Egyptian Rheumatologist最新文献

{"title":"Mental health problems among children with lupus nephritis","authors":"Heba T. Osman ,&nbsp;Dina Y. Afifi ,&nbsp;Zynab F. Mohammed ,&nbsp;Hend M. Abu Shady","doi":"10.1016/j.ejr.2024.08.002","DOIUrl":"10.1016/j.ejr.2024.08.002","url":null,"abstract":"<div><h3>Aim of the work</h3><p>To assess and compare depression, anxiety, and cognitive impairments in juvenile systemic erythematous lupus (JSLE) children with lupus nephritis (LN) during the induction and maintenance phases of treatment and to investigate the association with disease activity, damage and immunosuppressive medications.</p></div><div><h3>Patients and methods</h3><p>This study included 33 patients diagnosed as JSLE with LN. Attention and working memory were assessed by the working memory index Wechsler Intelligence Scale (WISC). Depression and anxiety were assessed by the Children Depression Inventory (CDI) and the Spence Children Anxiety Scale respectively. The SLE disease activity index 2000 (SLEDAI-2 K) was recorded.</p></div><div><h3>Results</h3><p>The mean age of the children was 11.6 ± 2.2 years, 88 % were females and 12 % males with disease duration of 16.9 ± 9.2 months and age at onset of 10.2 ± 2.3 years. Mean anxiety scores were higher among patients during the induction phase than those during maintenance phase (62.1 ± 7.2 and 40.2 ± 8.8 respectively; p &lt; 0.001). The depression score was higher in the induction (19 ± 5.5) than in the maintenance group (12.4 ± 5.6) (p = 0.002). Mean anxiety scores significantly correlated with SLEDAI-2 K and corticosteroids dose (r = 0.58 and r = 0.43, p = 0.0004 and p = 0.013 respectively) and a significant negative correlation with duration of corticosteroids and number of cyclophosphamide doses (r = 0.46 and r = 0.69, p = 0.008 and p = 0.0001 respectively).</p></div><div><h3>Conclusion</h3><p>Depression and anxiety levels were higher in children with LN during the induction phase of treatment than those in the maintenance phase. Mental health problems must be screened among children with LN and treating these problems can improve the medical and psychosocial outcomes.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"46 4","pages":"Pages 198-201"},"PeriodicalIF":1.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142058512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Egyptian patients with axial spondyloarthritis: The frequency and predictors of renal impairment","authors":"Dina M. Abd EL-Khalik ,&nbsp;Adel M. Elsayed ,&nbsp;Aya A. Abdallah ,&nbsp;Nashwa A. Morshedy","doi":"10.1016/j.ejr.2024.08.001","DOIUrl":"10.1016/j.ejr.2024.08.001","url":null,"abstract":"<div><h3>Aim of the work</h3><p>To determine the frequency of and risk factors for renal impairment in patients with axial spondyloarthritis (axSpA).</p></div><div><h3>Patients and methods</h3><p>Fifty axSpA patients participated in this study. In accordance with the Kidney Disease Outcomes Quality Initiative (K/DOQI) criteria, patients were split into two groups: group 1comprised renal impairment and group 2 comprised non-renal impairment. The ankylosing spondylitis (AS) disease activity score (ASDAS), Bath AS disease activity index (BASDAI) and estimated glomerular filtration rate were assessed.</p></div><div><h3>Results</h3><p>The mean age of patients was 38.9 ± 11.7 years, males were 54 % and the disease duration was 11.36 ± 6.1 years. The mean ASDAS score was 5.58 ± 1.38 and BASDAI was 5.18 ± 1.55. The eGFR was 76.4 ± 36.2 ml/min/1.73 m² and 28 % had positive human leucocytic antigen (HLA-B27). 80 % were receiving biologic therapy. Nephropathy by ultrasound and renal impairment were detected in 34 % and 52 % of the cases respectively. The cumulative dose of non-steroidal anti-inflammatory drugs (NSAIDs), C-reactive protein, erythrocyte sedimentation rate, low density cholesterol, blood urea nitrogen, creatinine, proteinuria, ASDAS and BASDAI were significantly higher in those with renal impairment(p = 0.0001, p = 0.0001, p = 0.001, p = 0.035, p = 0.0001, p = 0.0001, p = 0.0001, p = 0.001, p = 0.001 respectively) while the eGFR and high density lipoprotein were significantly lower (p = 0.001and p = 0.02). Only the cumulative dose of NSAIDs was a significantly independent variable influencing the development of renal impairment (OR=1.01, CI; 1.001–1.02, p = 0.024) at cut-off level &gt; 1166.3 g.</p></div><div><h3>Conclusions</h3><p>Renal impairment is frequent in axSpA patients with decreased eGFR and high disease activity. The cumulative dose of NSAIDs is a significant predictor of renal impairment.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"46 4","pages":"Pages 202-206"},"PeriodicalIF":1.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142058513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasoundhydrodistention in adhesivecapsulitis: Hospital versus home-based rehabilitation","authors":"Danilo Donati ,&nbsp;Roberto Tedeschi ,&nbsp;Paolo Spinnato ,&nbsp;Davide Pederiva ,&nbsp;Federico Pilla ,&nbsp;Cesare Faldini ,&nbsp;Maria Grazia Benedetti ,&nbsp;Enrico Guerra ,&nbsp;Marco Cavallo ,&nbsp;Marco Miceli ,&nbsp;Stefano Galletti ,&nbsp;Fabio Vita","doi":"10.1016/j.ejr.2024.06.003","DOIUrl":"https://doi.org/10.1016/j.ejr.2024.06.003","url":null,"abstract":"<div><h3>Background</h3><p>Adhesive capsulitis, or frozen shoulder, causes pain and reduces glenohumeral joint motion.</p></div><div><h3>Aim of the work</h3><p>This study aims to assesses ultrasound-guided hydrodistention with rehabilitation in hospital versus home settings.</p></div><div><h3>Patients and methods</h3><p>Forty patients with adhesive capsulitis were split into two groups: one received hydrodistention with hospital-assisted rehabilitation, and the other with home-based rehabilitation, following the same exercise protocol. Clinical assessments included range of motion (ROM), numeric pain rating scale (NPRS), shoulder pain and disability index (SPADI), disability of the arm, shoulder and hand (DASH), and assessment shoulder and elbow scale (ASES)</p></div><div><h3>Results</h3><p>The hospital-based group showed more rapid and substantial improvements in ROM and NPRS scores compared to the home-based group. The hospital-based group had a mean flexion ROM of 104.3 ± 31.6°, which increased to 149.5 ± 20.6° at the final follow-up. The home-based group started with a mean flexion ROM of 103.3 ± 29.2°, improving to 161.3 ± 23.2° by the end of the study. Both groups showed significant improvements, with the home-based group slightly outperforming in flexion ROM by the third follow-up. Initial NPRS scores were 4.7 ± 1.92 for the hospital-based group and 6.6 ± 1.63 for the home-based group. By the six-month mark, the hospital-based group’s SPADI score dropped to 17.4 ± 19.5, while the home-based group’s score was 10.5 ± 13.03. Both groups demonstrated significant improvements, with the hospital-based group showing slightly better outcomes at various follow-ups.</p></div><div><h3>Conclusion</h3><p>Hydrodistention combined with supervised rehabilitation is optimal for treating frozen shoulder, though home-based therapy is also effective. Both methods significantly benefit from hydrodistention, highlighting its importance in treatment strategies.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"46 4","pages":"Pages 166-170"},"PeriodicalIF":1.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1110116424000759/pdfft?md5=045611f9515672ed3bf1755c574098eb&pid=1-s2.0-S1110116424000759-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141541127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic mutations and left ventricular dysfunction in children with familial Mediterranean fever","authors":"Doaa AbdelAziz ,&nbsp;Hanan Zekri ,&nbsp;Huda Marzouk ,&nbsp;Antoine AbdelMassih ,&nbsp;Rehab Elrifi ,&nbsp;Hala Talaat","doi":"10.1016/j.ejr.2024.05.001","DOIUrl":"https://doi.org/10.1016/j.ejr.2024.05.001","url":null,"abstract":"<div><h3>Aim of the work</h3><p>To evaluate subclinical cardiac involvement and ventricular function in children with familial Mediterranean fever (FMF) using speckle-tracking modalities and Doppler tissue imaging (DTI) and to study the association between ventricular dysfunction and genetic mutations.</p></div><div><h3>Patients and methods</h3><p>Fifty children with FMF with no cardiac symptoms were compared to 50 matched control. Echocardiographic data was recorded, including global longitudinal strain (GLS) and global circumferential strain (GCS) for assessment of the left ventricle systolic function using speckle tracking technique and the (E/E') ratio between early filling velocity (E) and peak early diastolic myocardial lengthening velocity (E'). Genetic mutation testing for M694I, M694V, M680I, E148Q was performed.</p></div><div><h3>Results</h3><p>Patients' mean age was 10.7 ± 2.6 years, 27 (54 %) were girls, and 52 % had homozygous mutations. M694I (20 %), M694V (18 %), and M680I (16 %) were the most common mutations. Diastolic dysfunction indicators (average E/É) were significant compared to control (p = 0.004). Patients had lower GLSs (p = 0.0001) and GCSs (p &lt; 0.0001). The M680I mutation was associated with increased left ventricular end-diastolic volume (p = 0.005) and average E/E' (p = 0.002). M694I mutation was associated with increased E/E' (p = 0.048), decreased GLS (p = 0.016), and GCS (p = 0.023). The M694V mutation was associated with increased disease severity (p = 0.008). The combination of M680I and V726A mutations was associated with a reduced ejection fraction (p = 0.001).</p></div><div><h3>Conclusion</h3><p>Children with FMF tend to have subclinical left ventricular diastolic dysfunction. Certain genetic mutations increase the likelihood of systolic ventricular dysfunction.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"46 3","pages":"Pages 152-156"},"PeriodicalIF":0.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141073237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of musculoskeletal ultrasonography in the assessment of disease activity in juvenile idiopathic arthritis children","authors":"Tasneem E. El Naggar ,&nbsp;Samah I. Nasef ,&nbsp;Mohsen H. Elshahaly ,&nbsp;Kareem M. El Ashry ,&nbsp;Aziza S. Omar","doi":"10.1016/j.ejr.2024.04.004","DOIUrl":"https://doi.org/10.1016/j.ejr.2024.04.004","url":null,"abstract":"<div><h3>Aim of the work</h3><p>To assess synovitis and disease activity by musculoskeletal ultrasound (MSUS) and clinical examination in children with juvenile idiopathic arthritis (JIA).</p></div><div><h3>Patients and methods</h3><p>Forty-one JIA patients underwent clinical examination of the joints, juvenile arthritis disease activity score (JADAS-27) assessment, and laboratory investigations. Twenty-four joints for each patient were evaluated by MSUS, including knees, wrists, 10 proximal interphalangeal, and 10 metacarpophalangeal. The parameters evaluated were synovial effusion, hypertrophy, effusion plus hypertrophy, tenosynovitis, and subclinical synovitis based on the Outcome Measures in Rheumatology definitions.</p></div><div><h3>Results</h3><p>The mean age of children was 11.7 ± 3.2 years, the disease duration was 4.2 ± 2.6 years and they were polyarticular (n = 22), oligoarticular (n = 12), systemic onset (n = 6) and one had ERA. They were 29 females and 12 males. The mean JADAS27 was 7.7 ± 6.9. The total number of joints assessed clinically and by MSUS was 984. 107 (10.9 %) joints showed clinical findings, while 135 (13.7 %) showed ultrasonographic features of synovitis. On clinical examination, 17 (15.9 %) joints had limited range of motion, and 90 (84 %) joints were tender including 38 (35.5 %) swollen. On MSUS examination, 28 (20.7 %) joints showed synovial effusion, 79 (58.5 %) hypertrophy, and 28 (20.7 %) had both synovial effusion and hypertrophy. Power Doppler signals were detected in 27 joints. MSUS detected subclinical synovitis in 60 (6.1 %) joints. Synovial effusion plus hypertrophy showed moderate concordance with joint swelling (k = 0.42).</p></div><div><h3>Conclusion</h3><p>The MSUS examination has a significant role in the detection of synovitis and the evaluation of disease activity in JIA patients. It is more sensitive than clinical examination.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"46 3","pages":"Pages 125-129"},"PeriodicalIF":0.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140604717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender-driven thyroid dysfunction in systemic lupus erythematosus patients: Clinical significance of an overlooked association and global stance","authors":"Ibtisam M.A. Jali","doi":"10.1016/j.ejr.2024.05.002","DOIUrl":"https://doi.org/10.1016/j.ejr.2024.05.002","url":null,"abstract":"<div><h3>Aim of the work</h3><p>This study aimed to determine the association of thyroid dysfunction in systemic lupus erythematosus (SLE) patients.</p></div><div><h3>Patients and methods</h3><p>Out of a cohort including 312 adult SLE patients those with thyroid dysfunction (n = 53) were further evaluated. The medical history, clinical examination, laboratory investigations and medications received were recorded. The SLICC damage index (SLICC-DI) was assessed.</p></div><div><h3>Results</h3><p>Thyroid dysfunction formed 17 % of the patients and their mean age was 39.5 ± 11.5 years and disease duration 5.6 ± 3.3 years were comparable to those without thyroid disorder, however female gender was predominantly higher (F:M 52:1 vs 6.2:1, p &lt; 0.0001). The frequency of thyroid dysfunction was alike in Saudi (16 %) and non-Saudi (17.9 %) patients (p = 0.66). The majority of cases (96.2 %) had hypothyroidism, one with autoimmune thyroiditis, while only 2 (3.8 %) had hyperthyroidism. There was a significantly increased frequency of associated neuropsychiatric manifestations (64.2 % vs 45.2 %;p = 0.012), and hematological involvement (32.1 % vs 14.3 %; p = 0.011) and less complement (C4) consumption (15.1 % vs 23.6 %; p = 0.048) in those with thyroid dysfunction compared to those without. The frequency of anti-double stranded deoxyribonucleic acid (anti-dsDNA) positivity tended to be higher (71.7 % vs 66.8 %) and its titre significantly lower (316.3 ± 319.8 IU/ml vs 461.3 ± 459.1; p = 0.013). The SLICC-DI and mortality rate were comparable between groups. Only the presence of proteinuria inversely significantly correlated with the level of T4 (r = -0.31, p = 0.007).</p></div><div><h3>Conclusion</h3><p>Thyroid dysfunction forms a notable percentage of SLE patients with a prominent female gender propensity. The significant relation of thyroid disorders to neuropsychiatric manifestations, hematological involvement, C4 consumption and anti-dsDNA deserves recognition.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"46 3","pages":"Pages 147-151"},"PeriodicalIF":0.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141068821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics of systemic lupus erythematosus in Al Qassim region of Saudi Arabia","authors":"Ahmad AlShomar ,&nbsp;Idris Sula ,&nbsp;Hussam A. Alsulmi ,&nbsp;Mohamed Mahmoud Bakr","doi":"10.1016/j.ejr.2024.04.003","DOIUrl":"https://doi.org/10.1016/j.ejr.2024.04.003","url":null,"abstract":"<div><h3>Aim of the work</h3><p>The aim of the study is to explore the clinical manifestations, laboratory findings, and management of systemic lupus erythematosus (SLE) patients in Al Qassim region of Saudi Arabia.</p></div><div><h3>Patients and methods</h3><p>The clinical data, laboratory investigations, medications received and co-morbidities from SLE patients in Al Qassim region of Saudi Arabia were recorded.</p></div><div><h3>Results</h3><p>The 96 SLE patients were 87 (90.63 %) Saudi. 83 (86.5 %) were females and 13 (13.5 %) males (F:M 6.3:1). The mean age of the patients was 37.4 ± 11.9 years; at time of diagnosis was 32.3 ± 11.1 years, disease duration 5.1 ± 5.8 years. 9.3 % were hypertensive. The most common clinical manifestations were musculoskeletal (79 %) and constitutional (77 %) followed by mucocutaneous (42 %). Lupus nephritis was diagnosed in 25 % of patients and was confirmed by renal biopsy in 13.5 %. 4.2 % had thromboembolic disorders. Co-morbidities were present in 25 % and pregnancy complications were reported in 18 % of the females. Anemia was present in 63.5 %, leukopenia in 20 % and thrombocytopenia in 15 %. All patients tested positive for antinuclear antibodies, 80 % positive for anti-double-stranded deoxyribonucleic acid and 42.7 % anti-Smith. Antiphospholipid antibodies were detected in 46 % of patients and rheumatoid factor in 15.6 %. 93.8 % of patients received hydroxychloroquine, 76 % received steroids, 29.2 % mycophenolate mofetil, 4 patients received rituximab and 3 belimumab.</p></div><div><h3>Conclusion</h3><p>The most common clinical disease profile in SLE patients from AlQassim was musculoskeletal and constitutional symptoms. 25 % of the patients had LN and 25 % had co-morbidities. Anemia is a common laboratory finding, and hydroxychloroquine is the most common treatment.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"46 3","pages":"Pages 121-124"},"PeriodicalIF":0.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140604716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep disorders in rheumatoid arthritis patients","authors":"Mouna Brahem ,&nbsp;Azer Chebil ,&nbsp;Hayfa Abid ,&nbsp;Olfa Jomaa ,&nbsp;Rihab Sarraj ,&nbsp;Besma Jebali ,&nbsp;Sirine Abdellatif ,&nbsp;Amani ben Salem ,&nbsp;Haifa Hachfi ,&nbsp;Khalifa Mighri ,&nbsp;Mohamed Younes","doi":"10.1016/j.ejr.2024.03.001","DOIUrl":"https://doi.org/10.1016/j.ejr.2024.03.001","url":null,"abstract":"<div><h3>Aim of the work</h3><p>To determine the frequency of sleep disturbances in patients with rheumatoid arthritis (RA) and to identify associated factors.</p></div><div><h3>Patients and methods</h3><p>This study included 100 RA patients. The disease activity score (DAS28), tender joint count (TJC), swollen joint count (SJC), Visual Analog Scale (VAS)-pain and Health Assessment Questionnaire (HAQ) were assessed. Epworth Sleepiness Scale (ESS) and Pittsburgh Sleep Quality Index (PSQI) were used to assess sleep quality.</p></div><div><h3>Results</h3><p>The patients were 89 females and 11 males, mean age 53.2 ± 11.2 years (21–76 years) and disease duration was 11.1 ± 8.9 years (1–40 years).The meanTJC was 8.5 ± 7.9 (0–24), SJC 4 ± 4.8 (0–24) and VAS 51 ± 21 mm (10–90 mm). Their mean DAS28 was 3.9 ± 1.1 (1–6.15) and HAQ 1.3 ± 0.7 (0–2.9). The ESS was 7.9 ± 5.6 (0–24). 28 % of patients had signs of daytime sleepiness (ESS ≥ 11 points) with a significant association with female sex (p = 0.03), TJC (p = 0.03), SJC (p = 0.02), DAS28 (p = 0.05), VAS (p = 0.04) and HAQ (p &lt; 0.01). The mean Pittsburgh score was 6.9 ± 5.1 (0–19). 51 % of patients had disturbed sleep (PSQI &gt; 5.5 points). The most disturbed components were respectively sleep latency (1.5 ± 1.1), subjective sleep quality (1.25 ± 0.8) and sleep disorders (1.19 ± 0.8). Disturbed sleep assessed by PSQI had a significant association with TJC (p &lt; 0.01), SJC (p &lt; 0.01), C-reactive protein, nocturnal awakening (p &lt; 0.01), DAS28 (p &lt; 0.01), VAS-pain (p &lt; 0.01), HAQ (p &lt; 0.01), and corticosteroid intake (p = 0.01).</p></div><div><h3>Conclusion</h3><p>Half of the patients had sleep disorders with a significant association with disease activity parameters which underline the importance of ensuring remission or low level of activity to improve the quality of sleep of patients.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"46 3","pages":"Pages 107-111"},"PeriodicalIF":0.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140533878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pattern of uveitis in Behçet’s disease patients from a highly specialized university hospital-based tertiary care eye unit","authors":"Radwa Elzanaty ,&nbsp;Amr M.A. Wassef ,&nbsp;Mina Seif ,&nbsp;Mariam Fadel","doi":"10.1016/j.ejr.2024.04.001","DOIUrl":"https://doi.org/10.1016/j.ejr.2024.04.001","url":null,"abstract":"<div><h3>Aim of the work</h3><p>To determine the frequency and pattern of ocular manifestations including uveitis associated with Behcet’s disease (BD) in patients referred to a hospital-based tertiary care eye unit.</p></div><div><h3>Patients and methods</h3><p>This study included BD patients referred to the Uveitis Clinic, Cairo University Hospitals. Patterns of systemic and ocular disease were documented. Treatment and complications occurring during follow-up were added.</p></div><div><h3>Results</h3><p>The study included 113 patients (208 eyes). 86 % were males and 14 % females. Their mean age was 32.1 ± 9.5 years. Time lapse from diagnosis to referral was 3.8 ± 4.9 years. 15.9 % had unilateral eye involvement and 84.1 % bilateral. Most common presentation was panuveitis in 64.4 % of eyes, whereas 22.6 % presented with isolated posterior uveitis and 12 % with anterior uveitis. Vasculitis was a common finding at presentation in 27.4 %. During the course of ocular disease the most frequent complication was cataract in 27.4 % and 33 % of patients did not develop complications. At presentation, 47.6 % of eyes were worsening despite treatment, 28.8 % were stationary, 16.3 % were controlled and 7.2 % were improving. The mean best corrected visual acuity dropped from 0.48 ± 2.36 to 0.29 ± 0.32 between presentation and last follow up. Visual acuity was significantly reduced in those with panuveitis and optic neuritis (p &lt; 0.001). End-stage eye disease was present in 7.2 % at presentation.</p></div><div><h3>Conclusion</h3><p>Ocular Behcet’s is a frequent finding, especially panuveitis. Retinal vasculitis is not uncommon. Delayed referral to tertiary care eye unit remains a loop hole in the health care system. Cataract is a common complication during the course of the disease.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"46 3","pages":"Pages 112-116"},"PeriodicalIF":0.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140557745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of hsa-let-7f-5p and serum levels of interleukin-10, cystatin-C and transforming growth factor-beta in systemic lupus erythematosus patients with lupus nephritis","authors":"Dina M. Mekawy ,&nbsp;Manar M. Abdel-Aziz ,&nbsp;Raghda E. Ibrahim ,&nbsp;Shaimaa A.K. Rady ,&nbsp;Mohamed T. Hegazy ,&nbsp;Reham A. Dwedar ,&nbsp;Reham M. Raafat Hamed","doi":"10.1016/j.ejr.2024.04.005","DOIUrl":"https://doi.org/10.1016/j.ejr.2024.04.005","url":null,"abstract":"<div><h3>Aim of the work</h3><p>To investigate the impact of mi-RNA (hsa-let-7f-5p) expression, levels of cystatin C, serum interleukin-10 (IL-10), and transforming-growth-factor-beta (TGF-β) in systemic lupus erythematosus (SLE) patients with and without lupus nephritis (LN).</p></div><div><h3>Patients and methods</h3><p>The work included 60 SLE patients: thirty with and thirty without LN, along with thirty matched controls. The SLE disease activity index (SLEDAI) was assessed. Enzyme-linked-immunosorbent-assay (ELISA) was used to evaluate serum levels of TGF-β, IL-10, and Cystatin-C and expression of mi-RNA Let-7f-5p quantified using real-time polymerized-chain-reaction (PCR).</p></div><div><h3>Results</h3><p>The mean age of LN patients was 31.6 ± 8.4 years, twenty-eight females and 2 males. mi-RNA Let-7f-5p, serum TGFβ, IL10, and cystatin C were significantly higher in those with LN (4.4 ± 2, 357.6 ± 50.8 ng/mL, 173.1 ± 18 pg/mL and 8.03 ± 1.96 ng/mL) compared to case without (2.5 ± 0.92, 319.7 ± 44.4 ng/mL, 108.8 ± 22.8 pg/mL, and 3.43 ± 1.1 ng/mL) and control (1.03 ± 0.07, 210.3 ± 18.6 ng/mL, 56 ± 18.5 pg/mL and 2.53 ± 1.1 ng/ml)(p &lt; 0.001). In LN, mi-RNA Let-7f-5p and IL10 were significantly different in those with oral ulcers (n = 8)(p = 0.03, and p = 0.01 respectively). mi-RNA Let-7f-5p and TGF-β were significantly lower in those with headache (n = 3)(p &lt; 0.001, and p = 0.04 respectively). In patients without LN, TGF-β was significantly lower in those with malar rash (n = 10)(p = 0.04) and serum cystatin-C was lower in those with arthritis (n = 12)(p = 0.02). In LN, IL-10 significantly correlated with disease duration (r = 0.38,p = 0.04) and cystatin-C inversely with platelets (r = -0.42,p = 0.02), Cystatin-C correlated with mi-RNA Let-7f-5p (r = 0.45,p = 0.01) and inversely with SLEDAI (r = -0.44,p = 0.01).</p></div><div><h3>Conclusion</h3><p>The potential role of mi-RNA Let-7f-5p on LN with the possible involvement of TGFβ, IL10, and cystatin-C in the pathophysiology of both SLE and LN.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"46 3","pages":"Pages 130-134"},"PeriodicalIF":0.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140618611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}