsp;Tülin Düger ,&nbsp;Adem Küçük","doi":"10.1016/j.ejr.2024.04.006","DOIUrl":"https://doi.org/10.1016/j.ejr.2024.04.006","url":null,"abstract":"<div><h3>Aim of the work</h3><p>This study aimed to compare trunk position sense, spine posture and postural stability, among non-radiographic axial spondyloarthritis (nr-axSpA), ankylosing spondylitis (AS) patients and healthy controls and explore the potential relationships between these parameters and disease-related characteristics.</p></div><div><h3>Patients and methods</h3><p>Twenty four patients with AS, 23 patients with nr-axSpA, and 24 age and gender-matched healthy controls were participated in this study. A digital inclinometer was used to measure trunk repositioning error (TRE) and spine posture. Postural stability was evaluated with a stabilometric platform. In addition, disease activity, spinal mobility and functional capacity were evaluated with Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis Metrology Index and Bath Ankylosing Spondylitis Functional Index, respectively.</p></div><div><h3>Results</h3><p>The 47 patients mean age was 38.83 ± 9.3 years and were 34 females and 13 males. TRE was higher in AS and nr-axSpA patients compared to control (p &lt; 0.001). AS and nr-axSpA patients presented higher thoracic curvature and lower lumbal lordosis compared to controls (p &lt; 0.05) whereas there was no significant difference between nr-axSpA and AS (p = 0.97). The degree of thoracic curvature was higher in AS compared to nr-axSpA (p = 0.002). Mediolateral stability in eyes closed was significantly higher in AS and nraxSpA than control (p = 0.001). Time since onset of symptoms, which might affect radiographic spinal damage, was significantly associated with TRE in patients with AS (r = 0.703, p = 0.005).</p></div><div><h3>Conclusion</h3><p>Radiographic status may alter spinal mobility, spine posture and trunk position sense in axSpA patients. Different approaches might need to improve these parameters in different subtypes of axSpA.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140894748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}